Identification and Characterization of Antiviral Activity of Synthetic Compounds Against Mayaro Virus by Ana Paula Andreolla, Andrea Cristine Koishi, Alessandra Abel Borges, Larissa Albuquerque de Oliveira, Viviane Guedes de Oliveira, Nerilson Marques Lima, Eloah Pereira Ávila, Pedro Pôssa de Castro, Giovanni Wilson Amarante, Mauro Vieira de Almeida, Juliano Bordignon, Claudia Nunes Duarte dos Santos

“…<b>Background/objectives:</b> In Brazil, the co-circulation of arboviruses—such as dengue, Zika, yellow fever, and Chikungunya viruses—creates a complex epidemiological landscape, drawing attention from health authorities due to high morbidity and mortality rates. …”
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An immunoinformatics approach in designing high-coverage mRNA multi-epitope vaccine against multivariant SARS-CoV-2 by Ernawati Arifin Giri-Rachman, Al Mirahma Febri Kurnianti, Rizarullah, Aditya Hanung Setyadi, Anita Artarini, Marselina Irasonia Tan, Catur Riani, Dessy Natalia, Reza Aditama, Husna Nugrahapraja

“…Furthermore, molecular docking analysis revealed potent interactions between the validated 3D structure and the TLR4 and BCR receptors, while molecular dynamic simulations confirmed the stability of the VC-TLR4 and VC-BCR complexes. Additionally, mRNA codon optimization was performed to enhance vaccine expression efficiency, and secondary structure analysis indicated that the designed mRNA vaccine possessed a stable conformation. …”
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Field programmable silicon microring WDM transceiver leveraging monolithically integrated phase-change materials by Xing Yang, Shihuan Ran, Ziquan Li, Liangjun Lu, Yu Li, Ngon Phu Wai, MingHua Zhang, Guo-Qiang Lo, Jianping Chen, Linjie Zhou

“…These advancements position Sb2Se3-integrated MRRs as a promising solution for large-scale, energy-efficient photonic transceivers in next-generation optical communication systems.…”
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Predicting the strengths of basalt fiber reinforced concrete mixed with fly ash using AML and Hoffman and Gardener techniques by Kennedy C. Onyelowe, Viroon Kamchoom, Shadi Hanandeh, Ahmed M. Ebid, José Luis Llamuca Llamuca, Juan Carlos Cayán Martínez, Evlin Rose, Paul Awoyera, Siva Avudaiappan

“…These models benefit from advanced ensemble techniques that efficiently handle non-linear patterns and noise. SVR also performs admirably, whereas GEP and GMDHNN exhibit weaker predictive capabilities due to limitations in handling complex data dynamics. …”
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Evaluation of a CNN model to map vegetation classification in a subalpine coniferous forest using UAV imagery by Weibo Shi, Xiaohan Liao, Shaoqiang Wang, Huping Ye, Dongliang Wang, Huanyin Yue, Jianli Liu

“…Overall, this study provides an efficient and cost-effective method for monitoring and protecting natural forests, serving as a reference for selecting appropriate parameters in UAV-based deep learning remote sensing.…”
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Optimized Sampling Strategies for Isoniazid in East Asian Pediatric Populations Using Population Pharmacokinetics-Informed Approaches by Ju G, Liu X, Peng Y, Yang W, Xu N, He Q, Zhang C, Chen L, Yang N, Zhang G, Li C, Su P, Zhu X, Ouyang D

“…We employed a model-informed optimization approach based on INH population pharmacokinetic (PopPK) models.Methods: We selected PopPK models for children and East Asian adults and optimized the sampling strategy using PopED (Population Experimental Design), a method that helps identify the most efficient sampling points for maximizing parameter estimation accuracy. …”
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Identifying the Antecedents of Humble Leadership for Managers with a Meta-synthesis Approach by Tahereh Mohammadi, Adel Zahedbabelan, Ali Khaleghkhah, Hossein Taghavi Qarabulagh

“…Objective In the contemporary organizational landscape marked by increasing complexity and a demand for adaptability, the emphasis on bottom-up leadership aspects has gained prominence. …”
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Investigation of Dynamic Characteristics of an Automated Position Long-Stroke Pneumatic Actuator of Fabrication System by D. A. Korotych, V. S. Sidorenko, S. P. Prikhodko

“…A fragment of the program was selected as one of the illustrations. It showed that the software used the following indicators for calculations: target and reduced coordinates; absolute gas constant; coefficients of spring stiffness, resistance, adiabatic and viscous friction in the piston; compressor pressure; mass of the moving parts of the pneumatic actuator; strength of external resistances; diameters of the pipeline, the pneumatic cylinder piston and the braking device; length of the stroke of the cylinder piston; area of piston cavities and throttles; length of the pipeline and its internal volume. …”
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Optimization of the Pedagogical Process in Teaching Chemistry to First-Year Students of the Ural State Medical University by E. Yu. Ermishina, N. A. Naronova, N. N. Kataeva, K. O. Golitsyna, N. A. Belokonova

“…The pedagogical process carried out in teaching chemistry to first-year students of the medical and preventive faculty is a complex system that includes target, content, activity, performance, resource components. …”
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Determination of the metabolites, eicosanoids derived from polyunsaturated fatty acids in Drosophila tissue with high performance liquid chromatography tandem mass spectrometry by TAN Liangliang, SHEN Lirong

“…Lipid signaling that complicates our understanding of fatty acid signaling is highly complex and fine-tuned in mammal species. Fortunately, the small genetic model Drosophila melanogaster is considered to be an ideal model to investigate the flexible nature of eicosanoids signaling pathways. …”
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Reverse vaccinology and immunoinformatics approaches for multi-epitope vaccine design against Klebsiella pneumoniae reveal a novel vaccine target protein by Mayada M. Elfadil, Samah Omer A. Samhoon, Moaaz M. Saadaldin, Sabah A.E. Ibrahim, Ahmed Abdelghyoum M. Mohamed, Omnia H. Suliman, Osama Mohamed, Nadzirah Damiri, Mohd Firdaus-Raih, Sofia B. Mohamed, Qurashi. M. Ali

“…The construct was further optimized for mammalian expression, achieving an ideal GC content (48.27 %) and a codon adaptation index (CAI) of 1.0, facilitating efficient in silico cloning into the pcDNA3 vector. …”
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Determination of High Content of Molybdenum in Molybdenum Ore by Emission Spectrometry with Solid Sampling Technique by Xinwei GUO, Kun LI, Zhihong HAO, Jianzhen YAO, Jinli XU, Jinfeng BAI

“…., which are primarily based on liquid injection, with a lengthy analytical procedure, complex steps, and a measurable range of 0.01%-5.17%[16]. …”
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Constitutive model of metal rubber material considering plastic accumulation behavior by FENG Zhipeng, YANG Fang, FU Hailong, AI Shigang, WANG Yue, YUAN Liangyang

“…This advanced model provides an accurate description of the complex interaction mechanisms occurring among internal coils during loading and unloading processes.…”
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Human motor control during movements with high demands by Paul Kaufmann, Willi Koller, Elias Wallnöfer, Basilio Goncalves, Clara Scheer, Juliana Exel, Olivia Froschauer, Catherine Hlavac, Mathias Wiplinger, Lorenz Zweier, Arnold Baca, Hans Kainz

“…The temporal overlap between different synergies within one trial and the trial-to-trial similarity between different trials within one synergy were determined through the Pearson correlation of the activation coefficients (Figure 1A). STRESS Eight participants walked on a treadmill at a self-selected, constant velocity under two conditions in a random order. …”
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Characterization of a blaKPC-3-carrying plasmid in a clinical isolate of Klebsiella pneumoniae belonging to the emerging successful clone ST147 by Esther Recacha, Mercedes Delgado-Valverde, Marina R. Pulido, Elena Pérez-Nadales, Patricia Pérez-Palacios, Inés Portillo-Calderón, Juan Manuel Sánchez-Calvo, Irene Gracia-Ahufinger, Álvaro Pascual

“…ABSTRACT Klebsiella pneumoniae ST147 has emerged as a successful clone able to efficiently disseminate a number of carbapenemases, including blaKPC. …”
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An azo substituted quinoline‐malononitrile enzyme‐activable aggregation‐induced emission nanoprobe for hypoxia imaging by Zhirong Zhu, Shichang Liu, Xupeng Wu, Qianqian Yu, Yi Duan, Shanshan Hu, Wei‐Hong Zhu, Qi Wang

“…Abstract The development of efficient aggregation‐induced emission (AIE) active probes is crucial for disease diagnosis, particularly for tumors and cardiovascular diseases. …”
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The Effect of Hydraulic Partitioning on Prediction the Rate of Bed Load Transport in Gravel-bed Rivers using Support Vector Machine by Kiyoumars Roushangar, Mohammad Hosseini, Saman Shahnazi

“…After optimization of parameters for kernel function, the bed load transport rate was predicted and obtained results from different models were investigated in terms of correlation coefficient (R), Root mean square error (RMSE) and Nash-Sutcliffe (NSE). in order to assess the capability of SVM in quantification of bed load under varied hydraulic conditions, Froude number (Fr) and bed slope of channel (S0) were selected as a parameters describing the hydraulic conditions and median diameter of the sediment particles (D50) and shear Reynolds number (Re*) were considered as a representative of sediment characteristic. …”
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Structural model of determinants of medication adherence in elderly individuals with tuberculosis in Iran by Somayeh Hassani, Farahnaz Mohammadi Shahboulagi, Mahshid Foroughan, Payam Tabarsi, Gholamreza Ghaedamini Harouni, Hamidreza Jamaati, Mohammad Varahram, Seyed Mohammad Seyedmehdi, Niloufar Alizadeh, Seyed Alireza Nadji

“…Valid and reliable questionnaires were then administered to 305 elderly individuals with tuberculosis and their family caregivers to measure these selected variables. A structural model was employed to examine the relationship between concepts and predict medication adherence variance. …”
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基于数字图像比色法的食用油酸价检测研究Determination of acid value of edible oil by digital image colorimetry-based method by 李跃凡1，马改琴1，王媛媛1，张帆2，于修烛1LI Yuefan1, MA Gaiqin1, WANG Yuanyuan1, ZHANG Fan2, YU Xiuzhu1

“…Through the reaction between free fatty acid and copper soap staining solution to generate copper soap complex presenting indigo color, the relevant images were captured with a smartphone, and after standardized preprocessing, the appropriate color parameters were selected as the response values, and the model of the color response values and acid value was established by regression machine learning. …”
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Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth by Anna Maria Gasparri, Arianna Pocaterra, Barbara Colombo, Giulia Taiè, Chiara Gnasso, Alessandro Gori, Federica Pozzi, Andrew Smith, Fulvio Magni, Alessia Ugolini, Matteo Doglio, Maria Chiara Bonini, Anna Mondino, Angelo Corti, Flavio Curnis

“…Abstract Background The αvβ6- and αvβ8-integrins, two cell-adhesion receptors upregulated in many solid tumors, can promote the activation of transforming growth factor-β (TGFβ), a potent immunosuppressive cytokine, by interacting with the RGD sequence of the latency-associated peptide (LAP)/TGFβ complex. We have previously described a chromogranin A-derived peptide, called “peptide 5a”, which recognizes the RGD-binding site of both αvβ6 and αvβ8 with high affinity and selectivity, and efficiently accumulates in αvβ6- or αvβ8-positive tumors. …”
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