Genetic and functional characterization of inherited complex chromosomal rearrangements in a family with multisystem anomalies by He Fang, Stephen M. Eacker, Yu Wu, Whitney Neufeld-Kaiser, Mercy Laurino, Siobán Keel, Marshall S. Horwitz, Yajuan J. Liu

“…Conclusion: Combining cytogenetic and genomic methods provided comprehensive characterization and defined the breakpoints at high resolution in both proband and mother. This underscores the value of novel cytogenetic and genomic techniques in deciphering complex genome rearrangements and the significance of integrative genomic analysis and functional characterization in understanding clinical phenotypes.…”
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Selected Topics in Management and Modeling of Complex Systems: Editorial Introduction to Issue 16 of CSIMQ by Peter Forbrig

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A hierarchical model for community identification in complex networks through modularity and genetic algorithm by JinNuo Shi

“…Abstract In recent years, the identification of communities inside complex networks has garnered considerable interest, with numerous proposed methodologies emphasizing modularity. …”
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Groundwater recharge mechanisms inferred from isoscapes in a complex tropical mountainous region by Ricardo Sánchez‐Murillo, Christian Birkel

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A Data-driven M Dwarf Model and Detailed Abundances for ​​​​​​∼17,000 M Dwarfs in SDSS-V by Aida Behmard, Melissa K. Ness, Andrew R. Casey, Ruth Angus, Katia Cunha, Diogo Souto, Yuxi(Lucy) Lu, Jennifer A. Johnson

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Rotation Measure Jitter: Wavelength-dependent Scatter in Rotation Measure Related to Faraday Complexity by Jeroen M. Stil

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Response of land cover to multi-scale spatial effects in complex karst mountainous areas by Qingqing Dai, Zhongfa Zhou, Denghong Huang, Yue Yang, Huanhuan Lu, Ya Li

“…This study reveals the influence of spatial scale effects on land cover classification in karst regions from the perspectives of landscape patterns and topographic complexity. The research indicates:(1) When the spatial resolution increases from 5m to 30m, the study area exhibits trends of reduced landscape fragmentation, concentrated land use distribution, and decreased landscape heterogeneity;(2) Scale effects vary among land cover types, with the variations in PD, LSI and AI for construction land exceeding those of the corresponding indices for other land cover types;(3) The decline rates of PD in low and high topographic complexity areas are 49.87% and 37.69% respectively, LSI decline rates are 31.88% and 8.81%, and AI decline rates are 23.70% and 11.32%.…”
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Structural Repetition Detector for multi-scale quantitative mapping of molecular complexes through microscopy by Afonso Mendes, Bruno M. Saraiva, Guillaume Jacquemet, João I. Mamede, Christophe Leterrier, Ricardo Henriques

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Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes by Kenneth K Lee, Mihaela E Sardiu, Selene K Swanson, Joshua M Gilmore, Michael Torok, Patrick A Grant, Laurence Florens, Jerry L Workman, Michael P Washburn

“…We applied this technique to determine the organization of two well‐studied complexes, Spt–Ada–Gcn5 histone acetyltransferase (SAGA) and ADA, for which no comprehensive high‐resolution structures exist. …”
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Simple horizontal magnetic tweezers for micromanipulation of single DNA molecules and DNA—protein complexes by Christopher P. McAndrew, Christopher Tyson, Joseph Zischkau, Patrick Mehl, Pamela L. Tuma, Ian L. Pegg, Abhijit Sarkar

“…We report the development of a simple-to-implement magnetic force transducer that can apply a wide range of piconewton (pN) scale forces on single DNA molecules and DNA—protein complexes in the horizontal plane. The resulting low-noise force-extension data enable very high-resolution detection of changes in the DNA tether's extension: ∼0.05 pN in force and <10 nm change in extension. …”
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Advances in the structural characterization of complexes of therapeutic antibodies with PD-1 or PD-L1 by Mengzhen Jiang, Man Liu, Guodi Liu, Jiawen Ma, Lixin Zhang, Shenlin Wang

“…Applications of monoclonal antibodies (mAbs) to de-activate the PD-1-PD-L1 pathway could effectively reverse the phenotype of depleted activated thymocytes (T cells) to recover their anti-tumoral activities. High-resolution structures of the complexes of the therapeutic monoclonal antibodies with PD-1 or PD-L1 have revealed the key inter-molecular interactions and provided valuable insights into the fundamental mechanisms by which these antibodies inhibit PD-L1-PD-1 binding. …”
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Unveiling the immune microenvironment of complex tissues and tumors in transcriptomics through a deconvolution approach by Shu-Hwa Chen, Bo-Yi Yu, Wen-Yu Kuo, Ya-Bo Lin, Sheng-Yao Su, Wei-Hsuan Chuang, I.-Hsuan Lu, Chung-Yen Lin

“…Additionally, mySORT outperforms existing methods like CIBERSORT in accuracy and provides a wide range of data visualization features, such as hierarchical clustering and cell complexity plots. The toolkit and web application are freely available for the research community, providing enhanced resolution for conventional bulk RNA sequencing data and facilitating the analysis of immune microenvironment responses in immunotherapy. …”
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Prenatal Diagnosis of Complex Copy Number Variants in the Fetus and Associated Cytogenetic Findings in Parents by Wei Wang, Jing Wang, Ye Shi, Bin Zhang

“…Parental analysis was performed by CMA, G-band karyotype analysis, and whole-genome low-coverage mate-pair sequencing (WGL-MPS) based on the size of the fetal imbalances and method resolution. Results: Fetuses carrying complex CNVs were identified as being 0.4% (12/2746) in our cohort. …”
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Assessing data and sample complexity in unmanned aerial vehicle imagery for agricultural pattern classification by Linara Arslanova, Sören Hese, Marcel Fölsch, Friedemann Scheibler, Christiane Schmullius

“…This article assesses the use of high-resolution Unmanned Aerial Vehicle (UAV) data from commercial field sensors for classifying small-scale agricultural patterns in four crop types (Winter Wheat, Spring Barley, Rapeseed, and Corn) acquired at ground sample distances (GSDs) of 0.027 m, 0.053 m and 0.064 m. …”
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Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM by Agalya Periasamy, Pamela Ornelas, Thomas Bausewein, Naomi Mitchell, Jiamin Zhao, Leonie M. Quinn, Werner Kuehlbrandt, Jacqueline M. Gulbis

“…The translocase of the outer membrane (TOM) is the main protein-import pore of mitochondria, recognizing nascent precursors of mitochondrially targeted proteins and transferring them across the outer membrane. A 3.3 Å resolution map and molecular model of a TOM complex from Drosophila melanogaster, obtained by single-particle electron cryomicroscopy, is presented. …”
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CSA-Net: Complex Scenarios Adaptive Network for Building Extraction for Remote Sensing Images by Dongjie Yang, Xianjun Gao, Yuanwei Yang, Minghan Jiang, Kangliang Guo, Bo Liu, Shaohua Li, Shengyan Yu

“…Building extraction is significant for the intelligent interpretation of high-resolution remote sensing images (HRSIs). However, in some complex scenarios where the features of the building and its adjacent ground objects are similar, the current segmentation model cannot distinguish them effectively. …”
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Complex Cloud-Sea Background Simulation for Space-Based Infrared Payload Digital Twin by Wen Sun, Yejin Li, Fenghong Li, Guangsen Liu, Peng Rao

“…This method allows for generating multiband, multispecies, and multiscale complex cloud-sea scenario images for digital infrared payloads with high flexibility and confidence.…”
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Complex manipulation of microparticles exploiting the enhanced diattenuation of light in conjugation with phase contrast microscopy by Snigdhadev Chakraborty, Sauvik Roy, Srestha Roy, Jayesh Goswami, Gokul Nalupurackal, Krishna Kumari Swain, Ayan Banerjee, Basudev Roy

“…The motion on circular orbit works particularly well for high refractive index particles, and can usher a new domain of simultaneous complex manipulation and high quality visualization of nanoparticles, hitherto inaccessible in optical tweezers. …”
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Theoretical Study and Application of Rate Transient Analysis on Complex Fractured-Caved Carbonate Reservoirs by Qingyan Yu, Qi Wang, Pengcheng Liu, Jing Zhang, Qi Zhang, Xiaojuan Deng, Kai Feng

“…Using seismic inversion and reservoir static characterization, the result shows that the fractured-caved carbonate rocks in China are mainly caves with poor connectivity and complex oil-water distribution. Large-scale dissolved caves are mostly discrete and isolated, while the fractures are complex and various. …”
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A 3D reconstruction platform for complex plants using OB-NeRF by Sixiao Wu, Changhao Hu, Boyuan Tian, Yuan Huang, Shuo Yang, Shanjun Li, Shengyong Xu

“…High costs, slow processing times, intricate workflows, and limited automation often constrain the application of existing 3D reconstruction platforms.MethodsWe develop a 3D reconstruction platform for complex plants to overcome these issues. Initially, a video acquisition system is built based on "camera to plant" mode. …”
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