Characterizing pancytopenia in a large Asian cohort of people living with HIV: A 23-year nested case-control study by Xiangyi Shen, Xiaojing Song, Yanling Li, Xiaoxia Li, Lianfeng Lu, Xinmin Duan, Yang Han, Ling Luo, Huiting Liu, Wei Lv, Wei Cao, Taisheng Li

Get full text

Investigation of two different PACAP-38 (Pituitary Adenylate Cyclase Activating Polypeptide) formulated feeds on Atlantic salmon (Salmo salar) immune responses with Enteric Red Mou... by E Fajei, L Rivera Méndez, SK Whyte, J Velazquez, P Dantagnan, M Soto-Davila, T Rodríguez-Ramos, E Proskos, B Dixon, Y Carpio, M Estrada, MD Fast

“…Due to the anti-inflammatory effects of il10 and its pleiotropic nature, gene expression results in response to PACAP feeds may suggest a more complex regulation of inflammation in the PACAP-fed fish. …”
Get full text

Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch by Francisco J. Chorro, Francisco J. Chorro, Francisco J. Chorro, Luis Such-Miquel, Luis Such-Miquel, Samuel Cuñat, Oscar Arias-Mutis, Oscar Arias-Mutis, Patricia Genovés, Patricia Genovés, Manuel Zarzoso, Manuel Zarzoso, Antonio Alberola, Antonio Alberola, Luis Such-Belenguer, Luis Such-Belenguer, Irene Del Canto, Irene Del Canto

“…Under eleclazine perfusion, the VF activation patterns were less complex, and the arrhythmia stopped in 6 out of 11 experiments (55%; p < 0.05 vs. baseline).ConclusionEleclazine (GS6615) reduced the proarrhythmic electrophysiological changes induced by myocardial stretch and slowed and simplified activation patterns during VF in the experimental model used.…”
Get full text

pySTARBURST99: The Next Generation of STARBURST99 by Calum Hawcroft, Claus Leitherer, Oskar Aranguré, John Chisholm, Sylvia Ekström, Sébastien Martinet, Lucimara P. Martins, Georges Meynet, Christophe Morisset, Andreas A. C. Sander, Aida Wofford

“…Similar trends are found for He i and He ii , bolometric luminosity and wind momentum, with more complex relations found for hydrogen line EWs and UV β -slopes.…”
Get full text

Experience from Turkish centers participating in the Early Access Program (EAP): Preliminary real-world safety data of nivolumab (nivo) combined with ipilimumab (ipi) in pre-treate... by Nuri Karadurmus, Mehmet Ali Nahit Sendur, Burcak Karaca, Omer Fatih Olmez, Ilhan Hacibekiroglu, Hasan Senol Coskun, Serkan Degirmencioglu, Yasemin Kemal, Saadettin Kilickap, Ahmet Taner Sumbul, Burc Aydin, Hande Turna, Muhammet Ali Kaplan, Nalan Babacan, Umut Demirci, Alper Ata, Dilek Erdem, Ahmet Ozet, Huseyin Abali

Get full text

Mesoscale functional connectivity of amygdala to the auditory and prefrontal cortex of macaque monkeys revealed by INS-fMRI by Qianbing Li, An Ping, Yuqi Feng, Bin Xu, Baorong Zhang, Anna Wang Roe, Lixia Gao, Xinjian Li

“…Our study further revealed the functional connectivity among the amygdala subnucleus, the auditory cortex and the prefrontal cortex, and will shed light on the research for processing biologically meaningful complex sounds.…”
Get full text

Spatiotemporal single-cell analysis elucidates the cellular and molecular dynamics of human cornea aging by Dan Jiang, Ke Li, Yining Sun, Zicheng Zhang, Shuang Xie, Xintong Yu, Ruoqi Wang, Ying Feng, Qinxiang Zheng, Yajing Wen, Peter S. Reinach, Yuanyuan Du, Meng Zhou, Wei Chen

“…Results Spatiotemporal single-cell analysis revealed the complex cellular landscape, spatial organization and intercellular communication within the human cornea. …”
Get full text

Design and Calibration of Electron Stack Spectrometer for Diagnosing Hot Electron Temperature in Intense Laser-plasma Interactions by BO Nan1, 2, TIAN Baoxian2, WANG Haoran3, 4, WANG Naiyan2

“…The interaction of relativistic intense lasers with matter generates complex plasma environments characterized by extreme conditions, such as high temperatures and densities, which are critical to fields like laser-driven inertial confinement fusion (ICF), high-energy-density physics, and strong-field physics. …”
Get full text

Brain magnetic resonance imaging of patients with spinal muscular atrophy type 2 and 3 by Marloes Stam, Harold H.G. Tan, Ruben Schmidt, Martijn P. van den Heuvel, Leonard H. van den Berg, Renske I. Wadman, W. Ludo van der Pol

Get full text

Integrating immune library probing with structure-based computational design to develop potent neutralizing nanobodies against emerging SARS-CoV-2 variants by Lidia Cerdán, Katixa Silva, Daniel Rodríguez-Martín, Patricia Pérez, María A. Noriega, Ana Esteban Martín, Alfonso Gutiérrez-Adán, Yago Margolles, Juan A. Corbera, Miguel A. Martín-Acebes, Juan García-Arriaza, Juan Fernández-Recio, Luis A. Fernández, José M. Casasnovas

“…A Nb4-derived heavy chain antibody (hcAb4) recognized the spike (S) of the Wuhan, Beta, Delta, Omicron BA.1, and BA.5 SARS-CoV-2 variants. A high-resolution crystal structure of the Nb4 variable (VHH) domain in complex with the SARS-CoV-2 RBD (Wuhan) defined the Nb4 binding mode and interface. …”
Get full text

Mother’s Day Superstorms: Pre- and Post-storm Evolutionary Patterns of ARs 13664/8 by Mausumi Dikpati, Marianna B. Korsós, Aimee A. Norton, Breno Raphaldini, Kiran Jain, Scott W. McIntosh, Peter A. Gilman, Andre S. W. Teruya, Nour E. Raouafi

“…We conclude that the Mother’s Day superstorms were caused by enhanced magnetic complexity occurring due to intricate interactions among multiple active regions emerging at nearly the same locations. …”
Get full text

Large-scale EM data reveals myelinated axonal changes and altered connectivity in the corpus callosum of an autism mouse model by Guoqiang Zhao, Guoqiang Zhao, Ao Cheng, Jiahao Shi, Jiahao Shi, Peiyao Shi, Jun Guo, Chunying Yin, Hafsh Khan, Hafsh Khan, Jiachi Chen, Jiachi Chen, Pengcheng Wang, Pengcheng Wang, Jiao Chen, Jiao Chen, Ruobing Zhang

“…IntroductionAutism spectrum disorder (ASD) encompasses a diverse range of neurodevelopmental disorders with complex etiologies, including genetic, environmental, and neuroanatomical factors. …”
Get full text

Sparse transformer and multipath decision tree: a novel approach for efficient brain tumor classification by Pengcheng Li, Yuqi Jin, Monan Wang, Fengjie Liu

“…Although Swin Transformer is effective in handling high-resolution images, it encounters difficulties with small datasets and high computational complexity. …”
Get full text

Reconstructed hyperspectral imaging for in-situ nutrient prediction in pine needles by Yuanhang Li, Yuanhang Li, Jun Du, Jun Du, Chuangjie Zeng, Chuangjie Zeng, Yongshan Wu, Yongshan Wu, Junxian Chen, Junxian Chen, Teng Long, Teng Long, Yongbing Long, Yongbing Long, Yubin Lan, Yubin Lan, Xiaoliang Che, Tianyi Liu, Jing Zhao, Jing Zhao

“…However, its high cost and complexity hinder practical field applications.MethodsTo overcome these limitations, we propose a deep-learning-based method to reconstruct hyperspectral images from RGB inputs for in situ needle nutrient prediction. …”
Get full text

Sparse Cumulants Fitting for Direction-of-Arrival Estimation without Redundancy by Shuang Li, Xiaoxiao Jiang, Sai Ma, Yingguan Wang

“…Firstly, we derive that some fourth order cumulants of the array output are redundant and therefore are removed to reduce computational complexity. Then, the left cumulants are sparsely represented on an overcomplete basis and the DOAs are resolved by using a software package. …”
Get full text

Monocular depth sensing using metalens by Yang Fan, Lin Hung-I, Chen Peng, Hu Juejun, Gu Tian

“…Using a reconstruction algorithm that we developed, concurrent depth calculation and scene reconstruction with minimum distortion and high resolution in all three dimensions were demonstrated.…”
Get full text

Ecological Niche Modeling of Seventeen Sandflies Species (Diptera, Psychodidae, Phlebotominae) from Venezuela by Iomar Sanchez, Jonathan Liria, María Dora Feliciangeli

“…We used maximum entropy method for model construction based on 30 arc-second resolution environmental layers: 19 bioclimatic variables, elevation, and land cover. …”
Get full text

Single-cell analysis of the epitranscriptome: RNA modifications under the microscope by Eva Crespo-García, Alberto Bueno-Costa, Manel Esteller

“…The identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology. …”
Get full text

Bridging the gap: Reintegrating legal perspectives into project management by Armando Castro, Tristano Sainati

“…This paper examines the intersection of law and project management addressing the growing complexity and multifaceted nature of contemporary projects and their impacts on society. …”
Get full text

Study on Vibration Characteristics of Natural Gas Pipeline Explosion Based on Improved MP-WVD Algorithm by Huayuan Ma, Yuan Long, Xinghua Li, Mingshou Zhong, Jianyuan Wu, You Zhou

“…The HHT algorithm was applied to the data preprocessing of MP algorithm to reduce the computational complexity of the MP algorithm. It improved the computing efficiency and laid the foundation for big data analysis. …”
Get full text