Navigating ethical and legal challenges in the HEALthy Brain and Child Development Study: Lessons learned from the ethics, law, policy working group by Jenny Kingsley, Barbara Andraka-Christou, Seema K. Shah, Paul Spicer, Sharlene Newman, Pilar N. Ossorio

“…We explain the methods used to address these challenges, the ethical and legal tradeoffs that arose, and the resolution of challenges through the design of the study. …”
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Expanding the landscape of aging via orbitrap astral mass spectrometry and tandem mass tag integration by Gregory R. Keele, Yue Dou, Seth P. Kodikara, Erin D. Jeffery, Dina L. Bai, Erik Hultenius, Zichen Gao, Joao A. Paulo, Steven P. Gygi, Xiao Tian, Tian Zhang

“…We also identify both linear and non-linear proteomic trajectories with age, revealing complex protein dynamics over the adult lifespan. …”
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Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine by Karishma Sahoo, Prakash Lingasamy, Masuma Khatun, Sajitha Lulu Sudhakaran, Andres Salumets, Vino Sundararajan, Vijayachitra Modhukur

“…Aberrant methylation patterns enable early cancer detection and therapeutic stratification; however, their complex patterns necessitates advanced analytical tools. …”
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Data-driven prediction of rate of penetration (ROP) in drilling operations using advanced machine learning models by Guoli Huang, Sarah Kanaan Hamzah, Pinank Patel, T. Ramachandran, Aman Shankhyan, A. Karthikeyan, Dhirendra Nath Thatoi, Deepak Gupta, S. AbdulAmeer, Mariem Alwan, Zahraa Saad Abdulali, Mahmood Jasem Jawad, Hiba Mushtaq, Mohammad Mahtab Alam, Hojjat Abbasi

“…Abstract Predicting the rate of penetration (ROP) is critical for optimizing drilling performance, yet it remains a complex task due to the interplay of multiple geological and operational parameters. …”
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Current cutting-edge omics techniques on musculoskeletal tissues and diseases by Xiaofei Li, Liang Fang, Renpeng Zhou, Lutian Yao, Sade W. Clayton, Samantha Muscat, Dakota R. Kamm, Cuicui Wang, Chuan-Ju Liu, Ling Qin, Robert J. Tower, Courtney M. Karner, Farshid Guilak, Simon Y. Tang, Alayna E. Loiselle, Gretchen A. Meyer, Jie Shen

“…However, these approaches are inherently limited in their ability to resolve cellular heterogeneity or to capture the spatial organization of cells within tissues, thus hindering a comprehensive understanding of the complex cellular and molecular mechanisms underlying these diseases. …”
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A mathematical, classical stratification modeling approach to disentangling the impact of weather on infectious diseases: A case study using spatio-temporally disaggregated Campylo... by Giovanni Lo Iacono, Alasdair J C Cook, Gianne Derks, Lora E Fleming, Nigel French, Emma L Gillingham, Laura C Gonzalez Villeta, Clare Heaviside, Roberto M La Ragione, Giovanni Leonardi, Christophe E Sarran, Sotiris Vardoulakis, Francis Senyah, Arnoud H M van Vliet, Gordon Nichols

“…The approach is able to examine multiple factors and model how complex trends arise, e.g. the consistent steep increase in campylobacteriosis in England and Wales in May-June and its spatial variability. …”
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B-Scan and “En-Face” Spectral-Domain Optical Coherence Tomography Imaging for the Diagnosis and Followup of Acute Retinal Pigment Epitheliitis by Flore De Bats, Benjamin Wolff, Martine Mauget-Faÿsse, Claire Scemama, Laurent Kodjikian

“…The pathophysiology of ARPE remains complex and still poorly understood. These techniques help define the location and extent of structural damage occurring in this disease.…”
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Papillary thyroid carcinoma whole-slide images as a basis for deep learning by M. V. Fridman, A. A. Kosareva, E. V. Snezhko, P. V. Kamlach, V. A. Kovalev

“…The analysis of the influence of the representative sizes of fragments of histopathological images showed the problems in solving the classification tasks because of cutting and staining images specifics, morphological complex and textured differences in the images of the same class. …”
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Utilizing Sentinel-2 Remote Sensing for Water Quality Monitoring in Deran Lake, Bosnia and Herzegovina by A. Batina, A. Šiljeg, G. Pedić, M. Parać

“…This work reinforces the value of remote sensing for cost-effective, high-resolution monitoring of inland waters, improving water resource management across diverse ecosystems.…”
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Rules for setting off periods of application of measures of procedural coercion in the term of criminal punishment: problems of legislative regulation and law enforcement by Yu. Yu. Ksendzov

“…Research methodology encompasses both dialectical and formal cognition methods. It is based on a complex and comprehensive analysis and interpretation of statutory acts, legal reasonings of the Constitutional Court and the Supreme Court of Russian Federation as well as on judicial rulings regarding criminal cases and on doctrinal approaches to the current research subject.Main determinations and application field. …”
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Evaluating Water Levels From the Surface Water and Ocean Topography (SWOT) Mission in a Hyper‐Tidal Coastal and Estuarine Environment by I. D. Lichtman, P. S. Bell, C. Gommenginger, C. Banks, F. M. Calafat, J. Brown, S. D. P. Williams

“…SWOT's altimetry images reveal complex, changing spatial patterns across the Land‐Ocean Aquatic Continuum. …”
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Enhancement in dynamic range for dual-rotating retarder Mueller matrix polarimetry by Jiongying Lv, Shuan Yao, Nan Zeng, Caizhong Guan, Honghui He

“…These results highlight the potential of HDR MM imaging technology in extracting polarization information from complex biological samples with high resolution and contrast.…”
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The Prelacrimal Recess Approach: A Review of Surgical Applications, Outcomes, and Recent Advances by Yeon Hee Im, Soo Whan Kim, Chan-Soon Park, Dong-Hyun Kim

“…The PLRA is a safe and effective surgical method that offers favorable outcomes in disease management, symptom resolution, and anatomical preservation. With ongoing innovations and refinements, the PLRA is poised to remain a cornerstone of minimally invasive sinonasal surgery, enabling the precise and safe treatment of complex pathologies.…”
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Abnormalities in the genioglossus muscle and its neuromuscular synapse in leptin-deficient male mice by Srujith Medharametla, Garrett Borger, Shashir Gaonkar, Isabel Martinez-Pena y Valenzuela

“…This specificity underscores the complex impact of obesity on NMJ health and highlights the need for further investigation into muscle-specific responses to obesity-related stress. …”
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An Investigation of Infrared Small Target Detection by Using the SPT–YOLO Technique by Yongjun Qi, Shaohua Yang, Zhengzheng Jia, Yuanmeng Song, Jie Zhu, Xin Liu, Hongxing Zheng

“…To detect and recognize small-size and submerged complex background targets in infrared images, we combine a dynamic receptive field fusion strategy and a multi-scale feature fusion mechanism to improve the detection performance of small targets significantly. …”
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Classification of Hyperspectral Images of Explosive Fragments Based on Spatial–Spectral Combination by Donge Zhao, Peiyun Yu, Feng Guo, Xuefeng Yang, Yayun Ma, Changli Wang, Kang Li, Wenbo Chu, Bin Zhang

“…Hyperspectral imaging has high spectral resolution and can provide multidimensional reference information for the fragments to be classified. …”
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Evaluation of Pore-Type Carbonate Reservoir Connectivity Based on Electrical Imaging by SUN Jianmeng, CHENG Yaodong, HE Juan, LIU Zhang, CHEN Peiyuan

“…Compared with conventional clastic rock reservoir, carbonate rock reservoir has less porosity and permeability relationship, because of its strong heterogeneity and complex pore structure. There is a strong correlation between the connectivity of carbonate reservoirs and the characteristics of pore, and the connectivity is an important factor affecting the permeability of reservoirs. …”
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Dynamic Light Path and Bidirectional Reflectance Effects on Solar Noise in UAV-Borne Photon-Counting LiDAR by Kuifeng Luan, Jinhui Zheng, Wei Kong, Weidong Zhu, Lizhe Zhang, Peiyao Zhang, Lin Liu

“…The model’s adaptability to marine–terrestrial interfaces enhances precision in coastal monitoring and submarine mapping, offering transformative potential for geospatial applications requiring photon-counting LiDAR in complex environments. Key innovations include dynamic coupling of geometric optics and surface scattering physics, enabling robust spatiotemporal noise quantification, critical for high-resolution terrain reconstruction.…”
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Structural characterization and dynamics of AdhE ultrastructures from Clostridium thermocellum show a containment strategy for toxic intermediates by Samantha J Ziegler, Brandon C Knott, Josephine N Gruber, Neal N Hengge, Qi Xu, Daniel G Olson, Eduardo E Romero, Lydia-Marie Joubert, Yannick J Bomble

“…To better understand the function of the C. thermocellum AdhE, we used cryo-electron microscopy (cryo-EM) to obtain a 3.28 Å structure of the AdhE complex. This high-resolution structure, in combination with molecular dynamics simulations, provides insight into the substrate channeling of the toxic intermediate acetaldehyde, indicates the potential role of C. thermocellum AdhE to regulate activity and cofactor pools, and establishes a basis for future engineering studies. …”
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Single-cell transcriptomics and time-series metabolite profiling reveal the spatiotemporal regulation of flavonoid biosynthesis genes and phytohormone homeostasis by PAP1 in Arabid... by Bingxu Zhang, Thomas Ka Yam Lam, Linheng Chen, Chen Zhang, Liping Zhu, Hailei Zhang, Pengxi Wang, Jianing Wang, Zongwei Cai, Yiji Xia

“…Additionally, PAP1 overexpression leads to significant changes in phytohormone levels, particularly jasmonate and salicylate, indicating complex crosstalk between flavonoid biosynthesis and hormone homeostasis. …”
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