PO27 | B-cell lymphoproliferative disorder and acquired coagulopathy: an insidious link

“…The successful use of rituximab underscores the relevance of B-cell–directed immunosuppression in managing such complex cases, particularly in the context of clonal B-cell disorders. …”
Get full text

In-situ/operando study of Cu-based nanocatalysts for CO2 electroreduction using electrochemical liquid cell TEM by Jiawei Wan, Jiawei Wan, Qiubo Zhang, Ershuai Liu, Ershuai Liu, Yi Chen, Yi Chen, Jiana Zheng, Jiana Zheng, Amy Ren, Walter S. Drisdell, Walter S. Drisdell, Haimei Zheng, Haimei Zheng

“…Considering the complex reactions involving electrified solid-liquid interfaces and catalyst structural evolution with intermediates, systematic studies with multimodal approaches are crucial. …”
Get full text

The Use of the Masquelet Technique in the Treatment of Pathological Distal Third Femoral Fracture Secondary to Chronic Osteomyelitis by Razvan Cosmin Tudor, Daniel Vasile Timofte, Norin Forna, Oana Viola Badulescu, Liliana Savin, Tudor Pinteala, Dan Mihailescu, Tudor Ciobotariu, Alin Ciobica, Mihnea Theodor Sirbu, Paul Dan Sirbu, Serban Dragosloveanu, Bogdan Sorin Capitanu, Romica Cergan, Cristian Scheau

“…This case report highlights the application of Masquelet’s induced membrane technique (MIMT) in managing a complex distal femur defect in a 50-year-old male with a long-standing history of chronic osteomyelitis. …”
Get full text

Biparatopic binding of ISB 1442 to CD38 in trans enables increased cell antibody density and increased avidity by Jeremy Loyau, Thierry Monney, Marco Montefiori, Fedir Bokhovchuk, Jeremy Streuli, Matthew Blackburn, Arnaud Goepfert, Lydia N. Caro, Samitabh Chakraborti, Stefania De Angelis, Camille Grandclément, Stanislas Blein, M. Lamine Mbow, Ankita Srivastava, Mario Perro, Stefano Sammicheli, Eugene A. Zhukovsky, Michael R. Dyson, Cyrille Dreyfus

“…Here, we describe the discovery, optimization and characterization of the ISB 1442 antigen binding fragment (Fab) arms, their assembly to 2 + 1 format, and present the high-resolution co-crystal structures of the two anti-CD38 Fabs, in complex with CD38. …”
Get full text

Basolateral amygdala volume in affective disorders using 7T MRI in vivo by Benedikt Kürzinger, Stephanie Schindler, Martin Meffert, Anja Rosenhahn, Robert Trampel, Robert Turner, Peter Schoenknecht, Peter Schoenknecht, Peter Schoenknecht

“…BackgroundThe basolateral complex of the amygdala is a crucial neurobiological site for Pavlovian conditioning. …”
Get full text

NEDD4 E3 ligase-catalyzed NAMPT ubiquitination and autophagy activation are essential for pyroptosis-independent NAMPT secretion in human monocytes by Marisela Rodriguez, Haifei Xu, Annie Hernandez, Julia Ingraham, Jason Canizales, Fernando Teran Arce, Sara M. Camp, Skyler Briggs, Aikseng Ooi, James M. Burke, Jin H. Song, Joe G.N. Garcia

“…NAMPT ubiquitination and secretion involves autophagy activation as super-resolution microscopy analyses demonstrate NAMPT co-localization with autophagosome marker LC3B and eNAMPT secretion was significantly reduced by targeted ATG5 and ATG7 inhibition, critical components of the autophagy E3-like complex. …”
Get full text

Research on cardiac image segmentation algorithm based on improved level set modeling by Shuaishuai ZHANG, Ruixia LIU, Ke SHAN, Zhenhua GUO

“…Traditional segmentation methods, such as gradient descent, are often time-consuming, computationally complex, and costly. In contrast, the proposed approach breaks down a complex problem into several simpler sub-problems that can be solved sequentially to enable faster and more accurate resolution using the ADMM algorithm. …”
Get full text

Optimal selection of high-production well targets for fault-controlled fractured-vuggy reservoir in Shunbei oil and gas field, Tarim Basin by Lijun GAO, Haiying LI, Wei GONG, Wei YANG, Hongyan LI

“…As exploration efforts shift from the main No.1 and No.5 fault zones to the northeastern and northwestern fault zones in the eastern and western regions, the underground geological conditions become more complex, and exploration costs rise significantly. …”
Get full text

A New Protein–Ligand Trapping System to Rapidly Screen and Discover Small-Molecule Inhibitors of PD-L1 from Natural Products by Yazhuo Huang, Senfeng Sun, Runxin Yin, Zongtao Lin, Daidong Wang, Wanwan Wang, Xiangyu Fu, Jing Wang, Xinyu Lei, Mimi Sun, Shizhong Chen, Hong Wang

“…Chinese herbal medicines have played a significant role in the development of new and effective drugs, but how to identify the active ingredients from complex extracts of traditional Chinese herbal medicines was a research difficulty. …”
Get full text

Ammonia‐free natural rubber latex photo‐resin for sustainable 3D printing of highly stretchable and tough elastomers by Oliyad Dibisa, Allen Jonathan Román, Hannah Cabush, Grace O'Brien, Xiao Kuang, Tim A. Osswald

“…Furthermore, we demonstrated the feasibility of this formulation by printing complex geometries using a commercially available SLA printer. …”
Get full text

A High-Caliber View of the Bullet Cluster through JWST Strong and Weak Lensing Analyses by Sangjun Cha, Boseong Young Cho, Hyungjin Joo, Wonki Lee, Kim HyeongHan, Zachary P. Scofield, Kyle Finner, M. James Jee

“…Together with multiwavelength data, the complex mass distribution suggests that the merger history of the Bullet Cluster may be more complex than previous binary cluster merger scenarios.…”
Get full text

Application of a Dual-Stream Network Collaboratively Based on Wavelet and Spatial-Channel Convolution in the Inpainting of Blank Strips in Marine Electrical Imaging Logging Images:... by Guilan Lin, Sinan Fang, Manxin Li, Hongtao Wu, Chenxi Xue, Zeyu Zhang

“…Existing inpainting methods struggle to reconstruct complex geological textures while maintaining structural continuity, particularly in balancing low-frequency formation morphology with high-frequency fracture details. …”
Get full text

A multi-module enhanced YOLOv8 framework for accurate AO classification of distal radius fractures: SCFAST-YOLO by Yu Wang, Haifu Sun, Tiankai Jiang, JunFeng Shi, JunFeng Shi, Qin Wang, Qin Wang, Hongwei Yang, Hongwei Yang, Yusen Qiao

“…Third, our Feature-Driven Pyramid Network facilitates multi-resolution feature fusion across scales for improved detection. …”
Get full text

Effects of marine heat waves and cold spells on a polar shallow water ecosystem by Philipp Fischer, Holger Brix, Ingeborg Bussmann, Uta Ködel, Max Schwanitz, Claudia Schütze, Norbert Anselm, Markus Brand, Yvonne Jenniges, Sabine Kasten, Alexandra Kraberg, Miriam Lienkämper, Lisa Spotowitz, Ute Weber, Karen Wiltshire, Peter Dietrich

“…Abstract Global warming affects the Earth system in complex ways, often preventing a functional understanding of the underlying processes. …”
Get full text

Mechanisms of urate transport and uricosuric drugs inhibition in human URAT1 by Wenjun Guo, Miao Wei, Yunfeng Li, Jiaxuan Xu, Jiahe Zang, Yuezhou Chen, Lei Chen

“…Here, we report the structures of human URAT1 (hURAT1) in complex with substrate urate or inhibitors benzbromarone and verinurad at resolution ranges from 3.0 to 3.3 Å. …”
Get full text

Long arcuate fascicle in wild and captive chimpanzees as a potential structural precursor of the language network by Yannick Becker, Cornelius Eichner, Michael Paquette, Christian Bock, Cédric Girard-Buttoz, Carsten Jäger, Tobias Gräßle, Tobias Deschner, EBC Consortium, Philipp Gunz, Roman M. Wittig, Catherine Crockford, Angela D. Friederici, Alfred Anwander

“…It is likely that this neural architecture supporting complex communication was already present in the last common ancestor of hominins and chimpanzees 7 million years ago, enabling the evolution of language processes in the human lineage.…”
Get full text

Production and Analysis of a Landslide Susceptibility Map Covering Entire China by Guo Zhang, Yutao Liu, Zhenwei Chen, Zixing Xu, Yuan Yuan, Shunyao Wang, Weiqi Lian, Hang Xu, Zan Ding, Run Wang

“…China, with its complex geology and diverse climate, is highly prone to landslides, endangering public safety and infrastructure. …”
Get full text

TD-ESI-MS/MS for High-Throughput Screening of 13 Common Drugs and 4 Etomidate Analogs in Hair: Method Validation and Forensic Applications by Meng Li, Jinbo Li, Binling Zhu

“…The polydrug use patterns identified concurrent etomidate–amphetamine consumption (<i>n</i> = 5) and complex analog combinations (etomidate–isopropoxate–metomidate, <i>n</i> = 13), suggesting evolving abuse trends. …”
Get full text

Acoustic ejection mass spectrometry: An integrated pipeline for ultra-high throughput screening, reactivity profiling, and potency analysis of covalent BTK inhibitors by Ronghai Cheng, Adil Muneer, Maria Hercher, Bekim Bajrami, Reza Nemati

“…However, its application for screening covalent libraries has been hindered by low assay throughput, complex sample preparation, and high protein consumption associated with traditional liquid chromatography-MS (LC-MS) or solid-phase extraction-MS (SPE-MS) platforms. …”
Get full text

RANFIS-Based Sensor System with Low-Cost Multi-Sensors for Reliable Measurement of VOCs by Keunyoung Kim, Woosung Yang

“…In the latter stage, the complex nonlinear relationship of the data was modeled using the ANFIS to reliably handle data uncertainty and noise. …”
Get full text