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4701
Spatial Organization of Global Value Chains in the Optical and Electronic Equipment Industry
Published 2024-12-01“…The core of the model consists of three mega-level centers of the PRC, the USA and the Republic of Korea, around which three global clusters and three sub-cores have formed, controlled by the main cores, which stand out significantly from the general periphery, the centers of which are Japan, Germany and Taiwan. …”
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4702
Combination of fluorescent reagents with 2-(4-aminophenyl) benzothiazole and safranin O was useful for analysis of spore structure, indicating the diversity of Bacillales species s...
Published 2025-06-01“…Additionally, the localization of spore proteins was analyzed by green fluorescent protein (GFP)-fused strains and spore-forming-defective mutant strains of B. subtilis.ResultsFluorescence microscopy analysis revealed that safranin O exhibits two distinct fluorescence peaks, green and red, in Bacillales species in different regions of the spore structure, indicating the complexity and diversity within the spore structures. …”
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4703
Machine Learning-Based Virtual Screening and Molecular Modeling Reveal Potential Natural Inhibitors for Non-Small Cell Lung Cancer
Published 2025-04-01“…Our findings show that Gancaonin X, 5-hydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-2,3-dihydropyrano[2,3-h]chromen-4-one, (2S)-7-[[(2R)-3,3-dimethyloxiran-2-yl]methoxy]-5-hydroxy-2-phenyl-2,3-dihydrochromen-4-one, (2S)-5-hydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-2,3-dihydropyrano[2,3-h]chromen-4-one, and methyl 2-(methylamino)-5-[(3S)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-yl]benzoate establish strong interactions inside the binding region of NTRK, as a result of which stable complexes are formed. This study employs 100 ns molecular dynamics simulations to investigate the dynamic behavior of phytochemical-NTRK complexes, revealing stable interactions through RMSD, RMSF, Rg, and SASA analyses. …”
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4704
NLRs in plant immunity: Structural insights and molecular mechanisms
Published 2025-05-01“…Recent structural breakthroughs have shown how NLRs assemble into oligomeric resistosomes, such as ZAR1 and Sr35 forming Ca2+-permeable channels, and TNL resistosomes acting as NADases to generate signaling molecules. …”
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4705
Long-acting injectable biologics: a game-changer in immunopharmacology
Published 2025-08-01“…Long-acting injectable (LAI) biologics, a class of agents consisting of a biologically active compound – the active pharmaceutical ingredient (API) – and polymers that form a microparticle, suspension, or hydrogel, have recently emerged as a potentially revolutionizing modality in immunopharmacology. …”
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4706
Insecticidal activity of Delonix regia (Fabaceae) against the cotton leafworm, Spodoptera littoralis (Bois) with reference to its phytochemical composition
Published 2025-02-01“…Data showed that D. regia extracts affected consequences of protein changes compared to untreated S. littoralis larvae resulted in genetic changes, as well as inhibition of the insect’s important α-amylases, forming protein complexes, and influencing normal growth and development. …”
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4707
Case Report: FAP+ fibroblasts and SPP1+ macrophages in SMARCA2-deficient while SMARCA4-preserved poorly differentiated lung adenocarcinoma: two case reports and multi-omics analysi...
Published 2025-05-01“…Two ATPase subunits, SMARCA4 (which encodes BRG1) and SMARCA2 (which encodes BRM), facilitate this process by hydrolyzing ATP to energize the activity of the mammalian switch/sucrose-non-fermenting (mSWI/SNF) complexes. Clinically, SMARCA4-deficient non-small cell lung carcinoma (SMARCA4-dNSCLC) were associated with the poorly differentiated histologic manifestations and poor prognosis. …”
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4708
3D geological model reconstruction and collapse risk evaluation of old goaf in Dunqiu iron mine
Published 2025-04-01“…Abstract The complexity of goafs put forward higher requirements for detection methods. …”
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4709
Mechanisms of Crack Evolution in Clay Materials Under Varying Boundary Conditions
Published 2025-07-01“…In recent years, droughts and extreme weather events have witnessed increasing frequency around the globe, leading to a growing number of issues related to soil cracking that severely impact the stability of engineering projects and ecological environments. …”
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4710
Assessment Instrument Development for Maharah Qira'ah: A Case Study on Qira'ah Rasyidah Book Volume 5
Published 2025-06-01“…In the results of the analysis, this book does not have any form of assessment instrument so it is not easy to assess comprehension, critical thinking, and analytical skills in reading Arabic texts. …”
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4711
Modern experimental methods for assessing the effectiveness of tissue-engineered products for hyaline cartilage regeneration
Published 2025-07-01“…Despite the active study of TEHC, the results remain unsatisfactory. In this study, we have systematized data on the effectiveness and feasibility of methods to analyze structure, mechanical characteristics, cell interaction with the scaffold, and their ability to form new tissue before and after transplantation.…”
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4712
Continuous production of nanosized magnetite through low grade burial
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4713
Sorption of molecular hydrogen on the graphene-like matrix doped by N- and B-atoms
Published 2021-06-01“… The regularities of interaction of hydrogen molecules with graphene-like planes, where two carbon atoms are replaced by nitrogen or boron atoms, have been studied by the methods of quantum chemistry (DFT, B3LYP, 6-31G**). …”
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4714
New insights from mercury isotopes of a No.3 coal in Tengnan Coalfield, Shandong Province, Eastern China: With emphasis on source of harmful trace elements
Published 2025-07-01“…Mercury concentrations detected in ancient sedimentary deposits have frequently been employed as an indicator of volcanic activity, notably those associated with eruptions from large igneous provinces. …”
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4715
Efficient Manufacturing of Steerable Eversion Robots with Integrated Pneumatic Artificial Muscles
Published 2025-07-01“…However, their adoption has been hindered by the complexity of the current manufacturing techniques, which require individually sealing the artificial muscles. …”
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4716
Thermodynamic Properties of Aqueous Species Calculated Using the HKF Model: How Do Different Thermodynamic and Electrostatic Models for Solvent Water Affect Calculated Aqueous Prop...
Published 2019-01-01“…The Helgeson-Kirkham-Flowers (HKF) model is widely used for calculating standard state thermodynamic properties of ions and complexes over a wide range of temperatures and pressures. …”
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4717
METHOD FOR MEASURING ENERGY IN HEAT SUPPLY SOURCES
Published 2020-01-01“…When studying the energy characteristics of fuels, a previously unknown regularity was established: hydrocarbons ethylene, benzene and annelated hydrocarbons (naphthalene, anthracene, naphthacene, etc.) form the homologous series CnH(n+6)/2 with the homological difference C4H2, while all other series of hydrocarbons have a homological difference CH2.Conclusion. …”
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4718
Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection
Published 2025-06-01“…In addition, ZIKV affected the expression of FIS1 protein levels and the respiratory complexes of II, III, and IV in mice lacking Bmal1 expression in endothelial cells. …”
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4719
A scoping review of burden of disease studies estimating disability-adjusted life years due to Taenia solium.
Published 2022-07-01“…<h4>Eligibility criteria</h4>Studies must have calculated disability-adjusted life years relating to T. solium.…”
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4720
Variables associated with COVID-19 severity: an observational study of non-paediatric confirmed cases from the general population of the Basque Country, Spain
Published 2021-04-01“…The Classification and Regression Trees recursive partitioning methodology (based on n=13 792) suggested that among all associations, those with, age, sex, stratification of patient healthcare complexity, chronic consumption of blood and blood-forming organ, and nervous system drugs, as well as the total number of chronic Anatomical Therapeutic Chemical types were the most relevant. …”
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