A Central Role for Troponin C Amino-Terminal α-Helix in Vertebrate Thin Filament Ca²⁺-Activation by Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase

“…The 3D location of the N-helix within the troponin complex is also distinct between skeletal and cardiac troponin. …”
Get full text

A novel NKG2A alpaca nanobody targeting immune checkpoint blockade for the treatment of malignant melanoma by Xiang Guo, Xiang Guo, Xiang Guo, Congfang Guo, Dongxiao Li, Yuting Bai, Mureed Abbas, Mureed Abbas, Ruiwen Fan, Yiyan Zhao, Yiyan Zhao

“…Malignant melanoma (MM) is a severe and aggressive form of cancer that affects both humans and animals. …”
Get full text

Comparison of efficacy and safety of His-Purkinje system pacing versus cardiac resynchronisation therapy in patients with pacing-induced cardiomyopathy: protocol for a randomised c... by Junjun Chen, Liting Cheng, Junmeng Zhang, Zefeng Wang, Zhuo Liang, Jieruo Chen, Yongquan Wu, Xiao Du, Ruiqing Dong, Fei Hang, Xinlu Wang, Ziyu Wang

“…The primary outcome is the duration of QRS complex (QRS width), and the secondary outcomes are NT-proBNP (N terminal pro B type natriuretic peptide), C reactive protein, the number of antibiotics used, left ventricular ejection fraction, end systolic volume, end diastolic volume, the hospitalisation duration, the incidence of postoperative infection, pacemaker parameters (threshold, sensing and impedance), the 6-minute walking test, and quality of life (36-Item Short Form Survey scale), all-cause mortality, cardiovascular death, heart failure-related rehospitalisation rate, other rehospitalisation rates, major complication rates and procedure costs.Ethics and dissemination This study has been approved by the Beijing Anzhen Hospital Medical Ethics Committee (No. 2020043X).Trial registration number Chinese Clinical Trial Registry (ChiCTR2000034265).…”
Get full text

BME 2.0: Engineering the Future of Medicine by Michael I. Miller, Andrew O. Brightman, Frederick H. Epstein, K. Jane Grande-Allen, Jordan J. Green, Eileen Haase, Cato T. Laurencin, Elizabeth Logsdon, Feilim Mac Gabhann, Brenda Ogle, Chun Wang, George R. Wodicka, Rai Winslow

“…This article reviews what we believe will be the next wave of biomedical engineering (BME) education in support of the biomedical age, what we have termed BME 2.0. BME 2.0 was announced on October 12 2017 at BMES 49 (https://www.bme.jhu.edu/news-events/news/miller-opens-2017-bmes-annual-meeting-with-vision-for-new-bme-era/). …”
Get full text

Two case reports of B-cell lymphopenia associated with IGLL1 variants identified through newborn screening in Ukraine by Oksana Boyarchuk, Yaryna Romanyshyn, Ihor Savchak, Volodymyr Kravets, Volodymyr Kravets, Ivanna Shymanska, Halyna Makukh, Halyna Makukh

“…The IGLL1 gene encodes the surrogate light chain components λ5 and VpreB, which form a crucial part of the pre-B cell receptor complex. …”
Get full text

The effect of Ocimum basilicum on the prevention of postpartum depression symptoms and sleep quality: A triple-blind randomized controlled clinical trial by Monireh Abdi, Elham Rezaei, Mojgan Mirghafourvand, Fatemeh Ebrahimi, Laleh Payahoo, Alireza Shafiei-Kandjani, Solmaz Ghanbari-Homaie

“…Background: Postpartum depression is a multifactorial and complex disorder. Various approaches for preventing and treating this condition have been suggested. …”
Get full text

A Further Realization of Binary Genetic Algorithm to Design a Dual Frequency Band Rectenna for Energy Harvesting in 5G Networks by Yahiea Al Naiemy, Aqeel N. Abdulateef, Ahmed Rifaat Hamad, Mohammed Saadi Ismael, Balachandran Ruthramurthy, Taha A. Elwi, Lajos Nagy, Thomas Zwick

“… Energy-autonomous systems have evolved in response to the quick deployment of 5G networks and growing presence of Internet of Things (IoT) devices.   …”
Get full text

THE EFFECT OF EARLY SPRING FERTILIZING WITH AMMONIUM NITRATE ON THE YIELD AND QUALITY OF WINTER WHEAT VARIETIES IN THE DRY-STEPPE ZONE OF CHESTNUT SOILS OF THE VOLGOGRAD REGION by Vitaly L. Sapunkov

Get full text

Fine detection of floor water damage by three-dimensional direct current electric method based on cross-lane observation by Guanqun ZHOU, Hongda ZHAO, Weixin ZHANG, Xiaoping WU, Xikai LIANG, Zongtao WANG, Yafei WANG

“…The research indicates that: the inversion results of the cross-roadway observation can clearly display the vertical form of the low-resistance abnormal body. With the increase in depth, its inversion results have higher resolution. …”
Get full text

Effect of protrusion structure on the performance of an advanced hydrodynamic cavitation reactor: An entropy-based analysis by Gaoju Xia, Sivakumar Manickam, Jingwei Li, Zhiqiang Yin, Wenlong Wang, Xun Sun

Get full text

Biorefinery and Bioremediation Strategies for Efficient Management of Recalcitrant Pollutants Using Termites as an Obscure yet Promising Source of Bacterial Gut Symbionts: A Review by Rongrong Xie, Blessing Danso, Jianzhong Sun, Majid Al-Zahrani, Mudasir A. Dar, Rania Al-Tohamy, Sameh S. Ali

“…Lignocellulosic biomass (LCB) in the form of agricultural, forestry, and agro-industrial wastes is globally generated in large volumes every year. …”
Get full text

MADD-like pattern of acylcarnitines associated with sertraline use by Filippo Ingoglia, Mohsen Tanfous, Benjamin Ellezam, Katherine J. Anderson, Marzia Pasquali, Lorenzo D. Botto

“…The heterogeneous phenotypes associated with MADD have been classified into three groups: neonatal onset with congenital anomalies (type 1), neonatal onset without congenital anomalies (type 2), and attenuated and/or later onset (type 3). …”
Get full text

Options of improvement of efficacy of gastroesophageal reflux disease treatment by dioctaedric smectite by O. A. Storonova, A. S. Trukhmanov, N. Yu. Ivashkina, V. T. Ivashkin

“…On a background of therapy by PPI + Smecta acidic refluxes have been eliminated in 14 (93%), at PPI monotherapy — in 11 (73%), at Smecta monotherapy — in 100% of patients. …”
Get full text

Cognitive-behavioral therapy in the treatment of patients with chronic migraine and emotional impairment: A prospective randomized trial with a two-year follow-up period by Veronika A. Golovacheva, Anzhelika A. Golovacheva

“…Cognitive behavioral therapy (CBT) is promising in the complex treatment of patients with CM and emotional disorders. …”
Get full text

Overpressure formation mechanism in deep and ultra-deep layers in middle section of southern margin of Junggar Basin and its relationship with reservoir formation: a case study of... by Zhixin TIAN, Gang LIU, Xukai PENG, Changyu FAN, Gang WANG

“…In recent years, breakthroughs have been continuously made in deep and ultra-deep oil and gas exploration in the southern margin of the Junggar Basin. …”
Get full text

General principles of expanding the speed range of operation of autonomous power supply systems for passenger cars by S. L. Samoshkin, S. S. Mironov, O. S. Samoshkin, M. V. Khodenkov, A. S. Sarikov

“…It is solved by forcing the excitation of the generators.Analysis of modern systems of autonomous power supply of passenger cars showed that the expansion of the speed range of its operation can be achieved in three ways:•             raising the gear ratio of the gearbox to ensure it is switched on to the nominal mode at a carriage speed of 15 - 20 km/h without changing the parameters of the generator and the entire system of autonomous power supply;•             modernization of the electrical equipment complex for passenger cars to ensure the operation of the main power consumers and charge the battery while driving at low speeds (over 18 km/h) without changing the mechanical parameters and composition of the serial generator-drive unit;•             modernization of the generator in order to reduce its turnon revolutions to the power required to provide the main power consumers without changing the mechanical parameters of the drive.All three methods have its advantages and disadvantages, the choice of any of them is determined by the technical requirements for a specific car model.…”
Get full text

Epidemic Outbreak of Catheter-Associated Bloodstream Infections among Patients Receiving Renal Replacement Therapy by D. V. Kvashnina, O. V. Kovalishena, O. M. Sutyrina, I. V. Solov’yeva, I. V. Belova, A. G. Tochilina, I. Yu. Shirokova

“…Conclusion: the epidemic outbreak of CABSI in multidisciplinary hospital was identified and eliminated, The outbreak was the result of the circulation in the hospital of S. aureus hospital strain, which formed a reservoir among personnel and patients.…”
Get full text

The role of social determinants of health in woman’s intention to pregnancy: a model with the mediation of social support by Farzaneh Rashidi, Fereshteh Ghahremani, Zohreh Mahmoodi, Mahbobeh Ahmadi Doulabi

“…Abstract Background Childbearing intention is a complex issue that is influenced by a number of factor. …”
Get full text

Sedimentary processes controlling gas hydrate accumulation in the Shenhu area of the northern South China Sea by Wenlin Chen, Wenlin Chen, Chenyang Bai, Chenyang Bai, Chenyang Bai, Hongyuan Xu, Hongyuan Xu, Xiaolei Xu, Xiaolei Xu

“…During periods of low sea level and colder climate conditions, gravity flows preferentially develop fine-grained turbidite deposits. Sediments form in such sedimentological and environmental conditions promote gas hydrate accumulation. …”
Get full text

Diagnostics of Structural Thinking of Bachelors of Pedagogical Education as a Universal Pedagogical Competence by Daria A. Barkhatova, Daria S. Grushentseva

“…Each task reflected the level at which students developed structural thinking.The results of the study showed that many students have difficulties identifying the main idea in the text, and as a consequence, constructing its structure in the form of a mental diagram. …”
Get full text