Co-creating mental health promotion and prevention interventions with groups in vulnerable situations in Europe: a mixed-methods study protocol for co-creation implementation and p... by Raquel Teixeira, Cláudia de Freitas, Liuska Sanna, Eleonora Prina, Giulia Turrini, Amber S. Brizar, Cătălin Gherdan, Evaldas Kazlauskas, Austėja Dumarkaitė, Henrik Wasmus, Leonie Fleck, Ulrich Reininghaus, Melanie Mack, Chiara Scarampi, Maritta Välimäki, Maija Satamo, Wietse A. Tol

“…Abstract Background Co-creation has emerged as a crucial strategy for addressing complex public health challenges, including promotion and prevention of mental health concerns. …”
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Addressing the Socioemotional Dimension of Medical Education: Protocol for a Scoping Review of Student-Driven Development Strategies by Cintia Canato Martins, Marco Antônio Ribeiro Filho, Christian Guilherme Capobianco dos Santos, Luana Ribeiro Altrão lorino, João Daniel de Souza Menezes, Matheus Querino da Silva, Loiane Letícia dos Santos, Emerson Roberto dos Santos, Natalia Almeida de Arnaldo Silva Rodriguez Castro, Helena Landin Gonçalves Cristóvão, Randolfo dos Santos Júnior, Gerardo Maria de Araújo Filho, Patrícia da Silva Fucuta, Alba Regina de Abreu Lima, Vânia Maria Sabadoto Brienze, Denise Cristina Móz Vaz Oliani, Neide Aparecida Micelli Domingos, Maria Cristina de Oliveira Santos Miyazaki, Júlio César André

“… BackgroundThe current international context, marked by complex global challenges, necessitates the rapid intervention of higher education institutions to contribute to social transformation. …”
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Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…All annotations made on the slides were hidden from the other pathologists. The 6-week gap between viewings was managed independently by the trial management team. …”
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Data stewardship and curation practices in AI-based genomics and automated microscopy image analysis for high-throughput screening studies: promoting robust and ethical AI applicat... by Asefa Adimasu Taddese, Assefa Chekole Addis, Bjorn T. Tam

“…While 36 articles extensively discussed data interoperability and sharing, AI-model explain ability and data augmentation remained underexplored, indicating significant gaps. The integration of diverse data types—ranging from sequencing and clinical data to proteomic and imaging data—highlighted the complexity and expansive scope of AI applications in these fields. …”
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Integrated GIS, statistical modeling, and CMIP6-based assessment of groundwater irrigation quality in north-central Bangladesh for sustainable management by Md Touhidul Islam, Nilima Das, Md Rakibul Islam, Mahadi Hasan Joy, Mst Rimi Khatun, Nusrat Jahan, Nahidul Islam, Md Mazharul Islam, Sujan Chandra Roy, A.K.M. Adham

“…Focusing on the Brahmaputra River floodplain—where 80 % of irrigation relies on groundwater—the research addresses critical gaps in understanding spatiotemporal water quality variations. …”
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A Systematic Open Source Modeling Method for Energy and Power Systems: Solar PV Application by Peter Munyao Mutuku, Alan L. Leigh Jarvis, Andrew G. Swanson, Mohamed F. Khan

“…However, limited access to high-resolution, localized data reduces model accuracy, especially in regions with infrastructural constraints and complex weather conditions. This paper introduces a novel, systematic Open Source Modeling Method for Energy and Power Systems (OSM-MEPS). …”
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Global biogeography of N₂-fixing microbes: <i>nifH</i> amplicon database and analytics workflow by M. Morando, J. D. Magasin, S. Cheung, S. Cheung, M. M. Mills, J. P. Zehr, K. A. Turk-Kubo

“…To address these knowledge gaps, a bioinformatic workflow was designed that standardizes the processing of <i>nifH</i> amplicon datasets originating from high-throughput sequencing (HTS). …”
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Application of machine learning in early childhood development research: a scoping review by Akbar K Waljee, Amina Abubakar, Patrick N Mwangala, Faith Neema Benson, Daisy Chelangat, Willie Brink, Cheryl A Moyer

“…Artificial intelligence techniques, particularly machine learning (ML), offer an innovative approach by analysing complex datasets to detect subtle developmental patterns.Objective To map the existing literature on the use of ML in ECD research, including its geographical distribution, to identify research gaps and inform future directions. …”
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Target product profiles for digital health technologies including those with artificial intelligence: a systematic review by Trystan B. Macdonald, Trystan B. Macdonald, Trystan B. Macdonald, H. D. Jeffry Hogg, H. D. Jeffry Hogg, Jacqueline Dinnes, Jacqueline Dinnes, Lucy Verrinder, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, J. Kevin Dunbar, Ameenat Lola Solebo, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Felix Greaves, Carl Macrae, Carl Macrae, Russell Pearson, Adnan Tufail, Adnan Tufail, Xiaoxuan Liu, Xiaoxuan Liu, Xiaoxuan Liu, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston

“…Digital health technologies (DHTs), including those incorporating artificial intelligence (AI), have the potential to improve healthcare access, efficiency, and quality, reducing gaps between healthcare capacity and demand. Despite prioritisation in health policy, the adoption of DHTs remains limited, especially for AI, in part due to complex system requirements. …”
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Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression by Peipei Li, Menghe Liang, Junlin Zhu, Jian Chen, Lin Xia, Ziqi Jin, Xiao Zhang, Shuqing Zhang, Qi Wang, Zhen Liu, Yu Ping, Zhenxin Wang, Catherine CL Wong, Yi Zhang, Heng Yang, Zilu Ye, Yuting Ma

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Evaluation of the evidence-based practices for the management of PCOS in the Latin America context: the consensus of the Latin American Association of Gynecological Endocrinology (... by Poli Mara Spritzer, Germán Gonzalo Salazar Santos, Mónica Liliana Munevar Vega, Peter Chedraui, Susana Pilnik, Adriana Camero Lascano, Alejandra Belardo, Alejandra Elizalde Cremonte, Alejandra Vivas Ramírez, Alejandro Rosas Balán, Ana María Barragán, Angela María Gómez Quintero, Camila Andrea Camargo Rodríguez, Daniel Alejandro Buitrago, Germán Barón Castañeda, Guillermo Rossi, Inés de La Parra, Iván Darío Montes Suárez, Jorge Alejandro Michel Vergara, Lucas Bandeira Marchesan, Mariana Abril Barreto, Milagros Sánchez Torrejón, Selva Lima, Teresa de Jesús Ramos de Ferreira, Alejandro Manzur

“…Objectives Polycystic Ovary Syndrome (PCOS) is a complex condition affecting approximately 1 in 10 women of reproductive age. …”
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Barriers and facilitators to social-emotional health screening in pediatrics: Results from a qualitative study of practitioner perspectives by Michelle Scotton Franklin, Ainsley Buck, Reed Kenny, Sophie Hurewitz, Nathaniel Neptune, Rasheca Logendran, Ellie Winslow, Elizabeth J. Gifford, Gillian Sanders-Schmidler, Rushina Cholera

“…Our results identified significant gaps preventing universal SEH screening from being implemented. …”
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Can we rely on artificial intelligence to guide antimicrobial therapy? A systematic literature review by Sulwan AlGain, Alexandre R. Marra, Takaaki Kobayashi, Pedro S. Marra, Patricia Deffune Celeghini, Mariana Kim Hsieh, Mohammed Abdu Shatari, Samiyah Althagafi, Maria Alayed, Jamila I Ranavaya, Nicole A. Boodhoo, Nicholas O. Meade, Daniel Fu, Mindy Marie Sampson, Guillermo Rodriguez-Nava, Alex N. Zimmet, David Ha, Mohammed Alsuhaibani, Boglarka S. Huddleston, Jorge L. Salinas

“…By improving antimicrobial resistance prediction and optimizing antibiotic prescriptions, these technologies may support treatment strategies and address critical gaps in healthcare. This study evaluates the effectiveness of AI in guiding appropriate antibiotic prescriptions for infectious diseases through a systematic literature review. …”
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Bidirectional relationships between intolerance of uncertainty and generalized anxiety among adolescents: insights from cross-lagged panel network analysis by Haoxian Ye, Yunyi Li, Yike Huang, Yiming Zhang, Jiaxiong Zhang, Jiaqi Wang, Keying Liu, Yuyi Yao, Xinyu Shi, Yijia Liu, Fang Fan

“…Conclusions This study provides new insights into the reciprocal relationships between IU and generalized anxiety among adolescents, highlighting the complex interplay between vulnerability and mental health problems. …”
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Profiling Land Use Planning: Legislative Structures in Five European Nations by Dimitrios Koumoulidis, Ioannis Varvaris, Diofantos Hadjimitsis, Marzia Gabriele, Raffaella Brumana, Ioannis Gitas, Nikos Georgopoulos, Azadeh Abdollahnejad, Eleni Gkounti, Dimitris Stavrakoudis, Donatella Caniani, Andriy Dorosh, Roman Derkulskyi, Oksana Sakal, Shamil Ibatullin, Yevhenii Khan, Oleksandr Melnyk, Anne Fromage Mariette, Marc Tondriaux, Andrzej Perkowski, Adam Sieczka, Mariusz Maciejczak, Chryssa Kopra, Georgia Kostaki, Paraskevi Chantzi

“…Land use transformation, the longest-standing human-driven environmental alteration, is a pressing and complex issue that significantly impacts European landscapes and contributes to global environmental change. …”
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Design of the Focus on Restaurant Engagement to Strengthen Health (FRESH) study: leveraging systems science to work with independently-owned restaurants to increase access to and p... by Uriyoán Colón-Ramos, Emma C. Lewis, Anna Claire Tucker, Lisa Poirier, Chathurangi H. Pathiravasan, Michelle Estradé, Takeru Igusa, Julia A. Wolfson, Yeeli Mui, Veronica Vélez-Burgess, Audrey E. Thomas, Shuxian Hua, Lawrence J. Cheskin, Lawrence J. Cheskin, Antonio J. Trujillo, Ayoyemi T. Oladimeji, Stacey Williamson, Rosalinda Romero, Patricia Sánchez Hernández, Joel Gittelsohn

“…Independently-owned restaurants are a common prepared food source in minority low-income communities, but there are significant knowledge gaps on how to work with these restaurants to offer healthy food, due to underlying and dynamic complexities associated with providing healthy food options.MethodsThe Focus on Restaurant Engagement to Strengthen Health (FRESH) study addresses this complex problem by leveraging systems science approaches to work with independently-owned restaurants. …”
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‘It’s the perfect storm’: why are people with eating disorders at risk of suicide? A qualitative study by Una Foye, Saakshi Kakar, Niamh McNamara, Agnieszka Musial, Tom Jewell, Jessica R. Griffiths, Carol Kan, Gerome Breen, Rachel Rowan Olive, T. Suratwala, Aman Sidhu, Lizzie Mitchell, George Mycock, Katie Graden, Saskia Evans Perks, Elia Chitwa, Holly Whitehead, Ulrike Schmidt, Rina Dutta, Moritz Herle

“…Results Key themes identified include ‘no way out’: the unique role of eating disorders in suicidality across illness and recovery, the outsider experience: feeling unseen, misunderstood, and burdensome, sparks of hope: protective Factors against suicidality, and ‘they only see weight’: how gaps in ED care reinforce isolation and risk. These findings underscore the complex and multifaceted reasons why people with EDs are at risk of suicide, acknowledging the unique risk factors associated with the illness itself as well as the various risk periods that affect those with EDs. …”
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Selenium and its mechanisms mitigate cadmium toxicity in plants: Promising role and future potentials by Javed Hussian Sahito, Chenhui Ma, Jihong Zhang, Jianxin Li, Jiawen Zhao, Liqin Mu, Yuanyuan Zhang, Zeeshan Ghulam Nabi Gishkori, Dong Ding, Xuehai Zhang, Jihua Tang

“…Additionally, we also discussed research gaps and future research of Se to alleviate Cd induced toxicity. …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Scientific summary Background For older people and those with complex needs, the transition from hospital to home is risky. …”
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A Systematic Assessment of <i>Leishmania donovani</i> Infection in Domestic and Wild Animal Reservoir Hosts of Zoonotic Visceral Leishmaniasis in India by Gajala Deethamvali Ghouse Peer, Anjali Priyadarshini, Archana Gupta, Arpana Vibhuti, Elcio Leal, Antonio Charlys da Costa, Carlos Prudencio, Kirtanjot Kaur, Saheem Ahmad, V. Samuel Raj, Ramendra Pati Pandey

“…Species of the <i>L. donovani</i> complex have distinct enzootic, zoonotic, and anthroponotic life cycles that depend on the environment. …”
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