Innovative therapeutic strategies for cervical cancer: advances in pain management, angiogenesis inhibition, and peptide-based therapies by Beatrice Odei-Mensah, Samson A. Adeyemi, Lindokuhle M. Ngema, Hillary Mndlovu, Yahya E. Choonara

“…The disease is often accompanied by complex pain patterns due to tumour progression, nerve invasion, and treatment-related effects, which conventional therapies fail to adequately address. …”
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Increased vegetation disturbance intensity reduces soil nutrients while enhancing microbial network interactions by Boya Gao, Boya Gao, Boya Gao, Dan Xiao, Dan Xiao, Kaixun Yang, Kaixun Yang, Kaixun Yang, Mingming Sun, Mingming Sun, Mingming Sun, Shantong Luo, Shantong Luo, Shantong Luo, Wei Zhang, Wei Zhang, Kelin Wang, Kelin Wang

“…To address this knowledge gap, this study investigates how varying levels of vegetation disturbance influence soil properties, as well as the diversity, composition, and interactions of bacterial, fungal, and protist communities in a karst ecosystem. …”
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Knowledge of legal rights as a factor of refugee and asylum seekers’ health status: a qualitative study by Tara C Pilato, Faten Taki, Kaitlyn Sbrollini, Amanda Purington Drake, Brian Maley, Stephen Yale-Loehr, Jane L Powers, Natalya N Bazarova, Aparajita Bhandari, Gunisha Kaur

“…Several impediments to accessing healthcare and public benefits were identified, including pragmatic barriers (such as prohibitive costs or lack of insurance), knowledge gaps and mistrust of healthcare systems.Conclusions There is low health engagement by refugees and asylum seekers, as a result of multiple, complex factors impeding the ability of refugee and asylum seekers to access healthcare and other public benefits for which they are eligible—with resultant detrimental health effects. …”
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Historicizing Natural Hazards and Human-Induced Landscape Transformation in a Tropical Mountainous Environment in Africa: Narratives from Elderly Citizens by Violet Kanyiginya, Ronald Twongyirwe, David Mubiru, Caroline Michellier, Mercy Gloria Ashepet, Grace Kagoro-Rugunda, Matthieu Kervyn, Olivier Dewitte

“…Studying natural hazards in the context of human-induced landscape transformation is complex, especially in regions with limited information. …”
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A comprehensive review of rehabilitation approaches for traumatic brain injury: efficacy and outcomes by Ye Shen, Linzhi Jiang, Junmei Lai, Jiahui Hu, Feng Liang, Xingru Zhang, Fangfang Ma

“…Traumatic Brain Injury (TBI), particularly in moderate-to-severe cases, remains a leading cause of long-term disability worldwide, affecting over 64 million individuals annually. Its complex and multifactorial nature demands an integrated, multidisciplinary rehabilitation approach to address the diverse physical, cognitive, behavioral, and psychosocial impairments that follow injury. …”
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Utilising Macau Science Satellite-1 Data and Comprehensive Datasets to Develop a Lithospheric Magnetic Field Model of the Chinese Mainland by Yan Feng, Xinwu Li, Yuxuan Lin, Jiaxuan Zhang, Jinyuan Zhang, Yi Jiang, Qing Yan, Pengfei Liu

“…The relationship between these anomalies and heat flow in northeastern China appears less evident, suggesting a complex interplay of orogenic processes and surface mineralogy in shaping these magnetic signatures.…”
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Substance use disorders among African, Caribbean and Black (ACB) people in Canada: a scoping review protocol by LaRon E Nelson, Joseph D Nguemo, Ngozi Iroanyah, Winston Husbands, Geoffrey Maina, Irene Njoroge, Maureen Owino, Desmond Miller, Josephine Wong

“…Introduction Previous research demonstrated that substance use continues to be one of the most complex and prevalent problems among African, Caribbean and Black (ACB) people. …”
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Radiation therapist (RTT) perspectives on developing image-guided radiotherapy (IGRT) protocols for reirradiation by Aileen Duffton, Lynsey Devlin, Aoife Williamson, Derek Grose, Eilidh Tolmie, Linda MacLaren, Sharon McFadden, Rebecca Muirhead

“…Advanced radiotherapy planning and delivery have increased treatment possibilities for complex cases, including reirradiation. However, considerable gaps and variability in reirradiation image-guided radiotherapy (IGRT) and treatment delivery exist. …”
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Development and usability testing of a multifaceted intervention to reduce low-value injury care by Mélanie Bérubé, Alexandra Lapierre, Michael Sykes, Jeremy Grimshaw, Alexis F. Turgeon, François Lauzier, Monica Taljaard, Henry Thomas Stelfox, Holly Witteman, Simon Berthelot, Éric Mercier, Catherine Gonthier, Jérôme Paquet, Robert Fowler, Natalie Yanchar, Barbara Haas, Paule Lessard-Bonaventure, Patrick Archambault, Belinda Gabbe, Jason R. Guertin, Yougdong Ouyang, Lynne Moore, the Canadian Traumatic Brain Injury Research Consortium

“…Abstract Background Multifaceted interventions that address barriers and facilitators have been shown to be most effective for increasing the adoption of high-value care, but there is a knowledge gap on this type of intervention for the de-implementation of low-value care. …”
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DEVELOPMENT OF THE CONCEPT OF SUBSIDIARY LIABILITY AS A TOOL TO INCREASE THE EFFECTIVENESS OF THE INSTITUTION OF BANKRUPTCY AND ENSURE THE ECONOMIC SECURITY OF THE COUNTRY by V. N. Alferov, M. M. Korigova

“…However, the effectiveness of these measures remains insuficient, there are gaps in the implementation of the concept. In the work on the basis of practical experience of the application of the concept of subsidiary responsibility in Russia and foreign experience, proposals have been made to improve the concept, their implementation along with other proposals for the modernization of the institution of bankruptcy will increase the eficiency of the institution of bankruptcy and prevent emerging crisis phenomena in the economy, stabilize the financial situation of business entities and ensure the economic security of the country.Conclusions and relevance: the conducted research shows the importance of the concept of subsidiary liability in ensuring the effectiveness of the institution of bankruptcy and economic security of the country. …”
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Education and Symptom Reporting in an mHealth App for Patients With Cancer: Mixed Methods Development and Validation Study by Carolina Muñoz Olivar, Miguel Pineiro, Juan Sebastián Gómez Quintero, Carlos Javier Avendaño-Vásquez, Pablo Ormeño-Arriagada, Silvia Palma Rivadeneira, Carla Taramasco Toro

“…The early detection and management of the side effects are vital but complex. This study introduces a mobile health app designed to bridge the communication gaps between patients with cancer and health care providers. …”
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Longitudinal studies on breastfeeding among preterm infants: a scoping review by Xin Jiang, Lijing Ding, Na Wu, Yue Wan, Yiting Xu, Xiao Yao, Ke Ying Huo, Rong Huang

“…Conclusion This scoping review study provides the complex and evolving breastfeeding challenges faced by preterm infants, shaped by physiological, social, and psychological factors. …”
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Evaluating the Impacts of Community-Campus Engagement on Population Health in Ottawa and Thunder Bay, Canada: Protocol for a Mixed Methods Contribution Analysis by David Buetti, Cynthia Larche, Michael Fitzgerald, Isabelle Bourgeois, Erin Cameron, Kady Carr, Tim Aubry, Sydney Persaud, Claire E Kendall

“…Measuring the impacts of CCE is inherently complex due to factors such as diverse stakeholders, context-specific variables, and dynamic interactions within a community. …”
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What stops private hospitals from engaging with publicly funded health insurance schemes? A mixed-methods study on PMJAY/MJPJAY in Maharashtra, India by Shweta Marathe, Prashant Ingle, Deepali Yakkundi, Kerry Scott

“…Low private sector engagement was driven by multiple factors: at the policy level, insufficient state budgets, low reimbursement rates, fixed scheme packages, strict empanelment criteria, complex claims processes, and delayed reimbursements; at the hospital level, economic non-viability, concerns about patient load and profile, and limited administrative capacities; and at the operational level, inadequate monitoring mechanisms for PFHIS and empanelled hospitals, gaps in the empanelment process, and delays in patient pre-authorization and claims processing. …”
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562 Mapping and navigating translational resources with generative AI by Jonathan Gelfond, Meredith Zozus, Martin Goros, Jennifer Potter, Kimberly K. Summers, Susanne Schmidt, Stephanie Rowan, Laura Aubree Shay

“…Objectives/Goals: Translational researchers often struggle to navigate a complex constellation of institutional resources spanning the IRB to bioinformatics units. …”
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In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy by Maedeh Radandish, Niloofar Mashhadi, Amir Hossein Aghayan, Motahareh Taghizadeh, Sara Salehianfard, Sheida Yahyazadeh, Omid Vakili, Somayeh Igder

“…This review aims to synthesize current understanding of the complex interactions between stromal cells and TLSs, addressing existing gaps in mechanistic insight and exploring therapeutic avenues to exploit TLS plasticity. …”
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EXTERNAL QUALITY ASSESSMENT OF GENERAL EDUCATION AS A FACTOR OF TEACHERS’ PROFESSIONAL DEVELOPMENT by T. V. Potemkinа, T. I. Pudenko, A. A. Rudneva

“…Nowadays, foreign and Russian researchers state the lack of reliable tools for diagnostics of professional gaps among teachers. It is unjustified to draw conclusions about skill level of teachers, relying only on results which are shown by pupils when holding unified state examinations and monitoring tests. …”
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Understanding preconception care: a scoping review of knowledge, attitudes and practices among reproductive age individuals, healthcare workers and stakeholders in low- and middle-... by Yared Asmare Aynalem, Zohra Lassi, Janice Y Kung, Salima Meherali, Pauline Paul, Amber Hussain

“…The primary objective is to identify key gaps and research priorities to guide future efforts to improve maternal and child health.Design This review followed Arksey and O'Malley’s scoping review framework, with a comprehensive search across Medline, EMBASE, CINAHL and Scopus from inception to May 2025. …”
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Navigating the completing cancer treatment incentive in Malaysia: patient insights and implementation challenges by Nur Hidayati Abdul Halim, Nur Azmiah Zainuddin, Farhana Aminuddin, Nurul Athirah Naserrudin, Nor Zam Azihan Mohd Hassan

“…Conclusions The study highlights critical gaps in the CCTI program's design and delivery, including inadequate communication strategies, complex administrative processes, and a lack of transparency. …”
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Barriers to healthcare professionals screening, recognizing, and managing delirium in the adult patients receiving specialist palliative care: a mixed-methods systematic review by Fang Qian, Danyang Yao, Huanhuan Shi, Tao-Hsin Tung, Dongjun Bi

“…Conclusion The systematic review uncovered a complex interplay of barriers spanning individual, operational, organizational, and contextual levels in palliative settings. …”
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