Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway by Libo Wang, Libo Wang, Fei Lin, Runran Miao, Tianhao Zhao, Yuan Liu, Lin Yang, Min Zhang, Min Zhang

“…Docking simulations predicted that wogonin forms a stable complex with Sirt1 through hydrogen-bonding and hydrophobic interactions, which was further validated by biotin-affinity pulldown assays.ConclusionWogonin exerts protective effects against cardiac dysfunction and fibrosis in PF mice by modulating Sirt1/γ-H2AX-mediated pathways to reduce DNA damage and apoptosis. …”
Get full text

Relationship between BMI, indicators of lipid metabolism and diabetic neuropathy: a Mendelian randomization study by Yuanyuan Jia, Guanying Liu, Xuesong Li, Lijun Duan, Lifeng Zhao

“…This study addresses the critical gap in understanding the causal relationship between BMI, lipid metabolism, and diabetic neuropathy (DN). …”
Get full text

Enhancing Immoral Post Detection on Social Networks Using Knowledge Graph and Attention-Based BiLSTM Framework by Bibi Saqia, Khairullah Khan, Atta Ur Rahman, Sajid Ullah Khan, Mohammed Alkhowaiter, Wahab Khan, Ashraf Ullah

“…Various Natural Language Processing (NLP) approaches are being employed to detect subtle immoral posts; however, there remains a research gap due to the semantic and contextual complexity of natural language. …”
Get full text

Optimization of Electricity Consumption using Dielectric Barrier Discharge Method (DBD) by Noushin Dadashzadeh

“…By changing different discharge gaps, the gap has been optimized and as a result, optimized power consumption has been achieved.…”
Get full text

Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C by Vadym Sulimenko, Eduarda Dráberová, Vladimíra Sládková, Tetyana Sulimenko, Věra Vosecká, Omar Skalli, Pavel Dráber

“…Abstract Background G protein-coupled receptor kinase-interacting proteins (GITs) function as GTPase-activating proteins (GAPs) for small GTPases of the ADP-ribosylation factor (Arf) family. …”
Get full text

Error Classification and Static Detection Methods in Tri-Programming Models: MPI, OpenMP, and CUDA by Saeed Musaad Altalhi, Fathy Elbouraey Eassa, Sanaa Abdullah Sharaf, Ahmed Mohammed Alghamdi, Khalid Ali Almarhabi, Rana Ahmad Bilal Khalid

“…Moreover, existing tools are inadequate for detecting such errors in tri-model applications, leaving a critical gap in development support. To address this gap, the present study introduces a static analysis tool designed specifically for tri-model applications combining MPI, OpenMP, and CUDA in C++-based environments. …”
Get full text

Biogeography of freshwater plants in four major lakes in Kenya by Rebeccah Kwamboka Onwong’a, Collins Handa, Lewis Sitoki, Ayub M. O. Oduor

“…Despite their importance, there is a significant gap in our understanding of the macroecology of freshwater plants in tropical regions, where biodiversity is typically high, and ecosystems face substantial pressures from human activities. …”
Get full text

Development of Multimodal Physical and Virtual Traffic Reality Simulation System by Ismet Goksad Erdagi, Slavica Gavric, Aleksandar Stevanovic

“…As urban traffic complexity increases, realistic multimodal simulation environments are essential for evaluating transportation safety and human behavior. …”
Get full text

General framework of nonlinear factor interactions using bayesian networks for risk analysis applied to road safety and public health by Cinzia Carrodano

“…However, traditional linear models often fail to capture these complex interdependencies, leading to significant gaps in risk prediction. …”
Get full text

Generative AI in Shariah Advisory in Islamic Finance: An Experimental Study by Muhammad Noman Jokhio, Muhammad Asif Jaffer

“…However, their inconsistent ability to offer actionable guidance highlights gaps in handling complex scenarios. While these tools can enhance efficiency in Shariah advisory by streamlining routine tasks, their limitations underscore the need for human oversight and domain-specific refinement. …”
Get full text

Secure Coding in Five Steps by Mini Zeng, Feng Zhu

“…Our evaluation shows that the approach reduces complexity and encourages students to use secure coding practice in their future projects.…”
Get full text

From Photos to Performances: Exploring the Digital Transformation of Photovoice Through Velfies by Lucian Ciolan, Loredana Manasia

“…We argue that this performative, digital approach expands Photovoice methodology by bridging the gap between participant experience and researcher interpretation, capturing the complexities of lived educational experiences with greater depth and nuance.…”
Get full text

Considerations for educational developers working with academic applicants on writing diversity statements by Hima Rawal, Stefanie Baier

“…In response to the existing knowledge gap about what transpires after submitting diversity statements to hiring committees, we conducted a survey involving 299 academic hiring committee members serving between 2015 and 2021 at five predominantly white, research-focused institutions in the Midwest and Southwest. …”
Get full text

Interconnected Dynamic Components of Learner Language by Shamini Shetye

“… Second language development can be viewed as a complex and dynamic process in which learners follow non-linear trajectories and develop their language over a period of time (Larsen-Freeman, 2006). …”
Get full text

APG mergence and topological potential optimization based heuristic user association strategy by Zhirui HU, Meihua BI, Fangmin XU, Meilin HE, Changliang ZHENG

“…The η gap between N₀ =20 and N₀ =60 decreases from 1.4% to 0.4%, and the user rate gap decreases from 76 bit/(s·Hz)to 29 bit/(s·Hz). …”
Get full text

Landscapes of Trade by Merten Nefs

“…Thus, the overarching question in the research is: What historical, economic, and institutional dynamics shape the rampant expansion of the logistics complex in the Netherlands? This thesis seeks to contribute to filling six specific knowledge gaps related to the aforementioned six issues and therefore addresses six sub-questions. …”
Get full text

Assessing Fertility Knowledge Among Obstetrics and Gynecology Residents: A Multicenter Cross-Sectional Study by Hemasa Gul, Nabila Khan, Naila, Fatima, Huma Gul

Get full text

Resting-State Functional MRI in Dyslexia: A Systematic Review by Bruce Martins, Isabel A. B. Verrone, Mariana M. I. Sakamoto, Mariana Y. Baba, Melissa E. Yvata, Katerina Lukasova, Mariana P. Nucci

“…Conversely, increased connectivity in the right hemisphere (20%) may indicate the engagement of an alternative network and highlight the complexity of neural adaptations in dyslexia. <b>Conclusions:</b> The findings highlight a significant gap in the study of adult dyslexia and suggest that FC alterations predominantly affect the left hemisphere, with possible compensatory mechanisms in the right hemisphere. …”
Get full text

How to use video analysis in training with educators and teachers of early childhood: An operative model by Chiara Dalledonne Vandini

“…By adopting a participatory approach, this methodology helps bridge the gap between theory and everyday practice, enabling work on multiple levels. …”
Get full text

Exploring botanical diversity, ecological traits, and edaphic determinants in Kala Chitta National Park, Pakistan: Implications for conservation and management by Muhammad Waheed, Um e Hani, Fahim Arshad, Asma Jabeen, Saud Alamri, Manzer H. Siddiqui, Shiekh Marifatul Haq, Muhammad Shoaib, Rainer W. Bussmann

“…However, managing these protected areas effectively requires a grasp of the complex dynamics of plant ecosystems and edaphic factors. …”
Get full text