Dual SPE–HPLC–MS/MS Platform for Cross-Class Antiparasitic Surveillance: Simultaneous Quantification of Oxyclozanide and Levamisole Hydrochloride in Ovine Tissues with Applications... by Guonian Dai, Xuzheng Zhou, Weiwei Wang, Bintao Zhai, Jiang Li, Yangling Liu, Yong Zhang, Jiyu Zhang

“…This study presents a novel high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method for simultaneous determination of oxyclozanide (OXY) and levamisole hydrochloride (LEV) residues in ovine tissues, addressing the critical gap in cross-class antiparasitic drug monitoring. …”
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Trade-offs among human, animal, and environmental health hinder the uniform progress of global One Health by Ya Tian, Junze Zhang, Zonghan Li, Kai Wu, Min Cao, Jian Lin, Prajal Pradhan, Shengjie Lai, Jia Meng, Bojie Fu, Min Chen, Hui Lin

“…Summary: The One Health (OH) approach, integrating aspects of human, animal, and environmental health, still lacks robustly quantified insights into its complex relationships. To fill this knowledge gap, we devised a comprehensive assessment scheme for OH to assess its progress, synergies, trade-offs, and priority targets. …”
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Identification of biomarkers and target drugs for melanoma: a topological and deep learning approach by Xiwei Cui, Xiwei Cui, Jipeng Song, Qingfeng Li, Jieyi Ren

“…Despite the exponential growth of tumor data facilitated by next-generation sequencing (NGS), current analytical approaches predominantly emphasize single-gene analyses, neglecting critical insights into complex gene interaction networks. This study aims to address this gap by systematically exploring immune gene regulatory dynamics in melanoma progression.MethodsWe developed a bidirectional, weighted, signed, and directed topological immune gene regulatory network to compare transcriptional landscapes between benign melanocytic nevi and cutaneous melanoma. …”
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CD38 Deficiency Downregulates the Onset and Pathogenesis of Collagen-Induced Arthritis through the NF-κB Pathway by Yuna Du, Qianqian Dai, Huiqing Zhang, Qi Li, Kuangyu Song, Yingyuan Fu, Weiping Min, Zhenlong Liu, Rong Li

“…We demonstrated that in CD38-/- mice, the expression of the RelB gene and major histocompatibility complex II (MHC II) was decreased, accompanied with the inhibited T cell reaction in a mixed lymphocyte reaction (MLR) in bone marrow-derived DCs. …”
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How obstetricians experience stillbirth and perinatal loss: a systematic review and meta-synthesisAJOG Global Reports at a Glance by Frances Cates, Sara Wetzler, Tabitha Wishlade, Mehali Patel, Catherine E. Aiken, MB/BChir, PhD

“…A subset of obstetricians felt unprepared for the complexity of patient-provider interactions following stillbirth. …”
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Neural Modulation Alteration to Positive and Negative Emotions in Depressed Patients: Insights from fMRI Using Positive/Negative Emotion Atlas by Yu Feng, Weiming Zeng, Yifan Xie, Hongyu Chen, Lei Wang, Yingying Wang, Hongjie Yan, Kaile Zhang, Ran Tao, Wai Ting Siok, Nizhuan Wang

“…Conclusions: These findings emphasize the complex interplay between emotion modulation and depression, showcasing significant alterations in both PEA and NEA among depression patients. …”
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Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets by Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang

“…The pathogenesis of autoimmune diseases is complex, involving not only genetic predisposition (e.g., human leukocyte antigen variants), environmental triggers (e.g., infections), and a dysregulated immune response but also various interacting components that contribute to the development of diverse clinical phenotypes. …”
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Deciphering the mitigating role of silicon on tomato seedlings under lambda cyhalothrin and difenoconazole coexposure by Nabil Touzout, Adil Mihoub, Iftikhar Ahmad, Sabrina Lekmine, Hichem Tahraoui, Feriel Krache, Ehsan Ali, Sarfraz Hussain, Subhan Danish, Abdeltif Amrane, Hossam S. El-Beltagi, Nazih Y. Rebouh

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Targeting necroptosis in MCF-7 breast cancer cells: In Silico insights into 8,12-dimethoxysanguinarine from Eomecon Chionantha through molecular docking, dynamics, DFT, and MEP stu... by Maram B Alhawarri, Mohammad G Al-Thiabat, Amit Dubey, Aisha Tufail, Katreen Banisalman, Ghazi A Al Jabal, Eman Alkasasbeh, Esra'a Ibrahim Al-Trad, Bilal Harieth Alrimawi

“…In addition, the individual residue contribution analysis highlighted key interactions, with ARG149 showing a significant contribution (-176.24 kcal/mol) in the MLKL-SG-A complex. DFT and MEP studies corroborated these findings, revealing that the electronic structure of SG-A is conducive to stable binding interactions, characterized by a narrow band gap (~0.16 units) and distinct electrostatic potential favourable for necroptosis induction. …”
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Defining pH-associated ecological clusters and their responses to agricultural intensification by Yi Ren, Shunan Xu, Yuanyuan Yan, Zhiyun Chen, Liangliang Liu, Xing Zhou, Zucong Cai, Xinqi Huang

“…However, different microbial taxa exhibit varied responses to pH levels, and their ecological functions remain unclear. This gap limits our understanding of the precise pathways through which pH affects the structure and function of soil microbial communities. …”
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Microbial and metabolic profiles associated with HPV infection and cervical intraepithelial neoplasia: a multi-omics study by Xiaowen Pu, Xiao Wang, Jingjing Wang, Zhengrong Gu, Haiyan Zhu, Chao Li

“…Our findings address a significant gap in understanding the interplay between cervicovaginal secretion and cervical intratissue microbiomes, HPV infection, and CIN.…”
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Berberine Mediates Exosomes Regulating the Lipid Metabolism Pathways to Promote Apoptosis of RA-FLS Cells by Si-Fan Guo, Zhi-Bo Wang, Dan-Dan Xie, Ying Cai, Yan Wang, Xian Wang, Qiang Yang, Ai-Hua Zhang, Shi Qiu

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Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer by Chun-guang XIE, Ji-yang ZHANG, Tong YANG, Yu-liang HUANG, Shu-guang XIE, Hui ZHU, Jing-xuan SUN, Ping CHENG

“…This paper introduced a homemade high-performance proton transfer reaction time-of-fight mass spectrometer (PTR-TOF MS), which can be used for real-time online analysis and monitoring of complex organic gas mixtures. Proton transfer reaction ionization is one of the typical methods of “soft” ionization techniques, which generally takes water and hydronium ions as parent ions, and the objects which have higher proton affinity than water can be ionized. …”
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Oral history methods can reveal drivers of landscape transformation: Understanding land‐use legacies with local and traditional knowledge in Central Europe by Marianna Biró, Krisztina Molnár, Kinga Öllerer, Réka Szilágyi, Dániel Babai, Csaba Molnár, Zsolt Molnár

“…Local communities' ecological memory can play an important role in filling this gap by reconstructing the socio‐ecologically relevant indirect drivers and their interactions, as well as identifying vegetation characteristics that are legacies of previous land‐use practices. …”
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Chronic multimorbidity among older adults in rural South Africa by Stephen Tollman, Francesc Xavier Gómez-Olivé, Joshua A Salomon, Julia K Rohr, Jennifer Manne-Goehler, Angela Y Chang, Collin Payne, Alisha N Wade, Livia Montana

“…This study is one of the first to present the prevalence of multimorbidity that includes HIV in the complex epidemiological setting of South Africa, thus filling a gap in the multimorbidity literature that is dominated by studies in high-income or low-HIV prevalence settings.Methods Out of the full sample of 5059 people aged 40+, we analysed cross-sectional data on 10 conditions from 3889 people enrolled in the Health and Ageing in Africa: A longitudinal study of an INDEPTH Community in South Africa (HAALSI) Programme. …”
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Design, construction and efficiency analysis of bagasse-based charcoal packed horizontal lab-scale wetland for the removal of antibiotic-resistant bacteria by Misbah Batool Aslam, Talmeez U. R. Rehman, Amina Farrukh Alavi, Abdul Haleem, Abdul Haq, Safia Ahmed, Wasim Sajjad, Mohammed Bourhia, Ousman B. Mahamat, Khalid S. Almaary, Mahwish Ali

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Hybrid Graph Representation and Learning Framework for High-Level Synthesis Design Space Exploration by Pouya Taghipour, Eric Granger, Yves Blaquiere

“…However, there is still a gap in terms of their prediction accuracy. Indeed, modeling HLS-related problems using GNNs that efficiently capture the complex patterns arising from applied pragmas and low-level characteristics of HLS specifications is challenging. …”
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Detecting soil-transmitted helminth and Schistosoma mansoni eggs in Kato-Katz stool smear microscopy images: A comprehensive in- and out-of-distribution evaluation of YOLOv7 varian... by Mohammed Aliy Mohammed, Esla Timothy Anzaku, Peter Kenneth Ward, Bruno Levecke, Janarthanan Krishnamoorthy, Wesley De Neve, Sofie Van Hoecke

“…Expanding AI-driven diagnostic assessments to account for the complexities encountered in the field is essential for creating robust tools that can significantly contribute to the global elimination of STH and S. mansoni infections as public health problems by 2030, a goal put forth by the World Health Organization.…”
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Spaceborne remote sensing effectively maps species richness across taxonomic groups in a mountain landscape by Cornelius Senf, Lisa Geres, Tobias Richter, Kristin Braziunas, Felix Glasmann, Rupert Seidl, Sebastian Seibold

“…To improve the efficiency of conservation projects, spatially explicit information on species richness is needed, yet this information is challenging to generate from traditional biodiversity assessments. To fill this gap, we here explored the potential of spaceborne remote sensing techniques, including Sentinel-1, Sentinel-2 and EnMAP, for mapping species richness across four distinct taxonomic groups (fungi, plants, insects and birds) in a complex mountain landscape in the German Alps. …”
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Beyond Pairwise Interactions: Higher-Order Q-Analysis of fMRI-Based Brain Functional Networks in Patients With Major Depressive Disorder by Semen A. Kurkin, Nikita M. Smirnov, Rositsa Paunova, Sevdalina Kandilarova, Drozdstoy Stoyanov, Larisa Mayorova, Alexander E. Hramov

“…Major depressive disorder (MDD) is associated with complex disruptions in brain function, yet the underlying neural mechanisms remain incompletely understood. …”
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