Exploring Mechanical Features of 3D Head and Neck Cancer Models by Aleksandra Evangelista, Franca Scocozza, Michele Conti, Ferdinando Auricchio, Bice Conti, Rossella Dorati, Ida Genta, Marco Benazzo, Silvia Pisani

“…Head and neck squamous cell carcinoma (HNSCC) presents significant challenges in oncology due to its complex biology and poor prognosis. Traditional two-dimensional (2D) cell culture models cannot replicate the intricate tumor microenvironment, limiting their usefulness in studying disease mechanisms and testing therapies. …”
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Leverage Points and Cascading Impacts Analysis in Nexus Systems Using System Dynamics Modeling by Virginia R. Coletta, Irene Pluchinotta, Vassilios Pisinaras, Andreas Panagopoulos, Raffaele Giordano, Alessandro Pagano, Umberto Fratino, Alberto Montanari

“…Abstract Operationalizing the Water‐Ecosystem‐Food (WEF) Nexus approach for sustainable resource management is challenging due to the complexity, non‐linearity, and uncertainty of interconnected resources systems. …”
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Mutual Trade of BRICS Countries in the Logic of Integration Cooperation by I. V. Boiko

“…Moreover, while China’s export is oriented primarily to third country rather than to the BRICS market, the rest of the BRICS countries rely heavily on the import of Chinese goods. The significant gap in the level of economic development of the BRICS countries hinders centripetal interaction between them. …”
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Implementing and operating net zero buildings in South Africa by Rolien Terblanche, Cameron May, Jake Steward

“…The challenges to operate NZBs include high operating costs, complex operating manuals and a lengthy payback period. …”
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Img2Neuro: brain-trained neural activity encoders for enhanced object recognition by Mona A Aboelnaga, Mohamed W El-Kharashi, Seif Eldawlatly

“…For decades, the brain’s visual pathway has inspired machine and deep learning models, yet these models oversimplify the brain’s complex visual processing. This is manifested in the significant superiority of the brain in comparison to the developed models in terms of the accuracy and the amount of data needed for training. …”
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Identification of 1,400 metabolites as mediators of obesity in 473 gut microbiota taxa: a mediation Mendelian randomization study by Xiaomin Li, Qike Wu, Shan-peng Liu

“…Fms-related receptor tyrosine kinase 1 (FLT1), growth-associated protein 43 (GAP43), and SLIT and NTRK-like family member 1 (SLITRK1) plasma proteins had protective effects against obesity. …”
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Compositional Effects on the Tensile Behavior of Atomic Bonds in Multicomponent Cu_93−xZr_xAl₇ (at.%) Metallic Glasses by Tittaya Thaiyanurak, Olivia Gordon, Muyang Ye, Zhengming Wang, Donghua Xu

“…Probing bond behavior during deformation, however, is highly challenging, particularly for materials with complex chemical compositions and/or atomic structures, such as metallic glasses (MGs). …”
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The future of ammonia use in 30 years: a deliberative experimental study envisioning the perspective of a future generation by Yoshinori Nakagawa, Kentaro Hayashi, Kazuyo Matsubae, Kazuya Nishina, Bin-Le Lin, Tatsuyoshi Saijo

“…Social media summary A visioning experiment showed how scientists handle nitrogen trade-offs, imagining NH₃’s roles in a complex 2050 world. …”
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Advanced Queueing and Location-Allocation Strategies for Sustainable Food Supply Chain by Amirmohammad Paksaz, Hanieh Zareian Beinabadi, Babak Moradi, Mobina Mousapour Mamoudan, Amir Aghsami

“…<i>Results:</i> The results indicate that the proposed model, utilizing the grasshopper optimization algorithm (GOA), effectively addresses complex and large-scale food supply chain problems. …”
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Exploring Gait Recognition in Wild Nighttime Scenes by Haotian Li, Wenjuan Gong, Yutong Li, Yikai Wu, Kechen Li, Jordi Gonzàlez

“…However, recognition scenarios in practical applications are often more complex than those considered in existing studies. …”
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Developing entrustable professional activities for undergraduate operative dentistry clerkship by Ahsan Sethi, Muhammad Ainul Haq, Syed Jaffar Abbas Zaidi, Qaiser Ali Baig

“…This study aimed to address this critical gap by developing and validating a set of core Entrustable Professional Activities (EPAs) specifically for operative dentistry clerkships to enhance the practical competencies and readiness of dental graduates for effective and independent practice. …”
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Road Traffic Injury Prevention Initiatives: A Systematic Review and Metasummary of Effectiveness in Low and Middle Income Countries. by Catherine Staton, Joao Vissoci, Enying Gong, Nicole Toomey, Rebeccah Wafula, Jihad Abdelgadir, Yi Zhao, Chen Liu, Fengdi Pei, Brittany Zick, Camille D Ratliff, Claire Rotich, Nicole Jadue, Luciano de Andrade, Megan von Isenburg, Michael Hocker

“…Further road traffic injury prevention interventions should be performed in LMICs with patient-centered outcomes in order to guide injury prevention in these complex settings.…”
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Study on particle deposition and flow characteristics of edible chili oil in bending pipe conveyance in industrial production by Jiacheng Zhuang, Qiushi Shi, Zhi Han

“…These quantitative findings not only fill the research gap concerning high-viscosity, particulate-laden edible fluid systems but also provide concrete and practical guidelines for optimizing chili oil transport processes. …”
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A Networked Game Theoretic Model for Evaluating Resilience in Megaprojects: Integrating Stakeholder Interactions and Lifecycle Adaptability by Hongsi Zhang, Shukai Jiang, Xingwu Lin, Xiang Yu, Wenjiang Zheng

“…Megaprojects are complex systems comprising interdependent subsystems and diverse stakeholders, each contributing to the project’s resilience and long-term outcomes. …”
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Occupational Infections Among Workers in Europe: Protocol for a Scoping Review by Guglielmo Dini, Stefania Curti, Alborz Rahmani, Paolo Durando, Stefano Mattioli

“…During the last few decades, an increasing proportion of workers in Europe have been exposed to infectious biological agents in their workplace. Knowledge gaps on this topic in Europe have limited our understanding of the overall phenomenon in occupational settings. …”
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Reproducibility of a new device for robotic‐assisted TKA surgery by Domenico Alesi, Vito Gaetano Rinaldi, Tosca Cerasoli, Davide Valente, Giulio Maria Marcheggiani Muccioli, Stefano Zaffagnini

“…Abstract Purpose Enhancing implant placement to achieve optimal gap balance is crucial in total knee arthroplasty (TKA). …”
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“It’s like your body is fighting against you”: a cross-sectional qualitative interview study of quality of life in U.S. Black women diagnosed with endometriosis by Whitney S. Rice, Melanie Dakwa, Sofia Filippa, Ashi Parikh, Subasri Narasimhan

“…This study addresses this critical gap in the literature by exploring the quality of life experiences of U.S. …”
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Enabling analytical precision in microplastic analysis: innovative solutions for precise method validation, evaluation and quality control by Jovan Badzoka, Christoph Kappacher, Jakob Lauß, Lisa Obwaller, Anna Pavun, Christian W. Huck

“…Despite the growing number of studies documenting MP presence, the development of a standardized analytical protocol, particularly focusing on precise analytical method validation, remains a challenge. This gap arises from the complex nature of sample matrices and the diverse combinations of sample pretreatment and detection methodologies employed. …”
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Guidelines for Nonlinear Finite Element Analysis of Reinforced Concrete Columns with Various Types of Degradation Subjected to Seismic Loading by Seyed Sasan Khedmatgozar Dolati, Adolfo Matamoros, Wassim Ghannoum

“…Addressing this knowledge gap systematically and comprehensively through experimentation is difficult due to the prohibitive cost. …”
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Integration of Counter Shaft Shedding Mechanism into Indigenous Two-Heddle Loom: A Novel Approach by Divine Vidgedor, Moses Akrofi, Eric Bruce-Amartey Jnr., Ebenezer Kofi Howard

“…Modular Integration enabled the production of complex weave patterns, enhanced fabric quality, and increased productivity while preserving the loom's affordability and simplicity. …”
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