Unveiling the power of high-dimensional cytometry data with cyCONDOR by Charlotte Kröger, Sophie Müller, Jacqueline Leidner, Theresa Kröber, Stefanie Warnat-Herresthal, Jannis Bastian Spintge, Timo Zajac, Anna Neubauer, Aleksej Frolov, Caterina Carraro, DELCODE Study Group, Frank Jessen, Simone Puccio, Anna C. Aschenbrenner, Joachim L. Schultze, Tal Pecht, Marc D. Beyer, Lorenzo Bonaguro

“…Abstract High-dimensional cytometry (HDC) is a powerful technology for studying single-cell phenotypes in complex biological systems. Although technological developments and affordability have made HDC broadly available in recent years, technological advances were not coupled with an adequate development of analytical methods that can take full advantage of the complex data generated. …”
Get full text

Lung Cancer Management: Revolutionizing Patient Outcomes Through Machine Learning and Artificial Intelligence by Taghi Riahi, Bahareh Shateri‐Amiri, Amirhossein Hajialiasgary Najafabadi, Sina Garazhian, Hanieh Radkhah, Diar Zooravar, Sahar Mansouri, Roya Aghazadeh, Mohammadreza Bordbar, Shirin Raiszadeh

Get full text

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ by Philippe Frit, Himani Amin, Sayma Zahid, Nadia Barboule, Chloe Hall, Gurdip Matharu, Steven W. Hardwick, Jeanne Chauvat, Sébastien Britton, Dima Y. Chirgadze, Virginie Ropars, Jean-Baptiste Charbonnier, Patrick Calsou, Amanda K. Chaplin

“…However, their interaction within the NHEJ complexes is unclear. Here, we present cryo-EM structures of Pol λ in complex with the DNA-PK long-range synaptic complex, and Pol μ bound to Ku70/80-DNA. …”
Get full text

Remote sensing techniques to assess badlands dynamics: insights from a systematic review by Rosa Colacicco, Marco La Salandra, Isabella Lapietra, Alberto Refice, Domenico Capolongo

“…Unmanned Aerial Vehicles (UAVs), emerging since 2011, have bridged the gap between ground precision field studies and aerial scalability, becoming essential for 3D mapping and erosion monitoring in inaccessible terrain. …”
Get full text

From Asymmetry to Satisfaction: The Dynamic Role of Perceived Value and Trust to Boost Customer Satisfaction in the Tourism Industry by Ibrahim A. Elshaer, Alaa M. S. Azazz, Sameh Fayyad, Abdulaziz Aljoghaiman, Eslam Ahmed Fathy, Amr Mohamed Fouad

Get full text

Development and validation of mPCR-CEFA for detecting multiple deletion and non-deletion thalassemia genotypes by Jingping Xu, Jingping Xu, Baoyan Ren, Qixun Fang, Kangfeng Lin, Kangfeng Lin, Xingan Xing, Xingan Xing, Jingting Lin

“…Its ability to detect multiple genotypes simultaneously and resolve complex cases makes it particularly valuable for large-scale screening and clinical applications. …”
Get full text

Unveiling practical insights of eHealth implementation in Europe: a grey literature review on legal, ethical, financial, and technological (LEFT) considerations by B. E. Bente, N. Beerlage-de Jong, R. M. Verdaasdonk, J. E. W. C. van Gemert-Pijnen

“…However, it involves complex legal, ethical, financial, and technological (LEFT) challenges that can impede success. …”
Get full text

Gender Classification From Pashto Handwritten Text Images by Khan Sultan, Riaz Ahmad, Siraj Muhammad, Sulaiman Almutairi, Mohammed Abohashrh, Khalil Ullah, Abdallah Namoun, Ibrar Hussain

“…Although SVM, a widely used machine learning model, achieved an accuracy of 61.29%, YOLO8 reached a significantly higher accuracy of 77% in the same data set. This performance gap highlights the advantages of using advanced deep learning models for complex pattern recognition tasks in CV. …”
Get full text

Construction and Optimization of Integrated Yield Prediction Model Based on Phenotypic Characteristics of Rice Grown in Small–Scale Plantations by Jihong Sun, Peng Tian, Zhaowen Li, Xinrui Wang, Haokai Zhang, Jiangquan Chen, Ye Qian

“…Although machine learning can handle complex nonlinear problems to enhance prediction accuracy, further improvements in models are still needed to accurately predict rice yields in small areas facing complex planting environments, thereby enhancing model performance. …”
Get full text

Assessing AgERA5 and MERRA-2 Global Climate Datasets for Small-Scale Agricultural Applications by Konstantinos Soulis, Evangelos Dosiadis, Evangelos Nikitakis, Ioannis Charalambopoulos, Orestis Kairis, Aikaterini Katsogiannou, Stergia Palli Gravani, Dionissios Kalivas

“…The wine-making region of Nemea, Greece, with its complex and challenging terrain is used as a characteristic case study. …”
Get full text

A Preclinical Model of Human Liver Using Precision Cut Tissue Slice Culture [version 1; peer review: 2 approved] by Laura Randle, Christopher Goldring, Hassan Malik, Stephen Fenwick, Mohammed Bosakhar, Maria-Danae Jessel, Timothy Gilbert, Owen McGreevy

“…Preclinical models vary in complexity and cost. Traditional 2D cell cultures that are high throughput and cost effective, but lack the complexity of multicellular interactions. …”
Get full text

A biochemical screening platform to target chromatin states using condensates as a tool by Laura J. Hsieh, Tracy Lou, Muryam A. Gourdet, Emily Wong, Geeta J. Narlikar

“…Currently, there are no drug discovery approaches that target the complex multivalent protein interactions within a given dysfunctional chromatin state. …”
Get full text

eHealth literacy demands and cognitive processes underlying barriers in consumer health information seeking by Connie V. Chan, Jelena Mirkovic, Stephanie Furniss, David R. Kaufman

“…Although the gap between eHealth tools, users’ skills, and knowledge can be difficult to bridge, an understanding of the cognitive complexity and literacy demands can serve to reduce the gap between designer and consumer.…”
Get full text

Bridging the science - policy interface: A new era for South African research and the role of knowledge brokering by Linda Godfrey, Nikki Funke, Carmel Mbizvo

“…Government departments and agencies are faced with issues of increasing socio-ecological complexities around environmental sustainability and global change, which require them to make decisions that have the potential to impact greatly on society and economies. …”
Get full text

Replanting the Birthing Trees: A Call to Transform Intergenerational Trauma into Cycles of Healing and Nurturing by Catherine Chamberlain, Jacynta Krakouer, Paul Gray, Madeleine Lyon, Shakira Onwuka, Ee Pin Chang, Lesley Nelson, Valda Duffield, Janine Mohamed, Shaydeen Stocker, Yalmay Yunupingu, Sally Maymuru, Bronwyn Rossingh, Fiona Stanley, Danielle Cameron, Marilyn Metta, Tess M. Bright, Renna Gayde, Bridgette Kelly, Tatiana Corrales, Roz Walker, Tamara Lacroix, Helen Milroy, Alison Weatherstone, Kimberley A. Jones, Kristen Smith, Marcia Langton

“…However, colonisation, systemic violence and discrimination—including the forced removal of Aboriginal and Torres Strait Islander children, which continues today—have disrupted this foundation, leading to compounding cycles of intergenerational and complex trauma. The enduring impact of intergenerational and complex trauma is exemplified in increasing proportions of Aboriginal and Torres Strait Islander children being removed from their families and involved in the child protection and youth justice system—which represents a national crisis. …”
Get full text

Translating knowledge to practice: application of the public health apprenticeship by Mary Elizabeth Pendergrass, Angela L. Carman

“…As public health challenges continue to grow and deepen in complexity, public health workforce roles are becoming increasingly difficult to fill. …”
Get full text

Effects of Neuromuscular Training on Performance and Injury Prevention in Youth Team Sports: Development of an Evidence-Based Educational Program by Markus Tschopp, Nicklaus Hess, Pascal Andrey, Adrian Rothenbühler, Fabian Studer

“…By addressing the complexities of knowledge transfer and considering the needs of diverse stakeholders, this program aims to bridge the gap between research and practice in enhancing performance and preventing injuries among young athletes in team sports. …”
Get full text

Simulation analysis of path planning for workpiece clamping robots based on digital twin technology by Xin PAN, Min LIANG, Yanchao YIN, Zhong CHEN

“…Efficient path planning for manipulators is essential in modern CNC machining processes to ensure obstacle-free operations, particularly during complex tasks such as picking, handling, and clamping. …”
Get full text

Analytical model of Iran-Saudi Arabia relations from 1979 to 2024 by Sajad Mohseni

“…Extended AbstractIntroduction: As two powerful neighbors and regional rivals, Iran and Saudi Arabia have always maintained complex relations. Beyond the commonly cited geopolitical and ideological differences, the roots of their current relationship can arguably be found in a deeper layer of mutual actions and reactions. …”
Get full text

In-situ/operando study of Cu-based nanocatalysts for CO2 electroreduction using electrochemical liquid cell TEM by Jiawei Wan, Jiawei Wan, Qiubo Zhang, Ershuai Liu, Ershuai Liu, Yi Chen, Yi Chen, Jiana Zheng, Jiana Zheng, Amy Ren, Walter S. Drisdell, Walter S. Drisdell, Haimei Zheng, Haimei Zheng

“…Finally, we discuss advancements as well as the remaining gap in elucidating the structural-performance relationship of working catalysts. …”
Get full text