GABA outperforms iron and neuromelanin in detecting nigrostriatal alterations in early-stage Parkinson’s disease with RBD by Youmin Zhang, Pei Huang, Peng Liu, Yan Li, Zhijia Jin, Qiurong Yu, Xiaofeng Shi, Yu Liu, Zenghui Cheng, Peng Wu, Jinyuan Weng, Fangtao Liu, Ewart Mark Haacke, Ying Cui, Shengdi Chen, Naying He, Fuhua Yan

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Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis by Paul C. McDonald, James T. Topham, Shannon Awrey, Hossein Tavakoli, Rebekah Carroll, Wells S. Brown, Zachary J. Gerbec, Steve E. Kalloger, Joanna M. Karasinska, Patricia Tang, Rachel Goodwin, Steven J. M. Jones, Janessa Laskin, Marco A. Marra, Gregg B. Morin, Daniel J. Renouf, David F. Schaeffer, Shoukat Dedhar

“…Tumour Infiltrating neutrophils and NETs associate with ITGB1, CCDC25 and ILK, within clinical and experimental PDAC tumours. Functionally, exposure of PDAC cells to NETs identifies a cytoskeletal dynamic-associated CCDC25-ITGB1-ILK signaling complex which stimulates EMT and migration/invasion. …”
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Syk inhibitor attenuates lupus in FcγRIIb− /− mice through the Inhibition of DNA extracellular traps from macrophages and neutrophils via p38MAPK-dependent pathway by Kritsanawan Sae-khow, Awirut Charoensappakit, Kanyarat Udompornpitak, Wilasinee Saisorn, Jiraphorn Issara-Amphorn, Tanapat Palaga, Asada Leelahavanichkul

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Ardisia japonica (Thunb.) Blume and Lespedeza cuneata G. Don may treat chronic obstructive pulmonary disease by targeting HK2 and PTAFR by Xian Luo, Zheng Hang Ge, Shan Luo, Bo Li, Xun Zhou, Yi Yang, Yong Jiang, Tao Tan, Ke Lin Wang

“…These findings highlight the potential of HK2 and PTAFR as therapeutic targets for COPD. Functional analysis further indicated that HK2 and PTAFR were co-enriched in pathways such as the “chemokine signaling pathway” and “FC gamma R-mediated phagocytosis,” suggesting their involvement in immune responses. …”
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Feeding the Mind: The Role of Fermented Foods and Probiotics in Anxiety Treatment by Marta Ignatiuk-Chilkiewicz, Joanna Kałuska, Dominika Hakało, Adam Rafałowicz, Aleksandra Sokół, Klaudia Mościszko, Katarzyna Nowicka, Wiktor Klimek, Maria Majewska, Monika Olszanska

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The Dynamics of Shannon Entropy in Analyzing Climate Variability for Modeling Temperature and Precipitation Uncertainty in Poland by Bernard Twaróg

“…This study focuses on monthly distributions of temperature and precipitation, modeled using the bivariate Clayton copula function. A normal marginal distribution was adopted for temperature and a gamma distribution for precipitation, both validated using the Anderson–Darling test. …”
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OncoPSM: an interactive tool for cost-effectiveness analysis using partitioned survival models in oncology trial by Xulong Qiu, Xulong Qiu, Jidi Chen, Jidi Chen, Muting Wang, Kaixin Zheng, Ruixiong Li

“…However, many CEA tools are not specifically tailored to address the intricate cost composition resulting from the complex treatment regimens in oncology trials.MethodsWe extracted data from Kaplan-Meier (KM) curves, reconstructed individual patient data (IPD) using an iterative KM algorithm, and fitted parametric survival functions to the IPD data. …”
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WHSC1/NSD2 regulates immune infiltration in prostate cancer by Kunle Odunsi, Junko Matsuzaki, Takemasa Tsuji, Sebastiano Battaglia, Richard C. Koya, Prashant K Singh, Muzamil Y Want, James L Thorne, Ellen Karasik, Bryan Gillard, Eduardo Cortes Gomez, Amit Lugade

“…Flow cytometry was used to measure Major Histocompatibility complex (MHC) levels, MHC-bound ovalbumin and tumor infiltration. …”
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Immune-related gene characterization and biological mechanisms in major depressive disorder revealed based on transcriptomics and network pharmacology by Shasha Wu, Shasha Wu, Qing Jiang, Jinhui Wang, Jinhui Wang, Daming Wu, Yan Ren

“…BackgroundMajor depressive disorder (MDD) is a severe psychiatric disorder characterized by complex etiology, with genetic determinants that are not fully understood. …”
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Endoplasmic Reticulum-Targeted Phototherapy Remodels the Tumor Immunopeptidome to Enhance Immunogenic Cell Death and Adaptive Anti-Tumor Immunity by Weidong Xiao, Mingquan Gao, Banghui Mo, Xie Huang, Zaizhi Du, Shufeng Wang, Jianhong Chen, Shenglin Luo, Haiyan Xing

“…Immunopeptidomics profiling was used to identify high-affinity major histocompatibility complex class I (MHC-I) ligands. In vitro functional studies were conducted to evaluate dendritic cell maturation and T lymphocyte activation, while in vivo experiments were performed by combining the identified peptide with poly IC to evaluate anti-tumor immunity. …”
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Translational approach for dementia subtype classification using convolutional neural network based on EEG connectome dynamics by Thawirasm Jungrungrueang, Sawrawit Chairat, Kasidach Rasitanon, Praopim Limsakul, Krit Charupanit

“…Distinctive characteristics were found, including generalized Delta-band hyperconnectivity with increased complexity in AD and disrupted phase-based connectivity in Theta, Beta, and Gamma bands for FD. …”
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A novel electrochemical immunosensor based on biomaterials for detecting carcinoembryonic antigen biomarker in serum samples by Sajedeh Sobhanparast, Payam Shahbazi-Derakhshi, Jafar Soleymani, Amir Amiri-Sadeghan, Alireza Herischi, Nader Chaparzadeh, Younes Aftabi

“…The surface of a glassy carbon electrode (GCE) was modified using a layer-by-layer assembly method incorporating sodium alginate (SA), gold nanoparticles (AuNPs), and gamma-manganese dioxide/chitosan (γ.MnO₂-CS). This modification enhanced the functional surface area and electrode conductivity, thereby improving the electrochemical response and sensitivity for CEA detection. …”
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On estimation of the quadratic hazard rate model parameters: Simulation and application by M. Nagy, A. H. Mansi, Moustafa N. Mousa, M. E. Moshref, N. Youns, M. M. M. Mansour

“…Bayesian inference is then performed under both MLE and MPS approaches using independent informative priors (normal and gamma) and both symmetric (squared error) and asymmetric (linear exponential) loss functions to obtain point estimates and highest posterior density credible intervals. …”
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Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis by Barbara Vergani, Massimo Milione, Marco Vitellaro, Giulio Ferrero, Veronica Huber, Luca Lalli, Agata Cova, Paola Frati, Flavio Arienti, Licia Rivoltini, Simonetta Guarrera, Laura Cattaneo, Luca Sorrentino, Elena Daveri, Elena Casiraghi, Marta Zorza, Manuela Gariboldi, Patrizia Pasanisi, Daniele Morelli, Paola A Corsetto, Angela M Rizzo, Martina Stroscia, Vincenzo Lagano, Giovanna Sabella, Biagio E Leone

“…FChigh tumors exhibited reduced CD8+ T cells and increased regulatory T cells (Tregs). Functional transcriptional profiling depicted an immunosuppressed milieu characterized by reduced interferon gamma, memory CD8+ T cells, and activated macrophages mirrored by increased T-cell exhaustion and Treg enrichment. …”
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Clinical Presentations and Treatment Approaches in a Retrospective Analysis of 128 Intracranial Arteriovenous Malformation Cases by Corneliu Toader, Mugurel Petrinel Radoi, Milena-Monica Ilie, Razvan-Adrian Covache-Busuioc, Vlad Buica, Luca-Andrei Glavan, Christian-Adelin Covlea, Antonio Daniel Corlatescu, Horia-Petre Costin, Carla Crivoi, Leon Danaila

“…Conclusions: AVMs within the same Spetzler–Martin grade display considerable complexity, necessitating personalized treatment strategies. …”
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes by Nathalie Labarrière, Lucine Marotte, Sylvain Simon, Virginie Vignard, Emilie Dupre, Malika Gantier, Jonathan Cruard, Jean-Baptiste Alberge, Melanie Hussong, Cecile Deleine, Jean-Marie Heslan, Jonathan Shaffer, Tiffany Beauvais, Joelle Gaschet, Emmanuel Scotet, Delphine Fradin, Anne Jarry, Tuan Nguyen

“…Background Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. …”
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