Method for determining eigen numbers in heat conduction problems for a cylinder by E. V. Kotova, R. M. Klebleev, V. A. Kudinov

“…The advantage of the method is that the resulting solution contains only simple algebraic expressions, excluding special functions (Bessel function, Legendre function, gamma function).CONCLUSION. …”
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Estimation for Parameters of Life of the Marshall-Olkin Generalized-Exponential Distribution Using Progressive Type-II Censored Data by Ahmed Elshahhat, Abdisalam Hassan Muse, Omer Mohamed Egeh, Berihan R. Elemary

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Studies in fractal–fractional operators with examples by Rabha W. Ibrahim

“…By using the generalization of the gamma function (p-gamma function: Γp(.)), we introduce a generalization of the fractal–fractional calculus which is called p-fractal fractional calculus. …”
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Electrical synapse structure requires distinct isoforms of a postsynaptic scaffold. by Jennifer Carlisle Michel, Margaret M B Grivette, Amber T Harshfield, Lisa Huynh, Ava P Komons, Bradley Loomis, Kaitlan McKinnis, Brennen T Miller, Ethan Q Nguyen, Tiffany W Huang, Sophia Lauf, Elias S Michel, Mia E Michel, Jane S Kissinger, Audrey J Marsh, William E Crow, Lila E Kaye, Abagael M Lasseigne, Rachel M Lukowicz-Bedford, Dylan R Farnsworth, E Anne Martin, Adam C Miller

“…Using the Mauthner cell of zebrafish as a model, we previously found that the intracellular scaffolding protein ZO1b is a member of the ESD, localizing postsynaptically, where it is required for GJ channel localization, electrical communication, neural network function, and behavior. Here, we show that the complexity of the ESD is further diversified by the genomic structure of the ZO1b gene locus. …”
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Evaluation of the Effectiveness of Using the CFTR Modulator Ivacaftor/Lumacaftor in Children with Cystic Fibrosis in the Sverdlovsk Region (Prospective Cohort Study) by Yuliya O. Vasenyova, Irina V. Vakhlova, Oleg Yu. Averyanov

“…The usage of the CFTR modulator ivacaftor/lumacaftor showed a greater clinical effect in improving the functioning of the digestive organs: a decrease in the risk of hyperphosphatasemia and a significant decrease in the number of patients with high levels of gamma-GTP were established, a stable level of liver enzyme activity was noted, and a tendency to increase the activity of pancreatic elastase was revealed. …”
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BIOCHEMICAL SUBSTANTIATION OF COMBINED THERAPY APPLICATION IN THE ACUTE PHASE OF EXPERIMENTAL HELMINTHIASIS OF ANIMALS by E. A. Grishina, A. A. Erovichenkov

“…The above-mentioned complex of metabolic changes clearly reveals a disturbance in hepatocyte metabolism that leads to the decrease in detoxifying function of the liver. …”
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Modulation of Network Oscillatory Activity and GABAergic Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Medial Entorhinal Cortex by Nicola H. Morgan, Ian M. Stanford, Gavin L. Woodhall

“…These data indicate that cannabinoid-mediated effects on inhibitory synaptic activity may be constitutively active in vitro, and that modulation of CB1R activation using inverse agonists unmasks complex effects of CBR function on network activity.…”
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New composite phenotypes enhance chronic kidney disease classification and genetic associations. by Kim Ngan Tran, Heidi G Sutherland, Andrew J Mallett, Lyn R Griffiths, Rodney A Lea

“…In addition, SH2B3 locus showed strong evidence of colocalization with eGFR, supporting its role in kidney function. These results highlight the power of the multi-phenotype cPCA approach in understanding the genetic basis of CKD, with potential applications to other complex diseases.…”
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Tomatine Improves Glucose Metabolism and Mitochondrial Respiration in Insulin-Resistant Hepatocyte Cell Lines AML12 and HepG2 via an AMP-Activated Protein Kinase-Dependent Pathway by Yu Geon Lee, Donghwan Kim

“…In addition, tomatine enhanced mitochondrial oxidative function by restoring the oxygen consumption rate, increasing ATP production, and upregulating mitochondrial oxidative phosphorylation complex proteins. …”
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Efficiency of Remaxol Use in Supporting Treatment of Advanced Tuberculosis by V. M. Kolomiets, A. L. Kovalenko, E. V. Talikova

“…Changes in immune status and state of liver detoxification function were evaluated in dynamics (before and after hepatoprotective therapy course) taking in consideration level of cytokines (interleukins 1,4,6 and 10, tumor necrosis factor, interferon-gamma) and liver enzymes (AST, ALT). …”
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The Reliability of Diagnosing Schizophrenia Using the GRU Layer in Conjunction with EEG Rhythms by Pankaj Kumar Sahu, Karan Jain

“…This makes it possible to develop intense, deep versions of RDCGRU for more complex problems. The sigmoid activation function is implemented in the digital classifier's output nodes. …”
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Molecular and cellular mechanisms of adipogenesis by Alexander Dmitrievich Egorov, Dmitry Nikolaevich Penkov, Vsevolod Arsen'evich Tkachuk

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Study on Fluctuating Wind Characteristics and Non-Stationarity at U-Shaped Canyon Bridge Site by Zhe Sun, Zhuoyi Zou, Jiaying Wang, Xue Zhao, Feng Wang

“…The proportion of non-stationary samples increases with height. Autocorrelation function (ACF), partial autocorrelation function (PACF) tests, and power spectral density (PSD) analysis determined the optimal wavelet decomposition level for wind speed in this region. …”
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Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. by Hui H Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M Squillace, Chin-Lee Wu, Brendan D Manning

“…Loss of function of the TSC1-TSC2 complex results in constitutive mTORC1 signaling and, through mTORC1-dependent feedback mechanisms and loss of mTORC2 activity, leads to a concomitant block of Akt signaling to its other downstream targets.…”
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Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity. by Quanhui Dai, Kristina Preusse, Danni Yu, Rhett A Kovall, Konrad Thorner, Xinhua Lin, Raphael Kopan

“…To ask if HDAC2 activity contributes to Notch loss-of-function phenotypes, we used the HDAC2 inhibitor Valproic acid (VPA) and discovered it could prevent the intestinal consequences of NDD and gamma secretase inhibitors (DBZ or DAPT) treatment in mice and spheroids, suggesting synergy between HDAC activity and pro-differentiation program in intestinal stem cells.…”
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METABOLISM OF FATTY ACIDS IN LEFT VENTRICLE MYOCARDIUM AND THE EFFICACY PROGNOSIS OF CARDIO-RESYNCHRONIZING THERAPY IN DILATED CARDIOMYOPATHY PATIENTS by M. O. Gulya, Yu. B. Lishmanov, K. V. Zavadovsky, D. I. Lebedev

“…The data collected during metabolic myocardial gamma-scintigraphy may be used in the complex of methods that allow to predict the efficacy of cardio- resynchronizing therapy.…”
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Adipose triglyceride lipase protects renal cell endocytosis in a Drosophila dietary model of chronic kidney disease. by Aleksandra Lubojemska, M Irina Stefana, Sebastian Sorge, Andrew P Bailey, Lena Lampe, Azumi Yoshimura, Alana Burrell, Lucy Collinson, Alex P Gould

“…Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic accumulation of lipid droplets in kidney podocytes and in proximal tubule cells. …”
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Neurotransmitter power plays: the synaptic communication nexus shaping brain cancer by Jayanta Mondal, Jason T. Huse

“…Glutamatergic synapses utilize glutamate to propagate excitatory signals, while GABAergic synapses employ gamma-aminobutyric acid (GABA) to inhibit neuronal firing. …”
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Elucidating the role of KLRD1 in coronary atherosclerosis: harnessing bioinformatics and machine learning to advance understanding by Huan Liang, Xiao Liang, Man Zheng, Shoudong Wang

“…T cells CD8, Plasma cells, Dendritic cells activated, T cells CD4 memory resting, T cells CD4 memory activated, T cells gamma delta. Conclusions This research elucidates the complex relationship between KLRD1 and AS, underscoring its potential as a novel biomarker for diagnosing and monitoring the disease.…”
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Recurrent Infections in Allergic Pediatric Patients: An Immune System Problem? A Narrative Review by César Galván, Rafael Durán, Cristian Matos, Cristiana Indolfi, Angela Klain

“…<b>Conclusions:</b> Recurring infections in allergic pediatric patients result from significant immune dysfunction involving altered cytokine production and immune cell function. These complex interactions highlight the need for targeted therapeutic approaches that enhance immune responses and reduce infection risks. …”
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