Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…Analysis showed the differences detected occurred in entities known to produce differences in interpretation between pathologists. …”
Get full text

Spatial and socioeconomic patterns of COVID-19 in transition zones between municipalities in eastern Amazonia by Dinar Duarte Vasconcelos, Dinar Duarte Vasconcelos, Dinar Duarte Vasconcelos, Dinar Duarte Vasconcelos, Hermes Fonsêca de Medeiros, Hermes Fonsêca de Medeiros, Hermes Fonsêca de Medeiros, José Antonio Herrera, José Antonio Herrera, José Antonio Herrera, Lucas de Oliveira Lima, Lucas de Oliveira Lima, Lucas de Oliveira Lima, Pedro Fernando da Costa Vasconcelos, Pedro Fernando da Costa Vasconcelos, Pedro Fernando da Costa Vasconcelos, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma, Juarez Antonio Simões Quaresma

“…Analysis of the mortality rate indicates that all the socioeconomic variables tested are associated with this variable, but their effects interact in a complex way. The municipalities with higher numbers of residents per household and Gini coefficients had higher fatality rates, and municipalities with a higher GDP were more associated with higher hospitalization and mortality rates. …”
Get full text

Characterization of a blaKPC-3-carrying plasmid in a clinical isolate of Klebsiella pneumoniae belonging to the emerging successful clone ST147 by Esther Recacha, Mercedes Delgado-Valverde, Marina R. Pulido, Elena Pérez-Nadales, Patricia Pérez-Palacios, Inés Portillo-Calderón, Juan Manuel Sánchez-Calvo, Irene Gracia-Ahufinger, Álvaro Pascual

“…ABSTRACT Klebsiella pneumoniae ST147 has emerged as a successful clone able to efficiently disseminate a number of carbapenemases, including blaKPC. …”
Get full text

Sub-pA dark current infrared photodetection enabled by polarized water-intercalated heterojunctions by Chang Liu, Lin Tang, Yawei Lv, Long Chen, Yilu Qin, Sen Zhang, Shihao Zhao, Shuimei Ding, Xin Zhang, Pan Xu, Chao Ma, Xingqiang Liu, Fang Wang, Peng Wang, Xudong Wang, Yuan Liu, En-Ge Wang, Lei Liao, Xuming Zou

“…The confined water layer forms a clean, well-ordered interface and further generates a precisely oriented polarization field that depletes electrons in WSe2, significantly suppressing dark current to sub-pA levels across all biases, while enabling efficient tunneling of photogenerated holes. The device shows broadband photoresponse from the ultraviolet to mid-wave infrared (MWIR), with a room-temperature average detectivity exceeding 10¹⁰ cm Hz¹/² W⁻¹ in the MWIR. …”
Get full text

Global biogeography of N₂-fixing microbes: <i>nifH</i> amplicon database and analytics workflow by M. Morando, J. D. Magasin, S. Cheung, S. Cheung, M. M. Mills, J. P. Zehr, K. A. Turk-Kubo

“…Multiple datasets are efficiently and consistently processed with a specialized DADA2 pipeline to identify amplicon sequence variants (ASVs). …”
Get full text

Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice by Yan Gong, Yuzhuo Zhang, Xingda Chen, Zelin Zhou, Weicheng Qin, Yanchi Gan, Jiahui He, Jizhi Ma, Guifeng Chen, Qi Shang, Kai Tang, Honglin Chen, Yu Liu, De Liang, De Liang, Gengyang Shen, Xiaobing Jiang, Zhaojun Cheng, Zhaojun Cheng, Zhaojun Cheng

“…BackgroundThe origin of intervertebral disc degeneration (IDD) is highly complex, where both cartilage endplate remodeling and vertebral osteoporosis are of utmost importance. …”
Get full text

Identification of strengths and weaknesses of the healthcare system for persons living with rare diseases in Catalonia (Spain), and recommendations to improve its comprehensive att... by José Hernández-Rodríguez, Fernando Martínez-Valle, Xènia Acebes, Carmen Alerany, Jordi Antón, Gonzalo Calvo, Marian Corral, Jordi Cruz, M. Antònia Mangues-Bafalluy, José Mateo, Josefa Rivera, Albert Salazar, Roser Francisco, Cristina Mallol, Rita Reig-Viader, Ariadna Tigri-Santiña, Assumpta Ricart, Francesc Palau

“…Abstract Background Rare diseases (RDs) are a heterogeneous group of complex and low-prevalence conditions in which the time to establish a definitive diagnosis is often too long. …”
Get full text

An azo substituted quinoline‐malononitrile enzyme‐activable aggregation‐induced emission nanoprobe for hypoxia imaging by Zhirong Zhu, Shichang Liu, Xupeng Wu, Qianqian Yu, Yi Duan, Shanshan Hu, Wei‐Hong Zhu, Qi Wang

“…Abstract The development of efficient aggregation‐induced emission (AIE) active probes is crucial for disease diagnosis, particularly for tumors and cardiovascular diseases. …”
Get full text

Convergent construct validity and test-retest reliability of both German versions of the original and the revised Niigata PPPD Questionnaire: NPQ and NPQ-R by Sarah Chételat, Sarah Chételat, Eve-Yaël Gerber, Eve-Yaël Gerber, Sarah El Khadlaoui, Frank Behrendt, Frank Behrendt, Michaela Stark, Michaela Stark, Stefan Schädler, Stefan Schädler, Maximilian Maywald, Lena Fabritius, Johannes Gerb, Johannes Gerb, Denis Grabova, Wiebke Trost, Andreas Zwergal, Andreas Zwergal, Ralf Strobl, Ralf Strobl, Katrin Parmar, Katrin Parmar, Hans Ulrich Gerth, Hans Ulrich Gerth, Leo H. Bonati, Leo H. Bonati, Leo H. Bonati, Sandra Becker-Bense, Corina Schuster-Amft, Corina Schuster-Amft, Corina Schuster-Amft

“…Characteristic provocation factors are moving or complex visual stimuli and exclusion of organic diseases. …”
Get full text

Acellular porcine placental membranes as a novel biomaterial for tissue repair applications by Gustavo Henrique Doná Rodrigues Almeida, Luan Stefani Lima, Mariana Sversut Gibbin, Beatriz Lopomo, Rafael Oliveira Bergamo, Raquel Souza da Silva, Giovanna Vitória Consani Santos, Bruna Gomes Silva, Isabela Paulillo D’Onofrio, Henrique dos Santos, Lediane Pedroso Silva, Tais da Silva, Henrique Lança Fuzeti, Bianca Fuzeti Candian, Thais Naomi Gonçalves Nesiyama, João Victor Damin, Claudio Guilherme de Assis Oliveira, Lucas Paulo Jacinto Saavedra, Guilherme Henrique Gonçalves de Almeida, Douglas Lopes de Almeida, Jaqueline de Carvalho Rinaldi, Francielle Sato, Mauro Luciano Baesso, Luzmarina Hernandes, Flávio Vieira Meirelles, Rose Eli Grassi Rici, Durvanei Augusto Maria, Paulo Cezar de Freitas Mathias, Ana Claudia Oliveira Carreira, Ana Claudia Oliveira Carreira

“…Biological dressings derived from the extracellular matrix (ECM) of human placental tissues have proven effective in treating complex skin wounds and other anatomical sites, offering potential for new therapeutic applications. …”
Get full text

Timescales of Polycyclic Aromatic Hydrocarbon and Dust Continuum Emission from Gas Clouds Compared to Molecular Gas Cloud Lifetimes in PHANGS-JWST Galaxies by Jaeyeon Kim, Mélanie Chevance, Lise Ramambason, Kathryn Kreckel, Ralf S. Klessen, Daniel A. Dale, Adam K. Leroy, Karin Sandstrom, Ryan Chown, Thomas G. Williams, Sumit K. Sarbadhicary, Francesco Belfiore, Frank Bigiel, Enrico Congiu, Oleg V. Egorov, Eric Emsellem, Simon C. O. Glover, Kathryn Grasha, Annie Hughes, J. M. Diederik Kruijssen, Janice C. Lee, Debosmita Pathak, Ismael Pessa, Erik Rosolowsky, Jiayi Sun, Jessica Sutter, David A. Thilker

“…After star formation is detected in H α , mid-IR emission persists for 3–7 Myr during the stellar feedback phase, covering 70%–80% of the H α emission. …”
Get full text

Development of a portable laser-flash photolysis Faraday rotation spectrometer for measuring atmospheric total OH reactivity by B. Fang, N. Wei, W. Zhao, N. Yang, H. Zhou, H. Zhang, H. Zhang, J. Li, W. Zhang, Y. Lu, Y. Lu, Z. Zhu, Z. Zhu, Y. Liu, Y. Liu

“…To achieve efficient overlapping between the pump and probe laser and realize a long effective absorption path length, thus enabling high-sensitivity measurement, a specific Herriott-type pump–probe optical multi-pass cell was designed. …”
Get full text

Strong parameter hierarchy in the interstellar phosphorus chemical network by Marina Fernández-Ruz, Marina Fernández-Ruz, Izaskun Jiménez-Serra, Mario Castro, Mario Castro, Marta Ruiz-Bermejo, Jacobo Aguirre, Jacobo Aguirre

“…In this study, we introduce the Fisher Information Spectral Reduction (FISR) algorithm, a novel and computationally efficient method to reduce the complexity of such sloppy models. …”
Get full text

Individual muscle strengths in rehabilitation outcomes of distal radius fracture by Lunjian Li, Xuanchi Liu, Lihai Zhang

“…The non-linear relationship of contract forces to the scaling coefficients indicates the complexity of the musculoskeletal system. …”
Get full text

Accumulation of Reducing Sugars by Small-leaved Linden Flowers (Tilia cordata Miller, 1768) in the Voronezh Region of Russia by N. A. Dyakova, A. I. Slivkin, S. P. Gaponov, E. A. Bobina, L. A. Shishorina

“…At the same time, it is possible that saccharide complexes might have reacted with heavy metals instead of the complexing agent when levels of reducing sugars in the samples were quantitatively determined. …”
Get full text

Hierarchical diagnostic approach for performance problems in cloud computing platforms by MI Hai-bo1, WANG Huai-min1, CAI Hua2, YIN Gang1, ZHOU Qi2, SUN Ting-tao2, ZHOU Yang-fan3

“…A hierarchical diagnosis approach,namely Magnifier,was proposed,which models the execution path graph of a user request as component layer,module layer and function layer,and detects anomalies from higher layer to lower layer separately.Extensive experiments were conducted on the Alibaba cloud computing platform.The results indicate that,under the conditions of large volume of data and high complexity of execution paths,Magnifier can accurately and efficiently locate the prime causes of performance degradation.…”
Get full text

Implementasi Keamanan Ruangan Berbasis IoT dengan Sensor PIR, Telegram, dan Peringatan Suara by Adi Wibowo Adi, Fandi Kurniawan

“…The system also effectively sends real-time notifications to the Telegram app and provides efficient sound alerts. Thus, this system significantly enhances home security with minimal cost and complexity, offering convenience and quick response to users. …”
Get full text

The Design and Research of the Bolt Loosening Monitoring System in Combine Harvesters Based on Wheatstone Bridge Circuit Sensor by Yi Lian, Bangzhui Wang, Meiyan Sun, Kexin Que, Sijia Xu, Zhong Tang, Zhilong Huang

“…Utilizing LoRa wireless communication, the system effectively overcomes the wiring complexity and deployment difficulties of traditional agricultural machinery bolt monitoring systems. …”
Get full text

Optimization with Time and Frequency Constraints Using Automatic Differentiation: Application to an Aircraft Electrical Power Channel by Lucas Agobert, Laurent Gerbaud, Benoit Delinchant

“…Optimal sizing, on top of developing such a model, is a significant challenge for designers, particularly due to the complexity of incorporating efficiently both time-domain and frequency-domain constraints and objectives. …”
Get full text

Large-scale phylogenomic insights into the evolution of the Hymenochaetales by Heng Zhao, Fang Wu, Sundy Maurice, Igor N. Pavlov, Konstantin V. Krutovsky, Hong-Gao Liu, Yuan Yuan, Yu-Cheng Dai

Get full text