Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…The full costs of delivering DPC are significantly higher than the costs of performing the oral challenge test itself alone, which requires careful consideration by providers as to which delivery model is most efficient given their local case mix, service configuration and information technology service infrastructure. …”
Get full text

Hierarchical diagnostic approach for performance problems in cloud computing platforms by MI Hai-bo1, WANG Huai-min1, CAI Hua2, YIN Gang1, ZHOU Qi2, SUN Ting-tao2, ZHOU Yang-fan3

“…A hierarchical diagnosis approach,namely Magnifier,was proposed,which models the execution path graph of a user request as component layer,module layer and function layer,and detects anomalies from higher layer to lower layer separately.Extensive experiments were conducted on the Alibaba cloud computing platform.The results indicate that,under the conditions of large volume of data and high complexity of execution paths,Magnifier can accurately and efficiently locate the prime causes of performance degradation.…”
Get full text

Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…These data are readily available from National Hip Fracture Database and are thus ideal for efficient trial design. Client Services Receipt Inventory can be reduced for a definitive trial, removing equipment questions and some community health use questions. …”
Get full text

Intronomics-MIP: a snakemake pipeline for analyzing multilocus intron polymorphisms in species identification and population genomics by A. Scapolatiello, E. Boscari, L. Schiavon, N. Vitulo, L. Congiu

“…These MIPs serve as powerful multiple-allelic markers, primarily useful for distinguishing species, identifying cryptic species, disentangling species complexes and detecting hybridization, but can also be informative for assessing population structure without prior species knowledge. …”
Get full text

Predicting and comparing transcription start sites in single cell populations. by Shiwei Fu, Wei Vivian Li

“…It employs a Binomial generalized linear mixed model to accurately and efficiently detect differential TSS usage. We demonstrate the utility of scTSS through its application in analyzing transcriptional initiation from single-cell data of two distinct diseases. …”
Get full text

Individual muscle strengths in rehabilitation outcomes of distal radius fracture by Lunjian Li, Xuanchi Liu, Lihai Zhang

“…The non-linear relationship of contract forces to the scaling coefficients indicates the complexity of the musculoskeletal system. …”
Get full text

Document Relevance Filtering by Natural Language Processing and Machine Learning: A Multidisciplinary Case Study of Patents by Raj Bridgelall

“…Traditional semantic search methods based on keywords often fail to capture the complexity and variability in multidisciplinary terminology, leading to inefficiencies. …”
Get full text

DFT study of the adsorption properties and sensitivity of a B2N monolayer toward harmful gases by Rezvan Rahimi, Mohammad Solimannejad, Ashkan Horri

“…These findings are of great importance as they serve to demonstrate the remarkable sensing capabilities of a B2N monolayer in efficiently detecting SO2 gas. The desorption time for CO, NO, NO2, and O3 molecules is quite long, thereby indicating the remarkable stability of the B2N sheet for adsorption of these gases. …”
Get full text

Accumulation of Reducing Sugars by Small-leaved Linden Flowers (Tilia cordata Miller, 1768) in the Voronezh Region of Russia by N. A. Dyakova, A. I. Slivkin, S. P. Gaponov, E. A. Bobina, L. A. Shishorina

“…At the same time, it is possible that saccharide complexes might have reacted with heavy metals instead of the complexing agent when levels of reducing sugars in the samples were quantitatively determined. …”
Get full text

The Design and Research of the Bolt Loosening Monitoring System in Combine Harvesters Based on Wheatstone Bridge Circuit Sensor by Yi Lian, Bangzhui Wang, Meiyan Sun, Kexin Que, Sijia Xu, Zhong Tang, Zhilong Huang

“…Utilizing LoRa wireless communication, the system effectively overcomes the wiring complexity and deployment difficulties of traditional agricultural machinery bolt monitoring systems. …”
Get full text

PATIENTS REFERRED FOR BLEEDING SYMPTOMS OF UNKNOWN CAUSE: DOES EVALUATION OF THROMBIN GENERATION CONTRIBUTE TO DIAGNOSIS? by Elena Holm, Eva Zetterberg, Susanna Lövdahl, Erik Berntorp

“…In conclusion, the complexity of the mechanisms underlying clinical bleeding complicates the ability to use TG tests as reliable predictors of bleeding. …”
Get full text

Comparative evaluation of precipitation-temperature based drought indices (DIs): A case study of Moroccan Lower Sebou basin by Oualid Hakam, Abdennasser Baali, Touria El kamel, Youssra Ahouach, Khalil Azennoud

“…The results proved the fact that SPI is suitable to detect the drought duration and intensity compared to other indices with high correlation coefficients especially in sub humid regions, knowing that it tends to give more results that are humid in stations with semi-arid climates. …”
Get full text

Deciphering cell cycle organization of Toxoplasma endodyogeny by Mrinalini Batra, Clem Marsilia, Danya Awshah, Lauren M. Hawkins, Chengqi Wang, Dale Chaput, Daria A. Naumova, Elena S. Suvorova

“…The ToxoFUCCIS probe efficiently detected G2/M and Spindle Assembly Checkpoints, as well as the SB505124-induced TgMAPK1-dependent block. …”
Get full text

Echocardiographic Screening for Transcatheter Edge-to-Edge Mitral Valve Repair: Correlation Between Transthoracic and Transesophageal Assessment by Michela Bonanni, Fausto Pizzino, Giovanni Benedetti, Rosangela Capasso, Rachele Manzo, Giuseppe Iuliano, Giancarlo Trimarchi, Andreina D’Agostino, Umberto Paradossi, Alessia Gimelli, Sergio Berti, Massimiliano Mariani

“…Three levels of anatomic complexity were defined to determine eligibility for TEER. …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Main outcome measures The primary outcome was diagnostic model sensitivity and specificity for detecting bladder outlet obstruction, detrusor underactivity and detrusor overactivity, with 75.0% considered minimum clinically useful performance. …”
Get full text