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Suggested Topics within your search.
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Naphthyl-Substituted Ruthenium(II)–Arene Complexes: Exploring the Impact of Binding Modes on Cytotoxicity in Cancer and Normal Cell Lines
Published 2025-01-01“…Following a 24-h exposure, Ru2 exhibited an IC50 of 1.39 μg/mL against the Caco-2 cell line. Morphological analysis suggested that all complexes induced apoptosis in cancer cells. …”
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Probing of the Interaction Between Human Serum Albumin and A New Synthesized Pd(II) Complex Using Spectroscopic Methods
Published 2013-06-01“…In the present study, the interaction and side effects of a new designed anti-cancer compound (1,10-phenanthroline butyl dithiocarbamato palladium(II) nitrate) on HSA have been investigated by different spectroscopic (UV-visible, fluorescence and circular dichroism (CD)) techniques at two temperatures of 25 and 37°C. By the analysis of fluorescence spectra, it was observed that this complex has an ability to quench the intrinsic fluorescence of HSA through a static quenching procedure. …”
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Patient-derived iPSCs link elevated mitochondrial respiratory complex I function to osteosarcoma in Rothmund-Thomson syndrome.
Published 2021-12-01“…RTS iPSC-derived osteoblasts showed defective osteogenic differentiation and gain of in vitro tumorigenic ability. Transcriptome analysis of RTS osteoblasts validated decreased bone morphogenesis while revealing aberrantly upregulated mitochondrial respiratory complex I gene expression. …”
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Theoretical Study for Stabilizing Group 14 Elements by Five Different Carbene Ligands as L-E-E-L Complexes
Published 2024-06-01“…L acts as a strong donor ligand in this complex. Conclusions: the thermodynamic calculations and orbital analysis can predict that complexes of L=E−E=L are stable enough to become isolated in a condensed phase for all compounds. …”
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Complexity Meets Risk—The Next Generation of Genome-Edited Plants Challenges Established Concepts for Environmental Risk Assessment in the EU
Published 2025-06-01“…These plant phenotypes can exhibit profoundly altered morphological, physiological, or compositional characteristics, intentionally lacking equivalence with parental plants and non-modified comparators. Through the analysis of case studies involving GMPs with modifications of complex metabolic pathways, we evaluate the current practice of the comparative safety assessment approach applied in ERA in the European Union and its ability to inform ERA, particularly regarding environmental risks. …”
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Manipulating Electronic Effect of Nitrogen Donor-Based Ligands for Efficient Complexation and Separation of Palladium from Highly Acidic Solution
Published 2025-03-01“…However, the electronic effect of these ligands, a critical factor influencing their complexation ability with Pd(II), remains largely unexplored. …”
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Real-time prediction of the rate of penetration via computational intelligence: a comparative study on complex lithology in Southwest Iran
Published 2025-06-01“…In this study, five methodologies, including three artificial intelligence models (artificial neural networks [ANNs], support vector regression [SVR], random forest [RF]), a physical model, and a hybrid model, were evaluated for their ability to estimate the ROP on the basis of drilling data from a complex lithological area. …”
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A data-driven hybrid framework for voltage transformer ratio error prediction: Addressing challenges in complex power systems
Published 2025-09-01“…Experimental results demonstrate that the proposed framework effectively reduces the complexity of the original data, showing significant improvements across four performance metrics, and enhancing the accuracy and stability of VT ratio error predictions. …”
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In-vitro antiproliferative evaluation of newly synthesized titanium(IV) metallacyclic complexes on HeLa and MCF7 cell lines
Published 2025-08-01“…Gel electrophoresis assay displayed that CT-DNA had a limited cleavage ability when metal complexes with different activators were present. …”
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Synthesis, Characterization, DNA Interaction, and Antitumor Activities of La (III) Complex with Schiff Base Ligand Derived from Kaempferol and Diethylenetriamine
Published 2014-01-01“…A novel La (III) complex, [LaL(H2O)3]NO3·3H2O, with Schiff base ligand L derived from kaempferol and diethylenetriamine, has been synthesized and characterized by elemental analysis, IR, UV-visible, 1H NMR, thermogravimetric analysis, and molar conductance measurements. …”
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A Complex Systems Approach to Exoplanet Atmospheric Chemistry: New Prospects for Ruling Out the Possibility of Alien Life As We Know It
Published 2025-01-01“…To distinguish biological, abiotic, and anomalous sources (unidentified as abiotic or biotic) of biosignature gases, we take a complex systems approach implementing chemical reaction network analysis of planetary atmospheres. …”
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Effect of Cu-, Zn-containing complex based on a porous matrix on fibroblast proliferation, apoptosis, necrosis and nitric oxide production
Published 2021-10-01“…Study of HEF-15 functional potential indicates a higher level of cell proliferation and ability to produce NO after contact with the complex. …”
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“I Am Longing and Afraid to Depend on You”: A Case Report on Breakdowns of Therapeutic Alliance and Interpersonal Cycles in Complex Trauma
Published 2024-11-01“…Background: Patients with Complex Trauma (CT) may have an impaired ability to trust others and build intimate relationships due to non-integrated representations of self and others. …”
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Influences of Diet Quality, Nursery‐Habitat Complexity and Sex on Brain Development and Cognitive Performance of Brown Trout (Salmo trutta L.)
Published 2025-08-01“…ABSTRACT Access to omega‐3 long‐chain polyunsaturated fatty acids (n‐3 LC‐PUFA) and habitat complexity have been proposed to influence brain development and cognitive ability. …”
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Influence of weather and climatic conditions on the genetic and physiological system of winter wheat plants in arid conditions of the Central Caucasus, Russia
Published 2022-04-01“…In this regard, the purpose of this research work was to determine the influence of hydrothermal factors of the region on the pigment complex and the ability of plants to accumulate nitrogen, protein content in grain and productivity of various varieties of winter wheat.Material and Methods. …”
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