Screening of novel therapeutic targets and chimeric vaccine construction against antibiotic-resistant Yersinia Enterocolitica by Mohibullah Shah, Mohibullah Shah, Rouman Fatima, Asifa Sarfraz, Muhammad Umer Khan, Hasan Ejaz, Maqsood Alam, Shahid Aziz, Umar Nishan, Abid Ali, Ahmed Bari, Suvash Chandra Ojha

“…Four vaccine constructs were designed using the selected epitopes by adding the appropriate adjuvants and linkers. …”
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A gene expression atlas of Nicotiana tabacum across various tissues at transcript resolution by Shizhou Yu, Jufen Wan, Jufen Wan, Tenghang Xu, Tenghang Xu, Jie Zhang, Linggai Cao, Jie Liu, Hongfeng Liu, Xueliang Ren, Zhixiao Yang

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Formulation of multicriteria problem of routing and scheduling of manned and unmanned aircraft in a dynamic environment and approach to its solution using genetic algorithms by G. N. Lebedev, V. B. Malygin, D. A. Mikhaylin, T. Byo

“…The proposed approach will significantly improve the efficiency and quality of flight planning for the airline, taking into account the diversity of aircraft fleet, payload and environmental impact. …”
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Invasive Aquatic Weeds Suppress Predator–Prey Cascades: Evidence from a Mesocosm Study by Pierre William Froneman

“…The increased habitat complexity conferred by the water hyacinth root system provided refugia for zooplankton. …”
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Technology Advancements and the Needs of Farmers: Mapping Gaps and Opportunities in Row Crop Farming by Rana Umair Hameed, Conor Meade, Gerard Lacey

“…Farmers reported mixed reactions to current technologies, acknowledging efficiency improvements but highlighting barriers such as capital costs, technical complexity, and inadequate support systems. …”
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A novel 3D bilateral filtering algorithm with noise level estimation assisted by multi-temporal SAR. by Haiyan Zhang, Yang Liu, Guoyin Cai

“…The bilateral filter is widely employed in the field of image denoising due to its flexibility and efficiency. It calculates the weights of neighboring pixels based on both spatial and grayscale distances from the pixel to be denoised. …”
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Dopamine modulates persistent synaptic activity and enhances the signal-to-noise ratio in the prefrontal cortex. by Sven Kroener, L Judson Chandler, Paul E M Phillips, Jeremy K Seamans

“…Lower concentrations of exogenous DA (0.1 microM) had no effect on the up-state itself, but they selectively increased the efficiency of a train of EPSPs to evoke spikes during the Up-state. …”
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Self-supervised feature learning for acoustic data analysis by Ahmet Pala, Anna Oleynik, Ketil Malde, Nils Olav Handegard

“…Extracting useful acoustic features is an intricate task due to the inherent variability and complexity in biological targets, as well as environmental and technical factors influencing sound interactions. …”
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Presenting a multi-objective decision-making model for cost-time trade-off considering the time value of money and solving it using particle swarm optimization by Mohammadreza Shahriari

“…To achieve this, a bi-objective mathematical model is developed to support decision-makers in selecting the optimal schedule for project execution.Methodology: In this study, a bi-objective mathematical model is proposed to balance cost and time, incorporating a nonlinear cost function and the time value of money. …”
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Implementing Customized Electronic Quality Checklists to Reduce Errors and Improve Workflow in Radiotherapy by Zaheeda Mulla, Victor J. Joseph John, Rania Hashem, Hatim Z. Almarzouki, Abdullah Almohamad, Mohammad Attar, Hane Muamenah, Hanadi F. Habibullah, Hussam Hijazi

“…PURPOSEAdvancements in radiation oncology have improved treatment precision and effectiveness but increased procedural complexity and error risk because of higher patient volumes. …”
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kMetha-Mamba: K-means clustering mamba for methane plumes segmentation by Yuquan Liu, Hailiang Shi, Ke Cao, Shichao Wu, Hanhan Ye, Xianhua Wang, Erchang Sun, Yunfei Han, Wei Xiong

“…Finally, kMetha-Mamba utilizes a mamba-based decoder (MBD) with linear complexity and long-range dependencies to achieve high efficiency and precision segmentation. …”
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Characterization of an unusual SARS-CoV-2 main protease natural variant exhibiting resistance to nirmatrelvir and ensitrelvir by Dipendra Bhandari, Oksana Gerlits, Stephen Keable, Leighton Coates, Annie Aniana, Rodolfo Ghirlando, Nashaat T. Nashed, Andrey Kovalevsky, John M. Louis

“…Structural differences in four inhibitor complexes of MProD48Y/ΔP168 compared to wild-type are described. …”
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Identification and Evaluation of Indicators of Science, Technology, and Innovation in Policymaking from the Perspective of Experts by Esmaeil Shirali

“…Within the economic category, the indicators for the complexity of the production process average 3.97, the intensity of industrialization averages 3.72, and intellectual property payments average 3.59, indicating their high favorability. …”
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In Silico Evaluation of ERQ Bioactive Tripeptide as an Anticancer Agent and an Inhibitor of SARS-CoV-2 Enzymes by Gözde Yılmaz, Sefa Çelik, Ayşen Erbölükbaş Özel, Sevim Akyüz

“…Objective: Short peptides play a significant role in exploring drugs with higher selectivity and fewer side effects in cancer and COVID-19 therapies. …”
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An immunoinformatics approach in designing high-coverage mRNA multi-epitope vaccine against multivariant SARS-CoV-2 by Ernawati Arifin Giri-Rachman, Al Mirahma Febri Kurnianti, Rizarullah, Aditya Hanung Setyadi, Anita Artarini, Marselina Irasonia Tan, Catur Riani, Dessy Natalia, Reza Aditama, Husna Nugrahapraja

“…Furthermore, molecular docking analysis revealed potent interactions between the validated 3D structure and the TLR4 and BCR receptors, while molecular dynamic simulations confirmed the stability of the VC-TLR4 and VC-BCR complexes. Additionally, mRNA codon optimization was performed to enhance vaccine expression efficiency, and secondary structure analysis indicated that the designed mRNA vaccine possessed a stable conformation. …”
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Optimization of vehicle routing problems combining the demand urgency and road damage for multiple disasters by Ran Li, Xiaofei Ye, Shuyi Pei, Xingchen Yan, Tao Wang, Jun Chen, Pengjun Zheng

“…However, compared with single-hazard, multiple disasters confront the challenges of complexity, diversity, and demand urgency. To improve the efficiency of emergency material distribution under multiple disasters, this study first divided multiple disasters into three categories: independent scenario, sequential scenario, and coupling scenario. …”
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Novel Epigenetics Control (EpC) Nanocarrier for Cancer Therapy Through Dual-Targeting Approach to DNA Methyltransferase and Ten-Eleven Translocation Enzymes by Risa Mitsuhashi, Kiyoshi Sato, Hiroyoshi Kawakami

“…The formation of core–shell nanoparticles and complexation with pDNA were investigated and optimized by dynamic light scattering, zeta potential measurement, and agarose gel electrophoresis. …”
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Pharmacists’ Experiences on Adverse Drug Reactions in Saudi Arabia: A Cross-Sectional Study by Dalal Salem Bakheit Aldossari, Naeema Taha Alshalaan, Khuloud Salem Alshammari, Fatima Ahmed Lubbad, Mudhi Ratyan Alanazi, Neamah Ahmed Lubbad, Nada Suliman Fahad Alessa, Sheraz Ali

“…Background and objectives: As part of Vision 2030, Saudi Arabia aims to strengthen its healthcare system by enhancing efficiency, reducing medical errors, and ensuring drug safety. …”
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Artificial intelligence methods used in various aquaculture applications: A systematic literature review by Thurein Aung, Rafiza Abdul Razak, Adibi Rahiman Bin Md Nor

“…However, the review also uncovered substantial challenges that will continue limiting widespread adoption, including restricted access to representative data, prohibitive expenses, technical complexities, lack of social acceptance, and data privacy and security concerns. …”
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Optimizing Remote Sensing Image Retrieval Through a Hybrid Methodology by Sujata Alegavi, Raghvendra Sedamkar

“…Addressing the scaling and rotation variations in image capture, a flexible and dynamic algorithm, modified Deep Image Registration using Dynamic Inlier (IRDI), is introduced for image registration. Given the complexity of remote sensing images, feature extraction occurs at two levels. …”
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