Discovery of KRAS(G12D) selective degrader ASP3082 by Tomohiro Yoshinari, Takeyuki Nagashima, Hiroki Ishioka, Kohei Inamura, Yoshihiro Nishizono, Mamoru Tasaki, Kanako Iguchi, Atsushi Suzuki, Chikako Sato, Ayako Nakayama, Yasushi Amano, Yukihiro Tateishi, Yosuke Yamanaka, Fumio Osaki, Masayasu Yoshino, Kazuyuki Kuramoto, Tomoyoshi Imaizumi, Masahiko Hayakawa

“…Herein, we report the discovery and characterization of ASP3082, a KRAS(G12D)-selective degrader, and the crystal structure of the drug-induced ternary complex of KRAS(G12D)/ASP3082/VHL (von Hippel–Lindau). …”
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Fast Block Partitioning Algorithm for HEVC Based on Spatial Correlation and Image Texture by Yingbiao Yao, Xiaojuan Li

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Efficient Onboard Multitask AI Architecture Based on Self-Supervised Learning by Gabriele Inzerillo, Diego Valsesia, Enrico Magli

“…Experiments on three sample tasks of cloud segmentation, flood detection, and marine debris classification on a 7-W embedded system show competitive results with inference quality close to high-complexity state-of-the-art models and high throughput in excess of 8 Megapixel/s.…”
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Study of Complex Impedance Dispersion Model for Two-Phase Laminar Flow by CHENG Linfeng, KE Shizhen, SHI Hongwei, ZHANG Yuhang, LUO Hu, TAO Jie

“…Therefore, it is imperative to identify a more cost-effective and efficient measurement method. Complex impedance spectrum (CIS) detection technology emerges as a promising solution, offering advantages such as low cost, easy implementation, environmental friendliness, and safety. …”
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Path Planning Algorithm for Manipulators in Complex Scenes Based on Improved RRT* by Xiqing Zhang, Pengyu Wang, Yongrui Guo, Qianqian Han, Kuoran Zhang

“…The algorithm generates multiple candidate points per iteration, selecting a sampling point probabilistically based on heuristic values, thereby optimizing sampling efficiency and reducing unnecessary nodes. …”
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LCD: IDENTIFYING INFLUENTIAL NODES IN COMPLEX NETWORKS WITH LAYERED CLUSTERING AND DEGREE by Abdulhakeem Othman Mohammed

“…While numerous algorithms have been proposed in the literature, many struggle with either limited spreading efficiency or high computational complexity. To address this challenge, we present Layered Clustering Degree (LCD), an effective method for identifying a set of well-distributed spreaders with high spreading ability, while maintaining a computational complexity of  making it highly suitable for large-scale networks where both efficiency and computational complexity are essential. …”
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An Innovative Priority Queueing Strategy for Mitigating Traffic Congestion in Complex Networks by Ganhua Wu

“…The GPQ strategy provides a practical and adaptable solution for improving transportation efficiency in complex networks, bridging the gap between conventional routing techniques and emerging demands for dynamic congestion management.…”
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Software complex for simulation modelling of single nucleotide genetic polymorphism sites by M. M. Yatskou, D. D. Sarnatski, V. V. Skakun, V. V. Grinev

“…A software complex has been developed for simulation modelling and identification of single nucleotide polymorphism sites using machine learning methods. …”
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LINKING MARKETING AND HUMAN RESOURCES RECRUITMENT TO OBTAIN ORGANIZATIONAL EFFICIENCY by Nicoleta Valentina FLOREA

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Proteomics approaches – their potential for answering complex questions in meat science research by Elisabeth Huff-Lonergan, Steven M. Lonergan

“…New information can be used to make precise changes in management or genetic selection to improve the ability to efficiently produce the high-quality meat that customers and consumers expect. …”
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Analysis of Methods for Training Robotic Manipulators to Perform Complex Motion Trajectories by Yurii Senchuk, Fedir Matiko

“…The article examines current approaches to training robotic manipulators for executing complex tasks in dynamic and changing environments. …”
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A Complexity Reduction Method for Intra Prediction Method in HEVC Standard by Zahra Mirian, Mohammadreza Ramezanpour

“…High Efficiency Video Coding (HEVC) is considered the last standard for video compression with about 50% additional compression compared to the previous standard i.e. …”
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Key nodes identification in complex networks based on subnetwork feature extraction by Luyuan Gao, Xiaoyang Liu, Chao Liu, Yihao Zhang, Giacomo Fiumara, Pasquale De Meo

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Location-Based Relay Selection in Full-Duplex Random Relay Networks by Jonghyun Bang, Taehyoung Kim

“…Furthermore, we introduce a low-complexity relay selection algorithm that selects the relay node nearest to the potential relay location. …”
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The Complexity of Oxidative Stress in Human Age-Related Diseases—A Review by Alicja Płóciniczak, Ewelina Bukowska-Olech, Ewa Wysocka

“…One of the key contributors to aging and age-related diseases is oxidative stress, resulting from an imbalance between the generation of reactive oxygen species (ROS) and the efficiency of antioxidant defense systems. In this review, we introduce the concept of the oxidative stress complexity—a network encompassing ROS-generating systems, enzymatic and non-enzymatic antioxidants, and genetic determinants that collectively shape redox homeostasis. …”
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An Integrated Algorithm with Feature Selection, Data Augmentation, and XGBoost for Ovarian Cancer by Jingxun Cai, Zne-Jung Lee, Zhihxian Lin, Chih-Hung Hsu, Yun Lin

“…Once ovarian cancer reaches an advanced stage, the complexity and difficulty of treatment increase substantially, affecting patient survival rates. …”
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Deposit thickness control of the heat exchange equipment by hardware and software complex by E. V. Garnyshova, E. V. Izmaylova, Yu. V. Vankov

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Rapid equivalent simplification algorithm for complex underground mine ventilation networks by Jinzhang JIA, Wentian SHANG, Jian LIU, Lijun Deng

“…To address these challenges, a rapid equivalent simplification algorithm for complex mine ventilation networks is proposed. This algorithm employs strong connectivity component algorithms from graph theory to swiftly detect unidirectional loops within the network. …”
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Attention-enhanced StrongSORT for robust vehicle tracking in complex environments by Wei Xu, Xiaodong Du, Ruochen Li, Bingjie Li, Yuhu Jiao, Lei Xing

“…Third, the optimized CBH-Conv module employs Hardswish activation and depthwise separable convolution to mitigate gradient vanishing while maintaining real-time efficiency (achieving a 17% MOTA improvement at 213 FPS).Evaluated on the MOT-16 dataset, AE-StrongSORT demonstrates substantial improvements over the baseline StrongSORT, with 17%, 2.78%, and 9.99% gains in MOTA, HOTA, and IDF1 metrics respectively, alongside significant reductions in false/missed detections. …”
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An Effective Algorithm for Video-Based Parking and Drop Event Detection by Gang Li, Huansheng Song, Zheng Liao

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