Innovative dual-gene delivery platform using miR-124 and PD-1 via umbilical cord mesenchymal stem cells and exosome for glioblastoma therapy by Po-Fu Yueh, I-Tsang Chiang, Yueh-Shan Weng, Yu-Chang Liu, Raymond C. B. Wong, Cheng-Yu Chen, Justin Bo-Kai Hsu, Long-Bin Jeng, Woei-Cherng Shyu, Fei-Ting Hsu

“…Experimental results demonstrate that the UMSC/miR-124-PD-1 complex and its exosomes successfully induce apoptosis in GBM cells, significantly inhibiting tumor growth. …”
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Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes. by Josine L Min, George Nicholson, Ingileif Halgrimsdottir, Kristian Almstrup, Andreas Petri, Amy Barrett, Mary Travers, Nigel W Rayner, Reedik Mägi, Fredrik H Pettersson, John Broxholme, Matt J Neville, Quin F Wills, Jane Cheeseman, GIANT Consortium, MolPAGE Consortium, Maxine Allen, Chris C Holmes, Tim D Spector, Jan Fleckner, Mark I McCarthy, Fredrik Karpe, Cecilia M Lindgren, Krina T Zondervan

“…Since many genes and their interactions influence complex traits such as MetS, integrated analysis of genotypes and coexpression networks across multiple tissues relevant to clinical traits is an efficient strategy to identify novel associations.…”
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Anaerobic digestion of microalgae: microbial response and recovery after organic loading disturbances by Juline M. Walter, Silvia Greses, Live H. Hagen, Valerie C. Schiml, Phillip B. Pope, Cristina González-Fernández, Magnus Ø Arntzen

“…ABSTRACT Industrial anaerobic digestion (AD) represents a relevant energy source beyond today’s fossil fuels, wherein organic matter is recycled to methane gas via an intricate and complex microbial food web. Despite its potential, anaerobic reactors often undergo process instability over time, which is frequently caused by substrate composition perturbations, making the system unreliable for stable energy production. …”
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Rhizobacteria from vineyard and commercial arbuscular mycorrhizal fungi induce synergistic microbiome shifts within grapevine root systems by Romain Darriaut, Vincent Lailheugue, Jules Wastin, Joseph Tran, Guilherme Martins, Patricia Ballestra, Isabelle Masneuf-Pomarède, Nathalie Ollat, Virginie Lauvergeat

“…The combined inoculation of bacteria and AMF resulted in a more complex bacterial network with higher metabolic functionality than single inoculation treatments. …”
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Robust and Adaptive Tuning of PI Current Controllers for Grid-Forming Inverters by Florian Reisner, George Weiss

“…While very efficient in strong grids, such control architectures face stability problems if the grid short-circuit ratio becomes low. …”
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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…Therefore, the education system is forced to be reconstructed for preparation of holders of complex knowledge and competencies, generators of newideas and projects. …”
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Real-time mobile broadband quality of service prediction using AI-driven customer-centric approach by Ayokunle A. Akinlabi, Folasade M. Dahunsi, Jide J. Popoola, Lawrence B. Okegbemi

“…Since the traffic patterns experienced in MBB networks are largely complex, highly dynamic and heterogenous in nature; hence, statistical methods may not adjust adequately to the changing network conditions. …”
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The dynamics of chemoattractant receptors redistribution in the electrotaxis of 3T3 fibroblasts by Jagoda Gorzkowska, Wiktoria Kozak, Sylwia Bobis-Wozowicz, Ivan Cherepashuk, Zbigniew Madeja, Sławomir Lasota

“…However, this mechanism alone does not fully explain rapid responses to dcEF orientation changes indicating a more complex, multimodal mechanism of electrotaxis in these cells.…”
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Characterization and simulation of conglomerate reservoirs using core data of Triassic Baikouquan Formation, Mahu Depression by Xiangyang Li, Fengxia Li, Zhiwen Huang, Hancheng Ji, Haibo Wang, Liang Chen, Zhonghao Zhang, Xukai Shi

“…The results reveal that certain lithofacies types correlate strongly with higher fracturing success, providing insights that can guide more efficient hydraulic fracturing practices. By addressing the challenge of heterogeneity of the structure and composition in conglomerate reservoirs, this study offers a comprehensive framework for selecting optimal target intervals for hydraulic fracturing, which can significantly enhance hydrocarbon exploration and production strategies. …”
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Characteristics and prediction methods of coal spontaneous combustion for deep coal mining in the Ximeng mining area by Li MA, Wenbo GAO, Longlong TUO, Pengyu ZHANG, Zhou ZHENG, Ruizhi GUO

“…Objective The mining of deep coal seams in the Ximeng mining area within the Ordos Basin is subjected to complex environmental conditions like high in-situ stress, large water inflow, and severe air leakage, which lead to the encountered with elevated risks and difficult prediction of coal spontaneous combustion and posing challenges in predicting spontaneous combustion. …”
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Mechanisms of Low Temperature Thickening of Different Materials for Deepwater Water-Based Drilling Fluids by Zhongyi Wang, Jinsheng Sun, Kaihe Lv, Xianbin Huang, Zhenhang Yuan, Yang Zhang

“…As a coarse dispersion system, water-based drilling fluid has a complex composition of dispersed phase and dispersing medium. …”
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Surface protonation amplifies carbon nitride nanosheet-induced phospholipid extraction: Mechanistic insights into enhanced cytotoxicity by Yiping Feng, Jiayong Lao, Jingchuan Xue

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Integration of ordered porous materials for targeted three-component gas separation by Xue Jiang, Yu Wang, Hui Wang, Lu Cheng, Jian-Wei Cao, Jin-Bo Wang, Rong Yang, Dong-Hui Zhang, Run-Ye Zhang, Xiu-Bo Yang, Su-Hang Wang, Qiu-Yu Zhang, Kai-Jie Chen

“…As a proof of concept, two ultramicroporous nanocrystals (one for C2H2-selective and the other for CO2-selective) as the shell pores were respectively grown on a C2H6-selective ordered porous material as the core pore. …”
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TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1 by Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur, Matthias Peindl, Sarah Nietzer, Karina Epting, Gabriele Vacun, Gudrun Dandekar, Catherine Botteron, Christian Werno, Thomas Grunwald, Susanne M. Bailer

“…Viruses are able to efficiently penetrate cells, multiply, and eventually kill infected cells, release tumor antigens, and activate the immune system. …”
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Classifying and Localizing Abnormalities in Brain MRI Using Channel Attention Based Semi-Bayesian Ensemble Voting Mechanism and Convolutional Auto-Encoder by Syed Muhammad Ahmed Hassan Shah, Asad Ullah, Jawaid Iqbal, Sami Bourouis, Syed Sajid Ullah, Saddam Hussain, Muhammad Qasim Khan, Yaser Ali Shah, Ghulam Mustafa

“…The classification of brain tumors into multiple classes is recognized as a complex challenge within the field of medical imaging. …”
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Wind-induced transmission line interruption fragility models: An adaptive GAN-augmented probabilistic classification approach for extremely unbalanced data by Mazin Al-Mahrouqi, Abdollah Shafieezadeh, Jieun Hur, Jae-Wook Jung, Jeong-Gon Ha, Daegi Hahm

“…Additionally, we develop an advanced active learning framework that efficiently selects the most relevant instances from large, imbalanced datasets for model training. …”
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Accelerated carbonate weathering by immobilized recombinant carbonic anhydrase by Io Antonopoulou, Ayanne de Oliveira Maciel, Marikagiusy Di Giacomo, Maria Elena Russo, Ulrika Rova, Paul Christakopoulos, Piero Salatino, Antonio Marzocchella

“…CA immobilization could offer a mitigation strategy for the non-selective adsorption of the free enzyme on lime mud particles during the CO2 capturing reaction. …”
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Evaluating N₂O emissions and carbon sequestration in temperate croplands with cover crops: insights from field trials by V. Nasser, R. Dechow, M. Helfrich, A. Meijide, P. S. Rummel, P. S. Rummel, H.-J. Koch, R. Ruser, L. Essich, K. Dittert

“…Yet, their influence on nitrous oxide (<span class="inline-formula">N₂O</span>) emissions – a potent greenhouse gas – presents a complex challenge, with findings varying across different studies. …”
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The large language model diagnoses tuberculous pleural effusion in pleural effusion patients through clinical feature landscapes by Chaoling Wu, Wanyi Liu, Pengfei Mei, Yunyun Liu, Jian Cai, Lu Liu, Juan Wang, Xuefeng Ling, Mingxue Wang, Yuanyuan Cheng, Manbi He, Qin He, Qi He, Xiaoliang Yuan, Jianlin Tong

“…By highlighting the advantages of LLMs in handling complex clinical data, identifying interrelationships between features, and improving diagnostic accuracy, this study seeks to provide a more efficient and precise solution for the early diagnosis of TPE. …”
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Characterization of emerging H3N3 avian influenza viruses in poultry in China by Cheng Yan, Jianzhong Shi, Pengfei Cui, Yuan Chen, Congcong Wang, Yan Wang, Jiahao Miao, Yaping Zhang, Huihui Kong, Xianying Zeng, Guobin Tian, Chengjun Li, Yasuo Suzuki, Guohua Deng, Hualan Chen

“…Seventeen viruses were tested in mice and most replicated efficiently but were not lethal. Six viruses were tested in guinea pigs, and four of them transmitted efficiently via respiratory droplets. …”
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