Multicomponent thiolactone-based ionizable lipid screening platform for efficient and tunable mRNA delivery to the lungs by Álvaro Peña, Juan Heredero, Beatriz Blandín, Elena Mata, Diego De Miguel, Alfonso Toro, Teresa Alejo, Diego Casabona, Alexandre López, Ana Gallego-Lleyda, Esther Pérez-Herrán, Juan Martínez-Oliván, Javier Giménez-Warren

“…Abstract Ionizable lipids are essential components of lipid nanoparticles (LNPs) for efficient mRNA delivery. However, designing them for high protein expression, endosomal escape, and organ targeting is challenging due to complex structure-activity relationships. …”
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Sample-Efficient Multi-Agent DQNs for Scalable Multi-Domain 5G+ Inter-Slice Orchestration by Pavlos Doanis, Thrasyvoulos Spyropoulos

“…For (ii), we explore multi-agent DQN algorithms that can reduce action space complexity by orders of magnitude compared to standard DQN. …”
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High-entropy alloys catalyzing polymeric transformation of water pollutants with remarkably improved electron utilization efficiency by Ziwei Yao, Yidi Chen, Xiaodan Wang, Kunsheng Hu, Shiying Ren, Jinqiang Zhang, Zhao Song, Nanqi Ren, Xiaoguang Duan

“…The unique non-mineralization regime remarkably reduces PMS consumption and achieves a high electron utilization efficiency of up to 213.4%. Further DFT calculations and experimental analysis reveal that Fe and Co in HEA-NPs act as the primary catalytic sites to complex with PMS for activation, while Ni, Cu, and Pd serve as charge mediators to facilitate electron transfer. …”
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Flood risk mapping and performance efficiency evaluation of machine learning algorithms: Best practice in northern Iran by M. Shirmohammadi, M. Shirmohammadi, S. Pirasteh, W. Li, D. Mafi-Gholami

“…Flooding is one of the most devastating natural hazards, and inadequate management can amplify its impacts, leading to severe social, economic, and environmental consequences. Accurate and efficient flood risk mapping is essential for mitigating these effects and supporting effective disaster management strategies. …”
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Efficient Rescue of Retinal Degeneration in Pde6a Mice by Engineered Base Editing and Prime Editing by Zhiquan Liu, Siyu Chen, Alexander E. Davis, Chien‐Hui Lo, Qing Wang, Tingting Li, Ke Ning, Qi Zhang, Jingyu Zhao, Sui Wang, Yang Sun

“…Notably, the optimal PE system, delivered via dual adeno‐associated virus (AAV), precisely corrects the pathogenic mutation with average 9.4% efficiency, with no detectable bystander editing. This correction restores PDE6A protein expression, preserved photoreceptors, and rescued retinal function in Pde6a mice. …”
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Optimizing HVAC&R System Efficiency and Comfort Levels Using Machine Learning-Based Control Methods by Suroor M. Dawood, Raad Z. Homod, Alireza Hatami

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Structural and Economic Approach to the Selection of Peak Regulating Capacities at Thermal Power Plants by E. V. Bohdan, M. B. Karnitski

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Efficient Access to New Thienobenzo-1,2,3-Triazolium Salts as Preferred Dual Cholinesterase Inhibitors by Milena Mlakić, Maja Sviben, Ana Ratković, Anamarija Raspudić, Danijela Barić, Ivana Šagud, Zlata Lasić, Ilijana Odak, Irena Škorić

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An Efficient Fine-Grained Recognition Method Enhanced by Res2Net Based on Dynamic Sparse Attention by Qifeng Niu, Hui Wang, Feng Xu

“…This paper presents an efficient architecture built upon the Res2Net backbone, significantly enhanced by a dynamic Sparse Attention mechanism. …”
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Technical progress of construction and safe operation of underground gas storage under complex geological conditions by Qiqi WANYAN, Yun WANG, Dongxu LI, Hongcheng XU, Chun LI, Kang LI, Jingcui LI, Lifeng LI

“…In view of the characteristics of the developed gas reservoir fault system, largely buried depth, strong heterogeneity and complex gas-water distribution, breakthroughs were made in the construction and operation of gas reservoir and salt cavern type gas storages in China through over 20 years of hard working in research, and five technology series were formed, including (1) storage site selection and evaluation technology, (2) storage capacity design and evaluation technology, (3) efficient wellbore quality control technology, (4) large displacement injection-production design technology, and (5) risk identification and monitoring technology. …”
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Enhancing 3D A* path planning of intelligent bridge crane based on energy efficiency criteria by Heng YANG, Yue LI, Min LIU, Qing DONG

“…To address the problems of traditional three-dimensional (3D) A* algorithm, such as low planning efficiency, numerous path inflection points, and increased path complexity when the target point is surrounded by obstacles, a 3D A* path-planning algorithm based on energy efficiency criteria is proposed in this study. …”
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Development and Application of Efficient Oil Displacement System for Middle-Low Permeability and High Pour-Point Heavy Oil Reservoirs by Zhenfu Ma, Kai Zhang, Mengjie Zhao, Lu Liu, Chao Zhong, Jian Wang

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Unsupervised Learning for Distributed Downlink Power Allocation in Cell-Free mMIMO Networks by Mattia Fabiani, Asmaa Abdallah, Abdulkadir Celik, Omer Haliloglu, Ahmed M. Eltawil

“…Furthermore, an LSF-based radio unit (RU) selection algorithm is employed to activate only the contributing RUs, allowing efficient utilization of network resources. …”
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Background of Data Envelopment Analysis Implementation in Moscow Healthcare System: International and Russian Experience by Yu. V. Budarina

“…The publications were selected using the PRISMA guidelines. A complex of modern general scientific methods of cognition was also used: system and structural approach, analytical method, comparison, and generalization.Results. …”
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Distinguishing Difficulty Imbalances in Strawberry Ripeness Instances in a Complex Farmland Environment by Yang Gan, Xuefeng Ren, Huan Liu, Yongming Chen, Ping Lin

“…The existing strawberry ripeness detection algorithm has the problems of a low precision and a high missing rate in real complex scenes. …”
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Improved cancer detection through feature selection using the binary Al Biruni Earth radius algorithm by El-Sayed M. El-Kenawy, Nima Khodadadi, Marwa M. Eid, Ehsaneh Khodadadi, Ehsan Khodadadi, Doaa Sami Khafaga, Amel Ali Alhussan, Abdelhameed Ibrahim, Mohamed Saber

“…Metaheuristic algorithms have been employed to select features to address this issue. Although the efficacy of these algorithms has been demonstrated, challenges related to scalability and efficiency persist when handling large medical datasets. …”
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Camera systems and their user recognition reliability when entering an agri-food complex by Jaroslav Mrázek, Jakub Vošáhlík, Eva Olmrová, Martin Pexa, Zdeněk Aleš, Jakub Čedík

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Integration of Carbon Nanotubes into Manganese Dioxide Nanorods for Enhanced Enzymeless Electrochemical Glucose Sensing with High Sensitivity and Selectivity by Khawtar Hasan Ahmed, Alonso Moreno Zuria, Mohamed Mohamedi

“…These attributes are essential for accurate glucose detection in complex biological samples. The integration of MnO₂ nanorods with CNTs in freestanding nanostructures opens up exciting opportunities for developing high-performance, robust electrochemical sensors for diverse applications.…”
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A lightweight real-time unified detection model for rice and wheat ears in complex agricultural environments by Xiaojun Shen, Shuai Li, Fen Qiu, Lili Yao

“…Therefore, in response to the lack of research on the unified real-time detection of rice and wheat ear, this paper proposes a lightweight detection model, Light-Y, suitable for complex environments. …”
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Some innovations in pig farming and their zootechnical assessment by V. I. Khalak, B. V. Gutyj, O. M. Bordun

“…The purpose of this work was to investigate the life expectancy, duration of breeding use, and reproductive qualities of sows of the large white breed of French selection, based on the obtained data to develop a new way of evaluating sows according to their operational value, as well as to calculate the economic efficiency of their use in the conditions of the industrial complex. …”
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