TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy by Marco Donia, Özcan Met, Julie Westerlin Kjeldsen, Sine Reker Hadrup, Inge Marie Svane, Arianna Draghi, Anders Handrup Kverneland, Christina Heeke, Siri Amanda Tvingsholm, Marcus Svensson Frej, Vibeke Mindahl Rafa, Ulla Kring Hansen, Maria Ormhøj, Alexander Tyron, Agnete W P Jensen, Mohammad Kadivar, Amalie Kai Bentzen, Kamilla K Munk, Gitte N Aasbjerg, Jeppe S H Ternander, Tripti Tamhane, Christian Schmess, Samuel A. Funt, Søren Nyboe Jakobsen

“…The resulting T-cell products were assessed for phenotypic and functional characteristics.Results We identified an optimal Ag-scaffold for expansion of T-cells for ACT, carrying pMHC and interleukin-2 (IL-2) and IL-21, with which we efficiently expanded both virus-specific and tumor-specific CD8+ T cells from peripheral blood of healthy donors and patients, respectively. …”
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Optimization Method of Wind Turbine Locations in Complex Terrain Areas Using a Combination of Simulation and Analytical Models by Dinh Van Thin, Le Quang Sang, Nguyen Huu Duc

“…For areas with complex terrain, wind resource characteristics depend largely on terrain features, so the selection of turbine installation locations is very important. …”
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Effects of Ageing and Sex on Complexity in the Human Sleep EEG: A Comparison of Three Symbolic Dynamic Analysis Methods by Pinar Deniz Tosun, Derk-Jan Dijk, Raphaelle Winsky-Sommerer, Daniel Abasolo

“…The surrogate data analysis showed that LZC merely reflected spectral changes in EEG activity, whereas PE and PLZC reflected genuine changes in the nonlinear dynamics of the EEG. …”
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PROBLEMS OF FORMATION OF FINANCIAL-INVESTMENT PROJECTION OF A BALANCED SCORECARD IN VALUE-BASED ENTERPRISES OF MINING-METALLURGICAL COMPLEX by S. Faizova, M. Ivanova, S. Sannikova, O. Varyanichenko

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Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication. by Masha Sorin, Jennifer Cano, Supratik Das, Sheeba Mathew, Xuhong Wu, Kelvin P Davies, Xuanling Shi, S-W Grace Cheng, David Ott, Ganjam V Kalpana

“…INI1/hSNF5 is a component of the SWI/SNF complex that interacts with HIV-1 IN, is selectively incorporated into HIV-1 (but not other retroviral) virions, and modulates multiple steps, including particle production and infectivity. …”
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Enhanced deep learning model for apple detection, localization, and counting in complex orchards for robotic arm-based harvesting by Tantan Jin, Xiongzhe Han, Pingan Wang, Zhao Zhang, Jie Guo, Fan Ding

“…The growing demand for automation in the apple-harvesting industry remains challenging due to the complex and dynamic nature of orchard environments. …”
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Enhancing IDS for the IoMT based on advanced features selection and deep learning methods to increase the model trustworthiness. by Ahmed Muqdad Alnasrallah, Maheyzah Md Siraj, Hanan Ali Alrikabi

“…This study indicates that the proposed strategy decreases computational complexity and enhances IDS efficiency in resource-constrained IoMT environments.…”
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Crashing Fault Residence Prediction Using a Hybrid Feature Selection Framework from Multi-Source Data by Xiao Liu, Xianmei Fang, Song Sun, Yangchun Gao, Dan Yang, Meng Yan

“…This task plays a crucial role in software quality assurance by enhancing debugging efficiency and reducing testing costs. This study introduces SCM, a two-stage composite feature selection framework designed to address this challenge. …”
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Melanin-like nanofibers with highly ordered structures achieve ultrahigh specific electromagnetic interference shielding efficiency by Peng Chen, Shibo He, Tianyou Wang, Chencan Wang, Junru Tao, Yiwen Li

“…Conventional shielding materials often involve complex fabrication of conjugated composites or graphitization of organic materials, facing challenges in balancing their performance and processability. …”
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Identifying the Challenges of the Processes of Introducing and Commercializing Domestic Medical Equipment to the Market by Shahnaz Seyedi Dolatabad, Hessam Zandhessami, Hamed Afshari, Shirin Jalalinia

“…Conclusion: The research results showed that the process faces major challenges such as complexity of implementation steps, time-consuming nature, high costs, lack of transparency, and lack of coordination between regulatory agencies. …”
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Sectoral Efficiency and Resilience: A Multifaceted Analysis of S&P Global BMI Indices Under Global Crises by Milena Kojić, Slobodan Rakić, José Wesley Lima da Silva, Fernando Henrique Antunes de Araujo

“…This study investigates the complexity, efficiency, and sectoral interdependencies of the S&P Global BMI indices during critical global events, including the COVID-19 pandemic and the Russia–Ukraine war. …”
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Spatiotemporal Changes in Water-Use Efficiency of China’s Terrestrial Ecosystems During 2001–2020 and the Driving Factors by Jia He, Yuxuan Zhou, Xueying Liu, Wenjing Duan, Naiqing Pan

“…It provides a comprehensive reflection of ecosystems’ responses to various environmental factors, making it essential for understanding how ecosystems adapt to complex environmental changes. …”
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THE PROBLEM OF PATIENT-FOCUSED INNOVATION OF TOOTH-TECHNICAL MATERIALS SCIENCE IN THE CONTEXT OF INCREASING THE EFFICIENCY OF THE DENTAL TREATMENT by І.V. Yanіshen, O. L. Fedotov

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BlueRecording: A pipeline for the efficient calculation of extracellular recordings in large-scale neural circuit models. by Joseph James Tharayil, Jorge Blanco Alonso, Silvia Farcito, Bryn Lloyd, Armando Romani, Elvis Boci, Antonino Cassara, Felix Schürmann, Esra Neufeld, Niels Kuster, Michael Reimann

“…As the size and complexity of network simulations accessible to computational neuroscience grows, new avenues open for research into extracellularly recorded electric signals. …”
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Optimizing precision farming: enhancing machine learning efficiency with robust regression techniques in high-dimensional data by Nour Hamad Abu Afouna, Majid Khan Majahar Ali

“…To overcome these obstacles, reducing retraining time and resolving the complexity issue is essential for improving the machine learning algorithm’s performance, scalability, and efficiency, especially when dealing with large or high-dimensional datasets. …”
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Deformation, fracture characteristics and damage constitutive model of soft coal under true triaxial complex stress paths. by Chongyang Jiang, Lianguo Wang, Jiaxing Guo, Shuai Wang

“…Furthermore, based on the experimental results, a damage constitutive model for soft coal is developed that integrates damage mechanics, Weibull statistical distribution theory, and the Mogi-Coulomb criterion to effectively measure microelement strength under true triaxial complex stress paths. Comparing the theoretical model with the experimental curves demonstrates that the proposed damage constitutive model can effectively reflect the deformation strength characteristics of soft coal under true triaxial complex stress paths. …”
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Attachment as a Primary Mechanism in Physician Cognition and Bias During Complex Medical Cases: A Narrative Review by Rein C

“…Carrie Rein Department of Clinical Research and Leadership, the George Washington University School of Medicine and Health Sciences, Washington, DC, USACorrespondence: Carrie Rein, Email crein15@gwmail.gwu.eduIntroduction: In recent decades, improvements in diagnostic accuracy in medical cases have been minimal despite rapid advancements in technology. Moreover, in complex cases, diagnostic accuracy remains a significant challenge, often reflecting practices from the 18th and 19th centuries. …”
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Dynamic response and discrimination of gaseous sarin using a boron‐difluoride complex film‐based fluorescence sensor by Zhijie Zhou, Lei Zhang, Lingya Peng, Yingjie Li, Xiaolin Zhu, Yidi Wu, Zebiao Qiu, Gang He, Molin Qin, Haonan Peng, Yu Fang

“…Abstract This study presents a novel boron‐difluoride complex‐based fluorescent nanofilm sensor capable of detecting sarin vapors in the environment by reporting an output fluorescence signal. …”
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Fibrin monomer complex on postoperative day 1 is correlated with the volume of deep vein thrombosis after knee surgery by Manabu Akagawa, Hiroaki Kijima, Yoshiaki Kimura, Hidetomo Saito, Kimio Saito, Ikuko Wakabayashi, Takeshi Kashiwagura, Naohisa Miyakoshi

“…It has not been identified how to efficiently detect high‐risk DVT while minimizing bleeding complications from anticoagulation. …”
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Dissecting the genetic basis of fruiting efficiency for genetic enhancement of harvest index, grain number, and yield in wheat by Dipendra Shahi, Jia Guo, Md Ali Babar, Sumit Pradhan, Muhsin AVCI, Jordan McBreen, Zhao Liu, Guihua Bai, Paul St. Amand, Amy Bernardo, Matthew Reynolds, Gemma Molero, Sivakumar Sukumaran, John Foulkes, Jahangir Khan

“…The results suggest that optimizing intra-spike partitioning and utilizing marker-assisted selection (MAS) can enhance GY and HI.…”
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