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3401
Constitutive model of metal rubber material considering plastic accumulation behavior
Published 2025-01-01“…This advanced model provides an accurate description of the complex interaction mechanisms occurring among internal coils during loading and unloading processes.…”
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3402
Sensorless real-time solar irradiance prediction in grid-connected PV systems using PSO-MPPT and IoT-enabled monitoring
Published 2025-07-01“…Abstract Accurate prediction of solar irradiance is vital for optimizing the energy output and operational efficiency of grid-connected photovoltaic (PV) systems, especially under fluctuating environmental conditions. …”
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3403
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3404
Sustainable development of Cuban agricultural economy: Policy and practice
Published 2025-06-01“…The internal excitation for the sustainable development of Cuba's agricultural economy is mainly reflected in the following aspects: first, policy innovation and institutional support, such as the reform of land distribution and the diversification of agricultural cooperatives; second, technological innovation and the promotion of ecological agriculture have significantly improved resource utilization efficiency and ecological benefits; third, social mobilization and farmer participation, through the combination of material and spiritual incentives, fully mobilized the enthusiasm of farmers. …”
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3405
Designing a multi-epitope vaccine candidate against human rhinovirus C utilizing immunoinformatics approach
Published 2025-01-01“…Molecular dynamics and simulation studies revealed a stable Vaccine-TLR8 complex, with a binding energy of -296.15 and consistent RMSD values. …”
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3406
FACS-Proteomics strategy toward extracellular vesicles single-phenotype characterization in biological fluids: exploring the role of leukocyte-derived EVs in multiple sclerosis
Published 2025-05-01“…These findings indicate the complex interplay between inflammation and angiogenesis in RRMS. …”
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3407
Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer
Published 2023-01-01“…Cancer dimensions/survival time were monitored, while, at the molecular level, system biology approaches based on graph theory and experimental proteomic data were performed.Results SFNs were efficiently in vitro uptaken by cancer and dendritic cells. …”
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3408
Identification and Characterization of Antiviral Activity of Synthetic Compounds Against Mayaro Virus
Published 2025-05-01“…<b>Background/objectives:</b> In Brazil, the co-circulation of arboviruses—such as dengue, Zika, yellow fever, and Chikungunya viruses—creates a complex epidemiological landscape, drawing attention from health authorities due to high morbidity and mortality rates. …”
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3409
An immunoinformatics approach in designing high-coverage mRNA multi-epitope vaccine against multivariant SARS-CoV-2
Published 2025-09-01“…Furthermore, molecular docking analysis revealed potent interactions between the validated 3D structure and the TLR4 and BCR receptors, while molecular dynamic simulations confirmed the stability of the VC-TLR4 and VC-BCR complexes. Additionally, mRNA codon optimization was performed to enhance vaccine expression efficiency, and secondary structure analysis indicated that the designed mRNA vaccine possessed a stable conformation. …”
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3410
Field programmable silicon microring WDM transceiver leveraging monolithically integrated phase-change materials
Published 2025-05-01“…These advancements position Sb2Se3-integrated MRRs as a promising solution for large-scale, energy-efficient photonic transceivers in next-generation optical communication systems.…”
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3411
Predicting the strengths of basalt fiber reinforced concrete mixed with fly ash using AML and Hoffman and Gardener techniques
Published 2025-04-01“…These models benefit from advanced ensemble techniques that efficiently handle non-linear patterns and noise. SVR also performs admirably, whereas GEP and GMDHNN exhibit weaker predictive capabilities due to limitations in handling complex data dynamics. …”
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3412
Evaluation of a CNN model to map vegetation classification in a subalpine coniferous forest using UAV imagery
Published 2025-07-01“…Overall, this study provides an efficient and cost-effective method for monitoring and protecting natural forests, serving as a reference for selecting appropriate parameters in UAV-based deep learning remote sensing.…”
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3413
Optimized Sampling Strategies for Isoniazid in East Asian Pediatric Populations Using Population Pharmacokinetics-Informed Approaches
Published 2025-05-01“…We employed a model-informed optimization approach based on INH population pharmacokinetic (PopPK) models.Methods: We selected PopPK models for children and East Asian adults and optimized the sampling strategy using PopED (Population Experimental Design), a method that helps identify the most efficient sampling points for maximizing parameter estimation accuracy. …”
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3414
Research on Model Reconstruction Methods for Partial Point Cloud Information Loss
Published 2025-03-01“…However, large-sized and structurally complex parts face challenges such as blocks, which result in incomplete point cloud information. …”
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3415
The Circular Kitchen
Published 2024-09-01“…However, existing methods do not fully incorporate the complex, multiple use cycles inherent in circular products and components. …”
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3416
Reverse vaccinology and immunoinformatics approaches for multi-epitope vaccine design against Klebsiella pneumoniae reveal a novel vaccine target protein
Published 2025-09-01“…The construct was further optimized for mammalian expression, achieving an ideal GC content (48.27 %) and a codon adaptation index (CAI) of 1.0, facilitating efficient in silico cloning into the pcDNA3 vector. …”
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3417
Characterization of a blaKPC-3-carrying plasmid in a clinical isolate of Klebsiella pneumoniae belonging to the emerging successful clone ST147
Published 2025-07-01“…ABSTRACT Klebsiella pneumoniae ST147 has emerged as a successful clone able to efficiently disseminate a number of carbapenemases, including blaKPC. …”
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3418
An azo substituted quinoline‐malononitrile enzyme‐activable aggregation‐induced emission nanoprobe for hypoxia imaging
Published 2025-06-01“…Abstract The development of efficient aggregation‐induced emission (AIE) active probes is crucial for disease diagnosis, particularly for tumors and cardiovascular diseases. …”
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3419
Calculation Model of Multi-roll Straightening Process Based on Bilinear Hardening and Power Hardening
Published 2025-05-01“…For example, the power model—more consistent with the tensile stress-strain curve—shows a 4.65% error between theory, experiment, and simulation for total straightening force. Selecting an appropriate material model based on specific material characteristics is crucial to ensure accuracy and efficiency in the straightening process. …”
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3420
Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth
Published 2025-03-01“…Abstract Background The αvβ6- and αvβ8-integrins, two cell-adhesion receptors upregulated in many solid tumors, can promote the activation of transforming growth factor-β (TGFβ), a potent immunosuppressive cytokine, by interacting with the RGD sequence of the latency-associated peptide (LAP)/TGFβ complex. We have previously described a chromogranin A-derived peptide, called “peptide 5a”, which recognizes the RGD-binding site of both αvβ6 and αvβ8 with high affinity and selectivity, and efficiently accumulates in αvβ6- or αvβ8-positive tumors. …”
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