A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies by Lucie Perillat, Lucie Perillat, Andrew McFadyen, Andrew McFadyen, Andrew McFadyen, Patricia Furlong, James Anderson, James Anderson, James Anderson

“…By discussing these stages and parameters in detail, we aim to provide guidance on how to navigate the ethical complexities inherent to individualized interventions and offer a preliminary framework for balancing the interplay between research objectives and patient care needs. …”
Get full text

Entropy, Irreversibility, and Time-Series Deep Learning of Kinematic and Kinetic Data for Gait Classification in Children with Cerebral Palsy, Idiopathic Toe Walking, and Hereditar... by Alfonso de Gorostegui, Massimiliano Zanin, Juan-Andrés Martín-Gonzalo, Javier López-López, David Gómez-Andrés, Damien Kiernan, Estrella Rausell

“…Existing methods often isolate the analysis of gait variables, overlooking the whole complexity of biomechanical patterns and variations in motor control strategies. …”
Get full text

Comparing the Fate of eDNA by Particle Sizes and Molecule Lengths in Recirculating Streams by Pedro F. P. Brandão‐Dias, Elise Snyder, Jennifer L. Tank, Ursula H. Mahl, Brett Peters, Arial J. Shogren, Diogo Bolster, Gary A. Lamberti, Kyle Bibby, Scott P. Egan

“…ABSTRACT The detection of environmental DNA (eDNA) has revolutionized aquatic species monitoring, yet interpreting eDNA data remains challenging due to gaps in our understanding of eDNA ecology (i.e., origin, state, transport, and fate) and variability in how eDNA methods are applied across the literature. …”
Get full text

Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines by Mariana Leguia, Antón Vila-Sanjurjo, Diana Juarez, Alejandra Garcia-Glaessner, Ana I. Gil, Mayita Alvarez, Rubelio Cornejo, Sami Cherikh, Casey E. Gelber, Johannes B. Goll, Leigh M. Howard, Natalia Jimenez-Truque, Kathryn M. Edwards, C. Buddy Creech, Claudio F. Lanata

“…Given the technical complexity of our approach, our objective is to fill knowledge gaps, describe key quality metrics, and support future publications. …”
Get full text

Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review by Andreea M. Sandu, Mariana C. Chifiriuc, Corneliu O. Vrancianu, Roxana-E. Cristian, Cristina F. Alistar, Marian Constantin, Mihaela Paun, Alexandru Alistar, Loredana G. Popa, Mircea I. Popa, Ana C. Tantu, Manuela E. Sidoroff, Mara M. Mihai, Andreea Marcu, George Popescu, Monica M. Tantu

“…Despite promising avenues like integrated One Health approaches, optimized phage therapy, microbiome-based interventions, and targeted vaccine development, several knowledge gaps in clinical efficacy, standardization, and pathogen complexity remain to be answered.…”
Get full text

Prevalence and determinants of zoonotic malaria in the Greater Mekong Subregion (GMS) and Malaysia: systematic review and meta-analysis by Alex Ahebwa, Chutipong Sukkanon, Jeffrey Hii, Ratchadawan Ngoen-Klan, Uraiwan Arunyawat, Sylvie Manguin, Theeraphap Chareonviriyaphap

“…Conclusions This study contributes to the understanding of the transmission complexities of zoonotic malaria in the GMS countries and Malaysia, highlighting critical knowledge gaps and the need for a multidisciplinary approach to managing its further spread.…”
Get full text

Investigating the extent of PFAS contamination in the Upper Danube Basin across environmental compartments by Meiqi Liu, Ernis Saracevic, Thomas J. Oudega, Ali A. A. Obeid, Zsuzsanna Nagy-Kovács, Balázs László, Steffen Kittlaus, Ottavia Zoboli, Jörg Krampe, Julia Derx, Matthias Zessner

“…Despite increasing efforts to monitor PFAS in river systems, knowledge gaps remain regarding sources and emissions via different pathways. …”
Get full text

Understanding intergenerational dynamics and social support’s impact on health and well-being of older adults in South Asia: a scoping review by Selim Jahangir, Divya Sussana Patil, Jagriti Gangopadhyay, Tobias C. Vogt

“…Conclusion Although intergenerational support is still a significant factor in determining the well-being of older adults in South Asia, this study shows the complexity of intergenerational ambivalence, where caregiving responsibilities lead to both emotional stress and a sense of obligation. …”
Get full text

Practices and challenges of supervision and delegation in nursing in Africa: a scoping review by Amidu Alhassan, Victoria Leighton Sencherey, Christiana Bobuafor, Gifty Osei Berchie, Susanna Aba Abraham

“…Challenges in delegation were primarily related to staffing shortages, skill gaps, role misalignment, insufficient resources, and the complexity of tasks. …”
Get full text

“Voice is the New Blood”: a discourse analysis of voice AI health-tech start-up websites by Alden Blatter, Hortense Gallois, Emily Evangelista, Yael Bensoussan, Bridge2AI-Voice Consortium, Jean-Christophe Bélisle-Pipon, Yael E. Bensoussan, Olivier Elemento, Jean-Christophe Bélisle-Pipon, David Dorr, Satrajit Ghosh, Alistair Johnson, Phillip Payne, Maria E. Powell, Anaïs Rameau, Vardit Ravitsky, Alexandros Sigaras

“…We conclude that the lack of incentive to share key information about datasets is due to contextual factors that start-ups cannot control, mainly the absence of clear standards and regulatory guidelines for voice data collection. Addressing these complexities is essential to building trust and ensuring responsible integration of voice AI into healthcare systems.…”
Get full text

Functional Elements of Entrusted Professional Activities for Dental Educators: Protocol for a Scoping Review by Noraini Abu Bakar, Nurhanis Syazni Roslan, Muhammad Ainul Haq, Yasmin Mustafa Byrnes, Muhamad Saiful Bahri Yusoff

“…The concept of EPAs emerged from the complexities of competency-based medical education. This scoping review highlights the emerging yet underdeveloped field of EPAs for dental educators. …”
Get full text

DIGITAL HEALTH LITERACY AND CANCER MISINFORMATION/DISINFORMATION IN BRAZIL: IMPLICATIONS FOR SCIENTIFIC DISSEMINATION IN NUCLEAR MEDICINE AND ONCOLOGY by ROMULO SANTANA OSTHUES, Elba Cristina Sá de Camargo ETCHEBEHERE, Barbara Juarez AMORIM, Carmino Antonio DE SOUZA, Larissa Mansano DE SOUZA, Amira Al DERGHAM

“…The application of the proposed questionnaire in the Brazilian scenario will allow the identification of barriers and gaps in understanding the benefits of the Theranostic model, providing support for the development of educational strategies and scientific dissemination actions promoted by the Knowledge Dissemination team of CEPID CancerThera. …”
Get full text

Patients’ trajectory from tooth loss to dental rehabilitation and living with implant-supported dentures – a qualitative interview study by Gabriele Müller-Mundt, Philipp-Cornelius Pott, Lara Prinz, Simone Schaumann, Meike Stiesch, Nils Schneider, Franziska A. Herbst

“…The results underline the importance of comprehensive counselling and after care irrespectively of the complexity of the treatment. While iatrogenic complications and the risk of their chronification are rare, careful attention to these risks remains essential. …”
Get full text

Cohort profile: measuring adverse pregnancy and newborn congenital outcomes (MANGO) study in Kenya by Steven Brown, Kara Wools-Kaloustian, John M Humphrey, Edwin Were, Winnie Matelong, Rena C Patel, James G Carlucci, Megan S McHenry, Caitlin Bernard, Constantin T Yiannoutsos, Audrey Chepkemoi, Molly McPheron, Caroline Kerich, Harold Kooreman, Marylydia Kiano, Beverly S Musick

“…The facility’s size and complexity were barriers to newborn surface exam coverage overcome through staff training and cocreation of a standardised form for newborn surface exam documentation. …”
Get full text

Barriers and supports for Indigenous youth and young adults with childhood- onset chronic health conditions transitioning from pediatric to adult healthcare: a qualitative study by Andrew S. Mackie, Mandi Gray, Alyssa Chappell, Kira Dlusskaya, Rick Lightning, Larry Listener, Arrol Crier, Barbara Dumigan-Jackson, Audrey Thomas, Bonny Graham, Randy Littlechild, Joshua Lightning, Azure Johnson, Patricia Rain, Maxine Cutarm, Richard T. Oster

“…Conclusion This study demonstrates the complexity of the transition experience for Indigenous youth with pediatric onset chronic health conditions. …”
Get full text

Planning for Cultural Connectivity: Modeling and Strategic Use of Architectural Heritage Corridors in Heilongjiang Province, China by Lyuhang Feng, Jiawei Sun, Tongtong Zhai, Mingrui Miao, Guanchao Yu

“…The corridor network’s connectivity is evaluated using graph-theoretic indices (α, β, and γ), which indicate high levels of closure, structural complexity, and accessibility. The results yield the following key findings: (1) Historical architectural resources in Heilongjiang demonstrate significant coupling with the Chinese Eastern Railway and multi-ethnic cultural corridors, forming a “one horizontal, three vertical” spatial configuration. …”
Get full text

Lessons Learned From the Integration of Ambient Assisted Living Technologies in Older Adults’ Care: Longitudinal Mixed Methods Study by Oteng Ntsweng, Martin Kodyš, Zhi Quan Ong, Fang Zhou, Antoine de Marassé-Enouf, Ibrahim Sadek, Hamdi Aloulou, Sharon Swee-Lin Tan, Mounir Mokhtari

“…However, the challenge is that systematic research on the long-term use of AAL technologies remains in its nascent stages, leaving gaps in the understanding of the predictors that contribute to the routine embedding of AAL technologies in older adults’ care. …”
Get full text

Generative AI in construction risk management: a bibliometric analysis of the associated benefits and risks by Mohamed Abdelwahab Hassan Mohamed, M.K.S. Al-Mhdawi, Udechukwu Ojiako, Nicholas Dacre, Abroon Qazi, Farzad Rahimian

“…Purpose – The construction industry is under increasing pressure to improve risk management due to the complexity and uncertainty inherent in its projects. …”
Get full text

Value Propositions for Digital Shared Medication Plans to Boost Patient–Health Care Professional Partnerships: Co-Design Study by Benjamin Bugnon, Francesca Bosisio, Alain Kaufmann, Pascal Bonnabry, Antoine Geissbuhler, Christian von Plessen

“…Nevertheless, inaccurate medication lists and information gaps are common, particularly during care transitions, leading to avoidable harm, inefficiencies, and increased costs. …”
Get full text

Findings from a roundtable discussion with Pakistani stakeholders on measuring and valuing health and health-related quality of life for children and adolescents by Madeeha Malik, Azhar Hussain, Fredrick Dermawan Purba, Ning Yan Gu

“…Valuing children and adolescents’ health involves methodological and ethical complexities, particularly in determining whose preferences should be considered and how trade-offs between length and quality of life should be addressed. …”
Get full text