The impact of living with multiple long-term conditions (multimorbidity) on everyday life – a qualitative evidence synthesis by Emilia Holland, Kate Matthews, Sara Macdonald, Mark Ashworth, Lynn Laidlaw, Kelly Sum Yuet Cheung, Sebastian Stannard, Nick A. Francis, Frances S. Mair, Charlotte Gooding, Nisreen A. Alwan, Simon D. S. Fraser

“…Future research should involve patients as partners and focus on these evidence gaps.…”
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Lipidomic profiling of the cerebrospinal fluid in moyamoya angiopathy patients by Antonella Potenza, Gemma Gorla, Tatiana Carrozzini, Giuliana Pollaci, Michele Dei Cas, Francesco Acerbi, Ignazio G. Vetrano, Paolo Ferroli, Isabella Canavero, Rita Paroni, Nicola Rifino, Anna Bersano, Laura Gatti

“…Despite decades of research, the mechanisms underlying MA remain poorly clarified and current gaps in the understanding of pathogenesis have hampered the development of suitable preventive strategies and therapeutic options. …”
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An integrated, multidisciplinary management team intervention to improve patient-centeredness, HIV, and maternal-child outcomes in Lesotho: formative research on participatory impl... by Laura K. Beres, Mammatli Chabela, Matseliso Masitha, Zachary Catanzarite, Vincent J. Tukei, Lynne Mofenson, Appolinaire Tiam, Lauren Greenberg, Majoalane Mokone, Ramatlapeng Thabelo, Masepeli Nchephe, Tsietso Mots’oane, Laura Guay, Amy R. Knowlton

“…Abstract Background Reducing perinatal HIV transmission and optimizing maternal and child health (MCH) outcomes in high HIV prevalence settings is an urgent, but complex, priority. Extant interventions over-emphasize individual-level provider and patient behaviors, and neglect critical health systems-level changes. …”
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Factors influencing self-efficacy of healthcare professionals towards end-of-life care in acute care settings in Palestine: a cross-sectional study by Mohammed F. Hayek, Baraa F. Shayeb, Jamila Jalal Yaseen, Issa Hashim Othman, Abdulrahman Afif Taha, Amal Bilal Mustafa Naddaf, Mohammed Mays Njedat, Ruba Sayed Saleh, Nizar B. Said, Ahmad Ayed, Loai M. Zabin, Eman Alshawish, Jamal Qaddumi, Imad Thultheen

“…Abstract Background Caring for individuals at the end of life is a profound emotional and complex responsibility, especially within acute care settings where healthcare professionals must navigate the delicate balance between administering life-saving treatments and providing end-of-life care. …”
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Menstrual Health Education Using a Specialized Large Language Model in India: Development and Evaluation Study of MenstLLaMA by Prottay Kumar Adhikary, Isha Motiyani, Gayatri Oke, Maithili Joshi, Kanupriya Pathak, Salam Michael Singh, Tanmoy Chakraborty

“…However, existing general-purpose large language models (LLMs) are often ill-suited for this task, tending to exhibit low accuracy, cultural insensitivity, and overly complex responses. To address these limitations, we developed MenstLLaMA—a specialized LLM tailored to the Indian context and designed to deliver MHE empathetically, supportively, and accessibly. …”
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Remapping Body Representation Using Virtual Reality in Chronic Neuropathic Pain: Systematic Review by Maria Grazia Maggio, Mirjam Bonanno, Andrea Calderone, Amelia Rizzo, Nebahat Bulut, Mahmood Bahramizadeh, Alessandra Benenati, Francesco Tomaiuolo, Angelo Quartarone, Daniela Floridia, Rocco Salvatore Calabrò

“… BackgroundChronic neuropathic pain (CNP) is a common consequence of neurological conditions such as spinal cord injury (SCI), complex regional pain syndrome (CRPS), and phantom limb pain (PLP). …”
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The Application of Machine Learning Algorithms to Predict HIV Testing Using Evidence from the 2002–2017 South African Adult Population-Based Surveys: An HIV Testing Predictive Mode... by Musa Jaiteh, Edith Phalane, Yegnanew A. Shiferaw, Haruna Jallow, Refilwe Nancy Phaswana-Mafuya

“…By addressing the identified gaps in the existing healthcare framework, South Africa can enhance the efficacy of HIV testing and progress towards achieving the UNAIDS 2030 goal of eradicating AIDS.…”
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Effectiveness of care coordination interventions delivered to stroke survivors in low and middle-income countries: Systematic review and meta-analysis protocol. by Stephanopoulos Kofi Junior Osei, Anthony Danso-Appiah

“…<h4>Background</h4>Stroke survivors have complex and long-term care needs requiring navigation of multiple care services and providers. …”
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Determinants of Parental Attitudes towards Children’s Vaccination in Lithuania: An Online Survey by Kamilė Čeponytė, Eglė Narkevičiūtė, Aušra Beržanskytė, Sigita Burokienė

“…The formation of parents‘ attitudes towards children‘s vaccination is a complex process that is determined by parents‘ attitudes towards the health care system, lack of trust in doctors, and gaps in communication about the benefits and risks of vaccination. …”
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Biological contingency and adaptation to celibacy among girls aged 35 and over in Yazd city by Ahmad Kalateh Sadati, Fatemeh Jafari Naeimi, Sara Sadeghieh, Zahra Sadeghian Moghadam

“…Understanding ways to adapt to singleness, its complex and significant issues and problems, is a research need that can be of service to social policymakers. …”
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Permafrost‒vegetation controls on water availability over the Qinghai‒Tibet Plateau by Fang Ji, Lin-Feng Fan, Shan-Shui Yuan, Xing-Xing Kuang, Liu-Jun Zhu, Jun-Liang Jin, Ying-Ying Yao, Jian-Yun Zhang, Chun-Miao Zheng

“…While existing studies have established the hydrological consequences of permafrost degradation through altered soil hydraulics and water storage capacity, the complex interplay between thawing permafrost and vegetation dynamics—particularly their synergistic regulation of precipitation partitioning and runoff generation through root-zone water accessibility—are poorly understood, creating critical knowledge gaps in predicting long-term water availability trajectories. …”
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Comparative analysis of composition and spatial variations in the foregut microbiota of male and female donkeys by Yanwei Wang, Yanwei Wang, Yanwei Wang, Xiaotong Li, Xiaotong Li, Xiaotong Li, Zuowei Li, Zuowei Li, Zuowei Li, Qiaoqiao Han, Qiaoqiao Han, Qiaoqiao Han, Tong Hu, Tong Hu, Qiyue Zhang, Qiyue Zhang, Qiyue Zhang, Honglei Qu, Honglei Qu, Haihua Zhang, Yangyan Qu, Yangyan Qu, Donghui Shi, Qiugang Ma, Qiugang Ma, Shimeng Huang, Shimeng Huang

“…As the gut microbiota is also shaped by factors such as sex, age, diet, environment and genetics, many studies have on the complexity and diversity of hindgut microbial communities, while few studies have focused on the foregut microbiota of donkeys. …”
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Clinical genome sequencing in patients with hereditary breast and ovarian cancer: Concept, implementation and benefits by Dennis Witt, Marc Sturm, Antje Stäbler, Benita Menden, Lisa Ruisinger, Kristin Bosse, Ines Gruber, Andreas Hartkopf, Silja Gauß, German Demidov, Nicolas Casadei, Elena Buena Atienza, Kira Mehnert, Janna Witt, Caspar Gross, Leon Schütz, Christopher Schroeder, Stephan Ossowski, Andreas Dufke, Tobias B. Haack, Olaf Riess, Ulrike Faust

“…Data analysis showed less sequencing gaps and a more uniform coverage compared to a large cohort of in-house exomes. …”
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Transcriptomic insights into the synergistic effects of darkness and mechanical stimulation on peanut pod development by Lu Huang, Muhammad J. Umer, Hao Liu, Haifen Li, Runfeng Wang, Qianxia Yu, Shaoxiong Li, Rajeev K. Varshney, Manish K. Pandey, Yanbin Hong, Qing Lu, Xiaoping Chen

“…Despite some progress in understanding peanut pod development and its response to external environmental stimulation, numerous unresolved questions and knowledge gaps remain regarding the role of darkness and mechanical stimulation in this complex process. …”
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Co-designing and testing the learn together guidance to support patient and family involvement in patient safety investigations: a mixed-methods study by Jane O’Hara, Lauren Ramsey, Siobhan McHugh, Joseph Langley, Justin Waring, Ruth Simms-Ellis, Gemma Louch, Jenni Murray, Carl Macrae, John Baker, Rebecca Lawton, Daisy Halligan, Olivia Rogerson, Penny Phillips, Debra Hazeldine, Sarah Seddon, Joanne Hughes, Rebecca Partridge, Katherine Ludwin, Laura Sheard

“…Conclusions Investigations are complex, relational processes. Our guidance was found to be feasible, with stakeholders being positive about involvement and the impact on organisational learning. …”
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People’s knowledge, attitudes, and conflicts with carnivores in central hills, Sri Lanka by Ashan Thudugala, Hem Bahadur Katuwal, Nalindra Laxman, Vishwa Dushmantha, Ravindi Menikrama, Harsha Dissanayake, Chameera Dilshan, Ru-Chuan He, Rui-Chang Quan

“…Our study highlights the complex nature of human-carnivore interactions and emphasizes the need for educating people about carnivores. …”
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Multidimensional insights into the biodiversity of Streptomyces in soils of China: a pilot study by Ziguang Deng, Wei Yang, Tongtong Lin, Yaohai Wang, Xiaojing Hua, Xiaoyu Jiang, Junhao Chen, Dan Liu, Zhiqiang Ye, Yu Zhang, Michael Lynch, Hongan Long, Jiao Pan

“…This pilot study successfully addresses these gaps by conducting a preliminary exploration on the biodiversity of Streptomyces in Chinese soils from multiple perspectives, providing valuable insights for a deeper understanding of their biodiversity and a novel technical framework for future large-scale explorations of its diversity.…”
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Improving the capture and reporting of adverse events in clinical trials of non-pharmacological interventions: learnings from the PaCCSC/CST membership by Rayan Saleh Moussa, Jack Power, Vanessa Yenson, Belinda Fazekas, Celia Marston, Annmarie Hosie, Layla Edwards, Domenica Disalvo, Linda Brown, Imelda Gilmore, John Stubbs, Andrea Cross, Sally Fielding, Meera R. Agar

“…The second case example highlights the need for both systematic and simplified AE-reporting frameworks, particularly for clinical trials conducted in medically complex populations where participants may be at high risk of experiencing AEs. …”
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The influence of knowledge absorptive capacity on the knowledge-based enterprises performance by explaining the mediating role of innovation strategy and open innovation activities by Seyed Reza Seyed Javadin, Rasoul Nosratpanah, Aref Ashrafzadeh

“…Finally, the rejection of the mediating roles of Outbound and Inbound OI on FP indicates that further exploration is needed to understand the complexities of these relationships to provide a more comprehensive view of the OI landscape in KBEs. …”
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Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis-2 (AuToDeCRA-2) study: protocol for a single-centre, experimental medicine study investigating the route of delivery... by Ema-Louise Long, James Stanway, Michael White, Nicola Goudie, Julia Phillipson, Miranda Morton, Asma Abdul Malek, Philip Brown, Geoff Hide, Ralph Jackson, Colin Nice, John Tuckett, Julie Diboll, Amy Anderson, Arthur Pratt, Catharien M. U. Hilkens, John Isaacs

“…Expected challenges to this study include recruitment of potentially asymptomatic participants to a complex and intensive experimental medicine study. …”
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