Lineage-specific biology revealed by a finished genome assembly of the mouse. by Deanna M Church, Leo Goodstadt, Ladeana W Hillier, Michael C Zody, Steve Goldstein, Xinwe She, Carol J Bult, Richa Agarwala, Joshua L Cherry, Michael DiCuccio, Wratko Hlavina, Yuri Kapustin, Peter Meric, Donna Maglott, Zoë Birtle, Ana C Marques, Tina Graves, Shiguo Zhou, Brian Teague, Konstantinos Potamousis, Christopher Churas, Michael Place, Jill Herschleb, Ron Runnheim, Daniel Forrest, James Amos-Landgraf, David C Schwartz, Ze Cheng, Kerstin Lindblad-Toh, Evan E Eichler, Chris P Ponting, Mouse Genome Sequencing Consortium

“…The finished clone-based assembly of the mouse strain C57BL/6J reported here has over 175,000 fewer gaps and over 139 Mb more of novel sequence, compared with the earlier MGSCv3 draft genome assembly. …”
Get full text

Automated generation of discharge summaries: leveraging large language models with clinical data by Matthias Ganzinger, Nicola Kunz, Pascal Fuchs, Cornelia K. Lyu, Martin Loos, Martin Dugas, Thomas M. Pausch

“…Despite overall informativeness, essential details—such as patient history, lifestyle factors, and intraoperative findings—were frequently omitted, reflecting gaps in summary completeness. While the LLaMA3 model captured much of the clinical information, complex cases and temporal reasoning presented challenges, leading to factual inaccuracies, such as incorrect age calculations. …”
Get full text

Primary school students' experiences of science learning content and support provided during guided inquiry-based science fieldwork by Mirjam Asilevi, Sirpa Kärkkäinen, Jingoo Kang, Kari Sormunen, Sari Havu-Nuutinen

“…Findings indicate that students encountered the most difficulty with the ecosystem topic due to its complexity. Some also struggled with plant-related content, especially identifying plant names and features, which was linked to gaps in prior knowledge and misconceptions. …”
Get full text

Generative Artificial Intelligence-Enabled Facility Layout Design Paradigm by Fuwen Hu, Chun Wang, Xuefei Wu

“…Facility layout design (FLD) is critical for optimizing manufacturing efficiency, yet traditional approaches struggle with complexity, dynamic constraints, and fragmented data integration. …”
Get full text

Parents’ State and Trait Anxiety Levels During Bloodletting Attempts in the Pediatric Emergency Department by Ahmet Butun, Sema Bayraktar, Meltem Çatalbaş

“…Introduction: Parental stress and anxiety during pediatric bloodletting in the pediatric emergency department (PED) are influenced by a complex interplay of factors, including the child’s medical condition, unfamiliarity with procedures, healthcare-provider interactions, and parental knowledge gaps. …”
Get full text

Dynamic Connectivity Hub: Multiple ISPs Smart Aggregation for Optimized IoT Connectivity by Hany Ali, Mohamed A. Abouelatta, Khaled Y. Youssef

“…The increasing complexity of Internet of Things (IoT) networks demands scalable and adaptive solutions to ensure reliable and efficient connectivity. …”
Get full text

Operationalising participatory action research to evaluate early years’ population health services by Katie Chadd, Mariam Malik, Anuj Kapilashrami

“…Evaluating such interventions is complex. The study reported in this article evaluates a place-based public health initiative ‘A Better Start Southend’ (ABSS) aimed at facilitating early years’ development specifically. …”
Get full text

Socio-demographic drivers of household food waste management practices in Thailand. by Patranit Srijuntrapun, Pattama Ket-Um, Witsanu Attavanich

“…<h4>Objective</h4>The escalating food waste crisis, with millions of tons of food being discarded annually, highlights the pressing necessity to improve household food waste management practices. This complex and multifaceted challenge is a crucial element of a comprehensive national strategy for reducing food waste. …”
Get full text

Artificial Intelligence in cancer epigenomics: a review on advances in pan-cancer detection and precision medicine by Karishma Sahoo, Prakash Lingasamy, Masuma Khatun, Sajitha Lulu Sudhakaran, Andres Salumets, Vino Sundararajan, Vijayachitra Modhukur

“…Aberrant methylation patterns enable early cancer detection and therapeutic stratification; however, their complex patterns necessitates advanced analytical tools. …”
Get full text

Reporting complete chloroplast genome of endangered red mulberry, useful for understanding hybridization and phylogenetic relationships by Bibek Adhikari, Sanam Parajuli, Madhav P. Nepal

“…The results from this study provide insights into the chloroplast genome structure of M. rubra, offering a foundational data that bridges the knowledge gaps for addressing complex taxonomic complexities within the genus and for developing molecular markers to study population genetics, including introgressive hybridization.…”
Get full text

The Determinants of Two-Wheeled Vehicle Riders&#x2019; Riding Behavior and Their Consequences: A Literature Review, Conceptual E-TPB Model, and Research Agenda by Haibing Yang, Muhamad Nazri Borhan, Ahmad Nazrul Hakimi Ibrahim, Fazilatulaili Ali

“…This paper bridges the gaps between under-explored factors for data collection and data processing methods. …”
Get full text

Research on Heat Transfer Coefficient Prediction of Printed Circuit Plate Heat Exchanger Based on Deep Learning by Yi Su, Yongchen Zhao, Jingjin Wu, Ling Zhang

“…Moreover, research on explainability remains insufficient. To address these gaps, this study first constructs a dataset of heat transfer coefficients (h) through numerical simulations. …”
Get full text

Parent–child shared book reading challenges and facilitators: a systematic review and meta synthesis by Jiaopeng Nan, Yin Tian

“…Challenges encompassed limited resources and access, sociocultural and parental barriers such as time constraints and mental health difficulties, gaps in parental knowledge and skills, and engagement challenges related to child readiness and the use of digital books. …”
Get full text

Insights into Natural Products from Marine-Derived Fungi with Antimycobacterial Properties: Opportunities and Challenges by Muhammad Azhari, Novi Merliani, Marlia Singgih, Masayoshi Arai, Elin Julianti

“…This can lead to a higher risk of treatment failure due to poor patient adherence to the complex regimen. As a result, considerable research is necessary to identify alternative antituberculosis agents. …”
Get full text

Exploring integrated care for children with cerebral palsy: a stakeholder analysis by Silje Askeland, Veslemøy Guise, Karina Aase, Maren Kristine Raknes Sogstad

“…Conclusion Long-term care for children with CP and their families is complex, involving numerous stakeholders across various sectors, governed by regulations within different institutional contexts, challenging integrated care. …”
Get full text

International and Russian Legal Regulation of the Turnover of Crypto-assets: Conceptual-Terminological Correlation by Ia. K. Iarutin, E. E. Gulyaeva

“…Applied integrally, they allowed comprehending the architecture, “letter and “spirit” of the modern international financial law and national legislation in their conceptual-terminological correlation and to forecast further development and adjustment of the legal regulation of crypto-assets turnover.Results: it was found that there appears a stable trend in the crypto-assets turnover regulation, according to which “soft” law dominates among the law sources (this is especially notable in the sphere of international financial law compared, for example, with conventions or international treaties); at the same time, there is a strengthening trend of “fragmentation” of international law with regard to crypto-assets turnover; the authors mark inconsistency of the conceptual framework contained in international acts and in the Russian legislation, as well as the gaps in the regime of crypto-assets turnover at the level of national law; the trends and forecasts are presented referring to the development of international-legal regulation of the sphere of crypto-assets.Scientific novelty: consists, first of all, in a complex comparison, based on, among other aspects, the fundamentally new concepts of regulation of such progressive international-legal categories as cryptoasset, virtual asset, cryptocurrency, stablecoin, etc., some of them rarely used in the Russian legal discourse and actually never applied in legislation.Practical significance: the scientifically grounded proposals are formulated, aimed at improving the conceptual-terminological framework of the Russian legislation in the sphere of crypto-assets turnover, implementation of which will allow constructing a common legal space with the technologically most advanced states, will help to improve investment climate and financial attraction of the state; will improve the national-legal regime of crypto-assets turnover from the viewpoint of not only actual market demands, but also state security interests and improving competitiveness of the Russian legislation.…”
Get full text

Evaluating the Knowledge, Attitudes and Practices of Medical Laboratory Professionals Towards Implementing Enterprise Risk Management in Harare, Zimbabwe: A Cross‐Sectional Study by Donald Vhanda, Judy Mwenje, Reynold Vhanda, Kudzai Chinowaita, Itai James Blessing Chitungo, Tafadzwa Dzinamarira

“…The knowledge, attitude and practices show risk immaturity. ERM knowledge gaps exist among medical laboratory professionals. …”
Get full text

Robust Methods for Assessing the Characteristics of Locomotor Activity Based on Markerless Video Capture Data by M. I. Bogachev, K. R. Grigarevichius, N. S. Pyko, S. A. Pyko, M. Tsygankova, E. A. Plotnikova, T. V. Ageeva, Ya. O. Mukhamedshina

“…The movement trajectories of biological objects can be represented by time series exhibiting a complex multicomponent structure and non-stationary dynamics, thus limiting the effectiveness of conventional correlation and spectral time series analysis methods. …”
Get full text

Implementing the new WHO guidelines on HIV post‐exposure prophylaxis: perspectives from five African countries by Sarah Magni, Daniel Byamukama, Maryam Sani Haske, Jane Mukami, Idah Moyo, Judith D. Auerbach

“…Additional efforts will require engagement across multiple stakeholders to address remaining awareness gaps, logistical and regulatory obstacles, and political will. …”
Get full text

Toward a public health leadership national training agenda: a review of conceptual frameworks and core competencies by Emily M. Burke, Jordan A. Fox, Kaitlin Tager, Sara McDowell, Fawn Phelps, Howard Koh

“…These challenges are magnified by persistent workforce issues, including knowledge gaps, limited development opportunities, and concerns around long-term sustainability. …”
Get full text