Addressing the dynamic nature of reference data: a new nucleotide database for robust metagenomic classification by Jose Manuel Martí, Car Reen Kok, James B. Thissen, Nisha J. Mulakken, Aram Avila-Herrera, Crystal J. Jaing, Jonathan E. Allen, Nicholas A. Be

“…Recognizing that no current nt-based indices exist for the widely used Centrifuge classifier, and the last public version currently available was released in 2018, we addressed this critical gap by leveraging advanced high-performance computing resources. …”
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Review of Australian seaweed aquaculture: Limitations and opportunities with a focus on two candidate species Asparagopsis taxiformis (Delile) Trevisan (1845) and Chaetomorpha linu... by Joel Wynhorst, Benjamin Camer-Pesci, Ravi Fotedar, Janet Howieson

“…The candidacy of Asparagopsis taxiformis as a target species is discussed with reference to its complex life cycle and knowledge gaps pertaining to its practicality and safety as a livestock feed supplement. …”
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Vascular and glymphatic dysfunction as drivers of cognitive impairment in Alzheimer's disease: Insights from computational approaches by Gehan Fatima, Akm Ashiquzzaman, Sang Seong Kim, Young Ro Kim, Hyuk-Sang Kwon, Euiheon Chung

“…Alzheimer's disease (AD) is driven by complex interactions between vascular dysfunction, glymphatic system impairment, and neuroinflammation. …”
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COVID-19 Vaccines Effectiveness and Safety in Trinidad and Tobago: A Systematic Review and Meta-Analysis by Angel Justiz-Vaillant, Kimberly Roopnarine, Shaundell Solomon, Alyssa Phillips, Solange Sandy, Alyssa Subero, Sarah Seepersad, Nicholas Span, Phalmanie Ramnath, Akaasha Ramnarine, Bimala Ramdath, Chelsea Rampaul, Renissa Ramdial, Dana Phagoo, Thalia Ramdhanie, Vinaya Moonilal, Emily-Marie Poliah, Steffan Poonwassie, Karishta Punilal, Sarah Panchoo, Justice Parris, Steven Oudit, Trudy Muir, Johnson Nicholas-Joseph, Bijey Raj Pandit, Sanjeev Pakeerah, Vesham Sookoo, Patrice Richards, Tishia John, Darren Gopaul, Sachin Soodeen, Odette Arozarena-Barbosa, Arlene Williams, Chandrashehkar Unakal, Rodolfo Arozarena Fundora, Reinand Thompson, Patrick Eberechi Akpaka

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Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections by Joshua Osowicki, Hannah R. Frost, Kristy I. Azzopardi, Alana L. Whitcombe, Reuben McGregor, Lauren H. Carlton, Ciara Baker, Loraine Fabri, Manisha Pandey, Michael F. Good, Jonathan R. Carapetis, Mark J. Walker, Pierre R. Smeesters, Paul V. Licciardi, Nicole J. Moreland, Danika L. Hill, Andrew C. Steer

“…Abstract Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded vaccine development. …”
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Galectin-1 in Cardiovascular Pathogenesis: Unraveling Dual Roles and Mechanistic Insights in Emerging Research by Po-Yuan Chen, Chun-Yao Cheng, Chun-Chao Chen, Huan-Yuan Chen, Ju-Chi Liu, Wen-Rui Hao, Tzu-Hurng Cheng, Jin-Jer Chen

“…Galectin-1 (Gal-1), a β-galactoside-binding lectin, plays a complex role in cardiovascular diseases (CVDs), exerting both protective and pathological effects depending on the context. …”
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Strategic scaling initiatives and client networking dynamics for small and medium-sized enterprises growth: a comprehensive case study analysis by Ioannis Christodoulou, Satrio Utomo Putranto, Moustafa Haj Youssef, Aspasia Simillidou, Jana Chovancová

“…Its value lies in bridging the gap between theory and practice, shedding light on the intricate challenges facing SMEs in navigating growth complexities.…”
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Developing the Preventing Model of Transnational Crimes in Russia and Indonesia in the Age of Sanctions and Global Economic Instability by Toebagus Galang Windi Pratama, Ruslan Puzikov, Sergey Lantsov, Vadim Ponkratov, Ekaterina Khomenko, Larisa Vatutina, Gustavo Henrique Rodrigues Pessoa

“…The study results are expected to support the understanding of gaps in current strategies and simultaneously reinforce the utilization of a holistic approach in the fight against complex transnational criminal activities in a global context. …”
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Castleman Disease: Insights from a Case Series and Literature Review by Jerin James, Sanudev Sadanandan Vadakke Puthiyottil, Johan George, Arathi Edayattil, Vivek Mathew James, Swapna Dominic, Supriya N. K.

“…By integrating clinical experiences with literature, it advocates for refined diagnostic criteria and context-specific therapeutic algorithms, urging further research to address gaps in managing this complex disease.…”
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The Complementary Role of Cardiopulmonary Exercise Testing in Coronary Artery Disease: From Early Diagnosis to Tailored Management by Simone Pasquale Crispino, Andrea Segreti, Martina Ciancio, Dajana Polito, Emiliano Guerra, Giuseppe Di Gioia, Gian Paolo Ussia, Francesco Grigioni

“…While recommended tests are valuable, they may not fully capture the complex physiological responses to exercise or provide the necessary detail to tailor personalized treatment plans. …”
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Envisioning the future of wildlife in a changing climate: Collaborative learning for adaptation planning by Olivia E. Ledee, William H. Karasov, Karl J. Martin, Michael W. Meyer, Christine A. Ribic, Timothy R. Van Deelen

“…For each species, we completed a 2‐stage expert review that elicited dialogue on information gaps, management opportunities, and research priorities. …”
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Breakthroughs in diabetic retinopathy diagnosis and treatment using preclinical research models: current progress and future directions by Xi Peng, Yihua Peng, Ling Li, Lian Liu, Guangju Zhou, Yan Cai

“…The review identifies key findings from the literature, including translational gaps, emerging trends and untapped opportunities. …”
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Detailed assessment of night shift work aspects and potential mediators of its health effects: the contribution of field studies by Tara van der Grinten, Daniella van de Langenberg, Linda van Kerkhof, Barbara N. Harding, Barbara N. Harding, Barbara N. Harding, Anne Helene Garde, Caisa Laurell, Roel Vermeulen, Susan Peters, Jelle Vlaanderen

“…Such approaches will generate new hypotheses and inform the design of next-generation cohort and case–control studies, fostering a deeper understanding of this complex exposure and its health implications.…”
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Biophysical and Morphometric Characteristics of Sunflower Achenes: Implications for Industrial Processing and Byproduct Utilization by Jelena Ovuka, Jelena Jocković, Milan Jocković, Siniša Jocić, Sonja Gvozdenac, Miloš Krstić, Dušica Jovičić

“…Their byproducts indicate a complex interrelationship among the analyzed traits. …”
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Microneedles at the Forefront of Next Generation Theranostics by Chan Wang, Yuan Yang, Jiaqi Zhang, Hanrui Zhang, Qian Wang, Shengmei Ma, Pengfei Zhao, Zhou Li, Yuxin Liu

“…The evolution of microneedle design from solid to dissolvable forms broadens their utility from mere drug delivery to complex sensing and therapeutic applications, including insulin delivery for diabetes management, vaccination, and gene therapy. …”
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RnaXtract, a tool for extracting gene expression, variants, and cell-type composition from bulk RNA sequencing by Sophiane G. Bouirdene, Simon Gotty, Mickaël Leclercq, Charles Joly-Beauparlant, Emeric Texeraud, Steve Bilodeau, Arnaud Droit

“…Abstract RNA sequencing (RNA-seq) is a widely used method in transcriptomics research, offering insights into gene expression, variant discovery, and, when deconvoluted, the cellular composition of complex tissues. However, existing RNA-seq pipelines frequently emphasize gene expression analysis and often lack cell deconvolution and variant calling. …”
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The health workforce conundrum for burn care in Uttar Pradesh, India: a qualitative exploration by Vikash Ranjan Keshri, Samina Parveen, Seye Abimbola, Brijesh Mishra, Mohammed Fahad Khurram, Margie Peden, Robyn Norton, Jagnoor Jagnoor

“…First, the dynamics within the multidisciplinary team where complex relations, power and normative hierarchy hampered performance. …”
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Examining the nexus of infrastructure development and economic growth: Evidence from SAARC countries by Vinay Khandelwal, Varun Chotia, Prashant Sharma, Swati Soni, Sushil Kalyani

“…Policymakers are encouraged to consider these findings when designing synchronized public and private sector initiatives to bridge development gaps. By offering detailed insights into region-specific dynamics, this study enriches understanding of the complex interplay between infrastructure, finance, and economic growth in emerging economies.…”
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Mapping care provision for type 1 diabetes throughout Australia: a protocol for a mixed-method study by Jeffrey Braithwaite, Yvonne Zurynski, Jennifer Couper, Sophia Zoungas, Timothy Jones, Elizabeth Davis, David Bloom, Ann Carrigan, Rebecca Lake, Tony Huynh

“…This can lead to adverse outcomes such as cardiovascular disease and nephropathy. T1D treatment is complex, multidisciplinary, multiagency and life-long and should involve patient-centred, developmentally appropriate care. …”
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Emerging phenotype: Maturity-onset diabetes of the young type 5 (MODY-5) – mechanisms, clinical spectrum, and unmet needs by Fahrul Nurkolis, Rony Abdi Syahputra, Andika Priamas Nugrahanto, Nurpudji Astuti Taslim, Arifa Mustika, Raymond Rubianto Tjandrawinata, Dante Saksono Harbuwono, Sidartawan Soegondo

“…Moreover, the absence of validated biomarkers specific to Type 5 Diabetes further impedes timely and precise diagnosis, underscoring critical gaps in current clinical practice. Addressing these diagnostic and therapeutic gaps necessitates expanded genetic screening, enhanced clinician education, and the establishment of subtype-specific clinical guidelines. …”
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