Treating rare diseases with justice: Implications of a human rights-based approach by Stéphanie Dagron

“…The agenda 2030 serves as a remarkable example of these efforts, positioning health at the centre of the program, acknowledging the existence of social determinants of health, and affirming the necessity to tackle the causes of health inequities and attend to the needs of disadvantaged groups. Individuals with rare diseases face specific risks and challenges primarily due to unmet health needs stemming from a lack of research and development of suitable medical technologies. …”
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Changing primary care capacity in Canada: protocol for a cross-provincial mixed methods study by Erin Wilson, Agnes Grudniewicz, Antoine Sauré, Ian Scott, Alan Katz, M Ruth Lavergne, Claire Johnson, David Rudoler, Lindsay Hedden, Adrian MacKenzie, Rita McCracken, Ruth Martin-Misener, Helena Piccinini-Vallis, Sarah Spencer, Caroline Jose, Sandra Peterson, Rebecca H Correia, Julie Easley, Ted McDonald, Stephanie Welton, François Gallant, Émilie Dufour, Jennifer Hakim, Elizabeth Nethery, Hugh Shiplett, Sarah Simkin, Rachel Thelen

“…Introduction Despite having more family physicians (FPs) and nurse practitioners (NPs) per capita than ever before in Canada, there is a clear gap between population primary care needs and system capacity. Primary care needs may be shaped by population ageing, increasing clinical and social complexity and growing service intensity. …”
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Dermatologic Data From the Global Burden of Disease Study 2019 and the PatientsLikeMe Online Support Community: Comparative Analysis by Mindy D Szeto, Lina Alhanshali, Chandler W Rundle, Madeline Adelman, Michelle Hook Sobotka, Emily Woolhiser, Jieying Wu, Colby L Presley, Jalal Maghfour, John Meisenheimer, Jaclyn B Anderson, Robert P Dellavalle

“… AbstractThe Global Burden of Disease (GBD) study aims to characterize the worldwide prevalence and morbidity of major diseases, while PatientsLikeMe (PLM) is an online community providing patient-generated insights into lived experiences; for dermatologic conditions, quantitative comparisons of GBD and PLM data revealed expected demographic differences but also notable correlations, highlighting their potential as complementary data sources elucidating unmet patient needs and priorities.…”
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Acceptability of the R21/Matrix-M malaria vaccine alongside existing malaria interventions in the trial context by Jayne Webster, Brian Greenwood, Daniel Chandramohan, Alassane Dicko, Issaka Sagara, Djibrilla Issiaka, Adrian VS Hill, Halimatou Diawara, Fatoumata Koita, Seydou Traoré, Jane Grant, Mehreen Datoo, Mala Sylla, Abdrahmane Boncane Dicko

“…Implementation research is needed to evaluate and ensure co-coverage of complementary malaria control interventions, including SMC in seasonal settings, in the face of the scale-up of R21/Matrix-M and other malaria vaccines.…”
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Demonstration of a Silicon Photonic Circuit for Half-Add Operations Using Cascaded Microring Resonators by Xiaosuo Wu, Lin Deng, Yinghao Meng, Jianhong Yang, Yonghui Tian

“…For proof of principle, the thermo-optic modulation scheme that needs simpler fabrication processes is employed to modulate MRRs. …”
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Exploring the benefits and prescribing informations of combining East Asian herbal medicine with conventional medicine in the treatment of rheumatoid arthritis: A systematic review... by Hee-Geun Jo, Jihye Seo, Eunhye Baek, Donghun Lee

“…Conclusions: The findings suggest that EACM may serve as a valuable complementary strategy for RA patients insufficiently managed by CM alone. …”
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Perceived Symptoms in People Living with Impaired Glucose Tolerance by Susanne Andersson, Inger Ekman, Ulf Lindblad, Febe Friberg

“…Symptoms ought to be seen as complementary components in the health encounter and health conversation. …”
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Local genetic sex differences in quantitative traits by Emil Uffelmann, Christiaan de Leeuw, Marijn Schipper, Danielle Posthuma

“…We show these have complementary interpretations, where only the latter scale is informative for heritability. …”
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Heterosynaptic plasticity-induced modulation of synapses by Masoumeh Kourosh-Arami, Alireza Komaki, Masoumeh Gholami, Seyed Hossein Marashi, Sara Hejazi

“…The regular action of the brain needs to be balanced in several neuronal and synaptic features, one of which is synaptic plasticity. …”
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Investigation of illicit pregabalin in seized samples from Saudi Arabia by Fatimah M. Alamri, Fatimah M. Alamri, Sultan K. Alshmmari, Monerah A. Altamimy, Ibrahim A. Al Othaim, Yahya M. Alshehri, Rayed M. Alafraa, Ahmed D. Almalki, Turki A. Alkhalifah, Taher Sahlabji, Abubakr M. Idris, Abubakr M. Idris, Haitham Al-Hamoud, Yahya F. Jamous, Fahad S. Aldawasri

“…On the other hand, among 35 capsules, 5 (14.29%) exceeded pharmacopeial limits (95%–105% PGL content), while 6 (17.14%) contained <95% PGL.DiscussionThese results demonstrate significant variability in PGL content and the presence of adulterants, underscoring the need for robust analytical methods in forensic chemistry. …”
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Volatile-mediated plant interactions: an innovative approach to cultivar mixture selection for enhanced pest resilience by Dimitrije Markovic, Dimitrije Markovic, Gaëtan Seimandi-Corda, Gaëtan Seimandi-Corda, Vili Harizanova, Atanaska Stoeva, Sari Himanen, Stephanie Saussure, Andja Radonjic, Gordana Đurić, Ivana Lalićević, Sokha Kheam, Sokha Kheam, Merlin Rensing, Jannicke Gallinger, Jannicke Gallinger, Samantha M. Cook, Velemir Ninkovic

“…However, this applies only in specific combinations, creating a need to select cultivars that interact synergistically in mixtures. …”
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Herbal formulations, Product Nkabinde and Gnidia sericocephala, exhibit potent in vitro activity against HIV-1 infection by Khanyisile Mngomezulu, Khanyisile Mngomezulu, Paradise Madlala, Siphathimandla Authority Nkabinde, Magugu Nkabinde, Mlungisi Ngcobo, Nceba Gqaleni, Nceba Gqaleni, Nceba Gqaleni

“…These limitations highlight the need for novel, affordable therapeutic alternatives. …”
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Evaluation of the efficacy of Capacitive Resistive Monopolar Radiofrequency at 448 kHz in the physiotherapeutic treatment of female dyspareunia by Anna Abelló Pla, Anna Andreu-Povar, Laura Fabbi, Jordi Esquirol-Caussa, Judith Lleberia-Juanós, Antonio Gil-Moreno, Mireia Coll Omaña

“…No additional improvements were observed at three months, indicating the sustained benefits and emphasizing the need to evaluate maintenance strategies and consider psychological factors. …”
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Estrategia de superación metodológica para los gestores del proceso pedagógico en la Universidad de Ciencias Médicas de Holguín by Marylú Torres Batista, Elizabeth K. Leyva Sánchez, Pedro Augusto Díaz Rojas

“…Theoretical and empirical methods were used as well as statistical procedures for the scientific and teaching characterizations, and for identifying the need of methodological upgrading of these professionals, which together with the theoretical foundations allowed for the formulation of the strategy. …”
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Diagnostic Performance and Interobserver Agreement of the Vesical Imaging–Reporting and Data System (VI-RADS) in Bladder Cancer Staging: A Systematic Review by Alexandru Nesiu, Dorin Novacescu, Silviu Latcu, Razvan Bardan, Alin Cumpanas, Flavia Zara, Victor Buciu, Radu Caprariu, Talida Georgiana Cut, Ademir Horia Stana

“…Moreover, the variability in specificity suggests the need for standardized training and interpretation protocols. …”
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Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans by Zhuyun Bian, Ziyan Xu, Anushka Peer, Yeseul Choi, Shelby J. Priest, Konstantina Akritidou, Ananya Dasgupta, Tim A. Dahlmann, Ulrich Kück, Minou Nowrousian, Matthew S. Sachs, Sheng Sun, Joseph Heitman

“…Our study highlights the need for careful genetic analyses in determining essential genes, which is complementary to high-throughput approaches. …”
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Antifungal effects of andrographolide and its combination with amphotericin B against selected fungal pathogens by Gayus Sale Dafur, Tuan Noorkorina Tuan Kub, Kirnpal Kaur Banga Singh, Azian Harun, Fatmawati Lambuk, Rohimah Mohamud, Ramlah Kadir, Norzila Ismail, Norhayati Yusop

“…Despite advancements in antifungal therapies, the development of resistance to conventional drugs has compromised treatment outcomes, creating an urgent need for novel therapeutic approaches. Andrographolide, a key bioactive compound from Andrographis paniculata, has demonstrated broad-spectrum antimicrobial activity. …”
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Diagnostic challenges of brucellosis in humans and livestock in Tanzania: A thematic review by Isaac J. Mengele, Gabriel M. Shirima, Barend M. Bronsvoort, Luis E. Hernandez-Castro, Elizabeth A.J. Cook

“…This study suggests that there is a need for (1) training on public health education and brucellosis awareness among stakeholders in the livestock value chain; (2) providing scheduled continuing professional education with regard to brucellosis and other zoonotic diseases to health and livestock workers; (3) future brucellosis surveillance studies must focus on unrepresented regions; and (4) lastly, we recommend that the rose Bengal plate test (RBPT) and competitive enzyme-linked immunosorbent assay (cELISA) should be considered in brucellosis diagnostic schemes as a complementary tool to hasten the implementation of an ongoing national strategy for the prevention and control of brucellosis in humans and livestock in Tanzania. …”
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Novel insights into paclitaxel’s role on tumor-associated macrophages in enhancing PD-1 blockade in breast cancer treatment by In-San Kim, Seohyun Kim, Seong A Kim, Gi-Hoon Nam, Yoonjeong Choi, Minsu Kwon, Cherlhyun Jeong, Hanul Jung, Yeji Lee, Jiwan Woo, Yakdol Cho, Eunhae Kim, Yoon Kyoung Kim, Jaehyun Kim, Min Kyoung Jo, Dongjoo Lee, Hongyoon Choi

“…The efficacy of PTX in promoting antitumor immunity was elicited when combined with PD-1 blockade, suggesting a complementary interaction.Conclusions This study reveals how PTX boosts the effectiveness of PD-1 inhibitors in treating TNBC. …”
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Electrocatalytical Nitrite Oxidation via Manganese and Copper Oxides on Carbon Screen-Printed Electrode by Roberta Farina, Silvia Scalese, Alessandra Alberti, Stefania Maria Serena Privitera, Giuseppe Emanuele Capuano, Domenico Corso, Giuseppe Andrea Screpis, Serena Concetta Rita Reina, Guglielmo Guido Condorelli, Maria Anna Coniglio, Sebania Libertino

“…As a result, there is a continuing need to develop sensitive, real-time, low-cost, and portable systems for the accurate detection of trace levels of NO₂⁻ in drinking water. …”
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