Gut Microbiota and Mental Health: A Review of the Impact of Gut Bacteria on Depression and Anxiety Disorders by Aleksandra Pelczarska, Rafal Kaczorowski, Tomasz Forenc, Jaromir Hunia, Julia Górny, Michał Janiszewski, Jonasz Jurek, Marcin Komorowski, Alicja Kapciak

“…However, there remains a need for more well-designed, large-scale human studies to confirm these findings conclusively. …”
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Self-Disclosure and Social Support in a Web-Based Opioid Recovery Community: Machine Learning Analysis by Yu Chi, Huai-yu Chen, Khushboo Thaker

“…By uncovering interaction patterns, this study provides valuable insights for leveraging online support groups as complementary resources to traditional recovery interventions.…”
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Gut microbiome features associate with immune checkpoint inhibitor response in individuals with non-melanoma skin cancers: an exploratory study by Yujie Zhao, Jacqueline T. Ferri, James R. White, Megan D. Schollenberger, Kim Peloza, Cynthia L. Sears, Evan J. Lipson, Fyza Y. Shaikh

“…In summary, this exploratory study suggests gut microbiota features that are associated with ICI efficacy in individuals with non-melanoma skin cancers and highlights the need for larger studies to validate the results.IMPORTANCEPrior studies examining associations between ICI efficacy and the gut microbiome have focused primarily on individuals with melanoma, for whom ICI therapy was first approved. …”
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Acupuncture for Chronic Obstructive Pulmonary Disease: A 38-Year Bibliometric Landscape of Global Research Trends and Knowledge Evolution (1986–2024) by Wu K, Ruan C

“…This analysis suggests a need for a threefold strategy integrating multiscale neuroimaging validation, globalized trial standardization through CONSORT-Acupuncture frameworks, and equitable North-South knowledge exchange to address the growing burden of COPD-related dyspnea in aging populations. …”
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Alzheimer’s disease diagnosis using rhythmic power changes and phase differences: a low-density EEG study by Juan Wang, Juan Wang, Jiamei Zhao, Xiaoling Chen, Xiaoling Chen, Bowen Yin, Xiaoli Li, Xiaoli Li, Ping Xie, Ping Xie

“…ObjectivesThe future emergence of disease-modifying treatments for dementia highlights the urgent need to identify reliable and easily accessible tools for diagnosing Alzheimer’s disease (AD). …”
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Omega-3 Fatty Acids for the Treatment of Bipolar Disorder Symptoms: A Narrative Review of the Current Clinical Evidence by Evmorfia Psara, Sousana K. Papadopoulou, Maria Mentzelou, Gavriela Voulgaridou, Theophanis Vorvolakos, Thomas Apostolou, Constantinos Giaginis

“…Antipsychotics and mood stabilizers are known therapies that work, but their restrictions and disadvantages resulted in the need for complementary and alternative therapies, such as natural compounds. …”
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DNA methylation profiling for molecular classification of neuroblastoma by Maja Löfgren, Anna Djos, Shiva Rezaei, Medha Suman, Per Kogner, Tommy Martinsson, Susanne Fransson, Helena Carén

“…The interplay between genomic alterations and methylation patterns could give clues into the discrepancy and underscores the complexity of neuroblastoma biology and the need for further research and validation of clinical outcomes of the patients in the respective subclasses.…”
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Detecting and identifying Schistosoma infections in snails and aquatic habitats: A systematic review. by Bishoy Kamel, Martina R Laidemitt, Lijun Lu, Caitlin Babbitt, Ola Liota Weinbaum, Gerald M Mkoji, Eric S Loker

“…Droplet digital PCR (ddPCR) can play a complementary role if inhibitors are a concern, or more sensitivity or quantification is needed. …”
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Characteristics of Physical Exercise Programs and Their Effects on Quality of Life and Functional Capacity in Individuals with Chronic Obstructive Pulmonary Disease: A Scoping Revi... by Rafael Oliveira, João Paulo Brito, Halil İbrahim Ceylan, Maria de Brito Soares, Alexandre Duarte Martins, Tiago Vasconcelos, João Moutão, Susana Alves

“…Thus, there is a clear need for more high-quality research with robust methodological design in the context of exercise interventions for individuals with COPD.…”
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Utility of Generative Artificial Intelligence for Japanese Medical Interview Training: Randomized Crossover Pilot Study by Takanobu Hirosawa, Masashi Yokose, Tetsu Sakamoto, Yukinori Harada, Kazuki Tokumasu, Kazuya Mizuta, Taro Shimizu

“…ResultsAI-based stations scored lower across most categories, particularly in patient care and communication, than traditional stations (4.48 vs 4.95; PP ConclusionsThe comparable performance of generative AI in clinical reasoning highlights its potential as a complementary tool in medical interview training. One of its main advantages lies in enabling self-learning, allowing trainees to independently practice interviews without the need for simulated patients. …”
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(-)-Epigallocatechin-3-Gallate Suppresses Hyperexcitability in Rat Primary Nociceptive Neurons Innervating Inflamed Tissues: A Comparison with Lidocaine by Syogo Utugi, Yukito Sashide, Mamoru Takeda

“…<b>Objective:</b> Given the side effects and reduced efficacy of conventional local anesthetics in inflammatory conditions, there is a compelling need for complementary alternative medicine (CAM), particularly those based on phytochemicals. …”
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Decoding bacterial methylomes in four public health-relevant microbial species: nanopore sequencing enables reproducible analysis of DNA modifications by Valentina Galeone, Johanna Dabernig-Heinz, Mara Lohde, Christian Brandt, Christian Kohler, Gabriel E. Wagner, Martin Hölzer

“…Abstract Investigating bacterial methylation profiles provides essential complementary information to the native DNA sequence, significantly extending our understanding of how DNA modifications influence virulence, antibiotic resistance, and the ability of bacteria to evade the immune system. …”
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An overview of rapid non-culture-based techniques in various clinical specimens for the laboratory diagnosis of Talaromyces marneffei by Huamei Wei, Huamei Wei, Patcharin Thammasit, Artid Amsri, Artid Amsri, Kritsada Pruksaphon, Fenglian Deng, Joshua D. Nosanchuk, Sirida Youngchim

“…Therefore, non-culture techniques serve as important complementary and alternative methods for diagnosing talaromycosis. …”
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Exploring nurse and patient perspectives on WeChat-based prenatal education in Chinese public hospitals: a qualitative inquiry by Yushi He, Guangmei Fan, Guangrui Fan, Dandan Liu

“…Nonetheless, the findings underscore the need for hospital-level policies, structured training programs, and culturally sensitive strategies to address privacy concerns, manage workloads, and reduce digital disparities. …”
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The emerging role of next-generation sequencing in minimal residual disease assessment in acute lymphoblastic leukemia: a systematic review of current literature by Andreea-Iulia Ștefan, Andreea-Iulia Ștefan, Letiția-Elena Radu, Letiția-Elena Radu, Dumitru Jardan, Anca Coliță, Anca Coliță

“…The combination of NGS with MFC may provide complementary advantages.…”
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&beta;-Caryophyllene and Statins in Bone Fracture Healing &ndash; A Narrative Review by Marom H, Khan MA, Darvish N, Tornetta III P, Khoury A, Weil YA, Skelley NW, Allison DC, Meiron S, Ehrmann Barr T

“…It highlights the complementary mechanisms of these agents: BCP’s anti-inflammatory and osteogenic properties and statins’ ability to inhibit osteoclast activity and promote angiogenesis. …”
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Prevalence and Patterns of Use of Natural Health Products and Medicines in New Zealand: A Pilot Study Using an Online Market Research Panel by E Lyn Lee, Jeff Harrison, Joanne Barnes

“…Abstract Background Traditional, complementary and alternative medicine (TCAM), including natural health products (NHPs), are used by many consumers to address their [perceived] health needs. …”
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Automated Recognition of Abnormalities in Gastrointestinal Endoscopic Images – Evaluation of an AI Tool for Identifying Polyps and Other Irregularities by Weronika Jarych, Elżbieta Tokarczyk, Patryk Iglewski, Daria Ziemińska, Karina Motolko, Rafał Burczyk, Konrad Duszyński, Michał Kociński, Jan Reinald Wendt

“…However, the study also addresses significant challenges, including the necessity for large, heterogeneous datasets for model validation, the need for standardized AI applications, and the ethical implications of AI-assisted clinical decision-making. …”
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Hesperidin alleviates hypothyroidism-related cardiac dysfunction by targeting cardiac miRNAs, Nrf2/NF-κB signaling, oxidative stress and inflammation by Asmaa M. Gaber, Adel Abdel-Moneim, Eman S. Abdel-Reheim, Gamal Allam, Manal Abdul-Hamid, Ahmed Hosni, Ahmed Hosni

“…Accumulating evidence suggests that thyroid hormone replacement does not fully reverse the cardiovascular complications associated with the disease despite normalization of serum thyroid hormone levels, indicating a need for adjunctive, complementary, or alternative therapies. …”
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Synergistic effect between vancomycin and traditional Chinese medicine (TCM) herbs against methicillin-resistant Staphylococcus aureus (MRSA) infections by Prateek Porwal, Satish Kumar Sharma

“…This review highlights the need for further clinical trials to validate these findings and optimise combination protocols. …”
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