Evaluating the Implementation of fan-beam CT-guided online adaptive re-planning in definitive cervical cancer radiotherapy by Shuai Sun, Xinyue Gong, Xinyue Gong, Yongguang Liang, Yuliang Sun, Dan Que, Yangchun Xie, Shumeng He, Lei He, Hao Liang, Yijun Wang, Xinyi Wu, Cheng Wang, Bo Yang, Jie Qiu, Ke Hu, Fuquan Zhang

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Prehospital antibiotics and intravenous fluids for patients with sepsis: protocol for a 2×2 factorial randomised controlled trial by Nick Daneman, Tony Mazzulli, Rob Stenstrom, Gail Klein, Ruxandra Pinto, Lisa Burry, Sheldon Cheskes, Jim Christenson, Damon C. Scales, Anna Rogowsky, Ian R. Drennan, Morgan Hillier, Sandra Jenneson, Philip Moran, Andrew M. Morris, Laurie J. Morrison, Gordon D. Rubenfeld, Christopher W. Seymour, P. Richard Verbeek

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Myocarditis and neutrophil-mediated vascular leakage but not cytokine storm associated with fatal murine leptospirosisResearch in context by Stylianos Papadopoulos, David Hardy, Frédérique Vernel-Pauillac, Magali Tichit, Ivo G. Boneca, Catherine Werts

“…The funders had no implication in the design, analysis and reporting of the study.…”
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Synergistic Effects of BaTiO₃ and MFe₂O₄ (M = Mn, Ni, Cu, Zn, and Co) Nanoparticles as Artificial Pinning Centers on the Performance of YBa<sub>2</... by Amjad S. Dair, Yassine Slimani, Essia Hannachi, Faten Ben Azzouz, Munirah A. Almessiere

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Nivel de actividad física e inteligencia emocional en estudiantes chilenos de Pedagogía en Educación Física. Estudio transversal (Level of physical activity and emotional intellige... by Héctor Fuentes-Barría, Raúl Aguilera-Eguía, Juan Maureira-Sánchez, Olga Patricia López-Soto, Brenda Yuliana Herrera-Serna, Miguel Alarcón-Rivera

“…Objective: To evaluate emotional intelligence based on the level of physical activity presented by second-year students enrolled in the Physical Education program at the Central University of Chile, Santiago campus. …”
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Acute effect of a multi-ingredient pre-workout supplement on pacing and kinetic expression during shorter and longer bouts of high intensity functional training by Gerald T. Mangine, Christopher Staples, James W. Henley, Ashley Hines, Kristyn C. McGeehan, Wysmark Chaves, Wil King, Tiffany A. Esmat, John R. McLester, Jacob L. Grazer

“…The averages, standard deviation, and slope across rounds were calculated for all pacing and kinetic variables for separate 3-way (sex × workout durations × supplement conditions) repeated measures analysis of variance comparisons.Results Men and women completed a greater total volume load (~4.4%, p = 0.009) and repetitions at a faster rate (~2.2%, p = 0.043) during S compared to P and regardless of workout duration. …”
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Pharmacological and structural characterization of vibostolimab, a novel anti-TIGIT blocking antibody for cancer immunotherapy by Hongmei Wang, Maribel Beaumont, Wendy Blumenschein, Laurence Fayadat-Dilman, Mingmei Cai, Jing Yuan, Douglas Wilson, Thierry O Fischmann, Jeanne Baker, Tanya Keenan, Daniel Malashock, Eunseon Ahn, Komal Pradhan, Jeffery Grein, Srishti Chakravorty, Soheila Bahmanjah, David Ban, Ellen Chien, Mark Hsieh, Todd Mayhood, Janica C Wong, Mark A McCoy, Sybil M G Williams, Wolfgang Seghezzi, Jin-Hwan Han

“…The mouse surrogate anti-TIGIT antibodies were identified and used to extensively investigate the mechanism of action of anti-TIGIT antibodies as monotherapy or in combination with anti-programmed cell death protein-1 (PD-1) antibody in vivo by gene expression profiling and flow cytometry analyses with a mouse syngeneic tumor model.Results Structural analyses with solution NMR and X-ray crystallography revealed that vibostolimab binds the CC’C’’FG loop interface of TIGIT, completely competing for the binding site of CD155 with a larger coverage area than another anti-TIGIT antibody tiragolumab, consistent with surface plasmon resonance analysis, though mouse models with similar antibodies revealed no functional difference in antitumor efficacy. …”
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Bridging radiotherapy before chimeric antigen receptor T cells for B-cell lymphomas: an ILROG multicenter study by Nikhil Yegya-Raman, John P. Plastaras, Christopher M. Wright, Monica Chelius, Siqi Zhang, Jonathan A. Baron, Harper Hubbeling, Austin J. Sim, Timothy J. Robinson, Michael D. Jain, Brandon Imber, Beatrice Fregonese, Joachim Yahalom, Colton Ladbury, Savita Dandapani, Chelsea C. Pinnix, Jillian R. Gunther, Penny Q. Fang, Susan Y. Wu, Bouthaina S. Dabaja, Joanna C. Yang, Jessica Chew, Steve Braunstein, Sumi Sinha, Nathan M. Delinger, Susan Sun, Stephanie A. Terezakis, Gukan Sakthivel, Louis S. Constine, Amit K. Chowdhry, Patrick M. Reagan, Skyler Burke, Yolanda D. Tseng, Michael J. LaRiviere, Amit Maity, Stephen J. Schuster, Elise A. Chong, Nicholas B. Figura

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Insights from a Pseudo-Polygyny Cohort unmasking high sperm concentration and low forward motility as potential risk factors for recurrent failure of sperm donation IVF (RFDI), a s... by Tiancheng Zhang, Fan Dong, Xu Zhang, Ping Ping, Jin Qiu, Zhen Lu, Huachun Zou, Qian Xiao, Jianhui Li, Gaoyue Zhang, Huijuan Shi, Xiangfeng Chen

“…Funding: National Key R&D Program of China (2023YFC2705503), Fujian Province's Third Batch of Flexible Introduction of High-Level Medical Talent Teams (TD202307) and the National Key Technologies R&D Program (2023YFC2306700).…”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

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Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis by Barbara Vergani, Massimo Milione, Marco Vitellaro, Giulio Ferrero, Veronica Huber, Luca Lalli, Agata Cova, Paola Frati, Flavio Arienti, Licia Rivoltini, Simonetta Guarrera, Laura Cattaneo, Luca Sorrentino, Elena Daveri, Elena Casiraghi, Marta Zorza, Manuela Gariboldi, Patrizia Pasanisi, Daniele Morelli, Paola A Corsetto, Angela M Rizzo, Martina Stroscia, Vincenzo Lagano, Giovanna Sabella, Biagio E Leone

“…Multiparametric high-resolution flow cytometry analysis and bulk RNAseq of CRC tissue were conducted to evaluate the phenotype and transcriptomic program of immune cell infiltrate in relation to FC accumulation. …”
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Real-world data of cadonilimab in recurrent or metastatic cervical cancer in China: a multicentric study by Jian Chen, Haijuan Yu, Yingtao Lin, Dan Hu, Li Liu, Renliang Fan, Jianping Zou, Lele Zang, Yao Lin, Rong Lin, Dezhao Chen, Xiaoying Weng, Fenfang Shen, Shaoyu Wang, Wei Zeng, Qihua Tian, Yun Yi, Yuanfeng Chen, Jinjin Miao, Bo Zhang, Yinxia Zou, Fengming Gao, Fengming Gao, Rong Lian, Lin Yang, Yang Sun

“…The median PFS was 12.4 months, while the median OS has not yet been reached. Subgroup analysis showed a numerical trend toward longer median PFS in patients with PD-L1 CPS ≥ 1 compared with CPS &lt; 1 (14.0 vs. 12.8 months; P = 0.235). …”
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Leveraging the influenza sentinel surveillance platform for SARS-CoV-2 monitoring in Bangladesh (2020–2024): a prospective sentinel surveillance studyResearch in context by Md Ariful Islam, Md Zakiul Hassan, Zubair Akhtar, Saju Bhuiya, Tanzir Ahmed Shuvo, Probir Kumar Ghosh, Asadullah, Md Abdullah Al Jubayer Biswas, Mustafizur Rahman, Mohammad Jubair, Mst Noorjahan Begum, Yeasir Karim, Mohammed Ziaur Rahman, Mohammad Enayet Hossain, Mohammad Niaz Morshed Khan, Tahmina Shirin, Shah Niaz Md Rubaid Anwar, Ahmed Nawsher Alam, Mohammad Ferdous Rahman Sarker, Monalisa, Manjur Hossain Khan Jony, Mahbubur Rahman, Mahmudur Rahman, Mohammad Abdul Aleem, Fahmida Chowdhury

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Pulse oximetry and oxygen services for under-five children with community-acquired pneumonia attending primary and secondary level health facilities in Lagos, Nigeria (INSPIRING-La... by Hamish R Graham, Adegoke G Falade, Tim Colbourn, Eric D McCollum, Ayobami Adebayo Bakare, Carina King, Marco Ricci, James Beard, Christine Cassar, Obioma C Uchendu, Agnese Iuliano, Adamu Isah, Adams Osebi, Tahlil Ahmed, Rochelle Ann Burgess, Samy Ahmar, Paula Valentine, Ibrahim Haruna, Abdullahi Magama, Ibrahim Seriki, Temitayo Folorunso Olowookere, Matt MacCalla, Obioma Uchendu, Julius Salako, Funmilayo Shittu, Damola Bakare, Omotayo Olojede, Omotayo Emmanuel Olojede

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The impact of genetic ancestry on survival outcomes in pediatric rhabdomyosarcoma: A report from the Children’s Oncology Group by Ekene A. Onwuka, Christina L. Magyar, Bailey A. Martin-Giacalone, Michael E. Scheurer, Deborah A. Marquez-Do, Mark Zobeck, Elizabeth G. Atkinson, Erin R. Rudzinski, Michael A. Arnold, Donald A. Barkauskas, David Hall, Javed Khan, Jack F. Shern, Paul Scheet, Brian Crompton, Corinne M. Linardic, Douglas S. Hawkins, Rajkumar Venkatramani, Lisa Mirabello, Chad D. Huff, Melissa A. Richard, Philip J. Lupo

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Clinical and cost-effectiveness of percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones: the PUrE RCTs by Oliver Wiseman, Daron Smith, Kath Starr, Lorna Aucott, Rodolfo Hernández, Ruth Thomas, Steven MacLennan, Charles Terry Clark, Graeme MacLennan, Dawn McRae, Victoria Bell, Seonaidh Cotton, Zara Gall, Ben Turney, Samuel McClinton

“…The second study (larger stones) compared telescopic surgery with keyhole surgery. A computer program (random allocation) decided which treatment each person received. …”
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Model Biokinetika Sistem Kontak Stabilisasi Lumpur Air Lindi Berdasarkan Pengaruh Fosfor dan Variasi Waktu Detensi Unit Kontak by Muhammad Faiz Kahendran, Owen Jacob Notonugroho, Chusnul Arif, Ariani Dwi Astuti, Allen Kurniawan

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Evaluating <i>TAB2, IKBKB,</i> and <i>IKBKG</i> Gene Polymorphisms and Serum Protein Levels and Their Association with Age-Related Macular Degeneration and Its Treatment Efficiency by Alvita Vilkeviciute, Enrika Pileckaite, Akvile Bruzaite, Dzastina Cebatoriene, Greta Gedvilaite-Vaicechauskiene, Loresa Kriauciuniene, Dalia Zaliuniene, Rasa Liutkeviciene

“…The data obtained were analyzed using the “IBM SPSS Statistics 29.0” software program. <i>Results</i>: Our study revealed that <i>TAB2</i> rs237025 allele A was identified as a risk factor for early and exudative AMD development. …”
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Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium by Sangjun Lee, Choonghyun Ahn, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Seokyung An, Norie Sawada, Xiao-Ou Shu, Woon-Puay Koh, Hui Cai, Atsushi Hozawa, Seiki Kanemura, Chisato Nagata, San-Lin You, Daehee Kang, Rieko Kanehara, Yu-Tang Gao, Jian-Min Yuan, Wanqing Wen, Yumi Sugawara, Keiko Wada, Chien-Jen Chen, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Aesun Shin, Jeongseon Kim, Jung Eun Lee, Keitaro Matsuo, Nathaniel Rothman, You-Lin Qiao, Wei Zheng, Paolo Boffetta, Manami Inoue, Sue K. Park

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Efficacy and safety of trabeculectomy versus peripheral iridectomy plus goniotomy in advanced primary angle-closure glaucoma: study protocol for a multicentre, non-inferiority, ran... by Keith Barton, Tin Aung, Ling Jin, Ping Lu, Xiulan Zhang, Robert N Weinreb, Yi Zhang, Li Tang, Guangxian Tang, Hengli Zhang, Aiguo Lv, Huiping Yuan, Yunhe Song, Fengbin Lin, DENNIS S C LAM, Lin Xie, Kun Hu, Xiaohong Liang, Yingzhe Zhang, Wulian Song, Xiaomin Zhu, Xinbo Gao, Sujie Fan, Yuying Peng, Mengfei Liao, Xin Nie, Ki-Ho Park

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