The Association of Immune Cell Infiltration with Metastasis Location in De Novo Metastatic Triple Negative Breast Cancer: A Multicenter Cross-Sectional Study in Indonesia by Jeffry Beta Tenggara, Andhika Rachman, Joedo Prihartono, Lisnawati Lisnawati, Sonar Soni Panigoro, Didik Setyo Heriyanto, Ricci Steven, Kevin Tandarto, Samuel Juanputra, Aru Wisaksono Sudoyo

“…Immunohistochemistry (IHC) analysis was carried out on primary breast tumor tissues to evaluate the expressions of cluster of differentiation (CD)4 T-cells, CD8 T-cells, CD163, FOXP3 Tregs, and programmed death-ligand 1 (PD-L1), along with immune cells ratios showing antitumor-to-protumor activity (CD4/FOXP3, CD8/FOXP3, CD4/CD163, CD8/CD163). …”
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Mamá Empoderada: study protocol for a pilot trial of a novel parenting and mental health prevention intervention for migrant mothers with young children at the Mexico-US border by Gudelia Rangel, Shira M Goldenberg, Eileen Pitpitan, Kaylee Ramage, Ietza Bojorquez-Chapela, Cecilia Martinez-Torteya, Katherine Rosenblum, Chelsie Hernandez, Monica Alvarez

“…The control group will receive standard of care programming and will be offered participation in the intervention following completion. …”
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Impact of baseline left ventricular ejection fraction and body mass index on the effect of 24-week Ipragliflozin treatment on left ventricular diastolic function in patients with t... by Hiroki Teragawa, Atsushi Tanaka, Kanae Takahashi, Chikage Oshita, Yuko Uchimura, Nozomu Kamei, Hiroyuki Hirai, Michio Shimabukuro, Isao Taguchi, Yosuke Okada, Koichi Node

“…Several studies have assessed the effects of SGLT2 inhibitors on LV diastolic function, with conflicting results. In this sub-analysis of the Program of Ipragliflozin for Endothelial Dysfunction in Chronic Kidney Disease and Type 2 Diabetes (PROCEED) trial—including patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD)—we examined the effect of ipragliflozin compared with non-SGLT2 inhibitor standard therapy (control) on changes in the maximum early diastolic velocity to average early diastolic peak velocity (E/e’) ratio (an index of LV diastolic function) via echocardiography. …”
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Early assessment of IL8 and PD1+ Treg predicts response and guides treatment monitoring in cemiplimab-treated cutaneous squamous cell carcinoma by Teresa Troiani, Fabiana Napolitano, Luigi Formisano, Roberto Bianco, Daniela Russo, Daniela Esposito, Giuseppe Ercolano, Angela Ianaro, Alberto Servetto, Daniela Claudia Maresca, Marcella Scala, Annarita Amato, Stefania Belli, Claudia Maria Ascione, Angela Vallefuoco, Giovanna Attanasio, Fabio Somma, Silvia Varricchio, Massimo Mascolo, Claudia Costa, Alessia Villani, Massimiliano Scalvenzi, Gianfranco Orlandino

“…Gene Set Enrichment Analysis showed upregulation of interleukin (IL)2/STAT5 pathways and downregulation of Interferon signatures in non-responder patients compared with responders. …”
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Molecular mechanism of DdSOC1 gene regulating flower bud initiation in Diospyros deyangensis by WAN Jianqi, DING Yu, REN Han, LI Wenxia, YANG Yong, HUANG Jinmeng, GUAN Changfei

“…The physicochemical property of the encoded protein was predicted using Expasy ProtParam program. The MEGA7.0 software was used to create the phylogenetic tree. …”
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Development and validation of a novel combinational index of liquid biopsy biomarker for longitudinal lung cancer patient management by Min-Yi Liao, Yun-Jie Hao, Ching-Shan Luo, Ching-Mei Chen, Po-Hao Feng, Hsin-Yu Yang, Da-Jeng Yao, Kang-Yun Lee, Fan-Gang Tseng

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Reduced interhemispheric connectivity in traumatic brachial plexopathies after bionic reconstruction by Galia V Anguelova, Agnes Sturma, Oskar Aszmann, Mehmet S Yildirim, Anna Boesendorfer, Victor Schmidbauer, Karl-Heinz Nenning, Gregor Kasprian

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Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential by Keskin C, Aslan S, Baran MF, Baran A, Eftekhari A, Adıcan MT, Ahmadian E, Arslan S, Mohamed AJ

“…Especially their ability to inhibit the growth of antibiotic-resistant pathogenic bacteria at low concentrations compared to common antibiotics indicates that AO-AgNPs can be used as biomedical agents in various areas. …”
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Human versus Analogue Insulin for Youth with Type 1 Diabetes in Low-Resource Settings (HumAn-1): protocol for a randomised controlled trial by Éimhín Ansbro, Jing Luo, Chung-Chou H Chang, Kaushik Ramaiya, Bruce L Rollman, Sylvia Kehlenbrink, Sae-Rom Chae, Abigail Foulds, Claire Josey, Christina Lalama, Margaret L Prust, Bedowra Zabeen, Graham Ogle

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Building and implementing a level gauge wasted time With teachers and teachers in primary schools by   Muhammad Abdul Karim Taher

“…The current study aimed to measure مستوى هدر الوقت لدى المعلمين والمعلمات في المدارس الأبتدائية ، وقد قام الباحث ببناء مقياس هدر الوقت The level of waste of time among teachers and teachers in primary schools , and the researcher built a measure of wasting time والذي تكون بصيغته النهائية من ( 39 ) فقرة،بعد ان تم أس تخراج صدق وتمييز الفقرات ، وتم اس ت خراج صدق وثبات ال مقياس بأستخدام الوسائل الاحصائية المناسبة،وبعد أن طبق المقياس على عينة التحليل الاحصائي البالغة (400) معلما ومعلمة ، وكذلك طبق الباحث المقياس على عينة التطبيق النهائي البالغة (200) معلما ومعلمة Which will be in its final form (39) paragraph, having been as extraction sincerity and distinction paragraphs were as yet abscess validity and reliability of the scale using appropriate statistical methods, and after the measure was applied to a sample of statistical analysis amounting to (400) teachers, as well as dish researcher The sample on the final application sample of (200) is marked and marked والتي اختيرت بالاسلوب العشوائي الطبقي ،وقد توصلت الدراسة الى ان مقياس هدر الوقت ، يتمتع بخصائص سيكومترية جيدة ،ووجود مستوى عالي من Which was chosen by the method of random class , and the study found that the measure of time wasting , has good Sicometric characteristics, and a high level of هدر الوقت Wasting time لدى عينة البحث I have a research sample , ووجود أثر للجنس في , And the presence of a gender impact قياس Measurement مستوى هدر الوقت ولصالح عينة المعلمات , ووجود اثرا لسنوات الخبرة العلمية في هدرالوقت The level of waste of time and for the benefit of sample parameters , and the presence of years of scientific experience in the waste of time ولصالح الفئة الاولى ، For the first category , وقد أوصت الدراسة ا مكانية استخدام ال مقياس من قبل وزارة التربية ومدراء المدارس الأبتدائية The study recommended the use of the scale by the Ministry of Education and principals of primary schools , واقترحت الدراسة , The study suggested اجراء دراسة مماثلة على مدراء المدارس ومقارنة نتائجه ا مع نتائج الدراسة الحالية A similar study on school principals and comparing its results with the results of the current study ،وبناء برنامج أرشادي تربوي من أجل تبصير المعلمين والمعلمات باهمية الوقت وعدم هدره اثناء الدوام في المدارس الأبتدائية . , And the construction of educational educational program in order to enlighten teachers and teachers on the importance of time and not wasting it during work in elementary schools . …”
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Synthesizing field plot and airborne remote sensing data to enhance national forest inventory mapping in the boreal forest of Interior Alaska by Pratima Khatri-Chhetri, Hans-Erik Andersen, Bruce Cook, Sean M. Hendryx, Liz van Wagtendonk, Van R. Kane

“…The remote sensing data were collected under variable sky conditions (clear to overcast) throughout a 1-month growing-season period, and field data collected by United States Department of Agriculture (USDA) Forest Service, Forest Inventory and Analysis program (FIA). In this framework, we also studied the importance of topographic and remote sensing variables for the classification of forest types. …”
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Effect of integrating paediatric tuberculosis services into child healthcare services on case detection in Africa: the INPUT stepped-wedge cluster-randomised trial by Lise Denoeud-Ndam, Rhoderick Machekano, Anne Cecile Bissek, Rose Masaba, Millicent Ouma, Saint Just Petnga, Martina Casenghi, Appolinaire Tiam, Stephen Siamba, Nicole Herrera, Patrice Tchendjou, Leonie Simo, Boris Kevin Tchounga, Gordon Odhiambo Okomo

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Association of decreased glomerular filtration rate with renal hemodynamic disorders and inflammatory biomarkers in patients with medically-controlled hypertension of high cardiova... by O. A. Koshelskaya, O. A. Zhuravleva, I. V. Kologrivova, N. Yu. Margolis

“…The results of correlation analysis were used to determine the determinants of GFR decline. …”
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Examining the Effects of the Protection Motivation Theory–Based Online Intervention on Improving the Cognitive Behavioral Outcomes of Caregivers of Children With Atopic Diseases: Q... by Dequan Shen, Qinzhun Zhang, Jiayu Tang, Jiahui Wu, Hui Huang, Yuchang Xu, Yinan He, Jialu He, Chengyin Ye

“…All scales demonstrated good reliability and validity. Intention-to-treat analysis was used. ResultsCompared to the control group, the PMT-CBO group demonstrated significant improvements in overall PMT scores (Z=–6.289; P<.001) and most subdimensions (response efficacy, self-efficacy, threat severity, and response cost, with P<.05), except susceptibility (Z=–1.321; P=.19) and reward appraisals (Z=–0.989; P=.32). …”
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Circulating Hsp70: a tumor biomarker for lymph node metastases and early relapse in thoracic cancer by Dominik Lobinger, Nicholas Taylor, Verena Messner, Sophie Seier, Johannes Bodner, Erika Roberts, Ali Bashiri Dezfouli, Alan Graham Pockley, Seyer Safi, Gabriele Multhoff

“…Levels of circulating eHsp70 which are associated with the Programmed cell death protein 1 (PD-L1) status, gradually increased from early stage to metastatic disease, and patients with lymph node metastases in surgically treatable NSCLC had significantly higher eHsp70 levels than nodal negative patients. …”
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The sustainability of health interventions implemented in Africa: an updated systematic review on evidence and future research perspectives by Ucheoma Nwaozuru, Patrick Murphy, Ashley Richard, Chisom Obiezu-Umeh, Thembekile Shato, Ifeoma Obionu, Titilola Gbajabiamila, David Oladele, Stacey Mason, Bryce P. Takenaka, Lateef Akeem Blessing, Alexis Engelhart, Susan Nkengasong, Innocent David Chinaemerem, Onyekachukwu Anikamadu, Ebenezer Adeoti, Pranali Patel, Temitope Ojo, Olufunto Olusanya, Donna Shelley, Collins Airhihenbuwa, Gbenga Ogedegbe, Oliver Ezechi, Juliet Iwelunmor

“…The review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Studies were included if they reported on the sustainability of health interventions implemented in African countries. …”
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Development and validation of the Immune Profile Score (IPS), a novel multiomic algorithmic assay for stratifying outcomes in a real-world cohort of patients with advanced solid ca... by Yan Liu, Matthew Zibelman, Timothy Chan, Justin Guinney, Douglas Adkins, Ezra E W Cohen, Michelle M Stein, Halla Nimeiri, Sandip P Patel, Alia D Zander, Rossin Erbe, Ailin Jin, Sayantoni Mukhopadhyay, Ben Terdich, Mario G Rosasco, Nirali Patel, Chithra Sangli, Timothy Taxter, Seung Won Hyun, Brett M Mahon, A Kate Sasser, Michelle A Ting-Lin, Kyle A Beauchamp

“…IPS was consistently prognostic in programmed death-ligand 1 (PD-L1) (positive/negative), TMB (High/Low), microsatellite status (microsatellite instability (MSI)-High), and regimen (ICI only/ICI+other) subgroups. …”
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Potency of Lacticaseibacillus paracasei as an alternative to antibiotic growth promoter in broiler chicken challenged with avian pathogenic Escherichia coli by Widya Paramita Lokapirnasari, Lilik Maslachah, Amung Logam Saputro, Efi Rokana, Andreas Berny Yulianto, Zulfi Nur Amrina Rosyada, Muhammad Aviv Firdaus, Himatul Ilma Silfia, Ertika Fitri Lisnanti, Zein Ahmad Baihaqi, Tabita Dameria Marbun, Aswin Rafif Khairullah, Muhammad Shakeel

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Providing a Roadmap for the Adaption of Agricultural Sector to Water Scarcity Conditions (Case Study: Selected Crops of Tajan Basin, Iran) by H. Fouladi, H. Amirnejad, S. Shirzadi Laskookalayeh

“…GP is used to perform three types of analysis: Determining the required resources to achieve a desired set of objectives. …”
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Evaluation of mobile health technology combining telemonitoring and teleintervention versus usual care in vulnerable-phase heart failure management (HERMeS): a multicentre, randomi... by Sergi Yun, MD, ProfPhD Josep Comín-Colet, MD, Esther Calero-Molina, RN, Encarnación Hidalgo, RN, Núria José-Bazán, RN, Marta Cobo Marcos, MD, Teresa Soria, RN, Pau Llàcer, PhD, Cristina Fernández, MSc, José Manuel García-Pinilla, PhD, Concepción Cruzado, RN, Álvaro González-Franco, MD, Eva María García-Marina, RN, José Luis Morales-Rull, PhD, Cristina Solé, MD, Elena García-Romero, MD, Julio Núñez, PhD, José Civera, RN, Coral Fernández, RN, Mercedes Faraudo, RN, Pedro Moliner, PhD, Francesc Formiga, PhD, Javier de-Juan Bagudá, MD, Isabel Zegri-Reiriz, PhD, José María Verdú-Rotellar, PhD, Emili Vela, PhD, David Monterde, MSc, Jordi Piera-Jiménez, PhD, Gerard Carot-Sans, PhD, Cristina Enjuanes, PhD, Santiago Jiménez-Marrero, Alberto Garay, Raúl Ramos-Polo, Alexandra Pons-Riverola, Herminio Morillas, Sílvia Jovells-Vaqué, Marta Tajes, Rafael de la Espriella, Elisa Esther Rodríguez, Jessica Paola Rugeles, Maria del Carmen Moreno, Carla Castillo, Ainhoa Robles-Mezcua, Ramon Bascompte, Paola Macarena Beltran Troncoso, Rocío Rodríguez, Román Freixa Pamias, Olga Guri, Cristina Delso Gafarot, Sònia Sarret Vila, Angelique-Casas Thomsen, Jordi Fernández

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