Phytosomal delivery enhances bioactivity of Hylocereus costaricensis phenolic extract by Rosa Direito, Inês Sousa, Filipa Antunes, Sandra Maria Barbalho, Sandra Maria Barbalho, Sandra Maria Barbalho, Sandra Maria Barbalho, Sandra Simões, Sandra Simões, Maria Rosário Bronze, Maria Rosário Bronze, Maria Rosário Bronze, Maria Rosário Bronze, Catarina Reis, Catarina Reis, Maria Manuela Gaspar, Maria Manuela Gaspar, Maria Eduardo Figueira, Maria Eduardo Figueira

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Answering real-world clinical questions using large language model, retrieval-augmented generation, and agentic systems by Yen Sia Low, Michael L Jackson, Rebecca J Hyde, Robert E Brown, Neil M Sanghavi, Julian D Baldwin, C William Pike, Jananee Muralidharan, Gavin Hui, Natasha Alexander, Hadeel Hassan, Rahul V Nene, Morgan Pike, Courtney J Pokrzywa, Shivam Vedak, Adam Paul Yan, Dong-han Yao, Amy R Zipursky, Christina Dinh, Philip Ballentine, Dan C Derieg, Vladimir Polony, Rehan N Chawdry, Jordan Davies, Brigham B Hyde, Nigam H Shah, Saurabh Gombar

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Benzodiazepines interfere with the efficacy of pembrolizumab-based cancer immunotherapy. Results of a nationwide cohort study including over 50,000 participants with advanced lung... by Léa Montégut, Adrien Rousseau, Cinzia Ungolo, Lisa Derosa, Marine Fidelle, Carolina Alves Costa Silva, Bertrand Routy, Laurence Zitvogel, Benjamin Besse, Edoardo Pasolli, Guido Kroemer

“…Here, we report a retrospective analysis of the nation-wide French registry of advanced NSCLC patients treated with pembrolizumab. …”
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Development, validation, and clinical application of a machine learning model for risk stratification and management of cervical cancer screening based on full-genotyping hrHPV tes... by Binhua Dong, Zhen Lu, Tianjie Yang, Junfeng Wang, Yan Zhang, Xunyuan Tuo, Juntao Wang, Shaomei Lin, Hongning Cai, Huan Cheng, Xiaoli Cao, Xinxin Huang, Zheng Zheng, Chong Miao, Yue Wang, Huifeng Xue, Shuxia Xu, Xianhua Liu, Huachun Zou, Pengming Sun

“…Calibration and clinical utility were assessed with brier score, calibration curve and decision curve analysis (DCA). Findings: 1,112,846 women were recruited, of whom 599,043 were included in the analysis based on hrHPV full genotyping. …”
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The contribution of personalized video feedback to robotic partial nephrectomy training in realistic 3D tumor kidney models: design, production and implementation by Ahmet Furkan Sarıkaya, Kayhan Tarım, Ersin Köseoğlu, Arif Özkan, İbrahim Can Aykanat, Baris Esen, Umut Can Karaarslan, Mustafa Müdüroğlu, Şevval Kanlı, Murat Can Kiremit, Yakup Kordan, Mevlana Derya Balbay, Tarık Esen, Serdar Aydın, Serdar Aydın, Abdullah Erdem Canda, Abdullah Erdem Canda

“…Their surgical performance was evaluated based on dissection time, renorrhaphy time, total console time, and the amount of healthy renal parenchyma removed. Statistical analysis was conducted to compare improvements between the groups and assess the impact of video feedback on skill development.ResultsInitial comparisons between junior and senior residents showed no significant differences in their first operations, demonstrating that e-learning and proficiency-based simulation training effectively equalized skill levels before transitioning to realistic 3D model-based training. …”
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Establishment of an animal model of immune‐related adverse events induced by immune checkpoint inhibitors by Yuan Meng, Yingge Lv, Meng Shen, Wenwen Yu, Yumeng Liu, Ting Liu, Gen Liu, Shiya Ma, Zhenzhen Hui, Xiubao Ren, Liang Liu

“…Serum levels of ferritin, IL‐6, TNF‐α, IFN‐γ, and ALT were significantly elevated in the experimental group. Flow cytometry analysis revealed a substantial increase in CD3+T cells, Treg cells, and macrophages in the liver and lung tissues of mice in the experimental group compared with the control group, and the change trend of MDSCs was opposite. …”
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Rapid surge of reassortant A(H1N1) influenza viruses in Danish swine and their zoonotic potential by Pia Ryt-Hansen, Sophie George, Charlotte Kristiane Hjulsager, Ramona Trebbien, Jesper Schak Krog, Marta Maria Ciucani, Sine Nygaard Langerhuus, Jennifer DeBeauchamp, Jeri Carol Crumpton, Taylor Hibler, Richard J. Webby, Lars Erik Larsen

“…The internal gene cassette of Genotype 2 became increasingly dominant, not only in the H1pdm09N1av population, but also in other Danish enzootic swIAV subtypes. Phylogenetic analysis of the HA genes from H1pdm09N1av viruses revealed a monophyletic source, a higher substitution rate compared to other H1N1pdm09 viruses and genetic differences with human seasonal and other swine adapted H1N1pdm09 viruses. …”
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Beyond first-line therapy: efficacy and safety outcomes of continuing immunotherapy in extensive stage small cell lung cancer after PD-L1 inhibitor progression by Jianfeng Peng, Xueying Zhai, Xiaomei Liu, Zhaoqin Huang, Yimeng Wang, Peizhu Wu, Ran Gao, Xiangjiao Meng

“…Methods: A retrospective analysis was conducted on patients with ES-SCLC who experienced disease progression after receiving programmed cell death ligand 1 (PD-L1) inhibitors combined with standard chemotherapy as first-line treatment at three sites in China. …”
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Cancer cell-specific PD-L1 expression is a predictor of poor outcome in patients with locally advanced oral cavity squamous cell carcinoma by Thu Nguyen, Minyu Wang, Sean Macdonald, David Goode, Sevastjan Kranz, Paul Joseph Neeson, Kevin Thia, Joseph A Trapani, Lei Qin, Simone Belobrov, David Wiesenfeld

“…These initial findings were validated through differential gene expression analysis, gene set enrichment, and immune cell deconvolution in a The Cancer Genome Atlas cohort of 163 locally advanced OCSCC tumors. …”
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COPD patients with non-small cell lung cancer respond better to anti-PD-(L)1 immune checkpoint inhibitors by Augustin Boudoussier, Iban Larrouture, Pauline Henrot, Rémi Veillon, Claire Bardel, Camille Chautemps, Charline Caumont, Pierre Schilfarth, Michael Duruisseaux, Maeva Zysman

“…Abstract In studies evaluating the efficacy of anti-programmed cell death 1/ligand 1 immune checkpoint inhibitors (anti-PD-(L)1) among patients with non-small cell lung cancer (NSCLC), smokers tend to have better clinical outcomes than non-smokers. …”
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Acceptability of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine in Papua New Guinea: a qualitative stu... by Elvin Lufele, Sophie Pascoe, Alice Mengi, Alma Auwun, Nalisa Neuendorf, John W. Bolnga, Moses Laman, Stephen J. Rogerson, Kamala Thriemer, Holger W. Unger

“…Health workers and policymakers were concerned that, compared to SP alone, additional tablets, frequency (three-day regimen), and tablet size might be barriers to acceptability for users outside a non-trial setting. …”
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Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial by Mayank Goyal, Bijoy K. Menon, Johanna Ospel, Mohammed Almekhlafi, Charlotte Zerna, Raul Nogueira, Ryan McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian Buck, Kathy Heard, Manish Joshi, Diogo Haussen, Shawna Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Thalia S. Field, Dar Dowlatshahi, Brian van Adel, Richard Swartz, Ruchir Shah, Eric Sauvageau, Volker Puetz, Frank L. Silver, Bruce Campbell, René Chapot, Michael Tymianski, Michael D. Hill, on Behalf of the ESCAPE-NA1 Investigators

“…Results Four hundred forty-six patients were included in the analysis. Clinical outcomes were better in patients randomized to the nerinetide arm (mRS 0–2: 59.4% vs. 49.8%). …”
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Previous treatment decreases efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer by Lei Wang, Yafei You, Wenzhuo He, Yu Hou, Lan Li, Li Wang, Chang Jiang, Jiahong Yi, Yaoxiong Xia, Liangping Xia

“…Furthermore, patients previously treated with anti-programmed death-1 (PD-1) antibody or multikinase inhibitors (MKIs) showed worse median OS compared with those without previous anti-PD-1 antibody (5.0 vs. 22.0 months, P = 0.002) or MKIs (6.2 vs. 28.4 months, P = 0.015). …”
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SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study by Judith Breuer, Catherine F Houlihan, Nick Freemantle, David Partridge, Gaia Nebbia, Jacqui Prieto, Gee Yen Shin, Andrew Copas, Oliver Stirrup, Kenneth Laing, Rachel Williams, Helen Wheeler, Paul Randell, Ana da Silva Filipe, Maria-Teresa Cutino-Moguel, Tommy Rampling, Tabassum Khan, James Price, Eleni Nastouli, Katie Johnson, Sharon Glaysher, Scott Elliott, Helen Umpleby, Emanuela Pelosi, Emma Thomson, Cristina Venturini, Anna Riddell, Alison Cox, Andrew C Hayward, Malin Bergström, David Harrington, Charlotte Williams, Tanzina Haque, Dianne Irish, Adrienn Angyal, Marios Margaritis, Moira Spyer, Florencia Boshier, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Beckett, Themoula Charalampous, Raghavendran Kulasegaran Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Joseph Hughes, Tabitha Mahungu, Cassie Pope, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Adam A Witney, James Blackstone, Leanne Hockey, Georgia Marley, Christine Peters, Flavia Flaviani, Bindi Patel, Tom G S Williams, Rahul Batra, Jonathan D Edgeworth, Pinglawathee Madona, Jennifer Hart, Juanita Pang, Helena Tutill, Nadua Bayzid, Marius Cotic, Luke Green, Benjamin Lindsey, Amy State, Alison Cope, Peijun Zhang, Max Whiteley, Marta Gallis Ramalho, Stella Christou, Stavroula Louka, Hailey Hornsby, Benjamin Foulkes, Paige Wolverson, Joe Heffer, Nikki Smith, Salman Goudarzi, Chris Fearn, Kate Cook, Katie Loveson, Adhyana Mahamana, Buddhini Samaraweera, Siona Silveira, Stephen Aplin, Sarah Jeremiah, Matthew Harvey, Thea Sass, Ngee Keong Tan, Claudia Cardoso Pereira, Dan Frampton, Matt Byott, Judith Heaney, Emilie Sanchez, Stavroula M Paraskevopoulou

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Persistence of Ebola virus in semen among Ebola virus disease survivors in Sierra Leone: A cohort study of frequency, duration, and risk factors. by A E Thorson, G F Deen, K T Bernstein, W J Liu, F Yamba, N Habib, F R Sesay, P Gaillard, T A Massaquoi, S L R McDonald, Y Zhang, K N Durski, S Singaravelu, E Ervin, H Liu, A Coursier, J E Marrinan, A Ariyarajah, M Carino, P Formenty, U Ströher, M Lamunu, G Wu, F Sahr, W Xu, B Knust, N Broutet, Sierra Leone Ebola Virus Persistence Study Group

“…Participants were matched with the Sierra Leone EVD case database to retrieve cycle threshold (Ct) values from the qRT-PCR analysis done in blood during acute disease. A purposive sampling strategy was used, and the included sample composition was compared to the national EVD survivor database to understand deviations from the general male survivor population. …”
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Nivolumab plus low-dose ipilimumab in hypermutated HER2-negative metastatic breast cancer: a phase II trial (NIMBUS) by Romualdo Barroso-Sousa, Jorge Gomez Tejeda Zanudo, Tianyu Li, Sangeetha M. Reddy, Leisha A. Emens, Thomas M. Kuntz, Carolina Alves Costa Silva, Saud H. AlDubayan, Hoyin Chu, Beth Overmoyer, Paulina Lange, Molly K. DiLullo, Meagan Montesion, Julie Kasparian, Melissa E. Hughes, Victoria Attaya, Ameer Basta, Nancy U. Lin, Nabihah Tayob, Rinath Jeselsohn, Elizabeth A. Mittendorf, Sara M. Tolaney

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Intermediate-dose posttransplantation cyclophosphamide for myeloablative HLA-haploidentical bone marrow transplantation by Mustafa A. Hyder, Dimana Dimitrova, Ruby Sabina, Ashley DeVries, Jeannine S. McCune, Meredith J. McAdams, Francis A. Flomerfelt, Christi McKeown, Jennifer L. Sadler, Amy Chai, Thomas E. Hughes, Scott Napier, Anita Stokes, Jennifer Sponaugle, Kamil Rechache, Mark Parta, Jennifer Cuellar-Rodriguez, William D. Figg, Hyoyoung Choo-Wosoba, Seth M. Steinberg, Jennifer A. Kanakry, Christopher G. Kanakry

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Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir by Lorenzo Briganti, Arun S. Annamalai, Stephanie M. Bester, Guochao Wei, Jonathan R. Andino-Moncada, Satya P. Singh, Alex B. Kleinpeter, Meghna Tripathi, Binh Nguyen, Rajalingam Radhakrishnan, Parmit K. Singh, Juliet Greenwood, Lauren I. Schope, Reed Haney, Szu-Wei Huang, Eric O. Freed, Alan N. Engelman, Ashwanth C. Francis, Mamuka Kvaratskhelia

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Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events by Min Li, Geoffrey Liu, Elad Ziv, Rohit Thummalapalli, Adam Schoenfeld, Melinda C Aldrich, Scott Huntsman, Zoe Quandt, Christine M Lovly, Pooja Middha, Karmugi Balaratnam, Eduardo Cardenas, Christina J Falcon, Princess Margaret Lung Group, Matthew A Gubens, Khaleeq Khan, Devalben Patel, Luna Jia Zhan

“…Individuals in the top quintile of PRSAD had 4.8% ICI discontinuation for irAEs by 3 months, compared with 2% discontinuation by 3 months among patients in the bottom quintile (log-rank p=0.03). …”
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The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of Metabolic Syndrome by Hugo Y.-H. Lin, I-Ya Chen, Tzu-Ming Wang, Chia-Hung Yen, Yumay Chen, Yen-Hua Chen, Dao-Fu Dai, Jee-Fu Huang, Yi-Wen Chiu, Ming-Yu Yang

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