Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Objective This study examined real-world treatment patterns and outcomes in patients with melanoma brain metastasis (MBM) treated with first-line immunotherapy consisting of nivolumab plus ipilimumab or anti-programmed death-1 (PD-1) monotherapy (nivolumab or pembrolizumab) or targeted therapy consisting of BRAF/MEK inhibitors.Design Retrospective chart review study.Setting Academic medical centres, community hospitals and private practice offices.Participants Included patients diagnosed with melanoma with brain metastasis in the USA.Outcome measures The statistical analysis was descriptive in nature. …”
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Restoring natural killer cell activity in lung injury with 1,25-hydroxy vitamin D3: a promising therapeutic approach by Johnny Amer, Ahmad Salhab, Mohammad Abuawad

“…Naïve mice treated with DMSO (vehicle) were used as a control.ResultsFlow cytometry analysis displayed a high apoptotic rate in alveolar I/II cells of threefold in ALI mice as compared to naïve mice. …”
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Anti-CTGF/PD-1 bispecific antibody Y126S restrains desmoplastic and immunosuppressive microenvironment in pancreatic cancer by Wei Chen, Hai Huang, Wang Peng, Jingwen Liang, Shiru Chen, Yuchong Zhao, Mengdie Cao, Yilei Yang, Shuya Bai, Qiaodan Zhou, Jiamei Jiang, Yilin Gu, Ronghua Wang, Bin Cheng

“…Notably, Y126S significantly remodeled the TME and demonstrated superior tumor-specific accumulation compared with single α-PD-1 treatment, leading to markedly enhanced antitumor efficacy relative to its parental antibodies or their combination. …”
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The influence of metformin treatment on the circulating proteomeResearch in context by Ben Connolly, Laura McCreight, Roderick C. Slieker, Khaled F. Bedair, Louise Donnelly, Juliette A. de Klerk, Joline W.J. Beulens, Petra J.M. Elders, Göran Bergström, Mun-Gwan Hong, Robert W. Koivula, Paul W. Franks, Jochen M. Schwenk, Anders Gummesson, Ewan R. Pearson, Leen M. ‘t Hart, Moustafa Abdalla, Jonathan Adam, Jerzy Adamski, Kofi Adragni, Rosa Lundbye L. Allesøe, Kristine H. Allin, Anna A. Artati, Manimozhiyan Arumugam, Naeimeh Atabaki Pasdar, Tania Baltauss, Karina Banasik, Anna Barnett, Patrick Baum, Jimmy D. Bell, Susanna Bianzano, Roberto Bizzotto, Amelie Bonnefond, Caroline Anna A. Brorsson, Andrew A. Brown, Søren Brunak, Louise Cabrelli, Robert Caiazzo, Henna Cederberg, Elizaveta Chabanova, Marc Clos-Garcia, Matilda Dale, David Davtian, Adem Y. Dawed, Federico De Masi, Nathalie de Preville, Koen F. Dekkers, Harshal A. Deshmukh, Christiane Dings, Avirup Dutta, Beate Ehrhardt, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Juan Fernandez, Jorge Ferrer, Hugo Fitipaldi, Ian M. Forgie, Annemette Forman, Francesca Frau, Philippe Froguel, Gary Frost, Johann Gassenhuber, Giuseppe (Nick) N. Giordano, Toni Giorgino, Stephen Gough, Harald Grallert, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Gudmundsdóttir, Ramneek Gupta, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Ragna Haussler, Alison J. Heggie, Anita M. Hennige, Anita V. Hill, Reinhard W. Holl, Michelle Hudson, Bernd Jablonka, Ulrik Plesner Jacobsen, Christopher Jennison, Joachim Johansen, Angus G. Jones, Tugce Karaderi, Jane Kaye, Gwen Kennedy, Maria Klintenberg, Robert W. Koivula, Tarja Kokkola, Anitra D. Koopman, Azra Kurbasic, Teemu Kuulasmaa, Markku Laakso, Thorsten Lehr, Heather Loftus, Agnete Troen T. Lundgaard, Liwei Lyu, Anubha Mahajan, Andrea Mari, Gianluca Mazzoni, Mark I. McCarthy, Timothy J. McDonald, Donna McEvoy, Nicky McRobert, Ian McVittie, Miranda Mourby, Petra Musholt, Pascal Mutie, Rachel Nice, Claudia Nicolay, Giel Nijpels, Birgitte Nilsson, Colin N. Palmer, Francois Pattou, Imre Pavo, Helle K. Pedersen, Oluf Pedersen, Mandy H. Perry, Hugo Pomares-Millan, Cornelia P. Prehn, Anna Ramisch, Simon Rasmussen, Violeta Raverdi, Martin Ridderstråle, Neil Robertson, Marianne Rodriquez, Hartmut Ruetten, Femke Rutters, Peter Sackett, Nina Scherer, Nisha Shah, Sapna Sharma, Iryna Sihinevich, Nadja B. Sondertoft, Hans-Henrik Staerfeldt, Birgit Steckel-Hamann, Harriet Teare, Cecilia Engel E. Thomas, Elizabeth Louise L. Thomas, Melissa K. Thomas, Henrik S. Thomsen, Barbara Thorand, Claire E. Thorne, Joachim Tillner, Konstantinos D. Tsirigos, Andrea Tura, Mathias Uhlen, Sabine van Oort, Jagadish Vangipurapu, Helene Verkindt, Henrik Vestergaard, Ana Viñuela, Josef K. Vogt, Peter W. Wad Sackett, Mark Walker, Agata Wesolowska-Andersen, Brandon Whitcher, Margaret W. White, Alexander Efanov, Giuseppe N. Giordano, Gerard A. Bouland, Frédéric Burdet, Iulian Dragan, Andreas Festa, Michael K. Hansen, Dmitry Kuznetsov, Florence Mehl, Diana Marek, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Bernard Thorens, Mark Ibberson, Guy A. Rutter

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Safety and efficacy of neoadjuvant therapy with tislelizumab plus chemotherapy for locally advanced head and neck squamous cell carcinoma: a single-arm, retrospective study by Haifeng Liang, Wenting Liang, Jiawang Tian, Shibei Zheng, Yangzhou Su, Piao Huang, Renhui Chen, Zhong Guan, Qian Cai

“…Inhibitors targeting the programmed death 1 (PD-1) pathway have gained widespread clinical adoption. …”
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Improved Access to Behavioral Health Care for Patients in a Large New York City Behavioral Health Clinic by the Transition to Telemedicine by Aaron Reliford, Emily Zhang, Anni Liu, Olga Lanina, Sharifa Z. Williams, Navin Sanichar, Shabana Khan, Isaac Dapkins, William Gordon Frankle

“…Objective: To examine the transition to telemental health within the behavioral health program of a large federally qualified health center, The Family Health Centers at NYU Langone, in the 3 months following the onset of the COVID-19 pandemic—specifically impacts on show rates and access to care. …”
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Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses... by Brian Rini, Mariangela Mariani, Alessandra di Pietro, Paul Nathan, Christian Kollmannsberger, Marc-Oliver Grimm, Martin H Voss, Bradley A McGregor, Mehmet A Bilen, Yoshihiko Tomita, Bo Huang, Robert Amezquita, Matthew Tucker, Yu-Wei Chen

“…Objective We report post hoc analyses of efficacy with first-line avelumab plus axitinib or sunitinib according to baseline neutrophil-to-eosinophil ratio (NER) in patients with advanced renal cell carcinoma (aRCC) from the JAVELIN Renal 101 phase 3 trial.Methods and analysis Progression-free survival (PFS), overall survival (OS) and objective response per baseline NER were analysed in the overall population and in patients with programmed death ligand 1 (PD-L1+) tumours. …”
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Proteogenomic characterization of invasive breast tumors in young women by Praveen-Kumar Raj-Kumar, Jianfang Liu, Anthony R. Soltis, Nicholas W. Bateman, Qingrong Chen, Lori A. Sturtz, Brenda Deyarmin, Mariaelena Pierobon, Tamara A. Abulez, Anupama Praveen-Kumar, Xijun Zhang, Trinh Nguyen, Chunhua Yan, Ying Hu, Kate Guion, Jeffrey A. Hooke, Albert J. Kovatich, Leigh Fantacone-Campbell, Brad Mostoller, Leonid Kvecher, Stella Somiari, Patricia S. Steeg, Padma Sheila Rajagopal, Kathleen M. Darcy, Jerry S. H. Lee, Clifton L. Dalgard, Thomas P. Conrads, Emanuel F. Petricoin, Daoud Meerzaman, Matthew D. Wilkerson, APOLLO Research Network, Xiaoying Lin, Craig D. Shriver, Stanley Lipkowitz, Hai Hu

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The origin of modern North Africans as depicted by a massive survey of mitogenomes by Giulia Colombo, Elisabetta Moroni, Alessandro Raveane, Nicola Rambaldi Migliore, Vincenzo Agostini, Rosalinda Di Gerlando, Claudio Fiorini, Leonardo Caporali, Francesca Gandini, Elena Raimondi, Eugenia D’Atanasio, Hovirag Lancioni, Valerio Carelli, Maria Pala, Beniamino Trombetta, Andrea Novelletto, Jean-Michel Dugoujon, Alessandro Achilli, Antonio Torroni, Martin B. Richards, Fulvio Cruciani, Ornella Semino, Anna Olivieri

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Renoprotective Effects of Hydroxychloroquine and Folinic Acid via ET-1 and NLRP3 Modulation in Reducing Tubular Injury in A Rabbit Model of Methanol-induced Acute Kidney Injury by Prayuda Prayuda, I Gde Raka Widiana, Ketut Suega, Yenny Kandarini, Ni Wayan Winarti, Bambang Purwanto

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Distinct characteristics of BTLA/HVEM axis expression on Tregs and its impact on the expansion and attributes of Tregs in patients with active pulmonary tuberculosis by Peijun Tang, Peijun Tang, Xinghua Shen, Jianling Gao, Jianping Zhang, Yanjun Feng, Ji Zhang, Ziyi Huang, Ziyi Huang, Ziyi Huang, Xuefeng Wang

“…Furthermore, the expression of conventional T cells and of programmed death-ligand 1 (PD-L1) and programmed death-1 (PD-1) on Tregs in patients with active PTB was determined. …”
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Impact of dietary polyphenols from shredded, steam-exploded pine on growth performance, organ indices, meat quality, and cecal microbiota of broiler chickens by Chris Major Ncho, Vaishali Gupta, Akshat Goel, Chae-Mi Jeong, Ji-Young Jung, Si-Young Ha, Jeong-Uk Eom, Han-Sul Yang, Jae-Kyung Yang, Yang-Ho Choi

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The examination of physical function and cognitive outcomes in middle-to-older high-risk adults: an unsupervised clustering method by Joshua L. Gills, Joshua L. Gills, Megan D. Jones, Anthony Campitelli, Anthony Campitelli, Sally Paulson, Sally Paulson, Cody Diehl, Charles Rodgers, Charles Rodgers, Erica Madero, Jennifer R. Myers, Kelsey Bryk, Omonigho Michael Bubu, Omonigho Michael Bubu, Omonigho Michael Bubu, Jordan M. Glenn, Michelle Gray

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Characterization and simulation of AlGaN barrier structure effects in normally-off recessed gate AlGaN/GaN MISHEMTs by An-Chen Liu, Hsin-Chu Chen, Po-Tsung Tu, Yan-Lin Chen, Yan-Chieh Chen, Po-Chun Yeh, Chih-I Wu, Shu-Tong Chang, Tsung-Sheng Kao, Hao-Chung Kuo

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Post-treatment duration of positivity for standard and ultra-sensitive Plasmodium falciparum antigen-based rapid diagnostic tests, a cohort study from a low-endemic setting in Nami... by Henry Ntuku, Brooke Whittemore, Lucille Dausab, Ihn Kyung Jang, Allison Golden, William Sheahan, Xue Wu, Hannah Slater, Gonzalo J. Domingo, Smita Das, Elias Duarte, Lydia Eloff, Teun Bousema, Kjerstin Lanke, Cara Smith Gueye, Lisa M. Prach, Jaishree Raman, Petrina Uusiku, Stark Katokele, Roly Gosling, Bryan Greenhouse, Davis Mumbengegwi, Michelle S. Hsiang

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Allopurinol as cardioprotective agent in chronic coronary syndrome: In silico evaluation of its potential as Keap1/Nrf2 modulator by Kannan O. Ahmed, Mohammed A. Almogaddam, Hagar M. Mohamed, Bayan E. Ainousah, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Nawal A. Alharbi, Toga K. Mohamed, Bashir A. Yousef, Khalid Al Balushi, Abdulrahim A. Alzain

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Detection and molecular characterization of lumpy skin disease and bovine papular stomatitis viruses in lumpy skin disease-suspected outbreaks in Tanzania by Fredy T. Makoga, Jelly S. Chang’a, Irene K. Meki, Charles Mayenga, Tirumala B. K. Settypalli, Stella Bitanyi, Bishop Magidanga, Emma Peter, Augustino Chengula, Giovanni Cattoli, Charles E. Lamien

“…Furthermore, the single nucleotide polymorphism (SNP) at position 240 (A-> G) of the EEV gene differentiates the Tanzanian LSDVs from the group of ancient Kenyan LSDV isolates while the B22R sequences of the Tanzanian LSDV isolates differed from the LSDV Neethling and LSDV KSGP-0240 derived vaccines. Sequence analysis of the partial B2L gene of the Tanzanian parapoxvirus bovinestomatitis, formerly known as Bovine papular stomatitis virus (BPSV) showed a different BPSV strain circulating compared to publicly available sequences. …”
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Pretreatment and on-treatment ctDNA and tissue biomarkers predict recurrence in patients with stage IIIB–D/IV melanoma treated with adjuvant immunotherapy: CheckMate 915 by James Larkin, Jeffrey Weber, Georgina V Long, Jonathan Baden, Hao Tang, Corey Ritchings, Michele Del Vecchio, Keyur Desai, Daniel Tenney, Han Chang, Gina Fusaro, David Balli, Sonia Dolfi, Sheen Wang, Shu-Pang Huang

“…Purpose CheckMate 915 (NCT03068455) compared adjuvant nivolumab monotherapy versus combination nivolumab+ipilimumab in patients with resected stage III/IV melanoma. …”
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The impact of the SKILLZ intervention on sexual and reproductive health empowerment among Zambian adolescent girls and young women: results of a cluster randomized controlled trial by Lila A. Sheira, Chama Mulubwa, Calvin Chiu, Jenala Chipungu, Chelsea Coakley, Helene Smith, Ushma D. Upadhyay, Chansa Chilambe, Besa Chibwe, Jake M. Pry, Boyd Mkandawire, Maggie Musonda, Carolyn Bolton Moore, Jenny Liu

“…We conducted a difference-in-differences analysis to evaluate intervention impact over time. …”
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The latency time of SARS-CoV- 2 Delta variant in infection- and vaccine-naive individuals from Vietnam by Vera H. Arntzen, Manh Nguyen Duc, Marta Fiocco, Lan Truong Thi Thanh, Tam Nguyen Hoai Thao, Buu Mai Thanh, Tu-Anh Nguyen, Nhat Le Thanh Hoang, Marc Choisy, Lam Phung Khanh, Nga Le Hong, Ronald B. Geskus

“…Employing a Bayesian approach, using the program JAGS, made the analyses relatively straightforward. …”
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