Polyamines at the crossroad between cell metabolism and epigenetic regulation in acute leukemias by Francesca Pirini, Anna Ferrari, Mouna Jandoubi, Irene Azzali, Davide Angeli, Rossana Mondrone, Chiara Bracci, Francesca Ruggieri, Giovanni Martinelli, Giorgia Simonetti

“…Notably, the polyamine catabolic enzyme spermidine/spermine N1 acetyltransferase (SAT1) that is overexpressed in AML and associated with a myeloproliferative phenotype, is a tumor suppressor gene in ALL, suggesting diverse mechanisms of action across hematological malignancies according to the lineage commitment and the differentiation stage. In light of the promising results achieved in AML and ALL by selective targeting of protein arginine methyltransferase 5 (PRMT5) and methionine adenosyltransferase 2A (MAT2A), two enzymes at the crossroad between polyamine metabolism and protein methylation, in this review we examine and discuss the role of polyamines in epigenetic regulation and other biological processes supporting leukemic cell survival, proliferation and differentiation, which provides the opportunity to discover additional polyamine-related targets and design novel therapeutic combinations.…”
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Qualitative evaluation of the feasibility of a national whole-school program for reducing school violence and improving school climate in Chile by Verónica López, Claudia Carrasco-Aguilar, Pamela Jervis, Javier Torres-Vallejos, María Teresa Ramírez, Juan Pablo Álvarez González, Amanda Franulic

“…The results show a positive acceptance of the program, with high adherence and commitment from the schools. The most highly valued aspects of the program were the conceptual model based on a whole-school approach, the possibility of working with universities in their territories, and school climate networks that were viewed as professional learning communities. …”
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Applying a participatory system dynamics approach to childhood overweight and obesity in the local context: reflections from the LIKE project by Angie Luna Pinzon, Karien Stronks, Arnoud Verhoeff, David Vaandrager, Karen den Hertog, Wilma Waterlander

“…Instead, ensure sufficient attention is given to comprehending the dynamics of the local context, including existing initiatives and policy processes; (2) theory: dynamic and adaptive character; lesson: while the ability to encompass real-world dynamics is a foundational strength of system dynamics theory, its practical application can be constrained by more static elements, such as budget planning, and the need for clearly defined roles and responsibilities; and (3) theory: strong governance; lesson: SD projects require strong governance including strategic planning and enduring commitment, but in the absence of clear milestones or measurable impact on the short term. …”
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A narrative review of veterinary pharmacovigilance situations and prospects in East African countries by Yesuneh Tefera Mekasha, Sete Nigussie, Abibo Wondie Mekonen, Kassahun Berrie, Asnakew Mulaw, Melaku Getahun Feleke

“…Tanzania, Kenya, and Ethiopia have some institutional processes for veterinary pharmaceutical safety, but they lack thorough documentation, which suggests that this systems still require improvement. …”
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Sehat Card Plus in Khyber Pakhtunkhwa: Confronting challenges, strengthening governance, ensuring financial sustainability by Sameen Siddiqi, Shifa Salman Habib, Waqas Hameed, Asma Altaf Hussain Merchant, Junaid Ur Rehman Siddiqui, Kiran Sohail Azeemi, Adil Haider, Soonman Kwon, Viroj Tangcharoensathien

“…Results: Six thematic areas were identified: (i) Governance: Strong legislative commitment through the UHC Bill 2022, but with limited citizen representation in decision-making bodies; (ii) Organizational arrangements: Limited staff and dependence on SLIC limit monitoring and strategic management; (iii) Financing: Unplanned expansion challenges financial sustainability in economic crisis, as SCP is fully funded by provincial revenues; (iv) Service purchasing: State Life Insurance Corporation (SLIC) manages hospital empanellment and claims processing, though lack of involvement of health authorities; (v) Monitoring & evaluation: Independent monitoring systems are needed for transparency and quality assurance (vi) Communication and User Satisfaction : Beneficiary engagement and feedback mechanisms in SCP need improvement. …”
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An analytical framework for strategic alliance formation between a cooperative bank and a fintech start-up: An Italian case study by Francesca Bartolacci, Andrea Cardoni, Piotr Łasak, Wojciech Sadkowski

“…PURPOSE: The paper aims to identify the characteristics of the entities involved, the motivations and the processes of forming strategic alliances between a small cooperative bank and a fintech start-up. …”
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Development and implementation of a digital clinical decision support system to increase the quality of primary healthcare delivery in a refugee setting in Chad by B. Matthys, N. Monnier, M. Ngaradoumadji, Y. Toubangue, P. Delcroix, M. Pereira, T. Schmitz, J. Armour-Marshall, M. Zahorka, K. Sugimoto, M. Léchenne, D. Revault, K. Wyss, A. Montolnan

“…From the outset, the active involvement of a diverse group of local, national, and international technical stakeholders (clinicians, information and communication technology (ICT) specialists, health workers, and district health authorities) facilitated mutual knowledge sharing and product co-creation processes. The CDSS was adapted to the local context, which enhanced local ownership. …”
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Jawbone mesenchymal stromal cells attenuate acute inflammation via hematopoietic niche reinforcement by Xinyu Wang, Qianye Chen, Jiping Sun, Zihan Huang, Zijian Zhang, Tingwei Lu, Xiangru Huang, Siyuan Sun, Yuanqi Liu, Houwen Pan, Li Mei, Paul R. Cooper, Qinggang Dai, Lei Shen, Lingyong Jiang

“…The findings demonstrate that jawbone MSCs not only exhibit robust multilineage differentiation potential but also secrete CXCL12 and activate key B cell transcription factors (such as PAX5). This process significantly promotes HSC differentiation into B cells, improves survival rates in infected mice, and attenuates systemic inflammation. …”
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PSYCHOLOGICAL INVOLVEMENT AS A BASIS FOR STIMULATING THE ACTIVITY OF STUDENTS OF DEPARTMENTAL UNIVERSITIES by Natalia E. Serebrovskaya, Maria P. Shcherbakova, Darya M. Gnezdilova

“…Psychological engagement becomes the key-factor defining the success of tuition, adaptation to learning process and further professional activity in the ranks. …”
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Collaborative Governance dalam Kesiapsiagaan Bencana Gunung Sinabung di Kabupaten Karo Provinsi Sumatera Utara by Evi Yunita Kurniaty, Khasan Effendy, Megandaru W. Kawuryan, Layla Kurniawati

“…This study concludes the collaborative process of the Runggu of the Karo District Government on disaster management and the Runggu tradition in the village. …”
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La «transición a la democracia» en la Argentina frente a las cristalizaciones de la memoria by Marina Franco

“…Our approach is centered upon the problem of violation of human rights commited by the Armed Forces in order to analyze the process which lead to the sentences of those responsible.…”
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To Be or Not to Be? 教職召喚與專業認同對藝術大學師資生生涯決策自我效能、結果期待及生涯希望感的調節效果分析 To Be or Not to Be? An Analysis of the Moderating Effects of Teaching Calling and Professional Identity on Career De... by 陳嘉成 Chia-Cheng Chen, 洪兆祥 Chao-Hsiang Hung, 鄧鈞文 Chun-Wen Teng, 劉孟芳 Meng-Fang Liu

“…The moderation effects of professional identity and teaching calling were tested using the PROCESS macro for SPSS, with bootstrap methods applied to validate the significance of indirect effects. …”
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The Multi-Track Mind: How Video Essays Can Reinvigorate Creativity, Self-Expression, and Integrity in the Age of AI by Zach Udko

“…The final video essay allows students to highlight the individual nature of spectatorship and to commit to the ongoing and evolving process of situated thinking. …”
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New Constitutional Amendments in the Field of Judiciary inSerbia – A Step Towards Europe? by Dabetić, Valerija

“…This paper analyzes the adoption process of the constitutional amendments in Serbia in the context ofthe fulfillment of the European political criteria, namely – the Rule of Law. …”
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Identifying the factors affecting the growth of the employees of the country's property and documents registration organization by Najmeh Ahmadi, Kolsoum Nami, Nader Ghourchian, Parivash Jafari

“…Individual growth includes scientific background, responsibility, and professional commitment; and organizational growth includes livelihood, management, codified and comprehensive educational program, motivational programs, career evaluation and promotion system, improvement and modernization of human resources and work environment, comprehensive program of updating and improvement of work processes, and mental health of the work environment. …”
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Representation of the perception of effective factors on the implementation of Eric Cheng's knowledge management model in secondary schools of West Azarbaijan province by parivash mohammadi gheshlagh

“…Meanwhile, Knowledge leadership plays an essential role; because leaders should promote the value of knowledge in the organization, create motivation and commitment to share knowledge and encourage people towards knowledge management processes. …”
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Implementation gaps in food safety interventions: evidence from a multi-vocal review focusing on animal-source foods in Ethiopia by Meseret Bekele, Meseret Bekele, Delia Grace, Delia Grace, Theodore J. D. Knight-Jones, Florence Mutua, Johanna F. Lindahl, Johanna F. Lindahl, Johanna F. Lindahl, Meena Daivadanam

“…We identified several positive aspects that could contribute to the success of interventions, including renewed government commitment, financial support from development partners, and the presence of regional legal frameworks. …”
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Sustainable forest management: success and challenges in Ethiopia by Rusha Begna Wakweya

“…The outcomes of local-level forest governance depend on the quality, efficiency, and effectiveness of local policymaking and decision-making processes, as well as how power and authority are exercised locally. …”
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A review of recent progress in the design and integration of domestic heat pumps by Andreas V. Olympios, Paul Sapin, Matthias Mersch, Abdullah M. Maghrabi, Christos N. Markides

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The Impact of Brexit on Central and Eastern European Security by Valentin Naumescu, Agnes Nicolescu

“…This article examines the impact of the Brexit process on security policy and related political discourse in Central and Eastern Europe. …”
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