SNORA13 antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma by Yanzhi Wang, Huihui An, Yaou Zhang, Yaou Zhang, Qing Rex Lyu, Zhe Zhang

“…IndroductionColorectal cancer (CRC) is a prevalent malignancy and is the second leading cause of cancer-related mortality worldwide. 5-Fluorouracil (5-FU) is widely used in clinical intervention, however, drug resistance to 5-FU poses a significant challenge to treatment efficacy. …”
Get full text

The delaying effect of toripalimab on disease progression in patients with advanced hepatocellular carcinoma and changes in serum tumor markers by Zhuo Yin, Yaomin Xiao, Jiangxue Gu, Pei Hu, Jiandu Jing, Xia Wang, Yao Liu, Shirong Yan

“…Further prospective trials are needed to validate these findings and optimize combinatorial strategies.…”
Get full text

Development and Characterization of CD44-Targeted X-Aptamers with Enhanced Binding Affinity for Cancer Therapeutics by Hongyu Wang, Weiguo He, Miguel-Angel Elizondo-Riojas, Xiaobo Zhou, Tae Jin Lee, David G. Gorenstein

Get full text

In Vivo Evaluation of the Anti-Skin-Ageing Bioactivity of a Recombinant Dual Humanised Collagen and Poly-L-Lactic Acid by Mingjie Tong, Xin Zhou, Jiongni Zhong, Dengjian Qu, Wei Chen, Chun Chen, Yiting Wang, Yaoping Liu, Shaochuan Li, Yuan Xiao, Ning Wang, Chaowan Guo, Qiuling Xie, Sheng Xiong

“…In a D-galactose-induced ageing rat model, subcutaneous implantation of DuCol showcased time-dependent anti-ageing effects. Early-stage intervention (30 days post-injection) markedly upregulated COL1A1 expression through the TGF-β/Smad3 pathway activation, outperforming poly-<span style="font-variant: small-caps;">l</span>-lactic acid (PLLA) in collagen deposition. …”
Get full text

Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing by Jie Yang, Qingyu Han, Liping Li, Ruiping Zhang

“…Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. …”
Get full text

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy by Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li

“…Overall, this study unveils a feasible GRP78 nanobody‐directed therapy strategy for single or combinatorial cancer intervention. This work finds that C5‐PE38‐induced cell death stimulates STING‐dependent cytosolic DNA release to promote antitumor immunity, a mechanism not previously reported for PE38, providing valuable insights for its clinical use.…”
Get full text

Brain Neurotrophins and Plant Polyphenols: A Powerful Connection by Marco Fiore, Sergio Terracina, Giampiero Ferraguti

“…Lastly, future research directions are recommended, focusing on polyphenol bioavailability optimization, considering combinatory dietary stratagems, and proposing personalized nutritional interventions. …”
Get full text

Low Carotid Mean Flow Velocity: A Noninvasive Marker for Coronary Heart Disease—A Community-Based Study by Li-Chih Wu, Chao-Liang Chou, Shu-Hao Wu, Tzu-Wei Wu, Wei-Ren Lan, Chun-Fang Cheng, Shu-Xin Lu, Yih-Jer Wu, Li-Yu Wang

“…Of these, 165 individuals with physician-confirmed myocardial infarction or prior coronary intervention/surgery were classified as CHD cases; the remaining 3892 served as controls. …”
Get full text

IN-PATIENT OUTCOMES OF PHARMACOINVASIVE REPERFUSION STRATEGY FOR ST ELEVATION MYOCARDIAL INFARCTION by A. V. Khripun, M. V. Malevanny, Ya. V. Kulikovskikh, A. A. Kastanyan

“…The analysis performed, of 587 STEMI patients, who were referred to Regional Vascular Center “ROKB” of Rostov-na-Donu city from hospitals of the city and neighborhoods since January 2010 till June 2015, with the aim to undergo percutaneous coronary intervention (PCI) after thrombolytic therapy (TT) as PCS reperfusion strategy. …”
Get full text