Pericytes in castration-resistant prostate cancer associated with disease progression and immunotherapy response: insights from single-cell analysis by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Shigeo Horie, Zhitong Bing, Qi Hou

“…Notably, combinatorial application of PDGFR inhibitor and anti-PD-1 therapy elicited substantial synergistic antitumor effects in murine PCa models. …”
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Breaking down physical barriers: strategies to improve lymphocyte infiltration for effective neoantigen-based therapies by Ting-Ting Chen, Xiong Li, Yi Zhang, Xiao-Juan Kang, Shu-Fang Zhang, Tong Zhang, Deji Sangmao, Ya-Juan Zhu, De-Kui Zhang

“…Future efforts should integrate biomechanical interventions with immunotherapy, elucidate the interplay between mechanical signaling and immunometabolism, and optimize multi-target combinatorial approaches to enhance the clinical translation potential of neoantigen therapies.…”
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Insights into the Molecular Mechanisms and Novel Therapeutic Strategies of Stenosis Fibrosis in Crohn’s Disease by Yuan Zhou, Huiping Chen, Qinbo Wang, Guozeng Ye, Yingjuan Ou, Lihong Huang, Xia Wu, Jiaxi Fei

“…Despite the current pharmacological, endoscopic, and surgical interventions for fibrostenotic CD, their palliative nature and inability to reverse fibrosis highlight an unmet need for disease-modifying therapies. …”
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Unravelling Convergent Signaling Mechanisms Underlying the Aging-Disease Nexus Using Computational Language Analysis by Marina Junyent, Haki Noori, Robin De Schepper, Shanna Frajdenberg, Razan Khalid Abdullah Hussen Elsaigh, Patricia H. McDonald, Derek Duckett, Stuart Maudsley

“…Here, using the input of artificial intelligence systems to generate unbiased disease and aging mechanism profiles, we have aimed to identify key signaling mechanisms that may represent new disease-preventing signaling pathways that are ideal for the creation of disease-preventing chemical interventions. Using a combinatorial informatics approach, we have identified a potential critical mechanism involving the recently identified kinase, Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3) and the epidermal growth factor receptor (EGFR) that may function as a regulator of the pathological transition of health into disease via the control of cellular fate in response to stressful insults.…”
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Natural Killer Cell and Extracellular Vesicle-Based Immunotherapy in Thyroid Cancer: Advances, Challenges, and Future Perspectives by Kruthika Prakash, Ramya Lakshmi Rajendran, Sanjana Dhayalan, Prakash Gangadaran, Byeong-Cheol Ahn, Kandasamy Nagarajan Aruljothi

“…We further discuss latest advancements in NK cell-based immunotherapies, including strategies for ex vivo expansion, genetic modification, and combinatorial approaches with checkpoint inhibitors or cytokines. …”
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Immune factors and their role in tumor aggressiveness in glioblastoma: Atypical cadherin FAT1 as a promising target for combating immune evasion by Manvi Arora, Archismita Kundu, Subrata Sinha, Kunzang Chosdol

“…In addition, this review highlights currently available immunotherapies in clinical use or undergoing trials, and the potential of FAT1 as a promising target for combinatorial therapeutic interventions. Graphical Abstract…”
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Receptor-Based Strategies for Overcoming Resistance in Cancer Therapy by Naresh Sah, Abdul Althaf Shaik, Ganesh Acharya, Manikantha Dunna, Ashok Silwal, Sejal Sharma, Sabiha Khan, Sounak Bagchi

“…We also explore how other receptor tyrosine kinases can initially suppress tumor growth, yet often lead to resistance, underscoring the need for novel combinatorial approaches that incorporate advanced receptor modulation techniques. …”
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Anti-HBV treatment partially restores the dysfunction of innate immune cells and unconventional T cells during chronic HBV infection by Yiwen Shu, Yiwen Shu, Sumeng Li, Sumeng Li, Yanqin Du, Yanqin Du, Xin Zheng, Xin Zheng

“…Given that viral clearance fundamentally requires reconstitution of antiviral immunity, emerging therapeutic paradigms necessitate combinatorial strategies integrating direct-acting antiviral agents with immunomodulatory interventions. …”
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In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy by Maedeh Radandish, Niloofar Mashhadi, Amir Hossein Aghayan, Motahareh Taghizadeh, Sara Salehianfard, Sheida Yahyazadeh, Omid Vakili, Somayeh Igder

“…Additionally, the identification of robust biomarkers reflective of TLS functional states and the rigorous validation of stromal-targeted therapies within combinatorial treatment frameworks are imperative for advancing translational applications. …”
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Super-enhancers in immune system regulation: mechanisms, pathological reprogramming, and therapeutic opportunities by Xin Lai, Caizhi Li, Xinglinzi Tang, Xinyi Luo, Feiyan Wu, Yuhong Liang, Bihui Huang, Hang Li, Hang Li

“…Future advances in multi-omics profiling, single-cell resolution analyses, and combinatorial therapeutic strategies will be critical for translating SE biology into precision interventions that restore immune equilibrium in dysregulated conditions.…”
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Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond by Lin Jiao, Yanjun Si, Yushan Yuan, Xinxing Lei, Qian Jiang, Lijun Yang, Wenhao Mao, Binwu Ying, Liwei Ma, Ting Sun

“…By integrating molecular insights and clinical relevance, this work underscores NAT10 as a pivotal regulator of disease mechanisms and a potential target for future therapeutic interventions. Future research should address context-dependent roles, refine ac4C detection methods, and explore combinatorial therapies to overcome resistance mechanisms.…”
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Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics by Tiejun Feng, Fuda Xie, Leo M.Y. Lee, Zhiqiang Lin, Yifan Tu, Yang Lyu, Peiyao Yu, Jialin Wu, Bonan Chen, Ge Zhang, Gary M.K. Tse, Ka Fai To, Wei Kang

“…We highlight groundbreaking therapeutic innovations, including precision senolytics, senomorphics, and combinatorial strategies integrating immunotherapy, metabolic interventions, and epigenetic modulators. …”
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Modeling dynamic scenarios for safety, reliability, availability, and maintainability analysis by Cesar Augusto Gabe, Luciano Ondir Freire, Delvonei Alves de Andrade

“…Safety analysis uses probability combinatorial models like fault tree and/or event tree. …”
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Virtual reality navigation for the early detection of Alzheimer’s disease by Sayuri Shima, Reiko Ohdake, Yasuaki Mizutani, Harutsugu Tatebe, Riki Koike, Atsushi Kasai, Epifanio Bagarinao, Epifanio Bagarinao, Kazuya Kawabata, Kazuya Kawabata, Akihiro Ueda, Mizuki Ito, Junichi Hata, Shinsuke Ishigaki, Junichiro Yoshimoto, Hiroshi Toyama, Takahiko Tokuda, Akihiko Takashima, Hirohisa Watanabe, Hirohisa Watanabe

“…The hierarchical application of 3D VR PI and plasma p-tau181, in particular, may be an effective combinatorial biomarker for early AD neurodegeneration. …”
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Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain–muscle–liver axis to slow down aging and neurodegeneration: a narrative review by Jianda Kong, Yingao Xie, Rao Fan, Qinglu Wang, Ying Luo, Panpan Dong

“…Our synthesis highlights exercise as a pleiotropic intervention that transcends single-organ influences, instead leveraging multi-tissue networks to delay aging and neurodegeneration. …”
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PHF20L1: An Epigenetic Regulator in Cancer and Beyond by Yishan Wang, Qin Hu, Haixia Zhao, Lulu Zeng, Zhongwei Zhao, Xia Li, Qiaoyou Weng, Yang Yang, Minjiang Chen, Jiansong Ji, Rongfang Qiu

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Plant Compounds Inhibit the Growth of W12 Cervical Precancer Cells Containing Episomal or Integrant HPV DNA; Tanshinone IIA Synergizes with Curcumin in Cervical Cancer Cells by Linda Saxe Einbond, Jing Zhou, Kunhui Huang, Mario R. Castellanos, Emeka Mbazor, Michael Balick, Hongbao Ma, James A. DeVoti, Stephen Redenti, Hsan-au Wu

“…Our findings highlight the potential of these multifaceted phytochemicals to prevent and treat HPV-induced cervical cancer, offering a promising approach for combinatorial therapeutic intervention.…”
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Impact of Microparticle Transarterial Chemoembolization (mTACE) on myeloid‐derived suppressor cell subtypes in hepatocellular carcinoma: Clinical correlations and therapeutic impli... by Yuanxun Yue, Zhizhong Ren, Yaqin Wang, Ying Liu, Xiaowei Yang, Tianxiao Wang, Yating Bai, He Zhou, Qian Chen, Sujun Li, Yuewei Zhang

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Inhibition of Prostate Cancer Cells by 4,5-Dicaffeoylquinic Acid through Cell Cycle Arrest by Olivia Lodise, Ketki Patil, Igor Karshenboym, Scott Prombo, Chidinma Chukwueke, S. Balakrishna Pai

“…Even though current therapeutic management has contributed to reducing mortality, additional intervention strategies are warranted to further improve the outcomes. …”
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Leveraging flexible pipette-based tool changes to transform liquid handling systems into dual-function sample preparation and imaging platforms by Mohammad Nazeri, Jeffrey Watchorn, Sheldon Mei, Alex Zhang, Christine Allen, Frank Gu

“…This system enables real-time monitoring and characterization of dynamic processes, such as hydrogel crosslinking, without manual intervention. We used this system to characterize ionically crosslinked hydrogels, and monitored their properties over time, in a high-throughput and combinatorial manner. …”
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