Combinatorial targeting of NMDARs and 5-HT4Rs exerts beneficial effects in a mouse model of Alzheimer’s disease by Briana K. Chen, Holly C. Hunsberger, Alicia Whye, Louise C. Matthews, Alyson Yook, Moshe J. Willner, Ryan W. Logan, Stefanie Johns, Eric Weisblum, Christine A. Denny

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A novel combinatorial approach integrating experimental and computational analysis of antioxidant activity: Evaluating catechin and L-ascorbic acid in serum. by Ayeshum Rasool, Chinanu Chidi, Sophie Rigaut, Symone Carty, Chirine Soubra-Ghaoui, Richa Chandra

“…The computational results align with the experimental finding offering a unique combinatorial approach to assess antioxidant activity in both normal and hypertriglyceridemic serum, with potential implications for clinical interventions.…”
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Combinatorial phenethyl isothiocyanate and withaferin A targets multiple epigenetics pathways to inhibit MCF-7 and MDA-MB-231 human breast cancer cells by Mohammad Mijanur Rahman, Trygve O. Tollefsbol

“…Abstract Background Epigenetic phytochemicals are considered as an efficacious and safe alternative to synthetic drugs in drug discovery. In this regard, combinatorial interventions enable simultaneously targeting various neoplastic pathways to eradicate multiple tumorigenic clones. …”
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Biofilms and multidrug resistance: an emerging crisis and the need for multidisciplinary interventions by Mohd Fakharul Zaman Raja Yahya, Mohd Fakharul Zaman Raja Yahya, Mohd Taufiq Mat Jalil, Norashirene Mohamad Jamil, Nurul Hidayah Mohamad Nor, Nasser Alhajj, Rikson Siburian, Nazia Abdul Majid

“…While emerging natural and synthetic antimicrobial agents offer potential avenues for intervention, their effectiveness is often limited by issues such as poor bioavailability, toxicity, and production scalability. …”
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Dual-species proteomics and targeted intervention of animal-pathogen interactions by Yang Sylvia Liu, Chengqian Zhang, Bee Luan Khoo, Piliang Hao, Song Lin Chua

“…The Galangin-ciprofloxacin combinatorial therapy could eliminate P. aeruginosa biofilms in a fish wound infection model, and enabled animal survival. …”
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Suppressing the Endogenous Negative Influence Through Node Intervention in Social Networks by Satoshi Furutani, Tatsuhiro Aoshima, Toshiki Shibahara, Mitsuaki Akiyama, Masaki Aida

“…We formulate this problem as a combinatorial optimization problem on graphs. We prove that this problem is NP-hard and propose approximation algorithms to identify optimal intervention nodes that minimize the negative influence. …”
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Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions. by Piero Dalle Pezze, Glyn Nelson, Elsje G Otten, Viktor I Korolchuk, Thomas B L Kirkwood, Thomas von Zglinicki, Daryl P Shanley

“…This was characterised by poor network sensitivity, high signalling noise, low cellular energy, high inflammation and permanent cell cycle arrest suggesting an unsatisfactory outcome for treatments aiming to delay or reverse cellular senescence at late time points. Combinatorial targeted interventions are therefore possible for intervening in the cellular pathway to senescence, but in the cases identified here, are only capable of delaying senescence onset.…”
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Overproduction of endusamycin in Streptomyces endus subsp. aureus by Yingying Chang, Zhen Liu, Zixin Deng, Tiangang Liu

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Lipid metabolism in ferroptosis: mechanistic insights and therapeutic potential by Daoyun Sun, Daoyun Sun, Longfei Wang, Yufan Wu, Yi Yu, Yufeng Yao, Hongju Yang, Chunlin Hao

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Swimming combined with corn peptide counteracts high-fat diet-induced obesity through rescuing imbalanced gut flora by Qiuyue Wu, Ya Liu, Jinxiu Li, Tong Wu

“…Therefore, the combinatorial intervention of swimming and corn peptide can at least partially ameliorate HFD-induced gut microbiota dysbiosis and corresponding metabolic changes, promote energy metabolism, and contribute to body weight control and lipid-lowering effects in obese mice.…”
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ABCB1 confers resistance to carboplatin by accumulating stem-like cells in the G2/M phase of the cell cycle in p53null ovarian cancer by Danbi Lee, Hyun-Seok Jeong, Sun-Young Hwang, Yu-Gyeong Lee, Youn-Jung Kang

“…Our findings suggest that the ΔNp73-ABCB1 axis is a promising molecular target for carboplatin-resistant ovarian cancers harboring p53null mutations, which we uncovered could be utilized to increase the efficacy of conventional anti-cancer therapies, to develop more efficient combinatorial therapeutic interventions directed toward overcoming the chemoresistance and improving the survival rates in patients with ovarian cancer.…”
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Harnessing innate immunity against glioblastoma microenvironment by Wenbo Zhang, Wanhong Zhang, Henghao Wu, Xinsheng Han, Xinsheng Han

“…This review summarizes the pivotal role of innate immunity in GBM pathogenesis and explores novel combinatorial strategies that integrate innate immune modulation with checkpoint blockade, oncolytic virotherapy, and metabolic interventions to overcome therapeutic resistance in this lethal malignancy.…”
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CCR5 gene editing and HIV immunotherapy: current understandings, challenges, and future directions by Jia-Wen Wang, Jia-Hui Liu, Jian-Jun Xun

“…We further explore the synergistic potential of multiplex gene editing strategies—including CCR5, CXCR4, and HIV LTR loci—and the combinatorial mechanisms between gene editing technologies and immunotherapy. …”
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The dual role of nuclear factor erythroid 2-related factor 2 in hepatocellular carcinoma: mechanisms, clinical relevance, and therapeutic opportunities by Houhong Wang, Shang Bian

“…Preclinical and translational research on Nrf2-targeted therapies is evaluated, with a focus on combinatorial strategies overcoming resistance. Despite challenges in developing selective modulators, integrating multi-omics biomarkers and context-specific interventions offers promise for precision medicine in HCC.…”
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Clinical Phenotypes of Diabetic Peripheral Neuropathy: Implications for Phenotypic-Based Therapeutics Strategies by Jie-Eun Lee, Jong Chul Won

“…Innovations such as digital health platforms, regenerative therapies, and combinatorial pharmacotherapy are promising for addressing primary neuropathic pain and its associated complications. …”
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IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model by Gavin Lewis, Kirsten Malo, Thomas Rowland, Jenaya Hooks, Hao Yuan Liu, Sonam Popli, George Kukolj, Craig S. Pace

“…Research into a cure has focused on finite combinatorial interventions that aim to reduce HBV surface antigen (HBsAg), suppress virus specific immune tolerance, and induce an adaptive response that functionally controls the virus.MethodsIn C57BL/6 mice transduced with adeno-associated virus encoding the HBV genome, which replicate HBV and persistently express HBsAg at 104 IU/mL or higher, a combination of small interfering RNA (siRNA) knockdown of HBsAg expression followed by immunization with a self amplifying RNA therapeutic HBV vaccine failed to establish HBV control. …”
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A systemic approach to accident prevention: How control factors influence accident severity and losses across industries. by Jian Liu, Zhuqing Zhang, Rui Feng

“…These findings underscore the need for multi-level interventions-strengthening feedback loops, organizational oversight, and control processes-to mitigate accident severity in complex socio-technical systems, demonstrating the utility of configurational methods for understanding systemic failures.…”
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Bioengineered Nanozymes for Orthopedic Degenerative Diseases: From Catalytic Mechanisms to Multimodal Therapy by Lei Peng, Chen Yan, Honghao Song, Jiangang Shi, Kaiqiang Sun

“…Furthermore, we explore emerging combinatorial strategies employing nanonzyme delivery systems to achieve synergistic therapeutic outcomes and enhanced efficacy. …”
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Cumulative Transcutaneous Spinal Stimulation with Locomotor Training Safely Improves Trunk Control in Children with Spinal Cord Injury: Pilot Study by Liubov Amirova, Anastasia Keller, Goutam Singh, Molly King, Parth Parikh, Nicole Stepp, Beatrice Ugiliweneza, Yury Gerasimenko, Andrea L. Behrman

“…Adverse effects were monitored session to session, and trunk control was assessed pre- and post-intervention. Results: Across 130 interventions in three participants, 88.5% of sessions were free from adverse effects. …”
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Deep learning-based action recognition for analyzing drug-induced bone remodeling mechanisms by Li Qinsheng, Li Ming, Li Yuening, Zhao Xiufeng

“…IntroductionUnderstanding the mechanisms of drug-induced bone remodeling is critical for optimizing therapeutic interventions and minimizing adverse effects in bone health management. …”
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