Research progress on immunotherapy combined with neoadjuvant concurrent chemoradiotherapy in pMMR/MSS locally advanced rectal cancer by Yang He, Wendong Gu, Yingjie Shao

“…Although traditional neoadjuvant chemoradiotherapy (nCRT) has demonstrated efficacy in enhancing local disease control and promoting sphincter preservation, its impact on long-term survival outcomes remains suboptimal. In recent years, combinatorial approaches integrating immune checkpoint inhibitors (ICIs) with nCRT have garnered increasing research interest. …”
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Contretemps et devenirs : les temporalités plurielles de l’habiter à l’heure du développement durable by Sophie Némoz

“…Combinatorial operations rather than settled trajectories, the revisits of fields built ten years ago identify the inverse of a strategic framing about the sustainable development of human habitat. …”
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Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria by Hazim O. Khalifa, Hazim O. Khalifa, Atef Oreiby, Atef Oreiby, Temesgen Mohammed, Mohamed A. A. Abdelhamid, Mohamed A. A. Abdelhamid, Essam Nageh Sholkamy, Hamada Hashem, Ragab M. Fereig, Ragab M. Fereig

“…Furthermore, we highlight future directions in AgNP-based antimicrobial therapy, such as combinatorial treatments with antibiotics, advanced nanostructure modifications, and the integration of AgNPs into wound dressings, coatings, and biomedical devices. …”
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Advances in Immunotherapy for Glioblastoma Multiforme by Boyuan Huang, Hongbo Zhang, Lijuan Gu, Bainxin Ye, Zhihong Jian, Creed Stary, Xiaoxing Xiong

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A Personal Scientific Journey in Ophthalmology: Twenty-Five Years of Translating Research into Novel Therapies by Dario Rusciano

“…Future directions include combinatorial therapies and the application of artificial intelligence for treatment optimization. …”
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On the relationship between dominance order and $ \theta $-dominance order on multipartitions by Kai Zhou

“…With $ \theta $-dominance order on multipartitions, Bowman constructed integral cellular basis $ \{c^{\theta}_{{\mathfrak{s}}{\mathfrak{t}}}\} $. …”
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3d gravity as a random ensemble by Daniel L. Jafferis, Liza Rozenberg, Gabriel Wong

“…We show how the SD equations can be translated into a combinatorial problem about 3-manifolds.…”
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Assignment Technology Based on Improved Great Wall Construction Algorithm by Xianjun Zeng, Yao Wei, Yang Yu, Hanjie Hu, Qixiang Tang, Ning Hu

“…The problem of allocating multiple UAV tasks is a complex combinatorial optimization challenge, involving various constraints. …”
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Biomimetic Aggregation-Induced Emission Luminogens Mediated Effective Phototherapy and Immune Checkpoint Blockade for the Synergistic Treatment of Lung Cancer by Yang L, Wei M, Deng X, He L, Lin Y, Lin X, Zhou D, Li M, Qin A, Zhang L, Ouyang Z

“…Based on the AIE and immune checkpoint blockade (ICB) strategies, TB enhanced the antitumor activities of lung cancer by phototherapy and immunotherapy.Conclusion: The present work developed a type of biomimetic AIEgens, which overcame the inherent limitations of conventional AIEgens and leveraged immune recognition for targeted tumor accumulation. Furthermore, the integration of AIE-driven phototherapy with immune checkpoint blockade demonstrated potent synergistic antitumor efficacy, establishing a promising combinatorial strategy against aggressive lung malignancies.Keywords: aggregation-induced emission luminogens, T cells, phototherapy, immune checkpoint blockade, lung cancer…”
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Harnessing innate immunity against glioblastoma microenvironment by Wenbo Zhang, Wanhong Zhang, Henghao Wu, Xinsheng Han, Xinsheng Han

“…This review summarizes the pivotal role of innate immunity in GBM pathogenesis and explores novel combinatorial strategies that integrate innate immune modulation with checkpoint blockade, oncolytic virotherapy, and metabolic interventions to overcome therapeutic resistance in this lethal malignancy.…”
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Design of an energy efficient approximate BinDCT module in quantum cellular automata by Mohsen Vahabi, Ehsan Rahimi, Ali Newaz Bahar, Khan A. Wahid

“…The proposed BinDCT module integrates various sequential and combinatorial submodules, including multiplexers (MUXs), demultiplexers (DeMUXs), parallel-in-parallel-out right-shift registers (PIPO-RSRs), ripple carry adders (RCAs), and ripple borrow subtractors (RBSs). …”
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Control Strategy for PHEB Based on Actual Driving Cycle with Driving Style Characteristic by Jianping Gao, Zhenhai Xu, Xiaojie Gao

“…Based on the 6 driving cycles, the key parameters of rule-based control strategy are optimized and established by a combinatorial optimization algorithm in Isight. Then, an identification model to recognize the current condition based on the Learning Vector Quantization (LVQ) neural network has been built and trained offline, which is integrated in the control strategy for PHEB to invoke the corresponding optimized key control parameters in real time. …”
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Harmony Search Algorithm with Two Problem-Specific Operators for Solving Nonogram Puzzle by Geonhee Lee, Zong Woo Geem

“…This puzzle is known as an NP-complete combinatorial problem characterized by an exponential increase in the number of candidate solutions with increasing puzzle size. …”
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Spike-Based Bayesian-Hebbian Learning of Temporal Sequences. by Philip J Tully, Henrik Lindén, Matthias H Hennig, Anders Lansner

“…Moreover, sequence elements are shown to flexibly participate multiple times in the sequence, suggesting that spiking attractor networks of this type can support an efficient combinatorial code. The model provides a principled approach towards understanding how multiple interacting plasticity mechanisms can coordinate hetero-associative learning in unison.…”
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Science, Innovation аnd Investment: Prospective Aspects of Russian Industrialisation by O. S. Sukharev

“…This approach provides valuable insights for promoting R&D and integrating domestic patents into production processes.…”
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ClusterEmbed: Lightweight Protein Structure Prediction on PCs by Yuan Chuxin

“…Biological sequence design seeks to generate novel sequences, such as proteins, with optimized functional properties, a task complicated by vast combinatorial spaces and complex sequence-function relationships. …”
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Protein nanocages: A new frontier in mucosal vaccine delivery and immune activation by Lavanya Agnes Angalene J, Paopachapich Pa, Chheng Y Seng, Joon Haeng Rhee, Shee Eun Lee

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A guide for active learning in synergistic drug discovery by Shuhui Wang, Alexandre Allauzen, Philippe Nghe, Vaitea Opuu

“…Active learning, which integrates experimental testing into the learning process, has been proposed to address this challenge. …”
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Multiobjective Optimization Approach for Coordinating Different DG from Distribution Network Operator by Limei Zhang, Honglei Yang, Jing Lv, Yongfu Liu, Wei Tang

“…Integrating with analysis of uncertainties, this paper presented a multiobjective optimization approach for coordinating different DG from the perspective of Distribution Network Operator (DISOPER). …”
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Application of Regenerative Braking with Optimized Speed Profiles for Sustainable Train Operation by Leon Allen, Steven Chien

“…This paper presents a method for synergizing the energy-saving strategies of integrated coasting and regenerative braking in urban rail transit operations. …”
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