Highly durable and energy‐efficient probabilistic bits based on h‐BN/SnS2 interface for integer factorization by Joon‐Kyu Han, Jun‐Young Park, Shania Rehman, Muhammad Farooq Khan, Moon‐Seok Kim, Sungho Kim

“…Abstract As social networks and related data processes have grown exponentially in complexity, the efficient resolution of combinatorial optimization problems has become increasingly crucial. …”
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Large-scale signal propagation modes in the human brain by Youngjo Song, Pyeong Soo Kim, Benjamin A. Philip, Taewon Kim

“…However, a coherent framework remains elusive due to the combinatorial complexity of sequential states and methodological inconsistencies across studies. …”
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Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis by Jiachen Liu, Dianjie Zeng, Yinhuai Wang, Fei Deng, Shuiqing Wu, Zebin Deng

“…The molecular interaction mapping and pathway integration analysis provided further insights, suggesting potential strategies for combinatorial therapies. …”
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Monolithic 3D Oscillatory Ising Machine Using Reconfigurable FeFET Routing for Large‐Scalability and Low‐Power Consumption by Joon Pyo Kim, Song‐Hyeon Kuk, Hyun Wook Kim, Jaeyong Jeong, Juhyuk Park, Bong Ho Kim, Jongmin Kim, Aida Todri‐Sanial, Sanghyeon Kim

“…By leveraging the intrinsic OIM features of parallel computing together with M3D integration, it is reported that the M3D OIM outperforms reported OIMs in scalability and speed. …”
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A dual-inducible control system for multistep biosynthetic pathways by Andrés Felipe Carrillo Rincón, Alexandra J. Cabral, Andras Gyorgy, Natalie G. Farny

“…The improvement in control afforded by the integration of the toehold switches enabled the accumulation of a biosynthetic intermediate (lycopene) in the β-carotene synthesis pathway. …”
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Next Generation Power System Planning and Operation With Quantum Computation by Priyanka Arkalgud Ganeshamurthy, Kumar Ghosh, Corey O'Meara, Giorgio Cortiana, Jan Schiefelbein-Lach, Antonello Monti

“…Innovative solutions and developments are being inspected to tackle rising electrical power demand to be supplied by clean forms of energy. The integration of renewable energy generations, varying nature loads, importance of active role of distribution system and consumer participation in grid operation has changed the landscape of classical power grids. …”
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Selective JAK2 pathway inhibition enhances anti-leukemic functionality in CD19 CAR-T cells by Kohei Mitsuno, Masaya Suematsu, Yuki Naito, Azusa Mayumi, Hideki Yoshida, Shinya Osone, Toshihiko Imamura, Yozo Nakazawa, Shigeki Yagyu, Tomoko Iehara

“…Abstract The integration of molecular targeted therapeutics with chimeric antigen receptor T (CAR-T) cell therapy represents a novel strategy to amplify the anti-tumor efficacy of immunotherapy. …”
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CRISPR/Cas9 technology in tumor research and drug development application progress and future prospects by Han Han, Xiaoyan Sun, Xiaoyun Guo, Jiaxin Wen, Xiaoming Zhao, Weiqiang Zhou

“…Additionally, the article discusses key applications of CRISPR/Cas9 in anticancer drug discovery, including drug target identification, drug target screening and validation, combinatorial genetic screening, screening of small molecules to overcome resistance to CAR-T therapies, and multimodal functional genomics integration strategies. …”
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Lipid metabolism in ferroptosis: mechanistic insights and therapeutic potential by Daoyun Sun, Daoyun Sun, Longfei Wang, Yufan Wu, Yi Yu, Yufeng Yao, Hongju Yang, Chunlin Hao

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Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity by Seemadri Subhadarshini, Sarthak Sahoo, Shibjyoti Debnath, Jason A Somarelli, Mohit Kumar Jolly

“…This heterogeneity in PD-L1 can be aggravated by combinatorial dynamics of these regulators with IFNγ signaling. …”
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Engineering artificial cross-species promoters with different transcriptional strengths by Wenjie Zuo, Guobin Yin, Luyao Zhang, Weijiao Zhang, Ruirui Xu, Yang Wang, Jianghua Li, Zhen Kang

“…In this study, we analyzed and validated the primary structures of natural endogenous promoters from Escherichia coli, Bacillus subtilis, Corynebacterium glutamicum, Saccharomyces cerevisiae, and Pichia pastoris, and through strategic integration and rational modification of promoter motifs, we developed a series of cross-species promoters (Psh) with transcriptional activity in five strains (prokaryotic and eukaryotic). …”
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Engineering an Escherichia coli strain for enhanced production of flavonoids derived from pinocembrin by Erik K. R. Hanko, Christopher J. Robinson, Sahara Bhanot, Adrian J. Jervis, Nigel S. Scrutton

“…Lastly, by utilising a combinatorial library of plasmids encoding G. max F3H and Citrus unshiu FLS, we obtained a maximum galangin titre of 18.2 ± 5.3 mg/L. …”
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Natural Killer Cell Immune Checkpoints and Their Therapeutic Targeting in Cancer Treatment by Anqi Lin, Pengxi Ye, Zhengrui Li, Aimin Jiang, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo

“…Furthermore, this review comprehensively summarizes preclinical advancements in NK cell immune checkpoint blockade strategies, including single checkpoint blockade, combinatorial checkpoint approaches, and their integration with conventional therapeutic modalities. …”
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Modeling and Evolutionary Optimization on Multilevel Production Scheduling: A Case Study by Ruifeng Shi, Chunxia Shangguan, Hong Zhou

“…An integrated model, which can cope with the whole multilevel scheduling information simultaneously, is proposed in this paper, and a specific evolutionary algorithm is designed to solve the integrated model with a twin-screw coding strategy. …”
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Towards a computational- and algorithmic-level account of concept blending using analogies and amalgams by Tarek R. Besold, Kai-Uwe Kühnberger, Enric Plaza

“…We present the theoretical background, as well as an algorithmic proposal integrating higher-order anti-unification matching and generalisation from analogy with amalgams from CBR. …”
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Optimization and Security Analysis of Interconnected Security Control Based on Semantic of Process Communication by Bo LU, Yueming LU

“…Facing the demand of multi-domain security control in the integrated network of air and ground, to solve the problem that singleprocess regular matching restricts the performance of interconnected security gateway, the method of high-performance optimization of interconnected security control based on semantic security analysis of process communication was proposed.The interaction model of master-slave processes was described in a parallel programming language in the method.The state transition system semantics were given to accurately express the combined semantics of the master-slave processes.The security of master-slave processes in combinatorial semantics was analyzed, which ensured that the parallel running of processes had no deadlock and starvation, and was equivalent to the original regular matching.Experimental results showed that the proposed method could give full play to the advantages of multi-core hardware and reduced the context switching overhead of the scheduler.In the case of complex regular expressions, the method was an order of magnitude better than single-core running.…”
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Optimization and Security Analysis of Interconnected Security Control Based on Semantic of Process Communication by Bo LU, Yueming LU

“…Facing the demand of multi-domain security control in the integrated network of air and ground, to solve the problem that singleprocess regular matching restricts the performance of interconnected security gateway, the method of high-performance optimization of interconnected security control based on semantic security analysis of process communication was proposed.The interaction model of master-slave processes was described in a parallel programming language in the method.The state transition system semantics were given to accurately express the combined semantics of the master-slave processes.The security of master-slave processes in combinatorial semantics was analyzed, which ensured that the parallel running of processes had no deadlock and starvation, and was equivalent to the original regular matching.Experimental results showed that the proposed method could give full play to the advantages of multi-core hardware and reduced the context switching overhead of the scheduler.In the case of complex regular expressions, the method was an order of magnitude better than single-core running.…”
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CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer by Zhengkun Cai, Zeyuan Cheng, Lu Zhang, Yuhan Zhang, Jinming Shi, Jing Jin, Zeyun Mi, Zhiyong Yuan, Zhiqiang Wu

“…Abstract Radiotherapy (RT)-elicited antitumor immunity serves as a pivotal mechanism in RT-mediated tumor control. The strategic integration of RT with immunotherapies, particularly immune checkpoint blockade (ICB), is revolutionizing cancer therapeutics, demonstrating remarkable clinical potential. …”
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Genetic and transcriptional insights into immune checkpoint blockade response and survival: lessons from melanoma and beyond by Jiaxin Wen, Yanfeng Wang, Song Wang, Yuxin Liang, Xiaozhen Hu, Qiuxiang Ou, Hua Bao, Kuo Zhao, Youyu Wang

“…Abstract Background Integration of immune checkpoint inhibitors (ICIs) with non-immune therapies relies on identifying combinatorial biomarkers, which are essential for patient stratification and personalized treatment. …”
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Resources for Structural Optimization of Gas-hydrodynamic Measuring Transducers by Yevhen Pistun, Halyna Matiko, Hanna Krykh

“…A mathematical apparatus based on set theory and combinatorial analysis is proposed for synthesizing the possible structures of throttle diagrams, graph theory – for forming a set of measuring channels. …”
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