An Exact Solution Approach for the Bus Line Planning Problem with Integrated Passenger Routing by Evert Vermeir, Wouter Engelen, Johan Philips, Pieter Vansteenwegen

“…The bus line planning problem or transit network design problem with integrated passenger routing is a challenging combinatorial problem. …”
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The assessment of breast cancer biomarkers in diagnosis, prognosis and treatment monitoring: integrated analysis by Patrycja Królewska-Daszczyńska, Aleksandra Englisz, Maria-Laura Morawiec, Joanna Miśkiewicz, Maciej Gołębski, Aleksandra Mielczarek-Palacz

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Espacio literario relevante sobre el problema del vendedor viajero (TSP): contenido, clasificación, métodos y campos de inspiración Relevant literary space on travelling salesman p... by Jorge Ivan Pérez Rave, Gloria Patricia Jaramillo Álvarez

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Fast Task Scheduling With Model Predictive Control Integrating a Priority-Based Heuristic by Francesco Liberati, Manuel Donsante, Chiara Maria Francesca Cirino, Andrea Tortorelli

“…The use case motivating the work is given by the problem of managing the integration activities involved in the final assembly of the Vega rocket at the European space center in Kourou, French Guiana. …”
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Integrated Management of Strawberry Crown and Root Rot Caused by Fusarium solani in Greenhouse Conditions by Braw Azad Aziz, Qasim Abdullah Marzani

“…This study aimed to integrate multiple control strategies to mitigate the impact of F. solani on strawberry production. …”
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Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism by Goetz Hartleben, Kenji Schorpp, Yun Kwon, Barbara Betz, Foivos‐Filippos Tsokanos, Zahra Dantes, Arlett Schäfer, Ina Rothenaigner, José Manuel Monroy Kuhn, Pauline Morigny, Lisa Mehr, Sean Lin, Susanne Seitz, Janina Tokarz, Anna Artati, Jerzy Adamsky, Oliver Plettenburg, Dominik Lutter, Martin Irmler, Johannes Beckers, Maximilian Reichert, Kamyar Hadian, Anja Zeigerer, Stephan Herzig, Mauricio Berriel Diaz

“…Abstract By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi‐agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. …”
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Mechanisms and clinical advancements of cell-based immunotherapies in non-small cell lung cancer: an integrated perspective by Lixian Yang, Yaoyao Gong

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A Hiplot‐based web service for cold atmospheric plasma high‐throughput data integration and analysis on breast cancer by Xiaofeng Dai, Mingjie Wang, Yang Liu

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Analysis of the Impact of Renewable Energy Sources and Energy Storage Systems on Multi-Stage Transmission Network Expansion Planning by Mario D. Pastrana, Juan Carlos Cortez, Juan Camilo Lopez, Marina Lavorato, Marcos J. Rider

“…A method is developed to reduce the combinatorial search space to deal with high-dimensional problems. …”
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Reconfigurable Electro-optic Logic Circuits Using Microring Resonator-Based Optical Switch Array by Yonghui Tian, Guolin Zhao, Zilong Liu, Anqi Guo, Huifu Xiao, Xiaosuo Wu, Yinghao Meng, Lin Deng, Xiaonan Guo, Guipeng Liu, Jianhong Yang

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On q-double modified Laplace transform by Srikumar Panda, Praveen Agarwal, Arvind Kumar Sinha

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Integrated Analysis of microRNA Targets Reveals New Insights into Transcriptional–Post-Transcriptional Regulatory Cross-Talk by Simona Panni, Roberto Pizzolotto

“…In the present study, we have constructed a network of verified microRNA-mRNA interactions by integrating strong-evidence couples from different resources. …”
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SCM-DL: Split-Combine-Merge Deep Learning Model Integrated With Feature Selection in Sports for Talent Identification by Didem Abidin, Muhammed G. Erdem

“…The SCM-DL integrated with the RFE_DTC feature selection method achieved the highest performance for six features, yielding an accuracy rate of 97.40% and a Matthews Correlation Coefficient performance rate of 96.6%. …”
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ChromActivity: integrative epigenomic and functional characterization assay based annotation of regulatory activity across diverse human cell types by Tevfik Umut Dincer, Jason Ernst

“…Abstract We introduce ChromActivity, a computational framework for predicting and annotating regulatory activity across the genome through integration of multiple epigenomic maps and various functional characterization datasets. …”
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Integrate computation intelligence with Bayes theorem into complex construction installation: a heuristic two-stage resource scheduling optimisation approach by Jia Zhao, Wenhao Wang, Liyuan Zhang, Yan Ding

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Leveraging flexible pipette-based tool changes to transform liquid handling systems into dual-function sample preparation and imaging platforms by Mohammad Nazeri, Jeffrey Watchorn, Sheldon Mei, Alex Zhang, Christine Allen, Frank Gu

“…In this work we present a new hardware platform that integrates simultaneous pipetting and in-situ imaging using the Opentron OT-2 liquid handling robot. …”
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Plant Compounds Inhibit the Growth of W12 Cervical Precancer Cells Containing Episomal or Integrant HPV DNA; Tanshinone IIA Synergizes with Curcumin in Cervical Cancer Cells by Linda Saxe Einbond, Jing Zhou, Kunhui Huang, Mario R. Castellanos, Emeka Mbazor, Michael Balick, Hongbao Ma, James A. DeVoti, Stephen Redenti, Hsan-au Wu

“…Our findings highlight the potential of these multifaceted phytochemicals to prevent and treat HPV-induced cervical cancer, offering a promising approach for combinatorial therapeutic intervention.…”
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Integrating single-cell regulatory atlas and multi-omics data for differential treatment response and multimodal predictive modeling in CDK 4/6 inhibitor-treated breast cancer by Li Yan, Li Yan, Sijie Chen, Sijie Chen, Ran Ran, Ran Ran, Shidi Zhao, Shidi Zhao, Jing Huang, Jing Huang, Jin Yang, Jin Yang, Jin Yang, Jin Yang

“…The multimodal model (TPRI + top 30 DEGs + top 30 miRNAs) achieved superior prognostic accuracy (95%CI:0.6575-0.75).DiscussionThis study establishes TPRI as a novel biomarker for CDK4/6 inhibitor response prediction, validated through multi-omics integration and qPCR confirmation. The model provides actionable risk stratification, where high-risk patients may benefit from combinatorial mTOR-targeted therapies. …”
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High-throughput evaluation of half-metallicity of Co2MnSi Heusler alloys using composition-spread films and spin-integrated hard X-ray photoelectron spectroscopy by Ryo Toyama, Shunsuke Tsuda, Yuma Iwasaki, Thang Dinh Phan, Susumu Yamamoto, Hiroyuki Yamane, Koichiro Yaji, Yuya Sakuraba

“…We demonstrate high-throughput evaluation of the half-metallicity of Co2MnSi Heusler alloys by spin-integrated hard X-ray photoelectron spectroscopy (HAXPES) of composition-spread films performed with high-brilliance synchrotron radiation at NanoTerasu, which identifies the optimum composition showing the best half-metallicity. …”
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Corrigendum to “Integrated genomic, proteomic and cognitive assessment in Duchenne Muscular Dystrophy suggest astrocyte centric pathology” [Heliyon Volume 9, Issue 8, August 2023,... by Nalaka Wijekoon, Lakmal Gonawala, Pyara Ratnayake, Pulasthi Dissanayaka, Isuru Gunarathne, Dhammika Amaratunga, Roshan Liyanage, Sunethra Senanayaka, Saraji Wijesekara, Hemal H. Gunasekara, Kamala Vanarsa, Jessica Castillo, Yetrib Hathout, Ashwin Dalal, Harry W.M. Steinbusch, Eric Hoffman, Chandra Mohan, K. Ranil D. de Silva

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