Cumulative Transcutaneous Spinal Stimulation with Locomotor Training Safely Improves Trunk Control in Children with Spinal Cord Injury: Pilot Study by Liubov Amirova, Anastasia Keller, Goutam Singh, Molly King, Parth Parikh, Nicole Stepp, Beatrice Ugiliweneza, Yury Gerasimenko, Andrea L. Behrman

“…Conclusions: These findings provide the first evidence supporting the safety and feasibility of this combinatorial approach in pediatric SCI rehabilitation while emphasizing the importance of monitoring skin integrity and signs of autonomic dysreflexia. …”
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Reversing VTN deficiency inhibits the progression of pancreatic cancer and enhances sensitivity to anti-PD1 immunotherapy by Siqi Zhao, Zhaofeng Gao, Lingyu Hu, Yihan Li, Xiaoguang Wang, Xiaoping Li, Minjie Chen, Fei Chen, Zhengwei Song

“…The extracellular matrix protein vitronectin (VTN) has been implicated in tumor progression, but its specific role in pancreatic cancer progression and immunotherapy response remains unclear.MethodsThis study employed an integrative approach combining single-cell RNA sequencing, analysis of public databases, and functional assays. …”
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In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy by Maedeh Radandish, Niloofar Mashhadi, Amir Hossein Aghayan, Motahareh Taghizadeh, Sara Salehianfard, Sheida Yahyazadeh, Omid Vakili, Somayeh Igder

“…Future perspectives Future research should prioritize strategies aimed at promoting TLS maturation, disrupting immunosuppressive niches, and integrating TLS-modulating agents with existing immunotherapeutic regimens to enhance clinical efficacy. …”
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Molecular mechanisms and potential implications of ferroptosis, cuproptosis, and disulfidptosis in septic lung injury by Jiaxin Li, Han Liu, Zhitao Shan, Kezhuo Zhong, Qun Liang, Qun Liang

“…A signaling interaction diagram highlights actionable targets for combinatorial therapies.…”
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Sacrificio cortoplacista adaptativo 2opt (SCA_2opt): Una heurística inspirada en el pensamiento sistémico Sacrifice short-term adaptive 2-opt (SCA_2opt): A heuristic inspired by sy... by Jorge Pérez Rave, Patricia Jaramillo Álvarez

“…It is evident that systemic thinking is a field of inspiration viable for the development of combinatorial optimization methods; emerging questions for future developments are expressed, enabling to continue to integrate elements of the classical optimization with the systemic thought; areas traditionally seen as antagonistic, but whose dialogue is favourable in this article.…”
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Simultaneous cyclin D1 overexpression and p27kip1 knockdown enable robust Müller glia cell cycle reactivation in uninjured mouse retina by Zhifei Wu, Baoshan Liao, Julia Ying, Jan Keung, Zongli Zheng, Virpi Ahola, Wenjun Xiong

“…By establishing a safe, controlled method to promote MG proliferation in vivo while preserving retinal integrity, this work provides a valuable tool for combinatorial therapies integrating neurogenic stimuli to promote neuron regeneration.…”
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NIR Triggered Bionic Bilayer Membrane-Encapsulated Nanoparticles for Synergistic Photodynamic, Photothermal and Chemotherapy of Cervical Cancer by Ding J, Zhang X, Guo L, Xiong J, Zhang C, Du Z, Zhu L, Alifu N, Dong B

“…Both in vitro and in vivo experiments showed well phototherapy-chemotherapy effect of RBC@ICG-DOX NPs with low toxic side effects.Conclusion: Drug delivery, imaging and tumor synergies were accomplished through combinatorial strategies as well as bilayer membrane encapsulation, opening up a new platform for the design of future tumor combination therapies.Keywords: erythrocyte membrane modification, indocyanine green, adriamycin, combination therapy, cervical cancer…”
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Identification and validation of poor prognosis immunoevasive subtype of esophageal cancer with tumor-infiltrating SAMD3 + NK cell abundance by Xu Huang, Runze You, Fangyi Liu, Zitao Jian, Guanyou Zhou, Hao Yin, Mengyuan Wu, Tiantao Sun, Zhiyun Duan, Wenyi Xu, Shaoyuan Zhang, Xinyu Yang, Heng Jiao, Shuyi Yang, Qingle Wang, Jun Yin, Han Tang, Miao Lin, Lijie Tan

“…Our findings nominate SAMD3 inhibition as a combinatorial strategy to overcome immune checkpoint blockade resistance.…”
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Landing scheduling for carrier aircraft fleet considering bolting probability and aerial refueling by Genlai Zhang, Lei Wang, Zhilong Deng, Xuanbo Liu, Xichao Su, Haixu Li, Chen Lu, Kai Liu, Xinwei Wang

“…Then, taking the landing sequencing as decision variables, a combinatorial optimization model with a compound objective function is formulated. …”
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Emerging role of N-acetyltransferase 10 in diseases: RNA ac4C modification and beyond by Lin Jiao, Yanjun Si, Yushan Yuan, Xinxing Lei, Qian Jiang, Lijun Yang, Wenhao Mao, Binwu Ying, Liwei Ma, Ting Sun

“…Future research should address context-dependent roles, refine ac4C detection methods, and explore combinatorial therapies to overcome resistance mechanisms.…”
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Lignin Unlocks Stealth Carbon Sinks in Cold Seeps via Microbial Enzymatic Gatekeeping by Jialing Li, Jingchun Feng, Pandeng Wang, Mengzhuo Zhu, Yongji Huang, Ying Wu, Junning Fan, Junlin Hu, Xiyang Dong, Yingli Zhou, Xuanyu Tao, Si Zhang

“…Our findings establish 3 paradigm shifts: (a) The turnover rates of terrestrial organic carbon are likely underestimated in deep-sea ecosystems; (b) microbial consortia employ combinatorial enzymatic strategies distinct from terrestrial decomposition regimes; (c) methyl shunting from lignin breakdown primes methanogenic precursors, revealing cryptic linkages between refractory carbon cycling and greenhouse gas reservoirs.…”
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Tumor-associated bacteria activate PRDX1-driven glycolysis to promote immune evasion and PD-1 antibody resistance in hepatocellular carcinoma by Heng Zhang, Xi Lan, Liquan Cai, Xunfeng Gao, Feng Gao, Dan Yu, Jinlong Zhang, Jinhui Zhang, Qinwen Tai

“…These findings provide the first evidence linking intratumoral bacteria to PD-1 resistance via redox-regulated metabolism, proposing dual targeting of PRDX1 and gut microbiota as a novel combinatorial immunotherapy strategy.…”
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Planificación y optimización asistida por computadora de secuencias de ensamble mecánico // Computer aided Planning and optimization for mechanical assembly. by L. L. Tomás-García

“…</p><p>____________________________________________________________________________</p><p>Abstract<br />This work deals with the combinatorial problem of generating and optimizing feasible assembly<br />sequences and doing the process planning involving tools and work places. …”
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Mefloquine reduces the bacterial membrane fluidity of Acinetobacter baumannii and distorts the bacterial membrane when combined with polymyxin B by Nagendran Tharmalingam, Harikrishna Sekar Jayanthan, Jenna Port, Fernanda Cristina Possamai Rossatto, Eleftherios Mylonakis

“…Our findings highlight the potential of membrane-acting compounds, such as MFQ, to enhance combinatorial activity while mitigating polymyxin B-associated toxicity.…”
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TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1 by Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur, Matthias Peindl, Sarah Nietzer, Karina Epting, Gabriele Vacun, Gudrun Dandekar, Catherine Botteron, Christian Werno, Thomas Grunwald, Susanne M. Bailer

“…The aim of TheraVision was to establish a broadly applicable engineering platform technology for combinatorial oncolytic virus and immunotherapy. Through genetic engineering, an attenuated herpes simplex virus type 1 (HSV1) was generated that showed increased safety compared to the wild-type strain. …”
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Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism by Qiu-yu Zhao, Wen-jun Liu, Jian-guang Wang, He Li, Jia-lu Lv, Yumeng Wang, Chun Wang

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Statistical - Synoptic Analysis of the Extreme Precipitation in Western Iran by Mehrdad Kiani, Hasan Lashkari, Houshang Ghaemi

“…The main reason for heavy rainfall event on the region in autumn season has been the expansion of the Mediterranean cyclone and its integration with the Sudanese low pressure system and the warm and humidity air convection from the lower latitudes. 4-Conclusion Based on results, the main area of heavy rainfall is located on western slopes of Zagros, including Ilam and Marivan. …”
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Supply chain management and optimization in transportation logistics by Saoussen Krichen

“…The search space in combinatorial optimization problems is discrete and multidimensional. …”
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Cellular senescence in cancer: from mechanism paradoxes to precision therapeutics by Tiejun Feng, Fuda Xie, Leo M.Y. Lee, Zhiqiang Lin, Yifan Tu, Yang Lyu, Peiyao Yu, Jialin Wu, Bonan Chen, Ge Zhang, Gary M.K. Tse, Ka Fai To, Wei Kang

“…We highlight groundbreaking therapeutic innovations, including precision senolytics, senomorphics, and combinatorial strategies integrating immunotherapy, metabolic interventions, and epigenetic modulators. …”
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LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma by Yuxuan Li, Jie Zhu, Fengguang Zhai, Yidong Ge, Ziqing Zhan, Shuyan Wang, Lili Kong, Jianan Zhao, Lecheng Hu, Siyuan Wang, Jiaxin Shi, Jianing Mao, Zongdong Yu, Haoyun Wang, Jiabei Jin, Mengxiang Zhao, Hong Li, Xiaofeng Jin

“…Abstract While immune checkpoint inhibitors targeting programmed cell death-ligand 1 (PD-L1) demonstrate clinical efficacy in hepatocellular carcinoma (HCC), tumor cells frequently evade immune surveillance through PD-L1 overexpression, a phenomenon whose regulatory mechanisms remain poorly understood. Through integrated analysis of single-cell transcription sequence data, we identified aberrant upregulation of Lamin B2 (LMNB2) specifically in immunotherapy-sensitive HCC patients. …”
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