Identification of a novel cellobiose 2-epimerase from Acidobacteriota bacterium and its application for in-situ milk catalysis by Qiuqian Zeng, Qiuqian Zeng, Qiuqian Zeng, Xiaomei Lyu, Xiaomei Lyu, Xiaomei Lyu

“…In milk systems, Acba-CE achieves 28.5% lactose-to-epilactose conversion at refrigeration temperatures (10°C), demonstrating strong cold adaptability.DiscussionTo our knowledge, this is the first reported CE from the Acidobacteriota phylum, combining acidophilic activity with low-temperature adaptability. …”
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Searching for Paralytic Toxin, Tetrodotoxin, in Swedish Bivalve Shellfish by Aida Zuberovic Muratovic, Shyamraj Dharavath, Jonas Bergquist, Malin Persson, Elin Renborg, Heidi Pekar, Mirjam Klijnstra

“…Tetrodotoxin (TTX), earlier known as a tropical paralytic neurotoxin from pufferfish poisoning, has increasingly been occurring in edible marine species, including filter-feeding bivalves, from relatively cold marine waters of some European countries. The defined conditions that promote the production of TTX, its origin or the processes of its accumulation in seafood are still not clarified. …”
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Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade by Victoria E. Stefan, Daniela D. Weber, Roland Lang, Barbara Kofler

“…Here, we review current knowledge of the complex interplay of KDs and the anti-tumor immune response in the context of ICB therapy, to update our understanding of diet-induced immunometabolic reprogramming in cancer. …”
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Pediatric kidney transplantation in Europe, a clinical snapshot pilot by Loes Oomen, Charlotte M. H. H. T. Bootsma-Robroeks, Charlotte M. H. H. T. Bootsma-Robroeks, Antonia H. M. Bouts, Mar Carbonell Pradas, Romy Gander, Katrin Kienzl-Wagner, Paul König, Pedro Lopez Pereira, Olivier Dunand, Sara M. F. S. Mosca, Michal Pac, Ludmila Podracka, Agnieszka A. Prytula, Maria Sangermano, Renata Vitkevic, Jakub Zieg, Loes F. M. van der Zanden, Wout F. J. Feitz, Liesbeth L. de Wall

“…BackgroundPediatric kidney transplantations are rarely performed, and there is limited knowledge about the diversity in current clinical practices across Europe. …”
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Urban policies for in-house vaccination of vulnerable people during COVID-19 based on critical systems learning by M. Samadi-Foroushani, S. S. Miresmaeeli, A. Nasiri, Z. Molamohamadi

“…Finally, after dialectical discussions, system development solutions have been synthesized and integrated, and based on the importance level and certainty of the right assumption, certain planning regions have been detected.FINDINGS: Generally, healthcare services to vulnerable groups during the pandemic must be redefined based on the boundaries of control, knowledge, and legitimacy. According to the findings, 34 strategic defaults were identified and 17 defaults were proposed in the secure planning area, including: redefining the provision of healthcare services to vulnerable groups during the pandemics; providing services to all vulnerable groups during disasters through Tehran’s joint emergency response call center; providing stable financial resources to perform services to vulnerable populations during the pandemics; collecting, updating, and integrating the related databases (such as elderlies, patients, people with disabilities, etc.); training service providers (e.g. call center operators, vaccinators, etc.) in accordance with the specific situations of vulnerable groups; developing guidelines for providing in-house services to vulnerable people; obliging the managers to be accountable for obeying protective laws relating to vulnerable groups in disaster; identifying the potential capacities of the private sectors and nongovernmental organizations; considering a medical support team; consulting with advisors and caregivers of vulnerable groups; using temperature recording devices to ensure the cold chain of vaccines; and setting up local disaster management support bases in order to assure the agility of the provided services to the vulnerable populations in Tehran.CONCLUSION: The current study deals with the critical rethinking of providing health services to vulnerable populations during a pandemic, by designing a systemic intervention. …”
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Tapping into the potential of okra (Abelmoschus spp.) in Africa: integrating value-added traits into breeding by Mathieu A. T. Ayenan, Fabrice Vihou, Mwasilwa Ambali, Jacinta Adoma Opoku, Dorcas Olubunmi Ibiotye, Roland Schafleitner

“…However, several challenges hinder Africa from fully harnessing okra’s economic and nutritional benefits, including pest and disease pressures, salinity and cold stress, weak seed systems, insufficient market knowledge, and a lack of value addition. …”
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Public health aspects of Vibrio spp. related to the consumption of seafood in the EU by EFSA Panel on Biological Hazards (BIOHAZ), Konstantinos Koutsoumanis, Ana Allende, Avelino Alvarez‐Ordóñez, Declan Bolton, Sara Bover‐Cid, Marianne Chemaly, Alessandra De Cesare, Lieve Herman, Friederike Hilbert, Roland Lindqvist, Maarten Nauta, Romolo Nonno, Luisa Peixe, Giuseppe Ru, Marion Simmons, Panagiotis Skandamis, Craig Baker‐Austin, Dominique Hervio‐Heath, Jaime Martinez‐Urtaza, Eva Sanjuán Caro, Eckhard Strauch, Anne Thébault, Beatriz Guerra, Winy Messens, Ancuta Cezara Simon, Rubén Barcia‐Cruz, Elisabetta Suffredini

“…While some measures, like high‐pressure processing, irradiation or depuration reduce the levels of Vibrio spp. in seafood, maintaining the cold chain is important to prevent their growth. …”
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LsNAC46 regulates heat-resistance and growth in lettuce (Lactuca sativa L.) by Tao Yang, Shu-ping He, Guo-tao Huo, Ming-lu Tian, Li Du, Xiao Yang, Heng Xu, Guo-jun Ge, Hong-yang Zhao, Li-jun Luo, Shi-wei Wei

“…Lettuce prefers a cold and cool climate, and high temperatures can lead to many problems such as tip burn that decrease yield and quality. …”
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Identification and characterization of microRNAs in the liver of yak () associated with energy deficiency at high-altitude by Shuru Cheng, Fangping Shi, Zhixiong Tang, Feifei Yang, Quanlu Meng, Ting Liu

“…Conclusion This is the first, at the best of our knowledge, liver miRNA-seq profiling analysis of moderate yak cows subjected to the combined effects of cold and nutritional stress at high altitude. …”
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Factors influencing influenza vaccination coverage among kindergarten and primary school children in Zhejiang Province， 2023 by LI Minchao, TAO Jing, ZHANG Rui, WU Yumeng, HE Zhaokai, WU Chen

“…In contrast, vaccine hesitancy among parents [0.55 (0.43‒0.69)] and the belief that influenza is just a common cold [0.80 (0.65‒1.00)] were hindering factors.ConclusionThe influenza vaccination coverage among children is insufficient. …”
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Culturable Plastisphere from the 75° N Subarctic Transect as a Potential Vector of Pathogens and Antibiotic-Resistant Bacteria by Gabriella Caruso, Maria Papale, Alessandro Ciro Rappazzo, Maurizio Azzaro

“…The antibiotic susceptibility profiles pointed out that multiple antibiotic-resistant bacteria were also isolated, suggesting the need to shed light on the potential risks to human and animal health deriving from the plastisphere in remote cold regions as well.…”
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The development and validation of the extended active-passive social media use scale by Xiang Niu, Philippe Verduyn, James Gaskin, Sebastian Scherr, Dean McDonnell, Jin-Liang Wang

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The Impact of Seasonal Changes and Living Activities on Dwelling Patterns and the Form of Rural Houses

“…At first, some of the villages in the city of Urmia, in West Azerbaijan Province as one of the cold regions in the country are studied as prototypical models. …”
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Computational prediction for the formation of amides and thioamides in the gas phase interstellar medium by Mohamad Akbar Ali, Mohamad Akbar Ali, Sorakayala Thripati, Sorakayala Thripati

“…Despite this, our understanding of how nitrogen-containing compounds like formamide and urea, along with their sulfur analogs thioformamide and thiourea, form in the cold interstellar medium (ISM) remains incomplete. …”
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Nonvolcanic Carbon Dioxide Emission at Continental Rifts: The Bublak Mofette Area, Western Eger Rift, Czech Republic by Horst Kämpf, Alena Sophie Broge, Pouria Marzban, Masoud Allahbakhshi, Tobias Nickschick

“…This study presents the results of gas flux measurements of cold, mantle-derived CO2 release at the Bublák mofette field (BMF), located inside of the N-S directed Počátky Plesná fault zone (PPFZ). …”
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The impact of hypoxia on psychological and cognitive functioning in high-altitude climbers by Wiktoria Zamirska, Nadia Hornig, Aleksandra Kołodziej, Aleksandra Cieplak, Zuzanna Czyżewicz

“…The scope encompasses both acute and chronic exposure to high-altitude conditions, examining how hypoxia, in conjunction with environmental stressors such as cold, isolation, and physical exertion, impacts neurological function. …”
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Process Synchrony a Key Control of Resilience in a Subarctic Freshwater System by C. Spence, J. M. Galloway, N. Hedstrom, S. V. Kokelj, S. A. Kokelj, P. Muise, B. W. Newton, R. T. Patterson, M. F. J. Pisaric, G. T. Swindles

“…These conditions altered the catchment such that >50% of the water year streamflow now occurs during winter, shifting the catchment from a nival to a cold season pluvial hydrological regime. This regime shift has significantly changed the fraction of inorganic nitrogen export, but insufficiently to shift the biogeochemical regime. …”
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Molecular biology of the deadliest cancer – glioblastoma: what do we know? by Aly Ismailov, Aldo Spallone, Aldo Spallone, Alexey Belogurov, Alexey Belogurov, Alan Herbert, Alan Herbert, Maria Poptsova

“…Another key feature of glioblastoma is its “cold” microenvironment, characterized by robust immunosuppression. …”
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Lncrna nonratt021477.2 interference aggravates h2o2-induced oxidative stress in brl cells by Hong JI, Yue HUA, Chun-Wei LIU, Zi-Yi SHAO, Jia-Jun ZHANG, Shui-Qing YU

“…Long non-coding RNA (lncRNA) plays important biological regulatory functions at different levels. lncRNA NONRATT021477.2 (lncRNA77.2) was identified as a key gene under cold stress conditions in rats. From the literature, lncRNA77.2 may have important roles during antioxidant, but this conjecture requires investigation. …”
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Electroacupuncture Regulates Cannabinoid Receptor 1 Expression in a Mouse Fibromyalgia Model: Pharmacological and Chemogenetic Modulation by Yu-An Yeh, Hsin-Cheng Hsu, Ming-Chia Lin, Tzu-Shan Chen, Wei-Cheng Lin, Hsiang-Ming Huang, Yi-Wen Lin

“…To develop the mouse fibromyalgia model, mice were subjected to intermittent cold stress (ICS). Our results indicated that mechanical (2.09 ± 0.09 g) and thermal hyperalgesia (4.77 ± 0.29 s), which were evaluated by von Frey and Hargraves’ tests, were induced by ICS, suggesting successful modeling. …”
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