Cytochrome b5 occurrence in giant and other viruses belonging to the phylum Nucleocytoviricota by David C. Lamb, Jared V. Goldstone, Djamal Brahim Belhaouari, Julien Andréani, Ayesha Farooqi, Michael J. Allen, Steven L. Kelly, Bernard La Scola, John J. Stegeman

“…Abstract Cytochrome b5 is an electron transport protein found in eukaryotes and bacteria, and plays roles in energy production, lipid biosynthesis and cytochrome P450 biochemistry. …”
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Stable microbial community promotes aerobic methanotrophy in a large river-reservoir system by Qiong Tang, Zhe Li, Lunhui Lu, Yan Xiao, Xinghua Wu, Dianchang Wang

“…In the riverine and lacustrine zones, the keystone species shift from the Alphaproteobacteria class (Alpha-MOB) to the Gammaproteobacteria class (Gamma-MOB), indicating distinct mechanisms for maintaining community stability in these zones. …”
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CircSATB2 modulates fear extinction memory via Robo3-driven synaptic plasticity by Ziyue Xu, Jichun Shi, Runming Liu, Zhehao Li, Shuangxiang Xu, Hao Gong, Mingyue Fu, Hongyu Xu, Shuangqi Yu, Junhui Liu, Huiqing Wu, Xiang Li, Sha Liu, Wei Wei

“…Following extinction training and subsequent testing, we observed an essential role of circSatb2 in this dynamic process. RNA sequencing (RNA-seq) and bioinformatics analyses revealed that circSatb2 enhances the transcription of Roundabout Guidance Receptor 3 (Robo3), a key gene implicated in axon guidance and synaptic plasticity, which was validated by RT-qPCR. …”
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The Intersection of Epigenetics and Senolytics in Mechanisms of Aging and Therapeutic Approaches by Daiana Burdusel, Thorsten R. Doeppner, Roxana Surugiu, Dirk M. Hermann, Denissa Greta Olaru, Aurel Popa-Wagner

“…Epigenetics refers to heritable changes in gene expression without altering the DNA sequence, with mechanisms like DNA methylation, histone modification, and non-coding RNA regulation playing critical roles in aging. …”
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Identification and characterization of nine PAT1 genes subfamily in Medicago edgeworthii by Gaoping Tang, Tingting Ni, García-Caparrós Pedro, Li-Hua Meng, Xudong Sun

“…GRAS proteins represent a unique class of transcription factors that are exclusive to plants. …”
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MicroRNA in Glioblastoma: An Overview by Barbara Banelli, Alessandra Forlani, Giorgio Allemanni, Anna Morabito, Maria Pia Pistillo, Massimo Romani

“…MicroRNAs (miRNA) are a class of ncRNA of about 22 bp that regulate gene expression by binding to complementary sequences in the mRNA and silence its translation into proteins. …”
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HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia by Maria Tizu, Bogdan Calenic, Mihai Hârza, Bogdan M. Cristea, Ion Maruntelu, Andreea M. Caragea, Adriana Talangescu, Alina Dima, Alexandra E. Constantinescu, Ileana Constantinescu

“…This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology. …”
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miR-28: A Tiny Player in Cancer Progression and Other Human Diseases by Karol Kotarski, Marta Kot, Klaudia Skrzypek

“…MicroRNAs belong to a class of small non-coding RNA molecules that regulate gene expression post-transcriptionally. …”
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459 Development of small molecules targeting an epigenetic modulator for pediatric neuroblastoma by Joseph McPherson, William Pomerantz, Molly Sneddon, Anang Shelat, Wenwei Lin, Taosheng Chen, Marcus Fischer, Natalia Tretyakova

“…Discussion/Significance of Impact: These first-in-class chemical probes for BPTF PHD will enable further investigation of BPTF and high-risk neuroblastoma progression, as well as its role in other diseases. …”
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Phyllosphere mycobiome in two Lycopodiaceae plant species: unraveling potential HupA-producing fungi and fungal interactions by Liqun Lin, Cheng Li, Chiung-Chih Chang, Ran Du, Jiaojiao Ji, Li-Yaung Kuo, Ko-Hsuan Chen

“…We obtained 441 amplicon sequence variants (ASVs) from H. asiatica and 497 ASVs from D. complanatum. …”
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Genotypic characterization of extended-spectrum beta-lactamase-producing E. coli from dogs in northern Germany by Marco Werhahn Beining, Sebastian Guenther, Antina Lüebke-Becker, Stefan E. Heiden, Katharina Schaufler, Lothar Kreienbrock, Michael Schwabe

“…Whole-genome sequencing of these isolates revealed seven phylogroups. …”
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TaZFP 23, a new Cys2/His2-type zinc-finger protein, is a regulator of wheat (Triticum aestivum L.) growth and abiotic stresses by Shunxing Ye, Yuzhou Tang

“…The C2H2-type zinc finger proteins are a common class of transcription factors in plants that play crucial roles in regulating plant growth and development as well as responses to stresses. …”
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Transposable elements as stress adaptive capacitors induce genomic instability in fungal pathogen Magnaporthe oryzae. by Sonia Chadha, Mradul Sharma

“…For heat shock and copper stress exposed samples, eight TEs belonging to class I and II family were employed to obtain DNA profiles. …”
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Identification and evolution of novel cfr-carrying plasmids in XDR Klebsiella pneumoniae strains from a chicken farm by Yiming Feng, Tiantian Li, Shiyun Zhao, Mengxiang Zheng, Jiaxing Shen, Xiaoying Wu, Xuexue Li, Yajun Zhai, Li Yuan, Jianhua Liu, Gongzheng Hu, Yushan Pan, Dandan He

“…Antimicrobial susceptibility testing showed that these strains exhibited an extensively drug-resistant (XDR) phenotype, including resistance to 16 antibiotics across nine classes, notably tigecycline and colistin. Sequence analysis identified both strains as belonging to K10-ST6262, harboring 32 resistance genes and 5 virulence genes. …”
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Replication stress induces POLQ-mediated structural variant formation throughout common fragile sites after entry into mitosis by Thomas E. Wilson, Samreen Ahmed, Amanda Winningham, Thomas W. Glover

“…We propose an important role for mitotic TMEJ in nonrecurrent SV formation genome wide.…”
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T cell redirecting therapy for relapsed multiple myeloma by Melinda S. Y. Tan, Tamer Hellou, David Dingli

“…The approval of chimeric antigen receptor (CAR) T-cells and T-cell engagers (TCE) have considerably improved the survival in these patients with triple and penta-class refractory disease. This paper reviews the clinical outcomes associated with these novel immunotherapeutic agents, including their associated toxicities, their role and optimal sequencing within the treatment landscape of multiple myeloma. …”
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The Potential Link between Gut Microbiota and Serum TRAb in Chinese Patients with Severe and Active Graves’ Orbitopathy by Ting-Ting Shi, Lin Hua, Hua Wang, Zhong Xin

“…Thyrotropin receptor autoantibody (TRAb) stimulates orbital and periorbital tissues and plays a pivotal role in the development of GO. However, the association between gut microbiota and TRAb in GO patients has still remained elusive. …”
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Enhancer Extrachromosomal Circular DNA ANKRD28 Elicits Drug Resistance via POU2F2‐Mediated Transcriptional Network in Multiple Myeloma by Binzhen Chen, Jia Liu, Yaoxin Zhang, Changming Shi, Di Zhu, Guoqiang Zhang, Fei Xiao, Lu Zhong, Minyue Zhang, Lai Guan Ng, Honghui Huang, Tingting Lu, Jian Hou

“…Integrated multi‐omics analysis (H3K27ac ChIP‐seq, scRNA‐seq, scATAC‐seq, CUT&Tag, et al.) identifies eccANKRD28 as an active enhancer involved in drug resistance driven by the key transcription factor, POU class 2 homeobox 2 (POU2F2). POU2F2 interacts with sequence‐specific eccANKRD28 as well as RUNX1 and RUNX2 motifs to form the protein complex, which activates the promoter of oncogenes, including IRF4, JUNB, IKZF3, RUNX3, and BCL2. …”
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Cloning and Identification of Common Carp (<i>Cyprinus carpio</i>) <i>PI3KC3</i> and Its Expression in Response to CyHV-3 Infection by Xiaona Jiang, Lijing Tian, Wanying Ren, Chitao Li, Xuesong Hu, Yanlong Ge, Lei Cheng, Xiaodan Shi, Zhiying Jia

“…These results indicate that the full-length <i>CcPI3KC3</i> sequence was successfully cloned from common carp for the first time, and it might play an important role in the immune system of common carp against CyHV-3 infection. …”
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Transcription factor 4 is a key mediator of oncogenesis in neuroblastoma by promoting MYC activity by Nour A. Aljouda, Dewan Shrestha, Chelsea DeVaux, Rachelle R. Olsen, Satyanarayana Alleboina, Megan Walker, Yong Cheng, Kevin W. Freeman

“…We used genome‐wide expression profiling, TCF4 chromatin immunoprecipitation sequencing (ChIP‐seq) and TCF4 immunoprecipitation–mass spectrometry to determine the role of TCF4 in NB cells. …”
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