RET enhancer haplotype-dependent remodeling of the human fetal gut development program. by Sumantra Chatterjee, Lauren E Fries, Or Yaacov, Nan Hu, Hanna E Berk-Rauch, Aravinda Chakravarti

“…The major contribution to HSCR risk is from common sequence variants in RET enhancers with additional risk from rare coding variants in many genes. …”
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Discovery of novel non-retroviral endogenous viral elements reveals their long-term integration history in spiders by Hengrui Hu, Just M. Vlak, Zhihong Hu, Manli Wang

“…Abstract Endogenous viral elements (EVEs) are widespread in the genomes of various organisms and have played a crucial role in evolution. Historically, research on EVEs primarily focused on those derived from retroviruses; however, the significance of non-retroviral EVEs (nrEVEs) has gradually gained recognition. …”
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AI-driven innovation in antibody-drug conjugate design by Heather A. Noriega, Xiang Simon Wang

“…Antibody-drug conjugates (ADCs) represent a mechanistically defined class of targeted therapeutics that combine monoclonal antibodies with cytotoxic payloads to achieve selective delivery to antigen-expressing carcinoma cells. …”
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First description of archaeal communities in carbonate-rich seafloor and subseafloor sediments from the Southwestern Atlantic slope by Amanda Gonçalves Bendia, Fernanda Mancini Nakamura, Ana Carolina de Araújo Butarelli, Maria Carolina Pezzo Kmit, Raissa Basti Ramos, Camila Negrão Signori, Rafael Andre Lourenço, Michel Michaelovitch de Mahiques, Paulo Yukio Gomes Sumida, Vivian Helena Pellizari

“…We performed 16S rRNA gene sequencing, and found that the archaeal composition in surface sediments was mainly dominated by ammonia-oxidizing archaea within Nitrososphaeria class. …”
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First description of archaeal communities in carbonate-rich seafloor and subseafloor sediments from the Southwestern Atlantic slope by Amanda Gonçalves Bendia, Fernanda Mancini Nakamura, Ana Carolina de Araújo Butarelli, Maria Carolina Pezzo Kmit, Raissa Basti Ramos, Camila Negrão Signori, Rafael Andre Lourenço, Michel Michaelovitch de Mahiques, Paulo Yukio Gomes Sumida, Vivian Helena Pellizari

“…We performed 16S rRNA gene sequencing, and found that the archaeal composition in surface sediments was mainly dominated by ammonia-oxidizing archaea within Nitrososphaeria class. …”
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Hybrid effects in biobased benzoxazine vitrimer composites reinforced with flax and carbon fibres by Killian BOURDON, Vincent BOULIC, Dhahabia ABDALLAH BOINA, Pierre VERGE, Daniel F. SCHMIDT, Tim HUBER

“…Fibre-reinforced vitrimers are an emerging class of recyclable composites, but the influence of fibre type and stacking sequence on performance remains underexplored. …”
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Identification of subcellular localization of Arabidopsis AGO2 by ZHAO Li, XIA Wenqiang, CAI Xinzhong

“…Arabidopsis AGO comprises 10 proteins named from AtAGO1 to AtAGO10, which are grouped into three classes with AtAGO1, AtAGO5 and AtAGO10; AtAGO2, AtAGO3 and AtAGO7; and AtAGO4, AtAGO6, AtAGO8 and AtAGO9 as one class respectively. …”
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Genetic diversity of the KIR/HLA system and susceptibility to hepatitis C virus-related diseases. by Valli De Re, Laura Caggiari, Mariangela De Zorzi, Ombretta Repetto, Anna Linda Zignego, Francesco Izzo, Maria Lina Tornesello, Franco Maria Buonaguro, Alessandra Mangia, Domenico Sansonno, Vito Racanelli, Salvatore De Vita, Pietro Pioltelli, Emanuela Vaccher, Massimiliano Berretta, Cesare Mazzaro, Massimo Libra, Andrea Gini, Antonella Zucchetto, Renato Cannizzaro, Paolo De Paoli

“…KIR2DL5 and KIR2DS4 variants were performed using PCR and GeneScan analysis. HLA/class-I genotyping was performed using PCR-sequence-based typing. …”
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Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects. by Dustin K Bauknight, Victoria Osinski, Siva Sai Krishna Dasa, Anh T Nguyen, Melissa A Marshall, Julia Hartman, Matthew Harms, Gavin O'Mahony, Jeremie Boucher, Alexander L Klibanov, Coleen A McNamara, Kimberly A Kelly

“…The adipose targeting sequence peptide (ATS) could fit this role, as it has been shown to bind to adipose tissue endothelium and induce weight loss when delivered conjugated to a pro-apoptotic peptide. …”
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Creating and Validating a Ground Truth Dataset of Unified Modeling Language Diagrams Using Deep Learning Techniques by Javier Torcal, Valentín Moreno, Juan Llorens, Ana Granados

“…In particular, a dataset of six UML diagram classes was assembled, comprising a total of 2626 images (426 activity diagrams, 636 class diagrams, 352 component diagrams, 357 deployment diagrams, 435 sequence diagrams, and 420 use case diagrams). …”
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Comprehensive Identification of Long Non-coding RNAs in Purified Cell Types from the Brain Reveals Functional LncRNA in OPC Fate Determination. by Xiaomin Dong, Kenian Chen, Raquel Cuevas-Diaz Duran, Yanan You, Steven A Sloan, Ye Zhang, Shan Zong, Qilin Cao, Ben A Barres, Jia Qian Wu

“…We anticipate that these studies will advance the knowledge of this major class of non-coding genes and their potential roles in neurological development and diseases.…”
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Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans. by Leonie M Kamminga, Josien C van Wolfswinkel, Maartje J Luteijn, Lucas J T Kaaij, Marloes P Bagijn, Alexandra Sapetschnig, Eric A Miska, Eugene Berezikov, René F Ketting

“…RNA interference (RNAi)-related pathways affect gene activity by sequence-specific recruitment of Ago proteins to mRNA target molecules. …”
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Isolation of mitogen-activated protein kinase SlMAPK12 gene and characterization of its expression pattern in Solanum lycopersicum by KONG Fu-ling, WANG Jie, CHENG Lin, GUAN Xiao-yan, HE Yan-jun, LU Gang

“…These extracellular stimuli are perceived by the plant through a highly elaborate signaling network, which leads to an adaptive stress response at cellular and organismal levels. A specific class of serine/threonine protein kinases, mitogen-activated protein kinases (MAPKs) play an important role in the transduction of various extra- and intracellular signals and are conserved throughout eukaryotes. …”
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Emergence of tigecycline-resistant Klebsiella pneumoniae ST11 clone in patients without exposure to tigecycline by Rezvan Goodarzi, Mohammadreza Arabestani, Mohmmad Yousef Alikhani, Fariba Keramat, Babak Asghari

“… Introduction: Tigecycline is a unique class of semi-synthetic glycylcyclines developed to treat infections caused by multidrug-resistant Klebsiella pneumoniae. …”
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The mammalian longevity associated acetylome by S. Feldman-Trabelsi, N. Touitou, R. Nagar, Z. Schwartz, A. Michelson, S. Shaki, M. Y. Avivi, B. Lerrer, S. Snir, H. Y. Cohen

“…To further explore the role of acetylation, we develop the PHARAOH computational tool based on the 100-fold differences in longevity within the mammalian class. …”
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Characterisation of guided entry of tail-anchored proteins in Magnaporthe oryzae. by Felix Abah, Qiaojia Zheng, Xinru Chen, Linwan Huang, Xiaomin Chen, Jules Biregeya, Osakina Aron, Zonghua Wang, Wei Tang

“…Tail-anchored (TA) proteins are conserved across diverse organisms and belong to a class of polypeptides that are inserted into the membrane by a hydrophobic sequence located at the C-terminal region. …”
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MultiV_Nm: a prediction method for 2′-O-methylation sites based on multi-view features by Lei Bai, Fei Liu, Yile Wang, Junle Su, Lian Liu

“…As a crucial class of chemical modifications, 2′-O-methylation modification (abbreviated as Nm) is widely distributed in various organisms and plays a very important role in normal cellular physiological activities and the occurrence and development of diseases. …”
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University english teaching evaluation using artificial intelligence and data mining technology by Qiuyang Huang, Wenling Li, Mohd Mokhtar bin Muhamad, Nur Raihan binti Che Nawi, Xutao Liu

“…Data from the English teaching and evaluation system for Computer Science students in the 2018 class at Tianjin University of Science and Technology are collected, analyzed, and processed. …”
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The ILAE classification of epileptic seizures: the 2025 update by D. V. Blinov, A. S. Petrukhin, K. V. Voronkova, E. S. Akarachkova, O. V. Kotova, D. I. Korabelnikov, E. I. Rumyantseva, A. N. Mnatsakanyan

“…Key changes, compared to the previous version include: the removal of the term “onset” from mail seizure class names; introduction of classifiers and descriptors; the term “awareness” has been replaced with “consciousness”; seizures are now described as with or without observable manifestations (basic version) or by the chronological sequence of semiology (expanded version). …”
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A New Binning Method for Metagenomics by One-Dimensional Cellular Automata by Ying-Chih Lin

“…Characterizing the taxonomic diversity for the planet-size data plays an important role in the metagenomic studies, while a crucial step for doing the study is the binning process to group sequence reads from similar species or taxonomic classes. …”
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