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The inhibitory and anti-inflammatory effects of TMP269 on peste des petits ruminants virus replication
Published 2025-12-01“…The replication of many viruses is closely related to the regulation of histone deacetylases (HDACs). TMP269, a selective class IIa HDAC inhibitor, plays an important role in cancer therapy and also modulates viral replication. …”
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Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India
Published 2023-07-01“…The most appropriate hypothesis states that genetic susceptibility in the presence of environmental risk factors predisposes to SLE. HLA class II alleles are critical to immune response and are highly polymorphic. …”
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Genome‐Wide Analysis of the APETALA2/Ethylene‐Responsive Factor Gene Family in Carthamus tinctorius L.
Published 2025-01-01“…ABSTRACT The APETALA2/ethylene‐responsive factor (AP2/ERF) superfamily represents a class of transcription factors involved in plant growth, development, and stress responses. …”
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The role of long non‐coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications
Published 2025-08-01“…The advent of next‐generation sequencing and other high‐throughput technologies guided the discovery of a new class of molecules, non‐coding RNAs (ncRNAs) that play a role in many aspects of cellular physiology. …”
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Comparative analysis of antimicrobial resistance and genetic diversity of Bordetella bronchiseptica isolates obtained from swine within the United States
Published 2024-11-01“…IntroductionBordetella bronchiseptica is bacterial pathogen that is pervasive in swine populations and serves multiple roles in respiratory disease.MethodsThis study utilized whole-genome sequencing (WGS) analysis to assess the sequence type (ST), identify the genetic diversity of genes predicted to encode regulatory and virulence factors, and evaluated any potential antimicrobial resistance harbored by B. bronchiseptica isolates obtained from swine within the U.S.ResultsWhile a generally high degree of genomic conservation was observed among the swine B. bronchiseptica isolates, genetic diversity was identified within the fimNX locus and among the sequence type six (ST6) isolates. …”
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Nasal Microbiota Profiling as a Predictive Secondary Tool for COVID-19 Diagnosis: The Critical Role of Taxonomic Resolution
Published 2025-02-01“…In the present study, we have evaluated the predictive diagnostic potential of nasal microbiota by analyzing microbial community structures at different taxonomic level resolutions—species, genus, family, order, class and phylum—using Random Forest modelling. A total of 179 nasal swabs from COVID-19-positive (n = 85) and COVID-19-negative (n = 94) individuals were sequenced using a full-length 16S rRNA sequencing (Oxford Nanopore) approach. …”
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Remarks on the Relationship Between Fractal Dimensions and Convergence Speed
Published 2025-05-01“…This paper conducts an in-depth investigation into the fundamental relationship between the fractal dimensions and convergence properties of mathematical sequences. By concentrating on three representative classes of sequences, namely, the factorial-decay, logarithmic-decay, and factorial–exponential types, a comprehensive framework is established to link their geometric characteristics with asymptotic behavior. …”
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Phylogenetic diversity and community structure of Planctomycetota from plant biomass-rich environments
Published 2025-05-01“…Understanding the community structure within these habitats is essential for elucidating the ecological roles and metabolic capacities of specific microbial groups. …”
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Function of floral fragrance-related microRNAs and their targets in Hedychium coronarium
Published 2025-04-01“…Abstract Background Hedychium coronarium is highly valued for its intense fragrance, which may be influenced by the expression of microRNAs (miRNAs). miRNAs are a class of small RNAs that play conserved and pivotal regulatory roles throughout plant growth and development, modulating various aspects of plant metabolism. …”
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Comparison of virulence and resistance genes in Mannheimia haemolytica and Pasteurella multocida from dairy cattle with and without bovine respiratory disease
Published 2025-08-01“…AMR genes (22 genes) from 12 antimicrobial classes were identified in P. multocida isolates, while 11 AMR genes for seven antimicrobial classes were identified in M. haemolytica isolates. …”
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Three-Dimensional Modeling of <i>Camelus dromedarius</i> T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Lengt...
Published 2025-05-01“…Methods: The purpose was to investigate, in the absence of 3D structures, the role of Camdro γδ T cells, focusing on the binding interactions at the interface between the V-gamma and V-delta domains, and in complex with the CD1D, a major histocompatibily class I (MH1)-like glycoprotein presenting lipid antigen in association with B2M. …”
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Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus
Published 2025-07-01“…Circular RNAs (circRNAs) are a class of noncoding RNAs that are more stable, abundant, and structurally distinct compared to linear RNAs. …”
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Dynamics of bacterial communities across developmental stages of the litchi stink bug, Tessaratoma javanica
Published 2025-08-01“…Insect-associated bacteria play significant roles in their growth and development. We studied the bacterial communities linked to T. javanica using 16 S rRNA amplicon sequencing and predicted the functions of associated bacterial communities. …”
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