Strict relationship between phenotypic and plasmid-associated genotypic of multidrug-resistant Escherichia coli isolated from Taihe Black-Boned Silky Fowl farms by Li Zhang, Mengjun Ye, Yifan Dong, Lijuan Yuan, Jianjun Xiang, Xiren Yu, Qiegen Liao, Qiushuang Ai, Suyan Qiu, Dawen Zhang

“…The results demonstrated that high rates of antimicrobial resistance were observed, with 100 % and 29.4 % of isolates exhibiting resistance to four or more and eight or more antibiotic classes, respectively. According to whole-genome sequencing, a total of 143 ARGs were identified. …”
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Structural variant allelic heterogeneity in MECP2 duplication syndrome provides insight into clinical severity and variability of disease expression by Davut Pehlivan, Jesse D. Bengtsson, Sameer S. Bajikar, Christopher M. Grochowski, Ming Yin Lun, Mira Gandhi, Angad Jolly, Alexander J. Trostle, Holly K. Harris, Bernhard Suter, Sukru Aras, Melissa B. Ramocki, Haowei Du, Michele G. Mehaffey, KyungHee Park, Ellen Wilkey, Cemal Karakas, Jesper J. Eisfeldt, Maria Pettersson, Lynn Liu, Marwan S. Shinawi, Virginia E. Kimonis, Wojciech Wiszniewski, Kyle Mckenzie, Timo Roser, Angela M. Vianna-Morgante, Alberto S. Cornier, Ahmed Abdelmoity, James P. Hwang, Shalini N. Jhangiani, Donna M. Muzny, Tadahiro Mitani, Kazuhiro Muramatsu, Shin Nabatame, Daniel G. Glaze, Jawid M. Fatih, Richard A. Gibbs, Zhandong Liu, Anna Lindstrand, Fritz J. Sedlazeck, James R. Lupski, Huda Y. Zoghbi, Claudia M. B. Carvalho

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A Survey of the ATP-Binding Cassette (ABC) Gene Superfamily in the Salmon Louse (Lepeophtheirus salmonis). by Greta Carmona-Antoñanzas, Stephen N Carmichael, Jan Heumann, John B Taggart, Karim Gharbi, James E Bron, Michaël Bekaert, Armin Sturm

“…Eighteen sequences were assigned to ABC subfamilies known to contain drug transporters, i.e. subfamilies B (4 sequences), C (11) and G (2). …”
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In silico pooling of ChIP-seq control experiments. by Guannan Sun, Rajini Srinivasan, Camila Lopez-Anido, Holly A Hung, John Svaren, Sündüz Keleş

“…As next generation sequencing technologies are becoming more economical, large-scale ChIP-seq studies are enabling the investigation of the roles of transcription factor binding and epigenome on phenotypic variation. …”
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Integrated analysis of mutation data from various sources identifies key genes and signaling pathways in hepatocellular carcinoma. by Yuannv Zhang, Zhaoping Qiu, Lin Wei, Ruqi Tang, Baofeng Lian, Yingjun Zhao, Xianghuo He, Lu Xie

“…We identified 113 pathways that were significantly mutated in HCC samples and found that the mutated genes included in these pathways contained high percentages of known cancer genes, and damaging genes and also demonstrated high conservation scores, indicating their important roles in liver tumorigenesis. Five classes of pathways that were mutated most frequently included (a) proliferation and apoptosis related pathways, (b) tumor microenvironment related pathways, (c) neural signaling related pathways, (d) metabolic related pathways, and (e) circadian related pathways. …”
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Impact of the soil layer on the soil microbial diversity and composition of Pinus yunnanensis at the Ailao Mountains subtropical forest by Haonan Qiao, Haonan Qiao, Qingchao Zeng, Francis Martin, Francis Martin, Qi Wang

“…Microbial communities residing in forest soils play crucial roles in decomposing organic matter and recycling nutrients, making these ecosystems one of the most diverse habitats on Earth. …”
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Bacterial communities in Nilaparvata lugens (Stål) (Hemiptera: Delphacidae) showed significant variation among the developmental stages with functional diversity by Guru-Pirasanna-Pandi Govindharaj, Jaipal Singh Choudhary, Rudra Madhab Panda, G. Basana-Gowda, M. Annamalai, Naveenkumar Patil, Rashid Mumtaz Khan, Sushmita Banra, Kuldeep Srivastava, S.D. Mohapatra

“…This study analyzed the bacterial community across developmental stages using V3-V4 amplicon sequences of 16S rRNA gene. The microbiome was classified into 20 phyla, 38 classes, 77 orders, 155 families, and 273 genera, with Proteobacteria, Firmicutes, and Bacteroidetes dominating phyla. …”
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DNA repair and replicative stress addiction in neuroblastoma by Kaat Durinck, Meredith S. Irwin

“…While several effective chemotherapies work by increasing replication stress in cancer cells, recently, newer putatively less toxic small molecule-based approaches that directly target DNA damage response (DDR) pathway components such as ATR, CHK1 and PARP inhibitors are being evaluated in early phase trials for many cancers. NB sequencing studies have identified recurrent alterations (copy number and mutations) in many of these genes encoding critical DDR pathway proteins suggesting susceptibility to specific classes of DDR-targeting therapies. …”
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Resistome, virulome, anti-defense mechanisms, and prophages in Helicobacter pylori strains in Asia by Tushar Midha, Navoneel Giri, Somesh Baranwal

“…Background: Helicobacter pylori, an important human gastrointestinal bacterium, exhibits rising antibiotic resistance, posing a huge challenge to disease management. Despite their key roles in disease progression, limited information on H. pylori antibiotic resistance patterns and key virulence factors is available in Asia. …”
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Deep profiling of the novel intermediate-size noncoding RNAs in intraerythrocytic Plasmodium falciparum. by Chunyan Wei, Tengfei Xiao, Peng Zhang, Zhensheng Wang, Xiaowei Chen, Lianhui Zhang, Meixue Yao, Runsheng Chen, Heng Wang

“…Intermediate-size noncoding RNAs (is-ncRNAs) have been shown to play important regulatory roles in the development of several eukaryotic organisms. …”
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Diversity of endophytic bacteria in mulberry (Morus spp.) scions with different genetic resources by Yun-fei Zhang, Ying-ting Qin, Ze-yu Liu, Hao-ran Zheng, Xu-dong Hu, Xi-ling Wang

“…Endophytic bacteria in plants play crucial roles in promoting plant growth, facilitating nutrient acquisition, and enhancing stress tolerance. …”
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