IRX-related homeobox gene MKX is a novel oncogene in acute myeloid leukemia. by Stefan Nagel, Corinna Meyer, Claudia Pommerenke

“…Here, we examined the role of IRX-related homeobox gene MKX (also termed IRXL1 or mohawk) in normal and malignant hematopoiesis. …”
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High-Risk Neuroblastoma Stage 4 (NBS4): Developing a Medicinal Chemistry Multi-Target Drug Approach by Amgad Gerges, Una Canning

“…Childhood neuroblastoma (NB) is a malignant tumour that is a member of a class of embryonic tumours that have their origins in sympathoadrenal progenitor cells. …”
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Variations in the archaeal community in wetlands soils under various hydrologic conditions in the Yellow River Estuary by Qingqing Zhao, Jia Jia, Fanyong Song, Tianyuan Li, Wen Zhang, Yujie Huang

“…Here, the archaeal diversity and community structure in 0 - 20 cm soils from freshwater influenced wetlands (FIW), flooding freshwater and underground seawater influenced wetlands (MIW) and seawater influenced wetlands (SIW) in the Yellow River Nature Reserve were examined utilizing high-throughput sequencing of 16S rRNA gene sequencing. Based on the comparison of the alpha diversity indices, the abundance and diversity of the archaeal community in wetlands with varying hydrologic conditions did not significantly change (p > 0.05), with Thaumarchaeota and Marine_Group_I as the predominant archaeal phylum and class in all the three sampled sites, respectively. …”
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Biology, genetics, and ecology of the cosmopolitan ectomycorrhizal ascomycete Cenococcum geophilum by Huayong Wang, Annegret Kohler, Francis M. Martin, Francis M. Martin

“…As the only known ECM species within the large class Dothideomycetes, C. geophilum exhibits several characteristics that distinguish it from other ECM fungi. …”
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Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases by Cheng-Cheng Deng, Xue-Yan Xu, Yan Zhang, Long-Can Liu, Xuan Wang, Jun-Yi Chen, Liu-Yi Yao, Ding-Heng Zhu, Bin Yang

“…The immune cells are postulated to exert a pivotal role in the development of fibrotic skin disease. …”
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In vitro expression analysis of the ITGB3 c.598G/A mutation and its association with FNAIT by DING Haoqiang, YE Xin, XU Xiuzhang, XIA Wenjie, DENG Jing, LIU Jing, CHEN Yangkai, CHEN Dawei, XU Yaori

“…[Objective] To explore the role of the c.598G>A mutation of the ITGB3 gene in the occurrence of fetal and neonatal alloimmune thrombocytopenia (FNAIT) through its expression in vitro. …”
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Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity by Gracia Luque, Pilar Ortiz, Alfonso Torres-Sánchez, Alicia Ruiz-Rodríguez, Ana López-Moreno, Margarita Aguilera

“…Future research will be essential to evaluate these microbial taxa as potential biomarkers for biomonitoring the effect of BPA and its role as an obesogenic substance in children.…”
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<i>GSTD1</i> Mediates the Tolerance to Abamectin and Beta-Cypermethrin in the Fall Armyworm <i>Spodoptera frugiperda</i> by Qian Ding, Yangyang Liu, Baoxiang Dai, Yujie Han, Yan Zhang, Zhongyuan Deng, Lixiang Wang, Xianchun Li

“…Glutathione S-transferase (GST) is a class of detoxifying enzymes in the second stage of insect metabolism and plays a key role in insecticide resistance. …”
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Integron-Mediated Antimicrobial Resistance and Virulence Factors in <i>Salmonella</i> Typhimurium Isolated from Poultry by Elizabeth Kim, Nora Jean Nealon, Katherine A. Murray, Cydney Jardine, Roberta Magnuson, Sangeeta Rao

“…This study investigates antimicrobial-resistant (AMR) <i>Salmonella</i> Typhimurium in poultry, focusing on how class I integrons contribute to AMR and virulence. …”
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Genome-resolved transcriptomics reveals novel PCE-dehalogenating bacteria from Aarhus Bay sediments by Chen Zhang, Tom N. P. Bosma, Siavash Atashgahi, Hauke Smidt

“…Combining short- and long-read sequencing approaches, we assembled 37 medium-quality bins with over 75% completeness and less than 5% contamination. …”
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Detection of a Novel Gull-like Clade of Newcastle Disease Virus and H3N8 Avian Influenza Virus in the Arctic Region of Russia (Taimyr Peninsula) by Anastasiya Derko, Nikita Dubovitskiy, Alexander Prokudin, Junki Mine, Ryota Tsunekuni, Yuko Uchida, Takehiko Saito, Nikita Kasianov, Arina Loginova, Ivan Sobolev, Sachin Kumar, Alexander Shestopalov, Kirill Sharshov

“…All NDV sequences were obtained from the Herring gull, and other gull sequences formed a separate gull-like clade in the sub-genotype I.1.2.1, Class II. …”
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Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner by Wen Ge, Xiaohua Zhang, Jie Lin, Yangyang Wang, Xiao Zhang, Yu Duan, Xinchun Dai, Jiye Zhang, Yan Zhang, Mengyuan Jiang, Huanhuan Qiang, Zhijing Zhao, Xuebin Zhang, Dongdong Sun

“…Mitochondrial dysfunction plays a central role in DIC, primarily through disrupting mitochondrial dynamics. …”
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Link of TMPRSS2 expression with tumor immunogenicity and response to immune checkpoint inhibitors in cancers by Karthikeyan Subbarayan, Helena Bieber, Chiara Massa, Felipe Adonis Escalona Rodríguez, SM Al Amin Hossain, Lisa Neuder, Wafa Wahbi, Tuula Salo, Sandy Tretbar, Ahmed Al-Samadi, Barbara Seliger

“…Despite cancer patients often experience poorer outcomes following SARS-CoV-2 infection, the role of TMPRSS2 in different cancer types has not yet been analyzed in detail. …”
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Trehalose-6-phosphate synthase gene expression analysis under abiotic and biotic stresses in bottle gourd (Lagenaria siceraria) by Shuoshuo Wang, Wenli Li, Han Jin

“…Variable exon numbers were found in the LsTPS genes, with more exons in Class II than in Class I genes. GO term enrichment and cis-regulatory element analyses indicated that LsTPS genes participate in Tre synthesis and environmental stress responses. …”
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Genome-wide identification, characterization and expression analysis of CNGC Genes in moso bamboo (Phyllostachys edulis) by Jiaqi Tan, Xueyun Xuan, Shiying Su, Hui Guo, Yang Jiao, Zhijun Zhang

“…Multiple cis-elements involved in positive regulation were present in the ascending promoter domain of the CNGC gene sequence, with a role in abiotic stress and hormone signal transduction. …”
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Metabolomic Signatures Highlight Fiber-Degrading Bacteroides Species in Mediterranean Diet Response Among Ulcerative Colitis by Natasha Haskey, Jiayu Ye, Jessica Josephson, Maitreyi Raman, Sanjoy Ghosh, Deanna L. Gibson

“…Liquid chromatography-tandem mass spectrometry was employed to profile endogenous fecal metabolites, while 16S amplicon sequencing was utilized to profile the fecal microbiota. …”
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Comprehensive Analysis of N6-Methyladenosine (m6A) RNA Methylation Regulators and Tumour Microenvironment Cell Infiltration Involving Prognosis and Immunotherapy in Gastroesophagea... by Duanrui Liu, Mingjie Yuan, Zongming Wang, Liping Sun, Yusong Fang, Xiaoli Ma, Lulu Zhang, Yuanxin Xing, Jingyu Zhu, Yunyun Liu, Wenshuai Zhu, Shuqin Bao, Yanfei Jia, Yunshan Wang

“…RNA N6-methyladenosine (m6A) modification plays a non-negligible role in shaping individual tumour microenvironment (TME) characterizations. …”
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Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. by Ceri A Fielding, Rebecca Aicheler, Richard J Stanton, Eddie C Y Wang, Song Han, Sepehr Seirafian, James Davies, Brian P McSharry, Michael P Weekes, P Robin Antrobus, Virginie Prod'homme, Fabien P Blanchet, Daniel Sugrue, Simone Cuff, Dawn Roberts, Andrew J Davison, Paul J Lehner, Gavin W G Wilkinson, Peter Tomasec

“…This activating receptor recognizes eight distinct ligands (the MHC Class I polypeptide-related sequences (MIC) A andB, and UL16-binding proteins (ULBP)1-6) induced by cellular stress to promote recognition cells perturbed by malignant transformation or microbial infection. …”
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First opinion practice electronic health records are a useful source of descriptions of medication errors by Eirini Petrou, Eirini Petrou, Heather Davies, Heather Davies, Maria Aoun, Alan D. Radford, David Singleton, David Singleton, Peter-John M. Noble, David R. Killick

“…Identified MedEs were then classified by the linear sequence of medication therapy, the degree of harm caused, the role of the person who made the error, and the medication type involved.ResultsIn total, 6,665 EHRs were identified by the REGEX, of which a random 2,847 were manually reviewed, with 1,023 (35.9%) matching the MedEs case definition. …”
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Plasmid profile analysis of Escherichia coli isolates recovered from the beef production chain by Dr Libby Onyeka, Prof Abiodun Adesiyun, Prof Karen Keddy, Prof Peter Thompson

“…Introduction: Resistance plasmids play a vital role in the tranmission of antibiotic resistance genes (ARGs) from animals to humans through the food chain. …”
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