Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses by Heidi Harjunpää, Riku Somermäki, Guillem Saldo Rubio, Manlio Fusciello, Sara Feola, Imrul Faisal, Anni I Nieminen, Liang Wang, Marc Llort Asens, Hongxia Zhao, Ove Eriksson, Vincenzo Cerullo, Susanna C Fagerholm

“…We now show that the loss of β2-integrin-mediated adhesion of BM-DCs also leads to a generally suppressed metabolic profile, with reduced metabolic rate, decreased ROS production, and lowered glucose uptake in cells. …”
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Mitochondrial DNA depletion syndrome 13. A case report by G. S. Golosnaya, O. N. Krasnorutskaya, N. A. Ermolenko, V. L. Efimova, T. A. Larionova, D. M. Subbotin, D. A. Feklistov, M. D. Tysyachina

“…FBXL4-related encephalomyopathy is a multisystem disease primarily affecting the central nervous system, heart, and liver. It is characterized by different clinical manifestations such as lactic acidosis, developmental delay, generalized hypotension, nutritional disorders, and growth retardation. …”
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Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. by Fanggeng Zou, High Seng Chai, Curtis S Younkin, Mariet Allen, Julia Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Asha A Nair, Sumit Middha, Sooraj Maharjan, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Ryan Palusak, Sarah Lincoln, Gina Bisceglio, Constantin Georgescu, Naomi Kouri, Christopher P Kolbert, Jin Jen, Jonathan L Haines, Richard Mayeux, Margaret A Pericak-Vance, Lindsay A Farrer, Gerard D Schellenberg, Alzheimer's Disease Genetics Consortium, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner

“…Our findings have implications for the design and interpretation of eGWAS in general and the use of brain expression quantitative trait loci in the study of human disease genetics.…”
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Epidemiology of Mycobacterium tuberculosis complex infections in cattle and humans in the remote pastoral settings of southern Ethiopia by Temesgen Mohammed, Temesgen Mohammed, Fekadu Desta, Biniam Wondale, Biniam Wondale, Aboma Zewude, Aboma Zewude, Gezahegne Mamo, Hazim O. Khalifa, Hazim O. Khalifa, Berecha Bayissa, Gobena Ameni

“…Mycobacterial culture positivity was 13.4%, while spoligotyping identified Euro-American (EA), East African-Indian (EAI), Indo-Oceanic (IO), lineage 7, M. bovis, and M. africanum as the major lineages, with proportions of 67.3% (105/156), 22.4% (35/156), 6.4% (10/156), 1.9% (3/156), 1.3% (2/156), and 0.6% (1/156), respectively.ConclusionIn general, the prevalence of bovine TB was relatively lower than that recorded in intensive dairy farms in central Ethiopia. …”
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GRACE: protocol for a UK, secondary care, multicentre, assessor-blinded randomised controlled trial with a non-inferiority comparison to evaluate graduated compression stockings as... by John Norrie, Rebecca Lawton, Jonathan L Rees, Joseph Shalhoub, Beverley J Hunt, Zaed Hamady, Maria Kyrgiou, Tom Pinkney, Andrew D Beggs, Tamara Everington, Linda Williams, Simon Toh, Francine Heatley, Alun Davies, Matthew Machin, Nick Watkin, Sasha Smith, Sara Jasionowska, Alexander Liddle, Layla Bolton Saghdaoui

“…Following randomisation, participants will undergo surgery and be followed up centrally at 7, 21–35 and 90 days after their procedure. …”
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Rates of severe complications in patients undergoing colorectal surgery for deep endometriosis—a retrospective multicenter observational study by Gernot Hudelist, Matthias Korell, Michael Burkhardt, Radek Chvatal, Ezgi Darici, Desislava Dimitrova, Jan Drahonovsky, Bashar Haj Hamoud, Daniela Hornung, Bernhard Krämer, Guenter Noe, Peter Oppelt, Sebastian Daniel Schäfer, Beata Seeber, Uwe Andreas Ulrich, Rene Wenzl, Rudy Leon De Wilde, Pauline Wimberger, Birgit Senft, Joerg Keckstein, Eliana Montanari, Cloe Vaineau, Martin Sillem

“…Major complications may decrease with an increase in the volume of activity but this effect cannot be generally applied to all institutions and settings.…”
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An Overview of the Systematic Reviews About the Efficacy of Fluvoxamine on Depression by Luiz Henrique Junqueira Dieckmann, Michel Haddad, Thiago Wendt Viola, Franciele Franco Scarante, Naielly Rodrigues da Silva, Jair de Jesus Mari

“…Methods: A systematic search was conducted in MEDLINE and the Cochrane Central Register of Controlled Trials, including systematic reviews and meta-analyses of randomized controlled trials evaluating fluvoxamine’s efficacy. …”
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A cervical screening initiative for elderly women in Denmark by Malene Skorstengaard, Petra Hall Viborg, Ane Birgitte Telén Andersen, Berit Andersen, Mary Holten Bennetsen, Kirsten Marie Jochumsen, Tonje Johansen, Lise Grupe Larsen, Maja Ulrikka Bruun Laustsen, Rouzbeh Salmani, Reza Serizawa, Marianne Waldstrøm, Elsebeth Lynge

“…Material and methods Women born 1947 or before were personally invited to have a cell‐sample collected by their general practitioner. Screening‐ and follow‐up samples were analyzed in hospital laboratories in the five Danish regions and registered centrally. …”
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The recent trend of twin epidemic in the United States: a 10-year longitudinal cohort study of co-prescriptions of opioids and stimulantsResearch in context by Seungyeon Lee, Wenyu Song, David W. Bates, Richard D. Urman, Ping Zhang

“…Summary: Background: In recent years, the use of central nervous system stimulant medications has increased among the population already using opioids, referred to as a “twin epidemic.” …”
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Association of lower-limb strength with different fall histories or prospective falls in community-dwelling older people: a systematic review and meta-analysis by Ringo Tang-Long Zhu, Jenny Jing-Jing Zuo, Ke-Jing Li, Freddy Man Hin Lam, Arnold Yu Lok Wong, Lin Yang, Xue Bai, Man Sau Wong, Timothy Kwok, Yong-Ping Zheng, Christina Zong-Hao Ma

“…Conversely, low to very low quality of evidence showed that the RTD of a single muscle group could not predict prospective falls and was generally unable to identify fall history in older adults. …”
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Leveraging artificial intelligence for photo identification to aid CITES enforcement in combating illegal trade of the endangered humphead wrasse (Cheilinus undulatus) by C. Y. Hau, W. K. Ngan, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson, Y. Sadovy de Mitcheson

“…The beta version of ‘Saving Face’ is available, and general public users can contribute supplementary information for enforcement and continuous model optimization. …”
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Longitudinal field evaluation of outdoor Anopheles and non-Anopheles host-seeking in response to a volatile pyrethroid spatial emanator (SE) product among forest-dwelling indigenou... by Timothy A. Burton, Lepa Syahrani, Dendi Hadi Permana, Ismail Ekoprayitno Rozi, Rifqi Risandi, Siti Zubaidah, Syarifah Zulfah, Ma’as M. Maloha, Rusli Efendi, Maria Kristiana, Puji B. S. Asih, Din Syafruddin, Neil F. Lobo

“…Collections occurred near Bukit Duabelas National Park in central Sumatra, an area characterized by secondary forests undergoing widespread conversion to palm and rubber plantations. …”
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Assessing potential desflurane-induced neurotoxicity using nonhuman primate neural stem cell models by Cheng Wang, Leah E. Latham, Shuliang Liu, John Talpos, Tucker A. Patterson, Joseph P. Hanig, Fang Liu

“…Safety concerns about general anesthetics (GA), such as desflurane (a commonly used gaseous anesthetic agent), arose from studies documenting neural cell death and behavioral changes after early-life exposure to anesthetics and compounds with related modes of action. …”
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Does Bilirubin Have a Causal Relationship With Vitiligo? A Mendelian Randomization Study and Bioinformatics Analysis by Xu D, Yin Y, Teng Y, Huang Y, Yu Y, Tao X, Fan Y, Ding X

“…Bioinformatics analyses identified 136 DEGs in generalized vitiligo, 32 in segmental vitiligo, and 9 in non-segmental vitiligo. …”
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Intraoperative change in distal motor latency as a predictor for clinical outcome after mini-OCTR: a retrospective cohort study by Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chenpei Xu, Chenpei Xu, Chenpei Xu, Chenpei Xu, Chenpei Xu, Chenpei Xu, Biao Yan, Philippe Liverneaux, Philippe Liverneaux, Su Jiang, Su Jiang, Su Jiang, Su Jiang, Su Jiang, Su Jiang, Su Jiang

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Extranodal diffuse large B‐cell lymphoma: Clinical and molecular insights with survival outcomes from the multicenter EXPECT study by Si‐Yuan Chen, Peng‐Peng Xu, Ru Feng, Guo‐Hui Cui, Li Wang, Shu Cheng, Rong‐Ji Mu, Hui‐Lai Zhang, Xiao‐Lei Wei, Yong‐Ping Song, Kai‐Yang Ding, Li‐Hua Dong, Zun‐Min Zhu, Shen‐Miao Yang, Xin Wang, Ting‐Bo Liu, Jian‐Da Hu, Xiao‐Yun Zheng, Ou Bai, Jing‐Yan Xu, Liang Huang, Wei Sang, Ke‐Qian Shi, Fan Zhou, Fei Li, Ai‐Bin Liang, Hui Zhou, Si‐Guo Hao, Hong‐Hui Huang, Bin Xu, Wen‐Bin Qian, Cai‐Xia Li, Zhi‐Ming Li, Chong‐Yang Wu, Xiao‐Bo Wang, Wen‐Yu Shi, Shu‐Ye Wang, Yu‐Yang Tian, Xi Zhang, Ke‐Shu Zhou, Li‐Juan Cui, Hui Liu, Huo Tan, Qing Leng, Dong‐Lu Zhao, Ting Niu, Wei‐Li Zhao

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The 4Rs Framework of Sports Nutrition: An Update with Recommendations to Evaluate Allostatic Load in Athletes by Diego A. Bonilla, Jeffrey R. Stout, Michael Gleeson, Bill I. Campbell, Guillermo Escalante, Daniel Rojas-Valverde, Jorge L. Petro, Richard B. Kreider, Adrián Odriozola-Martínez

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Delivering nutrition interventions to women and children in conflict settings: a systematic review by Zulfiqar A Bhutta, Michelle F Gaffey, Jai K Das, Mariella Munyuzangabo, Fahad J Siddiqui, Sarah Meteke, Daina Als, Reena P Jain, Amruta Radhakrishnan, Shailja Shah, Anushka Ataullahjan, Zahra Ali Padhani, Wardah Ahmed

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Micro-costing analysis from Italian Guidelines for the management of sporadic primary hyperparathyroidism by Ilaria Valentini, Michele Basile, Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Alexia Giovanazzi, Roberto Novizio, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Stefano Laureti, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Franco Grimaldi, Renato Cozzi, Roberto Attanasio

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Educação Física: Avaliação das competências motoras em alunos de seis anos, do primeiro ano de escolaridade (Educación Física: Evaluación de las habilidades motoras en los estudian... by Ana Quitério Quitério, João Costa, Maria Martins, João Martins, Marcos Onofre, Erin Gerlach, Claude Scheuer, Christian Herrmann

“… Enquadramento teórico: As competências motoras (CM) básicas constituem um objetivo central da Educação Física, sendo reconhecidas como fundamentais para a literacia física das crianças e jovens.  …”
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