Decoding neuroinflammation in Alzheimer’s disease: a multi-omics and AI-driven perspective for precision medicine by Shiyu Lin, Yijun Zhan, Ruiqi Wang, Jian Pei

“…The development of single-cell RNA sequencing (scRNA-seq) has made it possible to analyze cellular heterogeneity in AD brain tissues at high resolution, breaking through the limitation of signal averaging in traditional large-scale tissue analysis. …”
Get full text

Examining Classic Bioimpedance Vector Patterns Between BMI Classifications Among Community-Dwelling Older Women by Kworweinski Lafontant, David H. Fukuda, Dea Chovatia, Cecil Latta, Chitra Banarjee, Jeffrey R. Stout, Rui Xie, Janet Lopez, Ladda Thiamwong

“…Bioelectrical impedance vector analysis (BIVA) is a non-invasive and accessible method for assessing body composition and cellular health (e.g., resistance/height, reactance/height, phase angle), yet little is known about how BMI categories differ in cellular health. …”
Get full text

Restauración volumétrica autóloga en pacientes con hemiatrofia adiposa facial by Alicia María Tamayo-Carbón, MD, Gloribeth Carrasco, MD, Melvis Anaya-Blanco, MD, Zainela Labordes-López, MD, Miguel del Toro-Pazos, MD, Diana Katherine Cuastumal-Figueroa, MD

“…Both sexes were included, between 19 and 75 years old, with facial asymmetry due to unilateral decrease in subcutaneous cellular tissue. Results: The average age was 47.9 years. …”
Get full text

CLINICAL AND IMMUNOLOGICAL STATUS OF PATIENTS WITH GENERALIZED PARODONDITIS ASSOCIATIED WITH CHRONIC HEPATITIS B VIRUS (HBV) INFECTION by V.I. Fesenko, S.V. Shvets

“…This type of immune status can be described as active in humoral and supresive in cellular on the link. Patients had dysimunohlobulinemiya that was determined by increased blood levels of IgG - to 17.7 ± 0.6 g / l, which is on average 1.3 times higher than similar rates in healthy individuals. …”
Get full text

Comparative Analysis of the Bioactivity and Anti-Inflammatory Effects Against Endotoxin in Mitochondria for Transplantation: Impact of Muscle Origin in Rats by Da-Wei Huang, Heng-Juei Hsu, Pei-Wen Chen, Ming-Tse Wu, Chia-En Wong, Chi-Chen Huang, Po-Hsuan Lee, Hui-Fang Chen, Jung-Shun Lee

“…Background: Mitochondria are essential for cellular energy production and cell survival. Mitochondrial dysfunction has been implicated in various neurological disorders, prompting the development of novel therapeutic approaches targeting these organelles. …”
Get full text

Analysis of mutations in precision oncology using the automated, accurate, and user-friendly web tool PredictONCO by Rayyan Tariq Khan, Petra Pokorna, Jan Stourac, Simeon Borko, Adam Dobias, Joan Planas-Iglesias, Stanislav Mazurenko, Ihor Arefiev, Gaspar Pinto, Veronika Szotkowska, Jaroslav Sterba, Jiri Damborsky, Ondrej Slaby, David Bednar

“…We demonstrate the applicability of the tool by presenting its usage for variants in two cancer-associated proteins, cellular tumour antigen p53 and fibroblast growth factor receptor FGFR1. …”
Get full text

Exposure to copper metal enhances the tolerance of An. gambiae s.s. over multiple generations while reducing both fertility and fecundity in this primary malaria vector. [version 1... by Adam Gbankoto, Rousseau Djouaka, Camille Dossou, Louckman Monra Seidou, Ghislain T. Tepa-Yotto, Danahé Adanzounon, Genevieve Tchigossou, Innocent Djègbè, Aldo Emmanuel C. Glokpon, Massioudou Koto Yérima Gounou Boukari, Eric Tossou, Donald Hessou-Djossou

Get full text

<i>Sulfurimonas microaerophilic</i> sp. nov. and <i>Sulfurimonas diazotrophicus</i> sp. nov.: Two Novel Nitrogen-Fixing and Hydrogen- and Sulfur-Oxidizing Chemolithoautotrophs With... by Yangsheng Zhong, Yufei Li, Zhaodi Wang, Liang Cui, Shiwei Lv, Han Zhu, Qing Yuan, Qiliang Lai, Shasha Wang, Lijing Jiang

“…Strain HSL1-7^T and HSL3-1^T were obligate chemolithoautotrophs, capable of using molecular hydrogen and thiosulfate as an energy source, and molecular oxygen and elemental sulfur as the electron acceptors for growth. Cellular fatty acid profiles revealed similar predominant components (C_16:1<i>ω7c</i>, C_16:0, C_18:1<i>ω7c</i>, and C_14:0) in both strains. …”
Get full text

Metabolomic profiling in heart failure as a new tool for diagnosis and phenotyping by Maria V. Kozhevnikova, Yuri N. Belenkov, Ksenia M. Shestakova, Anton A. Ageev, Pavel A. Markin, Anastasiia V. Kakotkina, Ekaterina O. Korobkova, Natalia E. Moskaleva, Ivan V. Kuznetsov, Natalia V. Khabarova, Alexey V. Kukharenko, Svetlana A. Appolonova

“…The observed metabolic similarities between HF with mildly reduced EF and HF with reduced EF phenotypes (AUC ROC 0.96) once again highlight the fundamental differences at the cellular and molecular levels between HF with preserved EF and HF with EF < 50%. …”
Get full text

Frequent failure of nutrients to increase plant biomass supports the need for precision fertilization in agriculture by Oliver H. Carroll, Eric W. Seabloom, Elizabeth T. Borer, W. Stanley Harpole, Peter Wilfahrt, Carlos A. Arnillas, Jonathan D. Bakker, Dana M. Blumenthal, Elizabeth Boughton, Miguel N. Bugalho, Maria Caldeira, Malcolm M. Campbell, Jane Catford, Qingqing Chen, Christopher R. Dickman, Ian Donohue, Mary Ellyn DuPre, Anu Eskelinen, Catalina Estrada, Philip A. Fay, Evan D. G. Fraser, Nicole Hagenah, Yann Hautier, Erika Hersh-Green, Ingibjörg S. Jónsdóttir, Taku Kadoya, Kimberly Komatsu, Luciola Lannes, Maowei Liang, Harry Olde Venterink, Pablo Peri, Sally A. Power, Jodi N. Price, Zhengwei Ren, Anita C. Risch, Grégory Sonnier, G. F. Veen, Risto Virtanen, Glenda M. Wardle, Elizabeth F. Waring, George Wheeler, Laura Yahdjian, Andrew S. MacDougall

Get full text

Forecasting Spatiotemporal Dynamics of Daytime Surface Urban Cool Islands in Response to Urbanization in Drylands: Case Study of Kerman and Zahedan Cities, Iran by Mohammad Karimi Firozjaei, Naeim Mijani, Solmaz Fathololoumi, Jamal Jokar Arsanjani

“…Various methods, including a random forest algorithm, spectral indices, Cellular Automata-Markov (CA-Markov) model, the cross-tabulation model, and spatial overlay and zonal statistics, were employed to assess and model the spatiotemporal changes in SUCII. …”
Get full text

Quantitative multiplexed analysis of gene and protein expression patterns in Yarrowia lipolytica by Erin Bredeweg, Galya Orr, Dehong Hu

“…Our findings highlight the need for single-cell resolution analyses to describe cellular dynamics and regulatory processes.…”
Get full text

Emerging technologies of single-cell multi-omics by Yi June Kim, Koichi Takahashi

“… The heterogeneity of the hematopoietic system was largely veiled by traditional bulk sequencing methods, which measure the averaged signals from mixed cellular populations. In contrast, single-cell sequencing has enabled the direct measurement of individual signals from each cell, significantly enhancing our ability to unveil such heterogeneity. …”
Get full text

Altered patterning of neural activity in a neuropathology by Clarissa Hoffman, Jingheng Cheng, Rodrigo Morales, Daoyun Ji, Yuri Dabaghian

“…Abstract The dynamics of neural circuits and their role in mediating cellular and organismal phenomena remain poorly understood, despite numerous efforts to dissect these processes through precise instantaneous measurements or longer-time averages and approximations. …”
Get full text

Testing the limits of gradient sensing. by Vinal Lakhani, Timothy C Elston

“…The ability to detect a chemical gradient is fundamental to many cellular processes. In multicellular organisms gradient sensing plays an important role in many physiological processes such as wound healing and development. …”
Get full text

Breeding of a new mid-to-late ripening apple cultivar Wangyuebingcui by XU Haihong, YANG Kai, LI Guangjin, ZHANG Guoqiang, TIAN Ge, AI Bohao, LI Xuqiang, WANG Junya

“…The waxy and blemish-free surface encases creamy-white flesh exhibiting dense cellular structure, notable crispness, and abundant juice secretion. …”
Get full text

A phase II/III, randomized, double-blind, placebo-controlled trial to evaluate immunogenicity and safety of the Gam-COVID-Vac combined vector vaccine in the prophylactic treatment... by Ahmed A.K. AlHammadi, Amna H. Alzaabi, Haneen B. Choker, Ahmed A. Ibrahim, Asma Bin Ishaq, Ahmed E. Mahboub, Reem S. Al Dhaheri, Mohamed N. Alzaabi, Timothy A. Collyns, Gehad ElGhazali, Stefan Weber, Basel K. Al-Ramadi

“…Conclusions: Gam-COVID-Vac vaccine showed a good safety profile and induced durable humoral and cellular immune responses. The viral-specific CD8+ T-cell response was more durable following vaccination than CD4+ T cell counterpart. …”
Get full text

Glioblastoma and Blood Microenvironment Predictive Model for Life Expectancy of Patients by Alexander N. Chernov, Sofia S. Skliar, Mikalai M. Yatskou, Victor V. Skakun, Sarng S. Pyurveev, Ekaterina G. Batotsyrenova, Sergey N. Zheregelya, Guodong Liu, Vadim A. Kashuro, Dmitry O. Ivanov, Sergey D. Ivanov

“…<b>Background:</b> Glioblastoma multiforme (GBM) is a very malignant brain tumor. GBM exhibits cellular and molecular heterogeneity that can be exploited to improve patient outcomes by individually tailoring chemotherapy regimens. …”
Get full text

Multi-scale approaches for high-speed imaging and analysis of large neural populations. by Johannes Friedrich, Weijian Yang, Daniel Soudry, Yu Mu, Misha B Ahrens, Rafael Yuste, Darcy S Peterka, Liam Paninski

“…Progress in modern neuroscience critically depends on our ability to observe the activity of large neuronal populations with cellular spatial and high temporal resolution. However, two bottlenecks constrain efforts towards fast imaging of large populations. …”
Get full text

Ecological Observations of the Effects of Magnetized Water on the Fresh Water Snail Physa acuta (Draparnoud, 1805) by Qater Al-Nada A. Al-Ibady, Emaduldeen A. Almukhtar, Khaalid A. Rasheed

“…The total length of animals in millimeters for control and those exposed to intensity respectively (1.9-10)(1.83-12.43) and lengths of shell pore(1.3-7)(1.3-6.75)and wide shell pore (0.88-3.75)(0.83-6.85) and height shell(1-6)(0.95-5.75). The averages of body weight in gram for control animals and those exposed to intensity were respectively (0.1078)(0.1631).The results obtained in this study  may be related to some important biological activities such as molecular and cellular during the growth period of the snails. …”
Get full text